| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Uma Devi P et al. | In vivo radioprotection by ocimum flavonoids: survival of mice. | 1999 | Radiat. Res. | pmid:9973087 |
| Kuiper GG et al. | Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. | 1998 | Endocrinology | pmid:9751507 |
| Kitsos CM and Stadtländer CT | Helicobacter pylori in liquid culture: evaluation of growth rates and ultrastructure. | 1998 | Curr. Microbiol. | pmid:9705648 |
| Bylka W and Matławska I | Flavonoids from Aquilegia vulgaris L. Part II. Derivatives of apigenin and luteolin. | 1997 Jul-Aug | Acta Pol Pharm | pmid:9511462 |
| Lin YM et al. | In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora. | 1997 | J. Nat. Prod. | pmid:9322359 |
| Aida Y et al. | Synthesis of 7-methoxyapigeninidin and its fungicidal activity against Gloeocercospora sorghi. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8987602 |
| Critchfield JW et al. | Inhibition of HIV activation in latently infected cells by flavonoid compounds. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8825617 |
| Lyckander IM and Malterud KE | Lipophilic flavonoids from Orthosiphon spicatus prevent oxidative inactivation of 15-lipoxygenase. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804120 |
| Akama T et al. | Novel 5-aminoflavone derivatives as specific antitumor agents in breast cancer. | 1996 | J. Med. Chem. | pmid:8784443 |
| Palomino OM et al. | Isoscutellarein 7-glucosyl(1-->2)xyloside from sixteen species of Sideritis. | 1996 | Phytochemistry | pmid:8728059 |
| Schüssler M et al. | Functional and antiischaemic effects of Monoacetyl-vitexinrhamnoside in different in vitro models. | 1995 | Gen. Pharmacol. | pmid:8690247 |
| Tschiersch K and Hölzl J | [Absorption and excretion of apigenin, apigenin-7-glycoside and herniarin after oral administration of extracts of Matricaria recutita (L.) (syn. Chamomilla recutita (L.) Rauschert)]. | 1993 | Pharmazie | pmid:8415854 |
| Mahmood N et al. | Inhibition of HIV infection by flavanoids. | 1993 | Antiviral Res. | pmid:8279812 |
| Lin M and Li SZ | [Studies on the chemical constituents of Populus tomentosa carr]. | 1993 | Yao Xue Xue Bao | pmid:8249602 |
| Engelhardt UH et al. | Determination of flavone C-glycosides in tea. | 1993 | Z Lebensm Unters Forsch | pmid:8237118 |
| Merfort I et al. | In vivo skin penetration studies of camomile flavones. | 1994 | Pharmazie | pmid:8073060 |
| Fullas F et al. | Cytotoxic constituents of Baccharis gaudichaudiana. | 1994 | J. Nat. Prod. | pmid:7931367 |
| Green MD et al. | Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. | 1994 Sep-Oct | Drug Metab. Dispos. | pmid:7835232 |
| Venturella P et al. | Three acylated flavone glycosides from Sideritis syriaca. | 1995 | Phytochemistry | pmid:7772308 |
| Toki K et al. | (Delphinidin 3-gentiobiosyl) (apigenin 7-glucosyl) malonate from the flowers of Eichhornia crassipes. | 1994 | Phytochemistry | pmid:7765361 |
| Liu M et al. | An acylated flavone C-glycoside from Glycyrrhiza eurycarpa. | 1994 | Phytochemistry | pmid:7765208 |
| Gaitan E et al. | Antithyroid effects in vivo and in vitro of vitexin: a C-glucosylflavone in millet. | 1995 | J. Clin. Endocrinol. Metab. | pmid:7714083 |
| Fuchs J and Milbradt R | Skin anti-inflammatory activity of apigenin-7-glucoside in rats. | 1993 | Arzneimittelforschung | pmid:7683883 |
| Green MD et al. | Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols. | 1995 | Arch. Biochem. Biophys. | pmid:7574722 |
| Fesen MR et al. | Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. | 1994 | Biochem. Pharmacol. | pmid:7520698 |
| Prabhakar MC et al. | Pharmacological investigations on vitexin. | 1981 | Planta Med. | pmid:7330108 |
| Yasukawa K et al. | [Studies on the constituents in the water extracts in crude drugs. IV. On the roots of Stellaria dichotoma L. var lanceolata Bge. (2(2)) (author's transl)]. | 1982 | Yakugaku Zasshi | pmid:7108760 |
| Li LD et al. | Studies on hawthorn and its active principle. II. Effects on cultured rat heart cells deprived of oxygen and glucose. | 1984 | J Tradit Chin Med | pmid:6570503 |
| Oksüz S et al. | 6-Methoxylated and C-glycosyl flavonoids from Centaurea species. | 1984 Sep-Oct | J. Nat. Prod. | pmid:6512542 |
| Matern U et al. | Conformational changes of apigenin 7-O-(6-O-malonylglucoside), a vacuolar pigment from parsley, with solvent composition and proton concentration. | 1983 | Eur. J. Biochem. | pmid:6303788 |
| Fourie TG and Snyckers FO | A flavone with antiinflammatory activity from the roots of Rhus undulata. | 1984 Nov-Dec | J. Nat. Prod. | pmid:6241941 |
| Della Loggia R et al. | [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them]. | 1981 Sep-Oct | Riv Neurol | pmid:6118937 |
| Ciaceri G and Attaguile G | [Influence of luteoline, apigenine and acacetine on experimental gastric ulcer]. | 1972 | Minerva Med. | pmid:5025773 |
| Barberan FA et al. | Isoscutellarein-7-O-[allosyl (1----2) glucoside] from Sideritis leucantha. | 1985 Jan-Feb | J. Nat. Prod. | pmid:4009184 |
| Chen ZN et al. | [Spectral analysis of clerodendrin, isolated from Clerodendron trichotomum Thunb]. | 1988 | Yao Xue Xue Bao | pmid:3257032 |
| Occhiuto F et al. | Study on the action mechanism of some flavones through registration of intracardiac potentials in anesthetized dogs. | 1988 | Pharmacol Res Commun | pmid:3211997 |
| Silfen J et al. | Bioflavonoid effects on in vitro cultures of Plasmodium falciparum. Inhibition of permeation pathways induced in the host cell membrane by the intraerythrocytic parasite. | 1988 | Biochem. Pharmacol. | pmid:3058128 |
| Xin Z et al. | UPLC-Orbitrap-MS/MS combined with chemometrics establishes variations in chemical components in green tea from Yunnan and Hunan origins. | 2018 | Food Chem | pmid:30381222 |
| Xu L et al. | Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects. | 2018 | J. Exp. Clin. Cancer Res. | pmid:30373602 |
| Rodriguez IF et al. | Morphological, histological, chemical and functional characterization of Prosopis alba flours of different particle sizes. | 2019 | Food Chem | pmid:30372982 |
| Li ZM et al. | Vitexin alleviates streptozotocin-induced sexual dysfunction and fertility impairments in male mice via modulating the hypothalamus-pituitary-gonadal axis. | 2019 | Chem. Biol. Interact. | pmid:30365938 |
| Vieira FN et al. | Long-Term Effect on Bioactive Components and Antioxidant Activity of Thermal and High-Pressure Pasteurization of Orange Juice. | 2018 | Molecules | pmid:30347848 |
| Šarić Mustapić D et al. | The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. | 2018 | Molecules | pmid:30301254 |
| Wang X et al. | Effect of apigenin on apoptosis induced by renal ischemia/reperfusion injury in vivo and in vitro. | 2018 | Ren Fail | pmid:30278824 |
| Han T et al. | Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. | 2018 | Eur J Med Chem | pmid:30243153 |
| Thangaiyan R et al. | Preventive effect of apigenin against isoproterenol-induced apoptosis in cardiomyoblasts. | 2018 | J. Biochem. Mol. Toxicol. | pmid:30152906 |
| Shin JW et al. | Scutellarin Ameliorates Learning and Memory Deficit via Suppressing [Formula: see text]-Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion. | 2018 | Am. J. Chin. Med. | pmid:30149759 |
| Kim HJ et al. | Spirodela polyrhiza and its Chemical Constituent Vitexin Exert Anti-Allergic Effect via ORAI1 Channel Inhibition. | 2018 | Am. J. Chin. Med. | pmid:30149756 |
| Feng X et al. | Characterization of the In Vivo and In Vitro Metabolites of Linarin in Rat Biosamples and Intestinal Flora Using Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry. | 2018 | Molecules | pmid:30149616 |
| Makanjuola SBL et al. | Apigenin and apigeninidin isolates from the Sorghum bicolor leaf targets inflammation via cyclo-oxygenase-2 and prostaglandin-E blockade. | 2018 | Int J Rheum Dis | pmid:30146750 |
| Chang JH et al. | Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses. | 2018 | J. Exp. Clin. Cancer Res. | pmid:30134935 |
| Mirzoeva S et al. | Apigenin Inhibits UVB-Induced Skin Carcinogenesis: The Role of Thrombospondin-1 as an Anti-Inflammatory Factor. | 2018 | Neoplasia | pmid:30118999 |
| Zhong Y et al. | Protective effects of apigenin against 3-MCPD-induced renal injury in rat. | 2018 | Chem. Biol. Interact. | pmid:30107153 |
| Zheng YZ et al. | The Substituent Effect on the Radical Scavenging Activity of Apigenin. | 2018 | Molecules | pmid:30103379 |
| Baruah TJ et al. | Vicenin-2: a potential radiosensitizer of non-small cell lung cancer cells. | 2018 | Mol. Biol. Rep. | pmid:30099686 |
| Chen S et al. | A UPLC-ESI-MS/MS Method for Simultaneous Quantitation of Chlorogenic Acid, Scutellarin, and Scutellarein in Rat Plasma: Application to a Comparative Pharmacokinetic Study in Sham-Operated and MCAO Rats after Oral Administration of Extract. | 2018 | Molecules | pmid:30037063 |
| Yang M et al. | Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway. | 2018 | Biomed. Pharmacother. | pmid:30021365 |
| Wu TC et al. | Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. | 2018 | Chem. Biol. Interact. | pmid:30016632 |
| van Dooren I et al. | In vitro gastrointestinal biotransformation and characterization of a Desmodium adscendens decoction: the first step in unravelling its behaviour in the human body. | 2018 | J. Pharm. Pharmacol. | pmid:30003542 |
| Okitsu N et al. | Identification and Characterization of Novel Nemophila menziesii Flavone Glucosyltransferases that Catalyze Biosynthesis of Flavone 7,4'-O-Diglucoside, a Key Component of Blue Metalloanthocyanins. | 2018 | Plant Cell Physiol. | pmid:29986079 |
| Mekawy AMM et al. | Apigenin pretreatment enhances growth and salinity tolerance of rice seedlings. | 2018 | Plant Physiol. Biochem. | pmid:29980098 |
| Lorizola IM et al. | Beet Stalks and Leaves ( L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice. | 2018 | Nutrients | pmid:29976910 |
| Ren K et al. | Apigenin Retards Atherogenesis by Promoting ABCA1-Mediated Cholesterol Efflux and Suppressing Inflammation. | 2018 | Cell. Physiol. Biochem. | pmid:29975943 |
| Zhang Y et al. | Apigenin suppresses mouse peritoneal fibrosis by down-regulating miR34a expression. | 2018 | Biomed. Pharmacother. | pmid:29966983 |
| Lim H et al. | Flavonoids interfere with NLRP3 inflammasome activation. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29960001 |
| Xia Y et al. | Apigenin Suppresses the IL-1β-Induced Expression of the Urokinase-Type Plasminogen Activator Receptor by Inhibiting MAPK-Mediated AP-1 and NF-κB Signaling in Human Bladder Cancer T24 Cells. | 2018 | J. Agric. Food Chem. | pmid:29945448 |
| Wong TY et al. | Co-administrating apigenin in a high-cholesterol diet prevents hypercholesterolaemia in golden hamsters. | 2018 | J. Pharm. Pharmacol. | pmid:29943490 |
| Wang J et al. | Scutellarin enhances osteoblast proliferation and function via NF-κB-mediated CXCR4 induction. | 2018 | Gene | pmid:29936266 |
| Jiang PY et al. | Protective effects of apigenin on LPS-induced endometritis via activating Nrf2 signaling pathway. | 2018 | Microb. Pathog. | pmid:29928944 |
| Wong TY et al. | Traversal of the Blood-Brain Barrier by Cleavable l-Lysine Conjugates of Apigenin. | 2018 | J. Agric. Food Chem. | pmid:29923397 |
| Zhou Z et al. | Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia‑reperfusion injury via upregulation of the PI3K/Akt pathway. | 2018 | Mol Med Rep | pmid:29901074 |
| Yang D et al. | Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line. | 2018 | Drug Des Devel Ther | pmid:29849451 |
| Bhattacharya S et al. | Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats. | 2018 | Nanomedicine | pmid:29802937 |
| Gu CB et al. | Characterization, culture medium optimization and antioxidant activity of an endophytic vitexin-producing fungus Dichotomopilus funicola Y3 from pigeon pea [Cajanus cajan (L.) Millsp.]. | 2018 | J. Appl. Microbiol. | pmid:29791772 |
| Ravisankar S et al. | Structural profile of soluble and bound phenolic compounds in teff (Eragrostis tef) reveals abundance of distinctly different flavones in white and brown varieties. | 2018 | Food Chem | pmid:29784316 |
| Zhu J et al. | Protective effects of Hand.- Mazz. (EBHM) extract in retinal neurodegeneration models. | 2018 | Mol. Vis. | pmid:29769797 |
| Li Y et al. | Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. | 2018 | Toxicol. Lett. | pmid:29753067 |
| Alzoman NZ et al. | CE-DAD Determination of Scutellarein and Caffeic Acid in Abelia triflora Crude Extract. | 2018 | J Chromatogr Sci | pmid:29750262 |
| Amiri M et al. | Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice. | 2018 | Phytother Res | pmid:29748995 |
| Oliveira DR et al. | Flavones-bound in benzodiazepine site on GABA receptor: Concomitant anxiolytic-like and cognitive-enhancing effects produced by Isovitexin and 6-C-glycoside-Diosmetin. | 2018 | Eur. J. Pharmacol. | pmid:29738701 |
| Jiang J et al. | Vitexin reverses the autophagy dysfunction to attenuate MCAO-induced cerebral ischemic stroke via mTOR/Ulk1 pathway. | 2018 | Biomed. Pharmacother. | pmid:29710456 |
| Pei Y et al. | Combined effect of apigenin and ferulic acid on frozen-thawed boar sperm quality. | 2018 | Anim. Sci. J. | pmid:29708294 |
| Feng Y et al. | Apigenin-7-O-β-d-(-6″-p-coumaroyl)-glucopyranoside pretreatment attenuates myocardial ischemia/reperfusion injury via activating AMPK signaling. | 2018 | Life Sci. | pmid:29705352 |
| Malar DS et al. | Grewia tiliaefolia and its active compound vitexin regulate the expression of glutamate transporters and protect Neuro-2a cells from glutamate toxicity. | 2018 | Life Sci. | pmid:29704481 |
| Hadrich F and Sayadi S | Apigetrin inhibits adipogenesis in 3T3-L1 cells by downregulating PPARγ and CEBP-α. | 2018 | Lipids Health Dis | pmid:29695233 |
| Lu Y et al. | Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway. | 2018 | PLoS ONE | pmid:29694408 |
| Dang Y et al. | Protective Effect of Apigenin on Acrylonitrile-Induced Inflammation and Apoptosis in Testicular Cells via the NF-κB Pathway in Rats. | 2018 | Inflammation | pmid:29687413 |
| You P et al. | Scutellarin suppresses neuroinflammation via the inhibition of the AKT/NF-κB and p38/JNK pathway in LPS-induced BV-2 microglial cells. | 2018 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:29680917 |
| Yang J et al. | Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells. | 2018 | Biomed. Pharmacother. | pmid:29680738 |
| Gurunathan S et al. | Antibacterial Efficacy of Silver Nanoparticles on Endometritis Caused by and in Dairy Cattle. | 2018 | Int J Mol Sci | pmid:29659523 |
| Karamać M et al. | Phenolic contents and antioxidant capacities of wild and cultivated white lupin (Lupinus albus L.) seeds. | 2018 | Food Chem | pmid:29655709 |
| Mo J et al. | Scutellarin protects against vascular endothelial dysfunction and prevents atherosclerosis via antioxidation. | 2018 | Phytomedicine | pmid:29655699 |
| Kumar KS et al. | Isolation, identification and characterization of apigenin from Justicia gendarussa and its anti-inflammatory activity. | 2018 | Int. Immunopharmacol. | pmid:29655057 |
| Paredes MD et al. | Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. | 2018 | Nutrients | pmid:29652818 |
| Zeng YQ et al. | Scutellarin Mitigates Aβ-Induced Neurotoxicity and Improves Behavior Impairments in AD Mice. | 2018 | Molecules | pmid:29642616 |
| Gentile D et al. | The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. | 2018 | PLoS ONE | pmid:29641549 |
| Kalogiouri NP et al. | Application of an advanced and wide scope non-target screening workflow with LC-ESI-QTOF-MS and chemometrics for the classification of the Greek olive oil varieties. | 2018 | Food Chem | pmid:29606472 |
| Hu WJ et al. | Apigenin enhances the antitumor effects of cetuximab in nasopharyngeal carcinoma by inhibiting EGFR signaling. | 2018 | Biomed. Pharmacother. | pmid:29604587 |
| Hu JJ et al. | Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation. | 2018 | Microb. Pathog. | pmid:29604422 |
| Hu M et al. | Vitexin protects dopaminergic neurons in MPTP-induced Parkinson's disease through PI3K/Akt signaling pathway. | 2018 | Drug Des Devel Ther | pmid:29588573 |