apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

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What genes are associated with apigenin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Jin UH et al. Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. 2018 Toxicol. Sci. pmid:29584932
Elhennawy MG and Lin HS Dose- and time-dependent pharmacokinetics of apigenin trimethyl ether. 2018 Eur J Pharm Sci pmid:29574080
Malar DS et al. Vitexin inhibits Aβ induced toxicity in Neuro-2a cells by augmenting Nrf-2/HO-1 dependent antioxidant pathway and regulating lipid homeostasis by the activation of LXR-α. 2018 Toxicol In Vitro pmid:29545167
Vrhovac Madunić I et al. Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells. 2018 Naunyn Schmiedebergs Arch. Pharmacol. pmid:29541820
Cheruvu HS et al. LC-MS/MS method for the simultaneous quantification of luteolin, wedelolactone and apigenin in mice plasma using hansen solubility parameters for liquid-liquid extraction: Application to pharmacokinetics of Eclipta alba chloroform fraction. 2018 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29518720
Zengin G et al. Multiple pharmacological approaches on Fibigia eriocarpa extracts by in vitro and computational assays. 2018 Fundam Clin Pharmacol pmid:29505673
Yang YC and Wei MC Development and characterization of a green procedure for apigenin extraction from Scutellaria barbata D. Don. 2018 Food Chem pmid:29478557
Chassagne F et al. A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases. 2018 Fitoterapia pmid:29477305
Witkowska-Banaszczak E Flavonoids from Trollius europaeus flowers and evaluation of their biological activity. 2018 J. Pharm. Pharmacol. pmid:29466602
Chledzik S et al. Pharmacological Effects of Scutellarin, An Active Component of Genus Scutellaria and Erigeron: A Systematic Review. 2018 Am. J. Chin. Med. pmid:29433387
Steyns JM and van Brederode J Variation in the substrate specificity of allozymes catalyzing flavone-O-glucoside biosynthesis in Silene plants. 1986 Biochem. Genet. pmid:2943268
Tao Y et al. Pharmacokinetic comparisons of six components from raw and vinegar-processed Daphne genkwa aqueous extracts following oral administration in rats by employing UHPLC-MS/MS approaches. 2018 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29428673
Srivastava A et al. Swertisin ameliorates diabetes by triggering pancreatic progenitors for islet neogenesis in Streptozotocin treated BALB/c mice. 2018 Biomed. Pharmacother. pmid:29428671
Zhu Q et al. Comparison of flavonoids and isoflavonoids to inhibit rat and human 11β-hydroxysteroid dehydrogenase 1 and 2. 2018 Steroids pmid:29425740
Brauch D et al. Changes in isovitexin-O-glycosylation during the development of young barley plants. 2018 Phytochemistry pmid:29421507
Sun Q et al. Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. 2018 Biochem. Biophys. Res. Commun. pmid:29408335
Ling T et al. Novel vitexin-inspired scaffold against leukemia. 2018 Eur J Med Chem pmid:29407975
Ashokkumar R et al. Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses. 2018 Biochem. Biophys. Res. Commun. pmid:29406244
Zhang X et al. Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway. 2018 Free Radic. Res. pmid:29400110
Melguizo-Rodríguez L et al. Effect of olive oil phenolic compounds on osteoblast differentiation. 2018 Eur. J. Clin. Invest. pmid:29392706
Ni G et al. Synthesis of Scutellarein Derivatives with a Long Aliphatic Chain and Their Biological Evaluation against Human Cancer Cells. 2018 Molecules pmid:29389889
Liu X et al. Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches. 2018 Nat Commun pmid:29386648
Rimal H et al. Hydroxylation of Resveratrol with DoxA In Vitro: An Enzyme with the Potential for the Bioconversion of a Bioactive Stilbene. 2018 J. Microbiol. Biotechnol. pmid:29385664
Ojo OA et al. Chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) Baill bark. 2018 J Basic Clin Physiol Pharmacol pmid:29381472
Cornara L et al. Zornia latifolia: a smart drug being adulterated by Stylosanthes guianensis. 2018 Int. J. Legal Med. pmid:29362872
Lv SX and Qiao X Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress. 2018 Biochem. Biophys. Res. Commun. pmid:29355527
Zhang G et al. Vitexin induces G2/M‑phase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells. 2018 Mol Med Rep pmid:29328424
Kim A and Lee CS Apigenin reduces the Toll-like receptor-4-dependent activation of NF-κB by suppressing the Akt, mTOR, JNK, and p38-MAPK. 2018 Naunyn Schmiedebergs Arch. Pharmacol. pmid:29264665
Kang CH et al. Apigenin promotes TRAIL-mediated apoptosis regardless of ROS generation. 2018 Food Chem. Toxicol. pmid:29247770
Vollmer M et al. Mutual Interaction of Phenolic Compounds and Microbiota: Metabolism of Complex Phenolic Apigenin-C- and Kaempferol-O-Derivatives by Human Fecal Samples. 2018 J. Agric. Food Chem. pmid:29236499
Hithamani G et al. Uptake of phenolic compounds from plant foods in human intestinal Caco-2 cells. 2017 J. Biosci. pmid:29229878
Grigalius I and Petrikaite V Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones. 2017 Molecules pmid:29215574
Gaitan E et al. Antithyroid and goitrogenic effects of millet: role of C-glycosylflavones. 1989 J. Clin. Endocrinol. Metab. pmid:2921306
Kowalczyk A et al. Insights into novel anticancer applications for apigenin. 2017 Adv Clin Exp Med pmid:29211364
Zhang J et al. The potential application of strategic released apigenin from polymeric carrier in pulmonary fibrosis. Exp. Lung Res. pmid:29206498
Wong TY et al. Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. 2017 Biomed. Pharmacother. pmid:29198743
Gao AM et al. Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis. 2018 Chem. Biol. Interact. pmid:29191453
Baluchnejadmojarad T et al. Scutellarin alleviates lipopolysaccharide-induced cognitive deficits in the rat: Insights into underlying mechanisms. 2018 Int. Immunopharmacol. pmid:29190543
Granato M et al. Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death. 2017 J. Exp. Clin. Cancer Res. pmid:29179721
Fan H et al. Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. 2017 Med. Sci. Monit. pmid:29172017
Gu C et al. Preparation of Vitexin Nanoparticles by Combining the Antisolvent Precipitation and High Pressure Homogenization Approaches Followed by Lyophilization for Dissolution Rate Enhancement. 2017 Molecules pmid:29165376
van Vugt-Lussenburg BMA et al. Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity. 2018 Reprod. Toxicol. pmid:29162470
Gómez-Zorita S et al. Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes. 2017 J Transl Med pmid:29162103
Wang J et al. Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. 2017 Int J Nanomedicine pmid:29158673
You L et al. Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. 2017 Bioorg. Med. Chem. Lett. pmid:29157862
Jeong KM et al. Identification of Major Flavone C-Glycosides and Their Optimized Extraction from Cymbidium kanran Using Deep Eutectic Solvents. 2017 Molecules pmid:29156555
Bai HH et al. Hydroxycinnamoylmalated flavone C-glycosides from Lemna japonica. 2018 Fitoterapia pmid:29154864
Radulovic K et al. A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation. 2018 Mucosal Immunol pmid:29139477
Wu T et al. Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1). 2017 Pharmacol Rep pmid:29128807
Liao M et al. Metabolites identificaion of two bioactive constituents in Trollius ledebourii in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. 2017 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29127056
He X et al. Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat. 2017 Am. J. Chin. Med. pmid:29121796
Wu W et al. Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique. 2017 Drug Deliv pmid:29115900
Crascì L et al. Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation. 2018 Drug Res (Stuttg) pmid:29108086
Madunić J et al. Apigenin: A dietary flavonoid with diverse anticancer properties. 2018 Cancer Lett. pmid:29097249
Venturini CL et al. Vitexin inhibits inflammation in murine ovalbumin-induced allergic asthma. 2018 Biomed. Pharmacother. pmid:29091859
Hou L et al. Scutellarin Inhibits Proliferation, Invasion, and Tumorigenicity in Human Breast Cancer Cells by Regulating HIPPO-YAP Signaling Pathway. 2017 Med. Sci. Monit. pmid:29079722
Kulikovskii VF et al. Study of Sedative Tea Phytocomplex within the Framework of Studies Aimed at Creation of a Rectal Dosage Form with Antihistaminic Effect. 2017 Bull. Exp. Biol. Med. pmid:29063320
Nabavi SF et al. Apigenin as neuroprotective agent: Of mice and men. 2018 Pharmacol. Res. pmid:29055745
Tu F et al. Angiogenic effects of apigenin on endothelial cells after hypoxia-reoxygenation via the caveolin-1 pathway. 2017 Int. J. Mol. Med. pmid:29039442
Mokashi P et al. Swertisin rich fraction from Enicostema littorale ameliorates hyperglycemia and hyperlipidemia in high-fat fed diet and low dose streptozotacin induced type 2 diabetes mellitus in rats. 2017 Biomed. Pharmacother. pmid:29031588
Medhat AM et al. Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. 2017 Tumour Biol. pmid:29022496
Yang B et al. Pharmacokinetic comparison of seven major bioactive components in normal and depression model rats after oral administration of Baihe Zhimu decoction by liquid chromatography-tandem mass spectrometry. 2018 J Pharm Biomed Anal pmid:28987996
Choi WH et al. Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice. 2017 Mol Nutr Food Res pmid:28971573
Dang Y et al. Protective effects of apigenin against acrylonitrile-induced subchronic sperm injury in rats. 2017 Food Chem. Toxicol. pmid:28963002
Zhao T et al. Novel apigenin-loaded sodium hyaluronate nano-assemblies for targeting tumor cells. 2017 Carbohydr Polym pmid:28962787
Liu Y et al. Effects of apigenin pretreatment against renal ischemia/reperfusion injury via activation of the JAK2/STAT3 pathway. 2017 Biomed. Pharmacother. pmid:28962085
Mehmood K et al. In Vitro Effect of Apigenin and Danshen in Tibial Dyschondroplasia Through Inhibition of Heat-Shock Protein 90 and Vascular Endothelial Growth Factor Expressions in Avian Growth Plate Cells. 2017 Avian Dis. pmid:28957003
Wu Y et al. Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase. 2017 Neurochem. Int. pmid:28947342
Lee JA et al. Effects of friedelin on the intestinal permeability and bioavailability of apigenin. 2017 Pharmacol Rep pmid:28939344
Mendel M et al. Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility-in vitro study. 2018 J. Vet. Pharmacol. Ther. pmid:28913883
Jiang Z et al. Determination of scutellarin in breviscapine preparations using quantitative proton nuclear magnetic resonance spectroscopy. 2016 J Food Drug Anal pmid:28911594
Tamayose CI et al. Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema. 2017 Int J Mol Sci pmid:28906474
Ganesan K and Xu B Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. 2017 Ann. N. Y. Acad. Sci. pmid:28891090
Zhong Y et al. Scaffold Hopping Strategy for the Design, Synthesis and Biological Activity Evaluation of Novel Hexacyclic Scutellarein Derivatives with a 1,3-Oxazine Ring Fused at A-ring. 2018 Med Chem pmid:28875860
Zhou RJ et al. Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. 2017 Biochem. Biophys. Res. Commun. pmid:28867192
Zhang L et al. Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. 2017 Mol Med Rep pmid:28849116
Zhao Q et al. Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensis. 2018 Mol Plant pmid:28842248
Viacava GE et al. Characterization of phenolic compounds in green and red oak-leaf lettuce cultivars by UHPLC-DAD-ESI-QToF/MS using MS scan mode. 2017 J Mass Spectrom pmid:28833875
Shan S et al. Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. 2017 J. Agric. Food Chem. pmid:28829588
Li F et al. Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy. 2017 Oxid Med Cell Longev pmid:28828145
Tu F et al. Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. 2017 Med. Sci. Monit. pmid:28821706
Tan GF et al. AgFNS overexpression increase apigenin and decrease anthocyanins in petioles of transgenic celery. 2017 Plant Sci. pmid:28818381
Liu S and Ho PC Intranasal administration of brain-targeted HP-β-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia. 2017 J. Pharm. Pharmacol. pmid:28809432
Fallatah O and Georges E Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. 2017 Int. J. Antimicrob. Agents pmid:28807879
Wang F et al. Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression. 2017 Chem. Biol. Interact. pmid:28803762
Wang M et al. Apigenin Impacts the Growth of the Gut Microbiota and Alters the Gene Expression of Enterococcus. 2017 Molecules pmid:28771188
Jin X et al. Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. 2017 Int J Nanomedicine pmid:28761344
Renda G et al. Evaluation of in vivo analgesic activity of Scrophularia kotscyhana and isolation of bioactive compounds through activity-guided fractionation. 2018 Nat. Prod. Res. pmid:28758426
Salazar-Aguilar S et al. Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. 2017 Nutrients pmid:28757593
Naik PM and Al-Khayri JM Extraction and Estimation of Secondary Metabolites from Date Palm Cell Suspension Cultures. 2017 Methods Mol. Biol. pmid:28755356
Chen L et al. Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. 2017 Arch Gerontol Geriatr pmid:28743056
Palacz-Wrobel M et al. Effect of apigenin, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW-264.7 macrophages. 2017 Biomed. Pharmacother. pmid:28738536
Gao C et al. Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells. 2017 Oncol. Rep. pmid:28737827
Britto SM et al. Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. 2017 Mutat. Res. pmid:28735741
Zhong Y et al. Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. 2017 Toxicon pmid:28734981
Ghazanfar K et al. Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. 2017 J Complement Integr Med pmid:28731312
Sun Y et al. Homogenate-assisted Vacuum-powered Bubble Extraction of Moso Bamboo Flavonoids for On-line Scavenging Free Radical Capacity Analysis. 2017 Molecules pmid:28696360
Jangdey MS et al. Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma. 2017 Drug Deliv pmid:28687053
Perez-Leal O et al. Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. 2017 J. Biol. Chem. pmid:28684421
Utispan K et al. Propolis Extracted from the Stingless Bee Trigona sirindhornae Inhibited S. mutans Activity In Vitro. Oral Health Prev Dent pmid:28674707