| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang W et al. | [Determination of scutellarin and rutin in Shenfukang capsules by reversed-phase high performance liquid chromatography]. | 2004 | Se Pu | pmid:15712871 |
| Proestos C et al. | RP-HPLC analysis of the phenolic compounds of plant extracts. investigation of their antioxidant capacity and antimicrobial activity. | 2005 | J. Agric. Food Chem. | pmid:15713039 |
| Ding L et al. | [Studies on the flavonoid constituents in herb of Eremosparton songoricum]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:15714817 |
| Meirinhos J et al. | Analysis and quantification of flavonoidic compounds from Portuguese olive (Olea europaea L.) leaf cultivars. | 2005 | Nat. Prod. Res. | pmid:15715265 |
| Wang LS et al. | [Study on the chemical constituents from Picria fel-tarrae]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15719682 |
| Steffan B et al. | Polyphenols from plants used in traditional Indonesian medicine (Jamu): uptake and antioxidative effects in rat H4IIE hepatoma cells. | 2005 | J. Pharm. Pharmacol. | pmid:15720788 |
| Tian J et al. | [Studies on the chemical constitutents in herb of Verbena officinalis]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:15724402 |
| Boutin JA et al. | Quinone reductase 2 substrate specificity and inhibition pharmacology. | 2005 | Chem. Biol. Interact. | pmid:15733542 |
| Materska M and Perucka I | Antioxidant activity of the main phenolic compounds isolated from hot pepper fruit (Capsicum annuum L). | 2005 | J. Agric. Food Chem. | pmid:15740069 |
| Yano S et al. | Flavones suppress the expression of the high-affinity IgE receptor FcepsilonRI in human basophilic KU812 cells. | 2005 | J. Agric. Food Chem. | pmid:15740078 |
| Chu Q et al. | Simultaneous determination of active ingredients in Erigeron breviscapus (Vant.) Hand-Mazz. by capillary electrophoresis with electrochemical detection. | 2005 | J Pharm Biomed Anal | pmid:15740914 |
| Li L et al. | Simultaneous determination of luteolin and apigenin in dog plasma by RP-HPLC. | 2005 | J Pharm Biomed Anal | pmid:15740925 |
| Fang J et al. | Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. | 2005 | FASEB J. | pmid:15746177 |
| Süzgeç S et al. | Flavonoids of Helichrysum compactum and their antioxidant and antibacterial activity. | 2005 | Fitoterapia | pmid:15752647 |
| Carette JE et al. | Replication-dependent transgene expression from a conditionally replicating adenovirus via alternative splicing to a heterologous splice-acceptor site. | 2005 | J Gene Med | pmid:15756711 |
| Ise R et al. | Expression profiling of the estrogen responsive genes in response to phytoestrogens using a customized DNA microarray. | 2005 | FEBS Lett. | pmid:15757668 |
| Yu J et al. | Antioxidant activity of citrus limonoids, flavonoids, and coumarins. | 2005 | J. Agric. Food Chem. | pmid:15769128 |
| Elmore E et al. | Correlation of in vitro chemopreventive efficacy data from the human epidermal cell assay with animal efficacy data and clinical trial plasma levels. | 2005 | J. Cell. Biochem. | pmid:15786488 |
| Kim JH et al. | The isolation and antioxidative effects of vitexin from Acer palmatum. | 2005 | Arch. Pharm. Res. | pmid:15789751 |
| Dicko MH et al. | Evaluation of the effect of germination on phenolic compounds and antioxidant activities in sorghum varieties. | 2005 | J. Agric. Food Chem. | pmid:15796598 |
| Song DH et al. | Gastrin stabilises beta-catenin protein in mouse colorectal cancer cells. | 2005 | Br. J. Cancer | pmid:15798764 |
| Plaza A et al. | Phenylpropanoid glycosides from Tynanthus panurensis: characterization and LC-MS quantitative analysis. | 2005 | J. Agric. Food Chem. | pmid:15826030 |
| Fernández SP et al. | Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. | 2005 | Eur. J. Pharmacol. | pmid:15840404 |
| Chen D et al. | Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. | 2005 | Biochem. Pharmacol. | pmid:15857606 |
| Zheng QS et al. | Mechanisms of apigenin-7-glucoside as a hepatoprotective agent. | 2005 | Biomed. Environ. Sci. | pmid:15861781 |
| Simons AL et al. | Human gut microbial degradation of flavonoids: structure-function relationships. | 2005 | J. Agric. Food Chem. | pmid:15884869 |
| Rithidech KN et al. | Protective effect of apigenin on radiation-induced chromosomal damage in human lymphocytes. | 2005 | Mutat. Res. | pmid:15886050 |
| Xing J et al. | Stability of baicalin in biological fluids in vitro. | 2005 | J Pharm Biomed Anal | pmid:15894449 |
| Yamada M et al. | Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15897466 |
| Kim DI et al. | Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: isolation of flavonoids of apigenin and luteolin as acting compounds. | 2005 | Toxicol. Appl. Pharmacol. | pmid:15922007 |
| Jeyabal PV et al. | Apigenin inhibits oxidative stress-induced macromolecular damage in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats. | 2005 | Mol. Carcinog. | pmid:15924350 |
| Hao X et al. | Validation of an HPLC method for the determination of scutellarin in rat plasma and its pharmacokinetics. | 2005 | J Pharm Biomed Anal | pmid:15925232 |
| Peng Y et al. | Determination of active components in rosemary by capillary electrophoresis with electrochemical detection. | 2005 | J Pharm Biomed Anal | pmid:15925471 |
| Ibrahim AR | Biotransformation of chrysin and apigenin by Cunninghamella elegans. | 2005 | Chem. Pharm. Bull. | pmid:15930780 |
| O'Toole SA et al. | Analysis of DNA in endometrial cancer cells treated with phyto-estrogenic compounds using comparative genomic hybridisation microarrays. | 2005 | Planta Med. | pmid:15931582 |
| Zhang L et al. | Analysis of flavonoids in leaves of Adinandra nitida by capillary electrochromatography on monolithic columns with stepwise gradient elution. | 2005 | J Sep Sci | pmid:15938186 |
| Peng J et al. | Preparative separation of isovitexin and isoorientin from Patrinia villosa Juss by high-speed counter-current chromatography. | 2005 | J Chromatogr A | pmid:15941046 |
| Christophoridou S et al. | Separation and identification of phenolic compounds in olive oil by coupling high-performance liquid chromatography with postcolumn solid-phase extraction to nuclear magnetic resonance spectroscopy (LC-SPE-NMR). | 2005 | J. Agric. Food Chem. | pmid:15941298 |
| Valentão P et al. | Effect of the conservation procedure on the contents of phenolic compounds and organic acids in chanterelle (Cantharellus cibarius) mushroom. | 2005 | J. Agric. Food Chem. | pmid:15941337 |
| Ng SP et al. | Evaluation of the first-pass glucuronidation of selected flavones in gut by Caco-2 monolayer model. | 2004 | J Pharm Pharm Sci | pmid:15946592 |
| Verbeek R et al. | Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice. | 2005 | Biochem. Pharmacol. | pmid:15946653 |
| Liu LZ et al. | Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer. | 2005 | Mol. Pharmacol. | pmid:15947208 |
| Min YS et al. | The effects of apigenin-7-O-beta-D-glucuronopyranoside on reflux oesophagitis and gastritis in rats. | 2005 | Auton Autacoid Pharmacol | pmid:15955027 |
| Mottet D et al. | Role for casein kinase 2 in the regulation of HIF-1 activity. | 2005 | Int. J. Cancer | pmid:15957168 |
| Kim DH et al. | Regiospecific methylation of naringenin to ponciretin by soybean O-methyltransferase expressed in Escherichia coli. | 2005 | J. Biotechnol. | pmid:15961179 |
| Huang ST et al. | Inhibitory effects of a rice hull constituent on tumor necrosis factor alpha, prostaglandin E2, and cyclooxygenase-2 production in lipopolysaccharide-activated mouse macrophages. | 2005 | Ann. N. Y. Acad. Sci. | pmid:15965085 |
| Lyu SY and Park WB | Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids. | 2005 | Arch. Pharm. Res. | pmid:15974445 |
| Jeong YJ et al. | Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids. | 2005 | Br. J. Nutr. | pmid:15975156 |
| Stojanović G et al. | In vitro antimicrobial activity of extracts of four Achillea species: the composition of Achillea clavennae L. (Asteraceae) extract. | 2005 | J Ethnopharmacol | pmid:15978758 |
| Correia H et al. | Polyphenolic profile characterization of Agrimonia eupatoria L. by HPLC with different detection devices. | 2006 | Biomed. Chromatogr. | pmid:15981197 |
| Kowalski J et al. | Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages. | 2005 May-Jun | Pharmacol Rep | pmid:15985724 |
| El Hajjaji H et al. | Chondrocytes, synoviocytes and dermal fibroblasts all express PH-20, a hyaluronidase active at neutral pH. | 2005 | Arthritis Res. Ther. | pmid:15987477 |
| Smolinski AT and Pestka JJ | Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver. | 2005 | J Inflamm (Lond) | pmid:15987517 |
| Hao X et al. | Study on the role of hepatic first-pass elimination in the low oral bioavailability of scutellarin in rats. | 2005 | Pharmazie | pmid:15997843 |
| Sudjaroen Y et al. | Isolation and structure elucidation of phenolic antioxidants from Tamarind (Tamarindus indica L.) seeds and pericarp. | 2005 | Food Chem. Toxicol. | pmid:16000233 |
| Zhao DB et al. | [Studies on chemical constituents in herb of Chondrilla piptocoma]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011281 |
| Chiang LC et al. | Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells. | 2006 | Cancer Lett. | pmid:16023288 |
| Zhong H et al. | Multivesicular liposome formulation for the sustained delivery of breviscapine. | 2005 | Int J Pharm | pmid:16023316 |
| Lacey M et al. | Dose-response effects of phytoestrogens on the activity and expression of 3beta-hydroxysteroid dehydrogenase and aromatase in human granulosa-luteal cells. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:16023337 |
| Zhang GH et al. | The anti-HIV-1 effect of scutellarin. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16023998 |
| Biondi DM et al. | Dihydrostilbene derivatives from Glycyrrhiza glabra leaves. | 2005 | J. Nat. Prod. | pmid:16038558 |
| Van Dross RT et al. | Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes. | 2005 | Mol. Carcinog. | pmid:16044407 |
| Wu K et al. | Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. | 2005 | World J. Gastroenterol. | pmid:16052672 |
| Duraj J et al. | Flavonoid quercetin, but not apigenin or luteolin, induced apoptosis in human myeloid leukemia cells and their resistant variants. | 2005 | Neoplasma | pmid:16059641 |
| Nazaruk J and Jakoniuk P | Flavonoid composition and antimicrobial activity of Cirsium rivulare (Jacq.) All. flowers. | 2005 | J Ethnopharmacol | pmid:16061337 |
| Huo CH et al. | [Studies on chemical constituents in herbs of Acanthus ilicifolius]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16075716 |
| Hernández-Romero Y et al. | Phytotoxic activity of bibenzyl derivatives from the orchid Epidendrum rigidum. | 2005 | J. Agric. Food Chem. | pmid:16076106 |
| Endale A et al. | Quantitative determination of the group of flavonoids and saponins from the extracts of the seeds of Glinus lotoides and tablet formulation thereof by high-performance liquid chromatography. | 2005 | J Chromatogr A | pmid:16078685 |
| Ahmad I et al. | Isolation of onosmins A and B, lipoxygenase inhibitors from Onosma hispida. | 2005 | Chem. Pharm. Bull. | pmid:16079517 |
| Pomilio AB et al. | Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana. | 1992 | J Ethnopharmacol | pmid:1608273 |
| Liu Y et al. | [Studies on chemical constituents from the flowers of Carthamus tinctorius L]. | 2005 | Zhong Yao Cai | pmid:16104502 |
| Piccinelli AL et al. | Anti-HIV activity of dibenzylbutyrolactone-type lignans from Phenax species endemic in Costa Rica. | 2005 | J. Pharm. Pharmacol. | pmid:16105232 |
| Welford RW et al. | Structural and mechanistic studies on anthocyanidin synthase catalysed oxidation of flavanone substrates: the effect of C-2 stereochemistry on product selectivity and mechanism. | 2005 | Org. Biomol. Chem. | pmid:16106293 |
| Abate A et al. | Apigenin decreases hemin-mediated heme oxygenase-1 induction. | 2005 | Free Radic. Biol. Med. | pmid:16109301 |
| Zhang Y et al. | [Effect of caffeic acid, seopoletin and scutellarin on rat retinal neurons in vitro]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16124607 |
| Miyahisa I et al. | Combinatorial biosynthesis of flavones and flavonols in Escherichia coli. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16133333 |
| Li N et al. | A possible quantitative method to improve the sensitivity of scutellarin in human plasma. | 2005 | Ann Chim | pmid:16136842 |
| Ueda Y et al. | Antianaphylactic and antipruritic effects of the flowers of Impatiens textori MIQ. | 2005 | Biol. Pharm. Bull. | pmid:16141562 |
| Lin CM et al. | Isovitexin suppresses lipopolysaccharide-mediated inducible nitric oxide synthase through inhibition of NF-kappa B in mouse macrophages. | 2005 | Planta Med. | pmid:16142640 |
| Svenningsen AB et al. | Biflavones from Rhus species with affinity for the GABA(A)/benzodiazepine receptor. | 2006 | J Ethnopharmacol | pmid:16168585 |
| Chiang LC et al. | Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:16173941 |
| Fiorani M and Accorsi A | Dietary flavonoids as intracellular substrates for an erythrocyte trans-plasma membrane oxidoreductase activity. | 2005 | Br. J. Nutr. | pmid:16176603 |
| Huang J et al. | Determination of aglycone conjugated metabolites of scutellarin in rat plasma by HPLC. | 2006 | J Pharm Biomed Anal | pmid:16181763 |
| Evers DL et al. | Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action. | 2005 | Antiviral Res. | pmid:16188329 |
| Cavaliere C et al. | Identification and mass spectrometric characterization of glycosylated flavonoids in Triticum durum plants by high-performance liquid chromatography with tandem mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:16200659 |
| Lin AS et al. | New cytotoxic flavonoids from Thelypteris torresiana. | 2005 | Planta Med. | pmid:16206043 |
| Lu Y et al. | Covalent attachment of the plant natural product naringenin to small glass and ceramic beads. | 2005 | BMC Chem Biol | pmid:16216122 |
| Peng Y et al. | Determination of phenolic compounds in Perilla frutescens L. by capillary electrophoresis with electrochemical detection. | 2005 | J. Agric. Food Chem. | pmid:16218656 |
| Cao F et al. | The physicochemical characteristics of freeze-dried scutellarin-cyclodextrin tetracomponent complexes. | 2005 | Drug Dev Ind Pharm | pmid:16221609 |
| Piantelli M et al. | Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions. | 2006 | J. Cell. Physiol. | pmid:16222712 |
| Pereira CA et al. | Distinction of the C-glycosylflavone isomer pairs orientin/isoorientin and vitexin/isovitexin using HPLC-MS exact mass measurement and in-source CID. | 2005 Sep-Oct | Phytochem Anal | pmid:16223084 |
| Wang W et al. | [A new natural product from the roots of Hedysarum multijugum]. | 2005 | Beijing Da Xue Xue Bao | pmid:16224530 |
| Llorens F et al. | The N-terminal domain of the human eIF2beta subunit and the CK2 phosphorylation sites are required for its function. | 2006 | Biochem. J. | pmid:16225457 |
| Shukla S et al. | Up-regulation of insulin-like growth factor binding protein-3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice. | 2005 | FASEB J. | pmid:16230333 |
| Koo H et al. | Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. | 2005 | J. Dent. Res. | pmid:16246933 |
| Huang JM et al. | Pharmacokinetics of scutellarin and its aglycone conjugated metabolites in rats. | 2005 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:16250252 |
| Wang Y et al. | Effects of bezafibrate on the expression of endothelial nitric oxide synthase gene and its mechanisms in cultured bovine endothelial cells. | 2006 | Atherosclerosis | pmid:16256120 |
| Yoon JH and Baek SJ | Molecular targets of dietary polyphenols with anti-inflammatory properties. | 2005 | Yonsei Med. J. | pmid:16259055 |
| Mavel S et al. | Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1). | 2006 | Bioorg. Med. Chem. | pmid:16263302 |
| Yulan S and Fang F | Sensitive liquid chromatography-tandem mass spectrometry method for the determination of scutellarin in human plasma: Application to a pharmacokinetic study. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16269273 |