apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Cardenas H et al. Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function. 2016 Int J Mol Sci pmid:26938530
García-Martínez O et al. Phenolic Compounds in Extra Virgin Olive Oil Stimulate Human Osteoblastic Cell Proliferation. 2016 PLoS ONE pmid:26930190
Srinivas NR Is the inhibition of the liver uptake and biliary excretion, via transporters, the likely mechanism for the increased exposure of vitexin-2''-O-rhamnoside with bile salts in rats? 2016 Biomed. Chromatogr. pmid:26928602
Dong ZX et al. An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin. 2016 Molecules pmid:26927039
Cao HH et al. Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma. 2016 Sci Rep pmid:26911838
Wu G et al. Growth temperature and genotype both play important roles in sorghum grain phenolic composition. 2016 Sci Rep pmid:26907726
Rosa SI et al. Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway. 2016 Phytomedicine pmid:26902402
Bridgeman BB et al. Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention. 2016 Cell. Signal. pmid:26876613
Tseng TH et al. Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 expression. 2017 Environ. Toxicol. pmid:26872304
Kesavan R et al. Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration. 2016 Nutr Metab Cardiovasc Dis pmid:26868432
Verma S et al. Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations. 2016 PLoS ONE pmid:26863418
Fonseca-Silva F et al. Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action. 2016 PLoS Negl Trop Dis pmid:26862901
Abugri DA et al. In vitro activity of Sorghum bicolor extracts, 3-deoxyanthocyanidins, against Toxoplasma gondii. 2016 Exp. Parasitol. pmid:26855040
Weng L et al. Apigenin reverses depression-like behavior induced by chronic corticosterone treatment in mice. 2016 Eur. J. Pharmacol. pmid:26826594
Dong ZX et al. Design, Synthesis, and Biological Evaluation of Scutellarein Derivatives Based on Scutellarin Metabolic Mechanism In Vivo. 2016 Chem Biol Drug Des pmid:26808289
Han F et al. Application of alkyl polyglycoside surfactant in ultrasonic-assisted extraction followed by macroporous resin enrichment for the separation of vitexin-2″-O-rhamnoside and vitexin from Crataegus pinnatifida leaves. 2016 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:26807707
Kiraly AJ et al. Apigenin inhibits COX-2, PGE2, and EP1 and also initiates terminal differentiation in the epidermis of tumor bearing mice. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:26802941
Ren B et al. Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats. 2016 Eur. J. Pharmacol. pmid:26801071
Dos Santos KC et al. Passiflora actinia hydroalcoholic extract and its major constituent, isovitexin, are neuroprotective against glutamate-induced cell damage in mice hippocampal slices. 2016 J. Pharm. Pharmacol. pmid:26800497
Veltmann M et al. Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. 2016 PLoS ONE pmid:26800359
An F et al. Attenuation of oxidative stress of erythrocytes by the plant-derived flavonoids vitexin and apigenin. 2015 Pharmazie pmid:26790189
Luan RL et al. Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice. 2016 Inflammation pmid:26782361
Wang Z et al. Scutellarin protects cardiomyocyte ischemia-reperfusion injury by reducing apoptosis and oxidative stress. 2016 Life Sci. pmid:26775564
Ku SK and Bae JS Vicenin-2 and scolymoside inhibit high-glucose-induced vascular inflammation in vitro and in vivo. 2016 Can. J. Physiol. Pharmacol. pmid:26766560
Zhu Q et al. Antinociceptive effects of vitexin in a mouse model of postoperative pain. 2016 Sci Rep pmid:26763934
Hou K et al. Ionic liquids-lithium salts pretreatment followed by ultrasound-assisted extraction of vitexin-4″-O-glucoside, vitexin-2″-O-rhamnoside and vitexin from Phyllostachys edulis leaves. 2016 J Chromatogr A pmid:26763300
Schmidt J Negative ion electrospray high-resolution tandem mass spectrometry of polyphenols. 2016 J Mass Spectrom pmid:26757070
Hu W et al. Apigenin-7-O-β-D-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock. 2016 Food Funct pmid:26750400
Wang W et al. Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor. 2016 PLoS ONE pmid:26730961
Yang MH et al. A new flavone C-glycoside and a new bibenzyl from Bulbophyllum retusiusculum. 2016 Nat. Prod. Res. pmid:26729275
Li LH et al. Apigenin inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells. 2015 Int J Clin Exp Pathol pmid:26722444
Lv H et al. Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways. 2016 Int. J. Biol. Sci. pmid:26722219
Cai M et al. Apigenin-7-O-β-D-(-6''-p-coumaroyl)-Glucopyranoside Treatment Elicits Neuroprotective Effect against Experimental Ischemic Stroke. 2016 Int. J. Biol. Sci. pmid:26722216
Nasr-Bouzaiene N et al. Immunomodulatory and cellular antioxidant activities of pure compounds from Teucrium ramosissimum Desf. 2016 Tumour Biol. pmid:26692099
Lin CH et al. Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. 2015 BMC Cancer pmid:26675309
Zhang S et al. Apigenin Attenuates Experimental Autoimmune Myocarditis by Modulating Th1/Th2 Cytokine Balance in Mice. 2016 Inflammation pmid:26658748
Wakx A et al. New in vitro biomarkers to detect toxicity in human placental cells: The example of benzo[A]pyrene. 2016 Toxicol In Vitro pmid:26657896
Fan J et al. Shear rheology and in-vitro release kinetic study of apigenin from lyotropic liquid crystal. 2016 Int J Pharm pmid:26657272
Chen RB et al. Deep Sequencing Reveals the Effect of MeJA on Scutellarin Biosynthesis in Erigeron breviscapus. 2015 PLoS ONE pmid:26656917
Nasr Bouzaiene N et al. Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells. 2016 Life Sci. pmid:26656314
Romero GB et al. Simple low-cost miniaturization approach for pharmaceutical nanocrystals production. 2016 Int J Pharm pmid:26642945
Kim SH et al. Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells. 2015 Anticancer Res. pmid:26637867
Hasnat MA et al. Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition. 2015 Molecules pmid:26633318
Basios N et al. Apigenin Attenuates Inflammation in Experimentally Induced Acute Pancreatitis-Associated Lung Injury. 2016 J Invest Surg pmid:26631908
Lee IC and Bae JS Anti-inflammatory effects of vicenin-2 and scolymoside on polyphosphate-mediated vascular inflammatory responses. 2016 Inflamm. Res. pmid:26621502
Lou SN et al. Phenolic content, antioxidant activity and effective compounds of kumquat extracted by different solvents. 2016 Food Chem pmid:26616917
Lee JA et al. Resveratrol as a Bioenhancer to Improve Anti-Inflammatory Activities of Apigenin. 2015 Nutrients pmid:26610561
Fang M et al. Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats. 2015 BMC Neurosci pmid:26608466
Mostafa NM et al. Cytotoxic activity and molecular docking of a novel biflavonoid isolated from Jacaranda acutifolia (Bignoniaceae). 2016 Nat. Prod. Res. pmid:26594904
Kawamura H et al. Ultrasonically enhanced extraction of luteolin and apigenin from the leaves of Perilla frutescens (L.) Britt. using liquid carbon dioxide and ethanol. 2016 Ultrason Sonochem pmid:26584980
Tian X et al. Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C. 2016 Biol. Pharm. Bull. pmid:26581323
Lee YM et al. Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress. 2016 Int. J. Oncol. pmid:26573871
Mangoyi R et al. Isolation and characterization of an antifungal compound 5-hydroxy-7,4'-dimethoxyflavone from Combretum zeyheri. 2015 BMC Complement Altern Med pmid:26573005
Li H et al. Separation of vitexin-4″-O-glucoside and vitexin-2″-O-rhamnoside from hawthorn leaves extracts using macroporous resins. 2015 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:26562804
Zemanova L et al. Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment. 2015 J. Nat. Prod. pmid:26529431
Morimoto Y et al. Apigenin as an anti-quinolone-resistance antibiotic. 2015 Int. J. Antimicrob. Agents pmid:26526895
Shi ZH et al. Synthesis and biological evaluation of methylated scutellarein analogs based on metabolic mechanism of scutellarin in vivo. 2015 Eur J Med Chem pmid:26523667
Li X et al. Apigenin, a potent suppressor of dendritic cell maturation and migration, protects against collagen-induced arthritis. 2016 J. Cell. Mol. Med. pmid:26515512
Wang WW et al. Scutellarin Alleviates Behavioral Deficits in a Mouse Model of Multiple Sclerosis, Possibly Through Protecting Neural Stem Cells. 2016 J. Mol. Neurosci. pmid:26514969
Seo HS et al. Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells. 2015 Biosci. Rep. pmid:26500281
Kang H et al. Anti-inflammatory effects of vicenin-2 and scolymoside in vitro and in vivo. 2015 Inflamm. Res. pmid:26482935
Bhardwaj M et al. Potential role of vitexin in alleviating heat stress-induced cytotoxicity: Regulatory effect of Hsp90 on ER stress-mediated autophagy. 2015 Life Sci. pmid:26475763
Xia F et al. Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus. 2015 Appl. Environ. Microbiol. pmid:26475103
Seo WD et al. Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5. 2015 Bioorg. Med. Chem. Lett. pmid:26471090
Chen C et al. Involvement of Bcl-2 Signal Pathway in the Protective Effects of Apigenin on Anoxia/Reoxygenation-induced Myocardium Injury. 2016 J. Cardiovasc. Pharmacol. pmid:26466327
Lin CH et al. Thrombin-induced IL-8/CXCL8 release is mediated by CK2, MSK1, and NF-κB pathways in human lung epithelial cells. 2015 Eur. J. Pharmacol. pmid:26463037
Shi ZH et al. Synthesis of scutellarein derivatives to increase biological activity and water solubility. 2015 Bioorg. Med. Chem. pmid:26455656
Guimarães R et al. Wild Roman chamomile extracts and phenolic compounds: enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase. 2016 Food Funct pmid:26446815
Li L et al. Scutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα. 2015 PLoS ONE pmid:26440524
Willenberg I et al. Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity. 2015 PLoS ONE pmid:26440517
Shukla S et al. Apigenin blocks IKKα activation and suppresses prostate cancer progression. 2015 Oncotarget pmid:26435478
Zhu H et al. Apigenin induced apoptosis in esophageal carcinoma cells by destruction membrane structures. 2016 Scanning pmid:26435325
Li R et al. Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain. 2016 Behav. Brain Res. pmid:26416673
Santos BL et al. Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression. 2015 Chem. Biol. Interact. pmid:26408079
Yang X et al. Apigenin attenuates myocardial ischemia/reperfusion injury via the inactivation of p38 mitogen‑activated protein kinase. 2015 Mol Med Rep pmid:26398147
Lakshmanan A et al. Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin. 2015 Oncotarget pmid:26397139
Liu Y et al. High-resolution hyaluronidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-necrosis constituents in Chinese plants used to treat snakebite. 2015 Phytochemistry pmid:26386983
Guimarães CC et al. The glycosylated flavonoids vitexin, isovitexin, and quercetrin isolated from Serjania erecta Radlk (Sapindaceae) leaves protect PC12 cells against amyloid-β25-35 peptide-induced toxicity. 2015 Food Chem. Toxicol. pmid:26385725
Shukla S et al. Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice. 2015 PLoS ONE pmid:26379052
Pápay ZE et al. Comparative evaluation of the effect of cyclodextrins and pH on aqueous solubility of apigenin. 2016 J Pharm Biomed Anal pmid:26363816
Sun J et al. Chemical Constituents and Antibacterial Properties of Indocalamus latifolius McClure Leaves, the Packaging Material for "Zongzi". 2015 Molecules pmid:26343625
Venditti A et al. Phytochemical analysis of Achillea ligustica All. from Lipari Island (Aeolian Islands). 2016 Nat. Prod. Res. pmid:26327332
Guo X et al. Synergistic interactions of apigenin, naringin, quercetin and emodin on inhibition of 3T3-L1 preadipocyte differentiation and pancreas lipase activity. Obes Res Clin Pract pmid:26314502
Fang J et al. Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1. 2015 Mol Med Rep pmid:26300442
Kawai K et al. Clerodendrin I, a New Neoclerodane Diterpenoid from Clerodendron trichotomum. 1999 Biosci. Biotechnol. Biochem. pmid:26300171
Samet I et al. Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. 2015 Differentiation pmid:26299581
Zhang L et al. Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells. 2015 Food Funct pmid:26292725
Li W et al. Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4). 2015 Biochem. Pharmacol. pmid:26291395
Patil RH et al. Anti-Inflammatory Effect of Apigenin on LPS-Induced Pro-Inflammatory Mediators and AP-1 Factors in Human Lung Epithelial Cells. 2016 Inflammation pmid:26276128
Lin S et al. Inhibition of chrysin on xanthine oxidase activity and its inhibition mechanism. 2015 Int. J. Biol. Macromol. pmid:26275460
Falcone Ferreyra ML et al. The Identification of Maize and Arabidopsis Type I FLAVONE SYNTHASEs Links Flavones with Hormones and Biotic Interactions. 2015 Plant Physiol. pmid:26269546
Farimani MM et al. Seco-ursane-type Triterpenoids from Salvia urmiensis with Apoptosis-inducing Activity. 2015 Planta Med. pmid:26252828
Cochran DB et al. Degradable poly(apigenin) polymer inhibits tumor cell adhesion to vascular endothelial cells. 2016 J. Biomed. Mater. Res. Part B Appl. Biomater. pmid:26251070
Lee W et al. Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo. 2015 Can. J. Physiol. Pharmacol. pmid:26243020
Zou H et al. Two new flavonoids from Selaginella uncinata. 2016 J Asian Nat Prod Res pmid:26238803
Bao YY et al. Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo. 2015 Oncol. Rep. pmid:26238658
Kubínová R et al. Anticholinesterase, antioxidant activity and phytochemical investigation into aqueous extracts from five species of Agrimonia genus. 2016 Nat. Prod. Res. pmid:26235662
Long HP et al. Involvenflavones A-F, six new flavonoids with 3'-aryl substituent from Selaginella involven. 2015 Fitoterapia pmid:26226107
Zhan YY et al. Inhibitory Effect of Apigenin on Pharmacokinetics of Venlafaxine in vivo and in vitro. 2015 Pharmacology pmid:26202346
Min JW et al. Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model. 2015 Neuropharmacology pmid:26187393