| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bardales JR et al. | CK2-mediated phosphorylation of a type II regulatory subunit of cAMP-dependent protein kinase from the mollusk Mytilus galloprovincialis. | 2007 | Arch. Biochem. Biophys. | pmid:17379180 |
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| Nangia-Makker P et al. | Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum. | 2007 | Int. J. Cancer | pmid:17437270 |
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| Chung CS et al. | Impact of adenomatous polyposis coli (APC) tumor supressor gene in human colon cancer cell lines on cell cycle arrest by apigenin. | 2007 | Mol. Carcinog. | pmid:17620292 |
| Wong SP et al. | Ultrasensitive cell-based bioassay for the measurement of global estrogenic activity of flavonoid mixtures revealing additive, restrictive, and enhanced actions in binary and higher order combinations. | 2007 | Assay Drug Dev Technol | pmid:17638535 |
| Shukla S et al. | Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. | 2007 | Cancer Res. | pmid:17638904 |
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| Favaro G et al. | Acidichromism and ionochromism of luteolin and apigenin, the main components of the naturally occurring yellow weld: a spectrophotometric and fluorimetric study. | 2007 | J Fluoresc | pmid:17710519 |
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| Tsuji PA and Walle T | Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line. | 2008 | Chem. Biol. Interact. | pmid:17884029 |
| Lim H and Kim HP | Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids. | 2007 | Planta Med. | pmid:17886198 |
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| Sarró E et al. | Phosphoinositide 3-kinase inhibitors protect mouse kidney cells from cyclosporine-induced cell death. | 2008 | Kidney Int. | pmid:17960138 |
| Lee WJ et al. | Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells. | 2008 | Toxicol. Appl. Pharmacol. | pmid:17961621 |
| Fan GJ et al. | Platelet-activating factor (PAF) receptor binding antagonists from Alpinia officinarum. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17964782 |
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| Lee SH et al. | Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer. | 2008 | Cancer Lett. | pmid:17967505 |
| Panda S and Kar A | Apigenin (4',5,7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice. | 2007 | J. Pharm. Pharmacol. | pmid:17976266 |
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| Nicholas C et al. | Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. | 2007 | J. Immunol. | pmid:17982104 |
| Galicka A and Nazaruk J | Stimulation of collagen biosynthesis by flavonoid glycosides in skin fibroblasts of osteogenesis imperfecta type I and the potential mechanism of their action. | 2007 | Int. J. Mol. Med. | pmid:17982699 |
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| El-Desouky SK et al. | A new cytotoxic acylated apigenin glucoside from Phyllanthus emblica L. | 2008 | Nat. Prod. Res. | pmid:17999342 |
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| Ha SK et al. | Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model. | 2008 Mar-Apr | Neurochem. Int. | pmid:18037535 |
| Lee JH et al. | Anti-inflammatory mechanisms of apigenin: inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion molecules. | 2007 | Arch. Pharm. Res. | pmid:18038911 |
| Choi SI et al. | Mechanism of apoptosis induced by apigenin in HepG2 human hepatoma cells: involvement of reactive oxygen species generated by NADPH oxidase. | 2007 | Arch. Pharm. Res. | pmid:18038912 |
| Ghanta S et al. | Oxidative DNA damage preventive activity and antioxidant potential of Stevia rebaudiana (Bertoni) Bertoni, a natural sweetener. | 2007 | J. Agric. Food Chem. | pmid:18038982 |
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| Yang L et al. | Metabolites of scutellarein in rat plasma. | 2008 Jan-Feb | J Asian Nat Prod Res | pmid:18058381 |
| Jin XY and Ren CS | [Effect and mechanism of apigenin on VEGF expression in human breast cancer cells]. | 2007 | Zhonghua Zhong Liu Za Zhi | pmid:18069627 |
| Wei YX et al. | [Studies on the chemical constituents of Gueldenstaedtia stenophylla]. | 2007 | Zhong Yao Cai | pmid:18074843 |