apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Coleta M et al. | Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity. | 2008 | Behav. Brain Res. | pmid:18249450 |
| Lee HE et al. | Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property. | 2016 | Behav. Brain Res. | pmid:26996316 |
| Li R et al. | Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain. | 2016 | Behav. Brain Res. | pmid:26416673 |
| Wang W et al. | [A new natural product from the roots of Hedysarum multijugum]. | 2005 | Beijing Da Xue Xue Bao | pmid:16224530 |
| Liu Q et al. | Apigenin inhibits cell migration through MAPK pathways in human bladder smooth muscle cells. | 2011 | Biocell | pmid:22423483 |
| Sun Q et al. | Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29408335 |
| Ashokkumar R et al. | Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29406244 |
| Lv SX and Qiao X | Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29355527 |
| Ogawa M et al. | Nuclear translocation of Xenopus laevis paxillin. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12727207 |
| Karmakar S et al. | Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19695221 |
| Zhou RJ et al. | Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28867192 |
| Li G et al. | Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28408212 |
| Brinkworth RI et al. | Flavones are inhibitors of HIV-1 proteinase. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1445308 |
| Thirusangu P et al. | Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28104392 |
| Ke Y et al. | Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27998773 |
| Hirano T et al. | Luteolin, a flavonoid, inhibits AP-1 activation by basophils. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16343431 |
| Gao ZX et al. | Scutellarin promotes in vitro angiogenesis in human umbilical vein endothelial cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20709020 |
| Lin CM et al. | Molecular modeling of flavonoids that inhibits xanthine oxidase. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054758 |
| Zhang GH et al. | The anti-HIV-1 effect of scutellarin. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16023998 |
| Segaert S et al. | The flavonoid apigenin suppresses vitamin D receptor expression and vitamin D responsiveness in normal human keratinocytes. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10652242 |