apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Li G et al. | Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28408212 |
Steyns JM and van Brederode J | Variation in the substrate specificity of allozymes catalyzing flavone-O-glucoside biosynthesis in Silene plants. | 1986 | Biochem. Genet. | pmid:2943268 |
Wiejak J et al. | Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. | 2013 | Biochem. J. | pmid:23782265 |
Sarno S et al. | Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). | 2003 | Biochem. J. | pmid:12816539 |
Llorens F et al. | The N-terminal domain of the human eIF2beta subunit and the CK2 phosphorylation sites are required for its function. | 2006 | Biochem. J. | pmid:16225457 |
Shanle EK et al. | Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligands. | 2011 | Biochem. Pharmacol. | pmid:21924251 |
Comalada M et al. | Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. | 2006 | Biochem. Pharmacol. | pmid:16934226 |
Casagrande F and Darbon JM | Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. | 2001 | Biochem. Pharmacol. | pmid:11322924 |
Walle T et al. | Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. | 2007 | Biochem. Pharmacol. | pmid:17250812 |
Ansó E et al. | Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism. | 2010 | Biochem. Pharmacol. | pmid:20153296 |
Bandyopadhyay S et al. | Attenuation of osteoclastogenesis and osteoclast function by apigenin. | 2006 | Biochem. Pharmacol. | pmid:16750176 |
Avallone R et al. | Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. | 2000 | Biochem. Pharmacol. | pmid:10751547 |
Silfen J et al. | Bioflavonoid effects on in vitro cultures of Plasmodium falciparum. Inhibition of permeation pathways induced in the host cell membrane by the intraerythrocytic parasite. | 1988 | Biochem. Pharmacol. | pmid:3058128 |
López-Posadas R et al. | Effect of flavonoids on rat splenocytes, a structure-activity relationship study. | 2008 | Biochem. Pharmacol. | pmid:18590707 |
Chen Y et al. | Glucuronidation of flavonoids by recombinant UGT1A3 and UGT1A9. | 2008 | Biochem. Pharmacol. | pmid:18565494 |
Feng X et al. | Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. | 2017 | Biochem. Pharmacol. | pmid:28414138 |
Lee WR et al. | Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. | 2002 | Biochem. Pharmacol. | pmid:11841797 |
Verbeek R et al. | The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells. | 2004 | Biochem. Pharmacol. | pmid:15276069 |
van Meeteren ME et al. | Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease. | 2004 | Biochem. Pharmacol. | pmid:15104250 |
Mandery K et al. | Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. | 2010 | Biochem. Pharmacol. | pmid:20797388 |
Fesen MR et al. | Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. | 1994 | Biochem. Pharmacol. | pmid:7520698 |
Hougee S et al. | Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages. | 2005 | Biochem. Pharmacol. | pmid:15627476 |
Niisato N et al. | Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells. | 2004 | Biochem. Pharmacol. | pmid:14757180 |
Verbeek R et al. | Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice. | 2005 | Biochem. Pharmacol. | pmid:15946653 |
During A and Larondelle Y | The O-methylation of chrysin markedly improves its intestinal anti-inflammatory properties: Structure-activity relationships of flavones. | 2013 | Biochem. Pharmacol. | pmid:24134915 |
Ko WC et al. | Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. | 2004 | Biochem. Pharmacol. | pmid:15476679 |
van Zanden JJ et al. | Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2. | 2005 | Biochem. Pharmacol. | pmid:15670588 |
Chen D et al. | Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. | 2005 | Biochem. Pharmacol. | pmid:15857606 |
Liu Y et al. | Effects of the natural flavone trimethylapigenin on cardiac potassium currents. | 2012 | Biochem. Pharmacol. | pmid:22583923 |
Arango D et al. | Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair. | 2012 | Biochem. Pharmacol. | pmid:22985621 |
Nagaprashantha LD et al. | Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer. | 2011 | Biochem. Pharmacol. | pmid:21803027 |
O'Prey J et al. | Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells. | 2003 | Biochem. Pharmacol. | pmid:14609732 |
Campbell EL et al. | The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. | 2004 | Biochem. Pharmacol. | pmid:15451406 |
Keum YS and Jeong YJ | Development of chemical inhibitors of the SARS coronavirus: viral helicase as a potential target. | 2012 | Biochem. Pharmacol. | pmid:22935448 |
Li W et al. | Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4). | 2015 | Biochem. Pharmacol. | pmid:26291395 |
Laberge RM et al. | Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress. | 2007 | Biochem. Pharmacol. | pmid:17359940 |
Vargo MA et al. | Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16844095 |
Thapa A et al. | Biflavonoids are superior to monoflavonoids in inhibiting amyloid-β toxicity and fibrillogenesis via accumulation of nontoxic oligomer-like structures. | 2011 | Biochemistry | pmid:21322641 |
Lolli G et al. | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. | 2012 | Biochemistry | pmid:22794353 |
Xie LP et al. | Inhibitory effects of some flavonoids on the activity of mushroom tyrosinase. | 2003 | Biochemistry Mosc. | pmid:12765534 |
Yang LL et al. | Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. | 2017 | Biochim Biophys Acta Mol Basis Dis | pmid:27903431 |
Singhal SS et al. | Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. | 2017 | Biochim Biophys Acta Rev Cancer | pmid:28359741 |
Kim K et al. | Galectin-3 expression in macrophages is signaled by Ras/MAP kinase pathway and up-regulated by modified lipoproteins. | 2003 | Biochim. Biophys. Acta | pmid:12788225 |
Paoli P et al. | The insulin-mimetic effect of Morin: a promising molecule in diabetes treatment. | 2013 | Biochim. Biophys. Acta | pmid:23352912 |
Pawlikowska-Pawlęga B et al. | FTIR, (1)H NMR and EPR spectroscopy studies on the interaction of flavone apigenin with dipalmitoylphosphatidylcholine liposomes. | 2013 | Biochim. Biophys. Acta | pmid:23088916 |
Caruana M et al. | Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro. | 2012 | Biochim. Biophys. Acta | pmid:22634381 |
Chan LP et al. | Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin. | 2012 | Biochim. Biophys. Acta | pmid:22554915 |
Shimmyo Y et al. | Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. | 2008 | Biochim. Biophys. Acta | pmid:18295609 |
King JC et al. | Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. | 2012 | Biochim. Biophys. Acta | pmid:22227579 |
Lagoa R et al. | Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria. | 2011 | Biochim. Biophys. Acta | pmid:22015496 |