apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yin F et al. | Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO). | 1999 Sep-Oct | Anticancer Res. | pmid:10628390 |
Alcaraz M et al. | Effects of bisphosphonates in combination with ionizing radiation and antioxidants on the growth of prostate and melanoma cells lines. | 2013 | Anticancer Res. | pmid:23898082 |
Seo HS et al. | Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells. | 2014 | Anticancer Res. | pmid:24922650 |
Kim SH et al. | Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells. | 2015 | Anticancer Res. | pmid:26637867 |
Koo H et al. | Influence of apigenin on gtf gene expression in Streptococcus mutans UA159. | 2006 | Antimicrob. Agents Chemother. | pmid:16436708 |
Wong IL et al. | Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania. | 2007 | Antimicrob. Agents Chemother. | pmid:17194831 |
Bach A et al. | The antioxidant quercetin inhibits cellular proliferation via HIF-1-dependent induction of p21WAF. | 2010 | Antioxid. Redox Signal. | pmid:19958256 |
Mahmood N et al. | Inhibition of HIV infection by flavanoids. | 1993 | Antiviral Res. | pmid:8279812 |
Nagai T et al. | In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase. | 1992 | Antiviral Res. | pmid:1444327 |
Evers DL et al. | Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action. | 2005 | Antiviral Res. | pmid:16188329 |