apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Li LL and Chen XM | [Preparation and spectral characterization of apigenin molecularly imprinted polymer]. | 2009 | Yao Xue Xue Bao | pmid:20055154 |
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Fu XZ et al. | [Design, synthesis and anti-oxidative evaluation of L-amino acid prodrugs of scutellarein]. | 2011 | Yao Xue Xue Bao | pmid:21800542 |
Qu LB et al. | [Interaction of bovine serum albumin with luteolin and apigenin]. | 2006 | Yao Xue Xue Bao | pmid:16856482 |
Luo P et al. | Scutellarin isolated from Erigeron multiradiatus inhibits high glucose-mediated vascular inflammation. | 2008 | Yakugaku Zasshi | pmid:18758143 |
Yasukawa K et al. | [Studies on the constituents in the water extracts in crude drugs. IV. On the roots of Stellaria dichotoma L. var lanceolata Bge. (2(2)) (author's transl)]. | 1982 | Yakugaku Zasshi | pmid:7108760 |
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Liang ZD et al. | [Effect of Apigenin on proliferation, cell cycle and apoptosis of mouse T cells in vitro]. | 2008 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:18394337 |
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Breinholt V et al. | Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat. | 1999 | Xenobiotica | pmid:10647909 |
Wang Y et al. | Intestinal transport of scutellarein and scutellarin and first-pass metabolism by UDP-glucuronosyltransferase-mediated glucuronidation of scutellarein and hydrolysis of scutellarin. | 2011 | Xenobiotica | pmid:21561321 |
Li J et al. | Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. | 2017 | World J. Gastroenterol. | pmid:28611514 |
Wu K et al. | Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. | 2005 | World J. Gastroenterol. | pmid:16052672 |
Hoensch H et al. | Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence. | 2008 | World J. Gastroenterol. | pmid:18407592 |
Hoensch HP and Oertel R | Emerging role of bioflavonoids in gastroenterology: Especially their effects on intestinal neoplasia. | 2011 | World J Gastrointest Oncol | pmid:21603032 |
Kowalski J et al. | [Apigenin inhibits release and gene expression of monocyte chemoattractant protein 1 (MCP-1) in J774.2 macrophages]. | 2006 | Wiad. Lek. | pmid:17338120 |
Sui H et al. | [Effect of high dose apigenin on antioxidase activity and DNA damage in rats]. | 2009 | Wei Sheng Yan Jiu | pmid:19267072 |
Sui H et al. | [Effects of apigenin on the expression of angiotensin-converting enzyme 2 in kidney in spontaneously hypertensive rats]. | 2010 | Wei Sheng Yan Jiu | pmid:21351633 |
Sui H et al. | [Endothelium-dependent vasorelaxation effects induced by apigenin on the thoracic aorta of rats and its possible mechanism]. | 2011 | Wei Sheng Yan Jiu | pmid:21861336 |
Chang CW et al. | Daphne Genkwa sieb. Et zucc. Water-soluble extracts act on enterovirus 71 by inhibiting viral entry. | 2012 | Viruses | pmid:22590685 |
Qian S et al. | Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity. | 2015 | Viruses | pmid:25835532 |
Shibata C et al. | The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels. | 2014 | Virology | pmid:25092460 |
Qin W et al. | Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose. | 2016 | Vascul. Pharmacol. | pmid:27473516 |
Chen F et al. | An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. | 2017 | Ultrason Sonochem | pmid:28427633 |
Kawamura H et al. | Ultrasonically enhanced extraction of luteolin and apigenin from the leaves of Perilla frutescens (L.) Britt. using liquid carbon dioxide and ethanol. | 2016 | Ultrason Sonochem | pmid:26584980 |
Medhat AM et al. | Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. | 2017 | Tumour Biol. | pmid:29022496 |
Hassoun SM et al. | Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. | 2017 | Tumour Biol. | pmid:28651490 |
Chen J et al. | The apoptotic effect of apigenin on human gastric carcinoma cells through mitochondrial signal pathway. | 2014 | Tumour Biol. | pmid:24805829 |
Wan Y et al. | miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. | 2017 | Tumour Biol. | pmid:28381178 |
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Ahlenstiel T et al. | Improved cold preservation of kidney tubular cells by means of adding bioflavonoids to organ preservation solutions. | 2006 | Transplantation | pmid:16436967 |
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Huang H et al. | effects of natural flavonoids on photosynthetic activity and cell integrity in Microcystis aeruginosa. | 2015 | Toxins (Basel) | pmid:25584428 |
Schrader KK | Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). | 2010 | Toxins (Basel) | pmid:22069655 |
Zhong Y et al. | Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. | 2017 | Toxicon | pmid:28734981 |
Yingprasertchai S et al. | Hyaluronidase inhibitors (sodium cromoglycate and sodium auro-thiomalate) reduce the local tissue damage and prolong the survival time of mice injected with Naja kaouthia and Calloselasma rhodostoma venoms. | 2003 | Toxicon | pmid:14602119 |
Çelik H et al. | In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase. | 2013 | Toxicology | pmid:23567315 |
Androutsopoulos VP et al. | CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells. | 2009 | Toxicology | pmid:19666078 |
Chaudhary A and Willett KL | Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John's wort. | 2006 | Toxicology | pmid:16271822 |
Khan TH and Sultana S | Apigenin induces apoptosis in Hep G2 cells: possible role of TNF-alpha and IFN-gamma. | 2006 | Toxicology | pmid:16289292 |
Sanderson JT et al. | Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. | 2004 | Toxicol. Sci. | pmid:15319488 |
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Barlas N et al. | The estrogenic effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar albino rats. | 2014 | Toxicol. Lett. | pmid:24487097 |
Das S et al. | Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro. | 2013 | Toxicol. Lett. | pmid:24070738 |
Wu DG et al. | Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells. | 2014 | Toxicol. Lett. | pmid:24148603 |
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Gaballah HH et al. | Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28025107 |
Lee WJ et al. | Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells. | 2008 | Toxicol. Appl. Pharmacol. | pmid:17961621 |
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Dai J et al. | Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells. | 2016 | Toxicol. Appl. Pharmacol. | pmid:27664007 |
Wang L et al. | Apigenin suppresses migration and invasion of transformed cells through down-regulation of C-X-C chemokine receptor 4 expression. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23743303 |
Kim DI et al. | Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: isolation of flavonoids of apigenin and luteolin as acting compounds. | 2005 | Toxicol. Appl. Pharmacol. | pmid:15922007 |
van Meeuwen JA et al. | Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts--a comparative study. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18201740 |
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Gulluce M et al. | Isolation of a flavonoid, apigenin 7-O-glucoside, from Mentha longifolia (L.) Hudson subspecies longifolia and its genotoxic potency. | 2015 | Toxicol Ind Health | pmid:23377117 |
Gulluce M et al. | Determination of antimutagenic properties of apigenin-7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp. longifolia with yeast DEL assay. | 2013 | Toxicol Ind Health | pmid:22491724 |
Siddique YH et al. | Antigenotoxic effect of apigenin against anti-cancerous drugs. | 2008 | Toxicol In Vitro | pmid:18206345 |
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