apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yuan K et al. | [Simultaneous determination of four glycosylflavones from Lophatherum gracile by RP-HPLC]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166010 |
Ren DC et al. | [Chemical study on aerial parts of Ligusticum chuanxiong]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17966355 |
Wang D et al. | [Studies on chemical constituents from herbs of Botrychium lanuginosum]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19216157 |
Zhang Y et al. | [Effect of caffeic acid, seopoletin and scutellarin on rat retinal neurons in vitro]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16124607 |
Che QM et al. | [Study on bile excretion of scutellarein]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17225543 |
Dong Q et al. | [Studies on chemical constituents from stellaria media. I]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17672340 |
Jiang Y et al. | [Studies on chemical components of Lobelia chinensis]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19445152 |
Hu BB et al. | [Determination of main flavone glycosides in Flos Chrysanthemi and observation of factors influenced contents]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17260789 |
You HS et al. | [Pharmacokinetic and tissue distribution study of scutellarin in rats]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18027669 |
Liu J and Xiong Y | [Advances in studies on pharmacokinetics of scutellarin and scutellarein]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:20352990 |
Qu L et al. | [Determination of vitexin-rhamnoside in Beagle dog plasma and preliminary pharmacokinetics of Yixintong sustained release tablets]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18720869 |
Cheng YB et al. | [Study on chemical constituents in rhizome of Smilax perfoliate]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015307 |
Shi S et al. | [Evaluation of brain-targeted trendence of scutellarin nasal administration]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21141499 |
Gu L et al. | [Quality specification of Perillae Fructus]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21046735 |
Li YR et al. | [Quality standard study on Vigna radiata]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:24754176 |
Liu Z et al. | [Determination of orientin and vitexin in Trollius chinesis preparation by HPLC]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15656135 |
He Y et al. | [Simultaneous determination of chlorogenic acid and vitexin 2"-rhamnoside in Crataegi Fructus extracts by HPLC]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22715732 |
Zhao DB et al. | [Studies on flavonoids from herb of Artemisia ordosica]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16381463 |
Huang Y et al. | [Simultaneous determination of protocatechuic acid, isoorientin and scutellarin in rat tissues after a single intravenous administration of compound hongcao for injection by UPLC-MS/MS]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22375405 |
Zhao DB et al. | [Studies on chemical constituents in herb of Chondrilla piptocoma]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011281 |
Shi T et al. | [Effect of apigenin on protein expressions of PPARs in liver tissues of rats with nonalcoholic steatohepatitis]. | 2015 | Zhonghua Gan Zang Bing Za Zhi | pmid:25880979 |
Shi XR et al. | [Apigenin affects semen parameters in male mice]. | 2010 | Zhonghua Nan Ke Xue | pmid:21171258 |
Yao HM et al. | [Effects of apigenin on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells]. | 2017 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:28545285 |
Xing Y et al. | [Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation]. | 2002 | Zhonghua Yi Xue Za Zhi | pmid:12509912 |
Wang LY et al. | [Apigenin regulates lipopolysaccharides-induced activation of inflammasome]. | 2011 | Zhonghua Yi Xue Za Zhi | pmid:22321793 |
Jin XY and Ren CS | [Effect and mechanism of apigenin on VEGF expression in human breast cancer cells]. | 2007 | Zhonghua Zhong Liu Za Zhi | pmid:18069627 |
Tatemoto H et al. | Inhibition of boar sperm hyaluronidase activity by tannic acid reduces polyspermy during in vitro fertilization of porcine oocytes. | 2006 | Zygote | pmid:17266786 |