apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tatemoto H et al. | Inhibition of boar sperm hyaluronidase activity by tannic acid reduces polyspermy during in vitro fertilization of porcine oocytes. | 2006 | Zygote | pmid:17266786 |
Jin XY and Ren CS | [Effect and mechanism of apigenin on VEGF expression in human breast cancer cells]. | 2007 | Zhonghua Zhong Liu Za Zhi | pmid:18069627 |
Xing Y et al. | [Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation]. | 2002 | Zhonghua Yi Xue Za Zhi | pmid:12509912 |
Wang LY et al. | [Apigenin regulates lipopolysaccharides-induced activation of inflammasome]. | 2011 | Zhonghua Yi Xue Za Zhi | pmid:22321793 |
Yao HM et al. | [Effects of apigenin on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells]. | 2017 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:28545285 |
Shi XR et al. | [Apigenin affects semen parameters in male mice]. | 2010 | Zhonghua Nan Ke Xue | pmid:21171258 |
Shi T et al. | [Effect of apigenin on protein expressions of PPARs in liver tissues of rats with nonalcoholic steatohepatitis]. | 2015 | Zhonghua Gan Zang Bing Za Zhi | pmid:25880979 |
Liu JQ et al. | [Studies on the chemical constituents from Chrysanthemum morifolium Ramat]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776368 |
Sang SM et al. | [Studies on the flavonol glycosides from the seeds of Vaccaria segetalis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512436 |
Zhang WD et al. | [Studies on flavone constituents of Erigeron breviscapus (Vant.) Hand.-Mazz]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516462 |
Zhang J et al. | [Studies on chemical constituents of leaves of Salix matsudana Koidz and their influence on lipolysis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516463 |
Chen S et al. | [Studies on flavonoids from Aquilegia oxysepala Trautv. et Mey]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12242797 |
Shi S et al. | [Evaluation of brain-targeted trendence of scutellarin nasal administration]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21141499 |
Gu L et al. | [Quality specification of Perillae Fructus]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21046735 |
Li K et al. | [Study on fragmentation of vitexin and isorhamnetin-3-O-beta-D-rutinoside using electrospray quadrupole time of flight mass spectrometry]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21506419 |
Yuan K et al. | [Simultaneous determination of four glycosylflavones from Lophatherum gracile by RP-HPLC]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166010 |
Yang SC et al. | [Study on optimal harvest time of Erigeron breviscapus]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260301 |
Wang XM et al. | [HPLC determination of four active components in dengzhanxixin injection]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18841764 |
Wang D et al. | [Studies on chemical constituents from herbs of Botrychium lanuginosum]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19216157 |
Yang HP et al. | [Studies on glycosides from Gentiana veitchiorum]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19149260 |
Xia CL et al. | [Chemical constituents from herbs of Swertia delavayi]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19086635 |
Jiang Y et al. | [Studies on chemical components of Lobelia chinensis]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19445152 |
Zhang Y et al. | [Effect of water stress on content of active constituents in Erigeron breviscaps]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19673373 |
Liu J and Xiong Y | [Advances in studies on pharmacokinetics of scutellarin and scutellarein]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:20352990 |
Zhao DB et al. | [Studies on flavonoids from herb of Artemisia ordosica]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16381463 |
Ren DC et al. | [Chemical study on aerial parts of Ligusticum chuanxiong]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17966355 |
Zhao DB et al. | [Studies on chemical constituents of Acroptilon repens]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17285986 |
Hu YM et al. | [Flavones from flowers of Sesamum indicum]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17583201 |
Lei N et al. | [Chemical constituents from a Tibetan medicine Arenaria kansuensis I]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17655145 |
Zhu B et al. | [Studies on chemical constituent and quantitative determination of Mallotus apelta]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17655150 |
Wu X et al. | [Studies on flavones in of Lavandula augustifolia]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17639984 |
Zhang S et al. | [Studies on chemical constituents of Eriophyton wallichii]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17639985 |
Wang M et al. | [Studies on constituents of Dendrobium gratiosissimum]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17608224 |
Dong Q et al. | [Studies on chemical constituents from stellaria media. I]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17672340 |
Hu BB et al. | [Determination of main flavone glycosides in Flos Chrysanthemi and observation of factors influenced contents]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17260789 |
You HS et al. | [Pharmacokinetic and tissue distribution study of scutellarin in rats]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18027669 |
Wang L et al. | [Studies on chemical constituents from bark of Morus nigra]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18330242 |
Su EN et al. | [Studies on chemical constituents from stems and leaves of Adenanthera pavanina]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18306745 |
Wang WS et al. | [Studies on the flavonoids in herb from Scutellaria barbata]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15631081 |
Yu ZW et al. | [Study on chemical constituents from Incarvillea arguta and their accelerating PC-12 cell differentiation]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16323541 |
Cheng YB et al. | [Study on chemical constituents in rhizome of Smilax perfoliate]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015307 |
Yang L et al. | [Studies on chemical constituents in rhizome of Matteuccia struthiopteris]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15503769 |
Huo CH et al. | [Studies on chemical constituents in herbs of Acanthus ilicifolius]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16075716 |
Liu Z et al. | [Determination of orientin and vitexin in Trollius chinesis preparation by HPLC]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15656135 |
Ding L et al. | [Studies on the flavonoid constituents in herb of Eremosparton songoricum]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:15714817 |
Wang LS et al. | [Study on the chemical constituents from Picria fel-tarrae]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15719682 |
Tian J et al. | [Studies on the chemical constitutents in herb of Verbena officinalis]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:15724402 |
Gu HF et al. | [Studies on chemical constituents from herb of Dracocephalum moldavica]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15706847 |
Su J et al. | [Determination of flavoniod-glycosides in Yixintong pills by HPLC]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15706914 |
Zhao DB et al. | [Studies on chemical constituents in herb of Chondrilla piptocoma]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011281 |
Dai C et al. | [Studies on chemical constituents from moss Rhodobryum roseum II]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17048608 |
Hua Y and Wang HQ | [Studies on the flavonoids from whole herbs of Seriphidium terrae-albae]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17048665 |
Zhu XX et al. | [Effect of vitexia-rhamnoside (V-R) on vasomotor factors expression of endothelial cell]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16780160 |
Zhang Y et al. | [Effect of caffeic acid, seopoletin and scutellarin on rat retinal neurons in vitro]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16124607 |
Che QM et al. | [Study on bile excretion of scutellarein]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17225543 |
Liu JY et al. | [Optimizing extraction process of Scutellaria barbata by golden section method]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18619346 |
Dawa ZM et al. | [Studies on chemical constituents of Saussurea laniceps]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18652351 |
Qu L et al. | [Determination of vitexin-rhamnoside in Beagle dog plasma and preliminary pharmacokinetics of Yixintong sustained release tablets]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18720869 |
He Y et al. | [Simultaneous determination of chlorogenic acid and vitexin 2"-rhamnoside in Crataegi Fructus extracts by HPLC]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22715732 |
Qin S and Wen X | [Simultaneous determination of 6 active components in Chrysanthemum morifolium by HPLC]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22779181 |
Ye S et al. | [Scutellarin starch microspheres' permeability through nasal mucosa of different animals in vitro]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22693914 |
Huang Y et al. | [Simultaneous determination of isoorientin, scutellarin and cynaroside in rat plasma and pharmacokinetics by UPLC-MS/MS]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22667158 |
Huang Y et al. | [Simultaneous determination of protocatechuic acid, isoorientin and scutellarin in rat tissues after a single intravenous administration of compound hongcao for injection by UPLC-MS/MS]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22375405 |
Han SL et al. | [Comparison of antioxidant activity between two species of chamomiles produced in Xinjiang by TLC-bioautography]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23672040 |
Zhu R et al. | [Study on estrogenic effect of genistein and apigenin in vitro]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23189742 |
Tong C and Wu X | [Determination of plasma protein binding rate of vitexin]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23126208 |
Li YL et al. | [Evaluation on preparation process of brevisapin colon-specific tables and its in vitro release]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23717958 |
He CH et al. | [Study on intestinal absorption kinetics of apigenin in rats]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23944080 |
Li XB et al. | [Simultaneous determination of chlorogenic acid, scutellarin, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid in different parts of Erigeron breviscapus by high-performance liquid chromatography]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:24199546 |
Liu T et al. | [Relationship between expression of chalcone synthase gene (CHS) and scutellarin content in Erigeron breviscapus]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:24199547 |
Zheng XX et al. | [Role of ERK/FoxO3a signal axis in inhibitory effect of vitexin 1 (VB-1) in HepG2 cell proliferation]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:25011268 |
Zhu LW et al. | [Pharmacokinetics of scutellarin and its derivant scutellarin ethyl ester in rats]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:24422411 |
Li YR et al. | [Quality standard study on Vigna radiata]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:24754176 |
Wu QP et al. | [Determination of five primary chemical constituents in Cassia angustifolia by HPLC]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18533485 |
Pang LL et al. | [Inhibitory effects of apigenin on the expression of GATA-3 and Th2 cytokines in asthmatic mice]. | 2010 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:20669675 |
Guo LL et al. | [Effect of scutellarin on expressions of nicotinic acetylcholine receptor protein and mRNA in the brains of dementia rats]. | 2011 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:21823425 |
Tian Y et al. | [The effect of apigenin on reproductive axis in female rats]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21845881 |
Sun J et al. | [Investigation on method speliality in identifying Fructus Crataegi with vitexin rhamnoside]. | 2001 | Zhong Yao Cai | pmid:11917841 |
Liu H et al. | [Study on effects of scutellarin on scavenging reactive oxygen]. | 2002 | Zhong Yao Cai | pmid:12599762 |
Cehn YS et al. | [Studies on the lowering blood sugar substances from agrimony (II)]. | 2010 | Zhong Yao Cai | pmid:20873555 |
Fang ZJ et al. | [Studies on HPLC fingerprint chromatogram of Folium Fici Microcarpa]. | 2008 | Zhong Yao Cai | pmid:19230396 |
Li XQ et al. | [Chemical constituents from leaves of Paulownia fortunei]. | 2008 | Zhong Yao Cai | pmid:18998567 |
Liu C et al. | [Neuroprotective effects of apigenin on acute transient focal cerebral ischemia-reperfusion injury in rats]. | 2008 | Zhong Yao Cai | pmid:18998572 |
Gao MH et al. | [Studies on chemical constituents from flowers of Chrysanthemum indicum]. | 2008 | Zhong Yao Cai | pmid:18826144 |
Rao GX et al. | [Studies on the chemical constituents of the leaves of Polygonum multiflorum]. | 2009 | Zhong Yao Cai | pmid:19764327 |
Hui TT et al. | [Studies on chemical constituents from rattan of Polygonum multiflorum]. | 2008 | Zhong Yao Cai | pmid:19112895 |
Wang WS et al. | [Studies on chemical constituents from Pteris multifida]. | 2008 | Zhong Yao Cai | pmid:19112896 |
Lu JQ et al. | [Studies on chemical constituents of Dendranthema indicum var. aromaticum]. | 2009 | Zhong Yao Cai | pmid:19445120 |
Li XQ et al. | [Studies on the chemical constituents from flower of Paulownia fortunei]. | 2009 | Zhong Yao Cai | pmid:19960943 |
Yuan NN et al. | [Studies on the chemical constituents of Blumea laciniata]. | 2009 | Zhong Yao Cai | pmid:19873734 |
Guo LL et al. | [Influence of scutellarin on oxidative stress and neuronal apoptosis of rats with dementia]. | 2011 | Zhong Yao Cai | pmid:21823483 |
Li XL et al. | [Study on chemical constituents from Desmodium styracifolium]. | 2007 | Zhong Yao Cai | pmid:17944190 |
Wei YX et al. | [Studies on the chemical constituents of Gueldenstaedtia stenophylla]. | 2007 | Zhong Yao Cai | pmid:18074843 |
Liu Y et al. | [Studies on chemical constituents from the flowers of Carthamus tinctorius L]. | 2005 | Zhong Yao Cai | pmid:16104502 |
Liu W et al. | [Effect of three flavones on enzyme activity of recombinant human phosphoinositide 3-kinase p110beta catalytic subunit]. | 2006 | Zhong Yao Cai | pmid:16722316 |
Zhai YJ et al. | [Preparation and in vitro characterization of apigemin-loaded nanostructured lipid carriers]. | 2011 | Zhong Yao Cai | pmid:22017012 |
Wang JL et al. | [Study on chemical constituents of the Ixeris chinensis]. | 2011 | Zhong Yao Cai | pmid:22506392 |
Peng XJ and Li C | [Study on the flavanone constitutes of Buddleja davidii]. | 2011 | Zhong Yao Cai | pmid:22372140 |
Cui SM et al. | [Determination of vitexin in plasma by HPLC-MS/MS method and its pharmacokinetics in rats]. | 2012 | Zhong Yao Cai | pmid:23252280 |
Chen J et al. | [Study on chemical constituents of Cardiospermum halicacabum]. | 2013 | Zhong Yao Cai | pmid:23901648 |