apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Asthma D001249 52 associated lipids
Astrocytoma D001254 15 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cystitis D003556 23 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Gastritis D005756 27 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Leiomyoma D007889 8 associated lipids
Leukemia D007938 74 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Melanoma D008545 69 associated lipids
Memory Disorders D008569 33 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neuroblastoma D009447 66 associated lipids
Pain D010146 64 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Parkinson Disease D010300 53 associated lipids
Precancerous Conditions D011230 48 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Seizures D012640 87 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Thrombosis D013927 49 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Translocation, Genetic D014178 20 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Cocaine-Related Disorders D019970 3 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Brain Infarction D020520 17 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Genomic Instability D042822 7 associated lipids
Chromosomal Instability D043171 5 associated lipids
Premature Birth D047928 6 associated lipids
Lymphoma, Primary Effusion D054685 2 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

Download all related citations
Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Tatemoto H et al. Inhibition of boar sperm hyaluronidase activity by tannic acid reduces polyspermy during in vitro fertilization of porcine oocytes. 2006 Zygote pmid:17266786
Jin XY and Ren CS [Effect and mechanism of apigenin on VEGF expression in human breast cancer cells]. 2007 Zhonghua Zhong Liu Za Zhi pmid:18069627
Xing Y et al. [Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation]. 2002 Zhonghua Yi Xue Za Zhi pmid:12509912
Wang LY et al. [Apigenin regulates lipopolysaccharides-induced activation of inflammasome]. 2011 Zhonghua Yi Xue Za Zhi pmid:22321793
Yao HM et al. [Effects of apigenin on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells]. 2017 Zhonghua Xin Xue Guan Bing Za Zhi pmid:28545285
Shi XR et al. [Apigenin affects semen parameters in male mice]. 2010 Zhonghua Nan Ke Xue pmid:21171258
Shi T et al. [Effect of apigenin on protein expressions of PPARs in liver tissues of rats with nonalcoholic steatohepatitis]. 2015 Zhonghua Gan Zang Bing Za Zhi pmid:25880979
Liu JQ et al. [Studies on the chemical constituents from Chrysanthemum morifolium Ramat]. 2001 Zhongguo Zhong Yao Za Zhi pmid:12776368
Sang SM et al. [Studies on the flavonol glycosides from the seeds of Vaccaria segetalis]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12512436
Zhang WD et al. [Studies on flavone constituents of Erigeron breviscapus (Vant.) Hand.-Mazz]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12516462
Zhang J et al. [Studies on chemical constituents of leaves of Salix matsudana Koidz and their influence on lipolysis]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12516463
Chen S et al. [Studies on flavonoids from Aquilegia oxysepala Trautv. et Mey]. 1999 Zhongguo Zhong Yao Za Zhi pmid:12242797
Shi S et al. [Evaluation of brain-targeted trendence of scutellarin nasal administration]. 2010 Zhongguo Zhong Yao Za Zhi pmid:21141499
Gu L et al. [Quality specification of Perillae Fructus]. 2010 Zhongguo Zhong Yao Za Zhi pmid:21046735
Li K et al. [Study on fragmentation of vitexin and isorhamnetin-3-O-beta-D-rutinoside using electrospray quadrupole time of flight mass spectrometry]. 2011 Zhongguo Zhong Yao Za Zhi pmid:21506419
Yuan K et al. [Simultaneous determination of four glycosylflavones from Lophatherum gracile by RP-HPLC]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19166010
Yang SC et al. [Study on optimal harvest time of Erigeron breviscapus]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19260301
Wang XM et al. [HPLC determination of four active components in dengzhanxixin injection]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18841764
Wang D et al. [Studies on chemical constituents from herbs of Botrychium lanuginosum]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19216157
Yang HP et al. [Studies on glycosides from Gentiana veitchiorum]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19149260
Xia CL et al. [Chemical constituents from herbs of Swertia delavayi]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19086635
Jiang Y et al. [Studies on chemical components of Lobelia chinensis]. 2009 Zhongguo Zhong Yao Za Zhi pmid:19445152
Zhang Y et al. [Effect of water stress on content of active constituents in Erigeron breviscaps]. 2009 Zhongguo Zhong Yao Za Zhi pmid:19673373
Liu J and Xiong Y [Advances in studies on pharmacokinetics of scutellarin and scutellarein]. 2009 Zhongguo Zhong Yao Za Zhi pmid:20352990
Zhao DB et al. [Studies on flavonoids from herb of Artemisia ordosica]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16381463
Ren DC et al. [Chemical study on aerial parts of Ligusticum chuanxiong]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17966355
Zhao DB et al. [Studies on chemical constituents of Acroptilon repens]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17285986
Hu YM et al. [Flavones from flowers of Sesamum indicum]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17583201
Lei N et al. [Chemical constituents from a Tibetan medicine Arenaria kansuensis I]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17655145
Zhu B et al. [Studies on chemical constituent and quantitative determination of Mallotus apelta]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17655150
Wu X et al. [Studies on flavones in of Lavandula augustifolia]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17639984
Zhang S et al. [Studies on chemical constituents of Eriophyton wallichii]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17639985
Wang M et al. [Studies on constituents of Dendrobium gratiosissimum]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17608224
Dong Q et al. [Studies on chemical constituents from stellaria media. I]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17672340
Hu BB et al. [Determination of main flavone glycosides in Flos Chrysanthemi and observation of factors influenced contents]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17260789
You HS et al. [Pharmacokinetic and tissue distribution study of scutellarin in rats]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18027669
Wang L et al. [Studies on chemical constituents from bark of Morus nigra]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18330242
Su EN et al. [Studies on chemical constituents from stems and leaves of Adenanthera pavanina]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18306745
Wang WS et al. [Studies on the flavonoids in herb from Scutellaria barbata]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15631081
Yu ZW et al. [Study on chemical constituents from Incarvillea arguta and their accelerating PC-12 cell differentiation]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16323541
Cheng YB et al. [Study on chemical constituents in rhizome of Smilax perfoliate]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15015307
Yang L et al. [Studies on chemical constituents in rhizome of Matteuccia struthiopteris]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15503769
Huo CH et al. [Studies on chemical constituents in herbs of Acanthus ilicifolius]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16075716
Liu Z et al. [Determination of orientin and vitexin in Trollius chinesis preparation by HPLC]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15656135
Ding L et al. [Studies on the flavonoid constituents in herb of Eremosparton songoricum]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15714817
Wang LS et al. [Study on the chemical constituents from Picria fel-tarrae]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15719682
Tian J et al. [Studies on the chemical constitutents in herb of Verbena officinalis]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15724402
Gu HF et al. [Studies on chemical constituents from herb of Dracocephalum moldavica]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15706847
Su J et al. [Determination of flavoniod-glycosides in Yixintong pills by HPLC]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15706914
Zhao DB et al. [Studies on chemical constituents in herb of Chondrilla piptocoma]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16011281
Dai C et al. [Studies on chemical constituents from moss Rhodobryum roseum II]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17048608
Hua Y and Wang HQ [Studies on the flavonoids from whole herbs of Seriphidium terrae-albae]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17048665
Zhu XX et al. [Effect of vitexia-rhamnoside (V-R) on vasomotor factors expression of endothelial cell]. 2006 Zhongguo Zhong Yao Za Zhi pmid:16780160
Zhang Y et al. [Effect of caffeic acid, seopoletin and scutellarin on rat retinal neurons in vitro]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16124607
Che QM et al. [Study on bile excretion of scutellarein]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17225543
Liu JY et al. [Optimizing extraction process of Scutellaria barbata by golden section method]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18619346
Dawa ZM et al. [Studies on chemical constituents of Saussurea laniceps]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18652351
Qu L et al. [Determination of vitexin-rhamnoside in Beagle dog plasma and preliminary pharmacokinetics of Yixintong sustained release tablets]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18720869
He Y et al. [Simultaneous determination of chlorogenic acid and vitexin 2"-rhamnoside in Crataegi Fructus extracts by HPLC]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22715732
Qin S and Wen X [Simultaneous determination of 6 active components in Chrysanthemum morifolium by HPLC]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22779181
Ye S et al. [Scutellarin starch microspheres' permeability through nasal mucosa of different animals in vitro]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22693914
Huang Y et al. [Simultaneous determination of isoorientin, scutellarin and cynaroside in rat plasma and pharmacokinetics by UPLC-MS/MS]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22667158
Huang Y et al. [Simultaneous determination of protocatechuic acid, isoorientin and scutellarin in rat tissues after a single intravenous administration of compound hongcao for injection by UPLC-MS/MS]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22375405
Han SL et al. [Comparison of antioxidant activity between two species of chamomiles produced in Xinjiang by TLC-bioautography]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23672040
Zhu R et al. [Study on estrogenic effect of genistein and apigenin in vitro]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23189742
Tong C and Wu X [Determination of plasma protein binding rate of vitexin]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23126208
Li YL et al. [Evaluation on preparation process of brevisapin colon-specific tables and its in vitro release]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23717958
He CH et al. [Study on intestinal absorption kinetics of apigenin in rats]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23944080
Li XB et al. [Simultaneous determination of chlorogenic acid, scutellarin, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid in different parts of Erigeron breviscapus by high-performance liquid chromatography]. 2013 Zhongguo Zhong Yao Za Zhi pmid:24199546
Liu T et al. [Relationship between expression of chalcone synthase gene (CHS) and scutellarin content in Erigeron breviscapus]. 2013 Zhongguo Zhong Yao Za Zhi pmid:24199547
Zheng XX et al. [Role of ERK/FoxO3a signal axis in inhibitory effect of vitexin 1 (VB-1) in HepG2 cell proliferation]. 2014 Zhongguo Zhong Yao Za Zhi pmid:25011268
Zhu LW et al. [Pharmacokinetics of scutellarin and its derivant scutellarin ethyl ester in rats]. 2013 Zhongguo Zhong Yao Za Zhi pmid:24422411
Li YR et al. [Quality standard study on Vigna radiata]. 2014 Zhongguo Zhong Yao Za Zhi pmid:24754176
Wu QP et al. [Determination of five primary chemical constituents in Cassia angustifolia by HPLC]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18533485
Pang LL et al. [Inhibitory effects of apigenin on the expression of GATA-3 and Th2 cytokines in asthmatic mice]. 2010 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:20669675
Guo LL et al. [Effect of scutellarin on expressions of nicotinic acetylcholine receptor protein and mRNA in the brains of dementia rats]. 2011 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:21823425
Tian Y et al. [The effect of apigenin on reproductive axis in female rats]. 2011 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21845881
Sun J et al. [Investigation on method speliality in identifying Fructus Crataegi with vitexin rhamnoside]. 2001 Zhong Yao Cai pmid:11917841
Liu H et al. [Study on effects of scutellarin on scavenging reactive oxygen]. 2002 Zhong Yao Cai pmid:12599762
Cehn YS et al. [Studies on the lowering blood sugar substances from agrimony (II)]. 2010 Zhong Yao Cai pmid:20873555
Fang ZJ et al. [Studies on HPLC fingerprint chromatogram of Folium Fici Microcarpa]. 2008 Zhong Yao Cai pmid:19230396
Li XQ et al. [Chemical constituents from leaves of Paulownia fortunei]. 2008 Zhong Yao Cai pmid:18998567
Liu C et al. [Neuroprotective effects of apigenin on acute transient focal cerebral ischemia-reperfusion injury in rats]. 2008 Zhong Yao Cai pmid:18998572
Gao MH et al. [Studies on chemical constituents from flowers of Chrysanthemum indicum]. 2008 Zhong Yao Cai pmid:18826144
Rao GX et al. [Studies on the chemical constituents of the leaves of Polygonum multiflorum]. 2009 Zhong Yao Cai pmid:19764327
Hui TT et al. [Studies on chemical constituents from rattan of Polygonum multiflorum]. 2008 Zhong Yao Cai pmid:19112895
Wang WS et al. [Studies on chemical constituents from Pteris multifida]. 2008 Zhong Yao Cai pmid:19112896
Lu JQ et al. [Studies on chemical constituents of Dendranthema indicum var. aromaticum]. 2009 Zhong Yao Cai pmid:19445120
Li XQ et al. [Studies on the chemical constituents from flower of Paulownia fortunei]. 2009 Zhong Yao Cai pmid:19960943
Yuan NN et al. [Studies on the chemical constituents of Blumea laciniata]. 2009 Zhong Yao Cai pmid:19873734
Guo LL et al. [Influence of scutellarin on oxidative stress and neuronal apoptosis of rats with dementia]. 2011 Zhong Yao Cai pmid:21823483
Li XL et al. [Study on chemical constituents from Desmodium styracifolium]. 2007 Zhong Yao Cai pmid:17944190
Wei YX et al. [Studies on the chemical constituents of Gueldenstaedtia stenophylla]. 2007 Zhong Yao Cai pmid:18074843
Liu Y et al. [Studies on chemical constituents from the flowers of Carthamus tinctorius L]. 2005 Zhong Yao Cai pmid:16104502
Liu W et al. [Effect of three flavones on enzyme activity of recombinant human phosphoinositide 3-kinase p110beta catalytic subunit]. 2006 Zhong Yao Cai pmid:16722316
Zhai YJ et al. [Preparation and in vitro characterization of apigemin-loaded nanostructured lipid carriers]. 2011 Zhong Yao Cai pmid:22017012
Wang JL et al. [Study on chemical constituents of the Ixeris chinensis]. 2011 Zhong Yao Cai pmid:22506392
Peng XJ and Li C [Study on the flavanone constitutes of Buddleja davidii]. 2011 Zhong Yao Cai pmid:22372140
Cui SM et al. [Determination of vitexin in plasma by HPLC-MS/MS method and its pharmacokinetics in rats]. 2012 Zhong Yao Cai pmid:23252280
Chen J et al. [Study on chemical constituents of Cardiospermum halicacabum]. 2013 Zhong Yao Cai pmid:23901648