apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lu JQ et al. | [Studies on chemical constituents of Dendranthema indicum var. aromaticum]. | 2009 | Zhong Yao Cai | pmid:19445120 |
Zhai YJ et al. | [Preparation and in vitro characterization of apigemin-loaded nanostructured lipid carriers]. | 2011 | Zhong Yao Cai | pmid:22017012 |
Peng XJ and Li C | [Study on the flavanone constitutes of Buddleja davidii]. | 2011 | Zhong Yao Cai | pmid:22372140 |
Dai H et al. | Scutellarin benzyl ester partially secured the ischemic injury by its anti-apoptosis mechanism in cardiomyocytes of neonatal rats. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:21906527 |
You HS et al. | [Absorption and transportation characteristics of scutellarin and scutellarein across Caco-2 monolayer model]. | 2010 | Zhong Xi Yi Jie He Xue Bao | pmid:20836977 |
Li C et al. | Structure-activity relationship of 7 flavonoids on recombinant human protein kinase CK2 holoenzyme. | 2009 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:19197122 |
Lin F et al. | [Inhibitory effect of jianpi-jiedu prescription-contained serum on colorectal cancer SW48 cell proliferation by mTOR-P53-P21 signalling pathway]. | 2016 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:27932756 |
Shu L et al. | [Effects of apigenin on self-renewal and 
uPAR expression in NCI-H446 cell line]. | 2016 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:27932755 |
Deng J et al. | [Proliferation and apoptosis of choriocarcinoma cell JEG-3 induced by VB2 and its in vitro mechanism]. | 2013 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:23719531 |
Ren HY and Tang XW | [Anti-proliferation and chemo-sensitization effects of apigenin on human lung cancer cells]. | 2011 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:21984153 |