apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yee SB et al. | Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells. | 2003 | Arch. Pharm. Res. | pmid:12643593 |
Sun XP et al. | Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. | 2017 | Arch. Pharm. Res. | pmid:28315259 |
Kwak JH et al. | Cytotoxic phenolic compounds from Chionanthus retusus. | 2009 | Arch. Pharm. Res. | pmid:20162394 |
Kim JM and Yun-Choi HS | Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica. | 2008 | Arch. Pharm. Res. | pmid:18704331 |
Lee S et al. | Phytochemical constituents from the herba of Artemisia apiacea. | 2002 | Arch. Pharm. Res. | pmid:12135098 |
Sim GS et al. | Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast. | 2007 | Arch. Pharm. Res. | pmid:17424933 |
Myoung HJ et al. | Apigenin isolated from the seeds of Perilla frutescens britton var crispa (Benth.) inhibits food intake in C57BL/6J mice. | 2010 | Arch. Pharm. Res. | pmid:21116776 |
Jang DS et al. | Constituents of the flowers of Platycodon grandiflorum with inhibitory activity on advanced glycation end products and rat lens aldose reductase in vitro. | 2010 | Arch. Pharm. Res. | pmid:20607492 |
Kim HJ et al. | Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes. | 2005 | Arch. Pharm. Res. | pmid:16276964 |
Jeong DM et al. | Comparative antioxidant activity and HPLC profiles of some selected Korean thistles. | 2008 | Arch. Pharm. Res. | pmid:18277604 |
Kim JW et al. | Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation. | 2012 | Arch. Pharm. Res. | pmid:22370792 |
Huang CS et al. | Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes. | 2013 | Arch. Toxicol. | pmid:22864849 |
Hakobyan A et al. | Apigenin inhibits African swine fever virus infection in vitro. | 2016 | Arch. Virol. | pmid:27638776 |
Wenzel P et al. | Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17541025 |
Kang HK et al. | Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. | 2009 | Arthritis Res. Ther. | pmid:19405952 |
El Hajjaji H et al. | Chondrocytes, synoviocytes and dermal fibroblasts all express PH-20, a hyaluronidase active at neutral pH. | 2005 | Arthritis Res. Ther. | pmid:15987477 |
Jangdey MS et al. | Development and optimization of apigenin-loaded transfersomal system for skin cancer delivery: in vitro evaluation. | 2017 | Artif Cells Nanomed Biotechnol | pmid:28050929 |
Lemmens-Gruber R et al. | Investigation of the spasmolytic activity of the flavonoid fraction of Achillea millefolium s.l. on isolated guinea-pig ilea. | 2006 | Arzneimittelforschung | pmid:17009839 |
Fuchs J and Milbradt R | Skin anti-inflammatory activity of apigenin-7-glucoside in rats. | 1993 | Arzneimittelforschung | pmid:7683883 |
Yang RY et al. | Content and distribution of flavonoids among 91 edible plant species. | 2008 | Asia Pac J Clin Nutr | pmid:18296355 |
Brahmbhatt SR et al. | Study of biochemical prevalence indicators for the assessment of iodine deficiency disorders in adults at field conditions in Gujarat (India). | 2001 | Asia Pac J Clin Nutr | pmid:11708609 |
Wong SP et al. | Ultrasensitive cell-based bioassay for the measurement of global estrogenic activity of flavonoid mixtures revealing additive, restrictive, and enhanced actions in binary and higher order combinations. | 2007 | Assay Drug Dev Technol | pmid:17638535 |
Wang Y et al. | Effects of bezafibrate on the expression of endothelial nitric oxide synthase gene and its mechanisms in cultured bovine endothelial cells. | 2006 | Atherosclerosis | pmid:16256120 |
Riccio P et al. | May diet and dietary supplements improve the wellness of multiple sclerosis patients? A molecular approach. | 2011 | Autoimmune Dis | pmid:21461338 |
Min YS et al. | The effects of apigenin-7-O-beta-D-glucuronopyranoside on reflux oesophagitis and gastritis in rats. | 2005 | Auton Autacoid Pharmacol | pmid:15955027 |
Mehmood K et al. | In Vitro Effect of Apigenin and Danshen in Tibial Dyschondroplasia Through Inhibition of Heat-Shock Protein 90 and Vascular Endothelial Growth Factor Expressions in Avian Growth Plate Cells. | 2017 | Avian Dis. | pmid:28957003 |
Iqbal MK et al. | Recovery of Chicken Growth Plate by Heat-Shock Protein 90 Inhibitors Epigallocatechin-3-Gallate and Apigenin in Thiram-Induced Tibial Dyschondroplasia. | 2016 | Avian Dis. | pmid:27902918 |
Somarathna KI et al. | A short-term intervention trial on HIV positive patients using a Sri Lankan classical rasayana drug - Ranahamsa Rasayanaya. | 2010 | Ayu | pmid:22131710 |
Soyman Z et al. | Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary. | 2017 | Balkan Med J | pmid:28443590 |
Gilani AH et al. | Antispasmodic effects of Rooibos tea (Aspalathus linearis) is mediated predominantly through K+ -channel activation. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:17076689 |
Coleta M et al. | Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity. | 2008 | Behav. Brain Res. | pmid:18249450 |
Lee HE et al. | Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property. | 2016 | Behav. Brain Res. | pmid:26996316 |
Li R et al. | Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain. | 2016 | Behav. Brain Res. | pmid:26416673 |
Wang W et al. | [A new natural product from the roots of Hedysarum multijugum]. | 2005 | Beijing Da Xue Xue Bao | pmid:16224530 |
Liu Q et al. | Apigenin inhibits cell migration through MAPK pathways in human bladder smooth muscle cells. | 2011 | Biocell | pmid:22423483 |
Sun Q et al. | Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29408335 |
Ashokkumar R et al. | Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29406244 |
Lv SX and Qiao X | Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29355527 |
Ogawa M et al. | Nuclear translocation of Xenopus laevis paxillin. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12727207 |
Karmakar S et al. | Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19695221 |
Zhou RJ et al. | Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28867192 |
Li G et al. | Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28408212 |
Brinkworth RI et al. | Flavones are inhibitors of HIV-1 proteinase. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1445308 |
Ke Y et al. | Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27998773 |
Hirano T et al. | Luteolin, a flavonoid, inhibits AP-1 activation by basophils. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16343431 |
Gao ZX et al. | Scutellarin promotes in vitro angiogenesis in human umbilical vein endothelial cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20709020 |
Lin CM et al. | Molecular modeling of flavonoids that inhibits xanthine oxidase. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054758 |
Zhang GH et al. | The anti-HIV-1 effect of scutellarin. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16023998 |
Gupta S et al. | Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11573952 |
Segaert S et al. | The flavonoid apigenin suppresses vitamin D receptor expression and vitamin D responsiveness in normal human keratinocytes. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10652242 |