apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mitchell KA et al. | Flavonoid characters contributing to the taxonomic revision of the Hebe parviflora complex. | 2001 | Phytochemistry | pmid:11261578 |
| Heijnen CG et al. | Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. | 2001 | Toxicol In Vitro | pmid:11259863 |
| Carini M et al. | LC coupled to ion-trap MS for the rapid screening and detection of polyphenol antioxidants from Helichrysum stoechas. | 2001 | J Pharm Biomed Anal | pmid:11199231 |
| Casagrande F and Darbon JM | Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. | 2001 | Biochem. Pharmacol. | pmid:11322924 |
| Ren YL and Yang JS | [Study on chemical constituents of Hemistepta lyrata Bunge]. | 2001 | Yao Xue Xue Bao | pmid:12579973 |
| Makino T et al. | Inhibitory effect of decoction of Perilla frutescens on cultured murine mesangial cell proliferation and quantitative analysis of its active constituents. | 2001 | Planta Med. | pmid:11270716 |
| Greenham J et al. | A distinctive flavonoid chemistry for the anomalous genus Biebersteinia. | 2001 | Phytochemistry | pmid:11198823 |
| Miean KH and Mohamed S | Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. | 2001 | J. Agric. Food Chem. | pmid:11410016 |
| Raso GM et al. | Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. | 2001 | Life Sci. | pmid:11213362 |
| Kitada C et al. | Differential expression of two cytochrome P450s involved in the biosynthesis of flavones and anthocyanins in chemo-varietal forms of Perilla frutescens. | 2001 | Plant Cell Physiol. | pmid:11773526 |
| Huang X et al. | 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors. | 2001 | J. Med. Chem. | pmid:11384234 |
| Fischer H et al. | Partial restoration of defective chloride conductance in DeltaF508 CF mice by trimethylamine oxide. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11404245 |
| Nejaty H et al. | Differing effects of endocrine-disrupting chemicals on basal and FSH-stimulated progesterone production in rat granulosa-luteal cells. | 2001 | Exp. Biol. Med. (Maywood) | pmid:11395928 |
| Yin F et al. | Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. | 2001 Jan-Feb | Anticancer Res. | pmid:11299771 |
| Bylka W | Isovitexin o-glucosides from Aquilegia vulgaris L. | 2001 Jul-Aug | Acta Pol Pharm | pmid:11693732 |
| Matławska I | Flavonoid compounds in the flowers of Kitaibelia vitifolia Willd. (Malvaceae). | 2001 Mar-Apr | Acta Pol Pharm | pmid:11501790 |
| Kim HR et al. | Flavonoids differentially inhibit guinea pig epidermal cytosolic phospholipase A2. | 2001 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11993721 |
| Nazaruk J and Gudej J | Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L. | 2001 Sep-Oct | Acta Pol Pharm | pmid:11876448 |
| Takahama U et al. | Oxidation of quercetin by salivary components. Quercetin-dependent reduction of salivary nitrite under acidic conditions producing nitric oxide. | 2002 | J. Agric. Food Chem. | pmid:12105964 |
| Salah AM et al. | Estrogenic and cholinergic properties of the methanol extract of Ruellia praetermissa Sceinf. ex. Lindau (Acanthaceae) in female rats. | 2002 | Phytomedicine | pmid:11924764 |
| Nagao T et al. | Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. | 2002 | Biol. Pharm. Bull. | pmid:12132661 |
| Brantner AH et al. | HET-CAM bioassay as in vitro alternative to the croton oil test for investigating steroidal and non-steroidal compounds. | 2002 | ALTEX | pmid:12098009 |
| Lorentz A et al. | Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins. | 2002 | Blood | pmid:11807000 |
| Koo H et al. | Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. | 2002 | Oral Microbiol. Immunol. | pmid:12485324 |
| Wang H et al. | Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex. | 2002 | Planta Med. | pmid:12494329 |
| Xing Y et al. | [Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation]. | 2002 | Zhonghua Yi Xue Za Zhi | pmid:12509912 |
| Prescott AG et al. | In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana. | 2002 | Phytochemistry | pmid:12126705 |
| Liu Y and Hu M | Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. | 2002 | Drug Metab. Dispos. | pmid:11901089 |
| Hien TV et al. | Radioprotective effects of vitexina for breast cancer patients undergoing radiotherapy with cobalt-60. | 2002 | Integr Cancer Ther | pmid:14664747 |
| Walle UK and Walle T | Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements. | 2002 | Drug Metab. Dispos. | pmid:11950788 |
| Ohno S et al. | Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells. | 2002 | J. Steroid Biochem. Mol. Biol. | pmid:11948020 |
| Zou L et al. | Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products. | 2002 | Phytomedicine | pmid:12046870 |
| Bito T et al. | Flavonoids differentially regulate IFN gamma-induced ICAM-1 expression in human keratinocytes: molecular mechanisms of action. | 2002 | FEBS Lett. | pmid:12044887 |
| Myhrstad MC et al. | Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. | 2002 | Free Radic. Biol. Med. | pmid:11864778 |
| Lin CM et al. | Molecular modeling of flavonoids that inhibits xanthine oxidase. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054758 |
| Rawel HM et al. | Interactions of different phenolic acids and flavonoids with soy proteins. | 2002 | Int. J. Biol. Macromol. | pmid:12063116 |
| Rozema J et al. | The role of UV-B radiation in aquatic and terrestrial ecosystems--an experimental and functional analysis of the evolution of UV-absorbing compounds. | 2002 | J. Photochem. Photobiol. B, Biol. | pmid:11849977 |
| Breinholt VM et al. | In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids. | 2002 | Food Chem. Toxicol. | pmid:11955666 |
| Grayer RJ et al. | Scutellarein 4'-methyl ether glycosides as taxonomic markers in Teucridium and Tripora (Lamiaceae, Ajugoideae). | 2002 | Phytochemistry | pmid:12127590 |
| Gil-Izquierdo A et al. | Effect of processing techniques at industrial scale on orange juice antioxidant and beneficial health compounds. | 2002 | J. Agric. Food Chem. | pmid:12188615 |
| Kim TJ et al. | Effects of apigenin on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells. | 2002 | Planta Med. | pmid:12142993 |
| Channavajhala P and Seldin DC | Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis. | 2002 | Oncogene | pmid:12149649 |
| Rager I et al. | Rapid quantification of constituents in St. John's wort extracts by NIR spectroscopy. | 2002 | J Pharm Biomed Anal | pmid:12008122 |
| Kim MK et al. | Relationships of urinary phyto-oestrogen excretion to BMD in postmenopausal women. | 2002 | Clin. Endocrinol. (Oxf) | pmid:11940043 |
| Vanhoenacker G et al. | Chemotaxonomic features associated with flavonoids of cannabinoid-free cannabis (Cannabis sativa subsp. sativa L.) in relation to hops (Humulus lupulus L.). | 2002 | Nat Prod Lett | pmid:11942684 |
| Lin CM et al. | Prevention of cellular ROS damage by isovitexin and related flavonoids. | 2002 | Planta Med. | pmid:11988866 |
| Ross JA and Kasum CM | Dietary flavonoids: bioavailability, metabolic effects, and safety. | 2002 | Annu. Rev. Nutr. | pmid:12055336 |
| Tsai SC and Seto E | Regulation of histone deacetylase 2 by protein kinase CK2. | 2002 | J. Biol. Chem. | pmid:12082111 |
| Gupta S et al. | Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells. | 2002 | Oncogene | pmid:12032841 |
| Zhu CC et al. | Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation. | 2002 | J. Biol. Chem. | pmid:12023974 |