apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chaudhary A and Willett KL | Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John's wort. | 2006 | Toxicology | pmid:16271822 |
Kim HJ et al. | Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes. | 2005 | Arch. Pharm. Res. | pmid:16276964 |
Domingo-Domenech J et al. | Activation of nuclear factor-kappaB in human prostate carcinogenesis and association to biochemical relapse. | 2005 | Br. J. Cancer | pmid:16278667 |
Park J et al. | Inhibition of interleukin-4 production in activated T cells via down-regulation of NF-AT DNA binding activity by apigenin, a flavonoid present in dietary plants. | 2006 | Immunol. Lett. | pmid:16280168 |
Nikolova M and Asenov A | Surface flavonoid aglycones in newly studied plant species. | 2006 | Nat. Prod. Res. | pmid:16286319 |
Khan TH and Sultana S | Apigenin induces apoptosis in Hep G2 cells: possible role of TNF-alpha and IFN-gamma. | 2006 | Toxicology | pmid:16289292 |
Hu XM et al. | Neuroprotective effects of scutellarin on rat neuronal damage induced by cerebral ischemia/reperfusion. | 2005 | Acta Pharmacol. Sin. | pmid:16297343 |
Nassar MI | Flavonoid triglycosides from the seeds of Syzygium aromaticum. | 2006 | Carbohydr. Res. | pmid:16297892 |
Young JE et al. | Phytochemical phenolics in organically grown vegetables. | 2005 | Mol Nutr Food Res | pmid:16302198 |
Labib S et al. | Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds. | 2006 | Mol Nutr Food Res | pmid:16317785 |
Li LP and Jiang HD | Determination and assay validation of luteolin and apigenin in human urine after oral administration of tablet of Chrysanthemum morifolium extract by HPLC. | 2006 | J Pharm Biomed Anal | pmid:16318906 |
Delazar A et al. | Two acylated flavonoid glycosides from Stachys bombycina, and their free radical scavenging activity. | 2005 | Pharmazie | pmid:16320954 |
Capodice JL et al. | Complementary and alternative medicine for chronic prostatitis/chronic pelvic pain syndrome. | 2005 | Evid Based Complement Alternat Med | pmid:16322807 |
Cushnie TP and Lamb AJ | Antimicrobial activity of flavonoids. | 2005 | Int. J. Antimicrob. Agents | pmid:16323269 |
Yu ZW et al. | [Study on chemical constituents from Incarvillea arguta and their accelerating PC-12 cell differentiation]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16323541 |
Kim JY et al. | Eupatilin blocks mediator release via tyrosine kinase inhibition in activated guinea pig lung mast cells. | 2005 | J. Toxicol. Environ. Health Part A | pmid:16326424 |
Zheng YN et al. | Effects of compounds in leaves of Salix matsudana on arachidonic acid metabolism. | 2005 | Yakugaku Zasshi | pmid:16327246 |
Ulanowska K et al. | Differential antibacterial activity of genistein arising from global inhibition of DNA, RNA and protein synthesis in some bacterial strains. | 2006 | Arch. Microbiol. | pmid:16328542 |
Lawson K et al. | B23 is a downstream target of polyamine-modulated CK2. | 2005 | Mol. Cell. Biochem. | pmid:16342411 |
Hirano T et al. | Luteolin, a flavonoid, inhibits AP-1 activation by basophils. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16343431 |
Eddy SF et al. | Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells. | 2005 | Cancer Res. | pmid:16357145 |
Floryk D and Huberman E | Differentiation of androgen-independent prostate cancer PC-3 cells is associated with increased nuclear factor-kappaB activity. | 2005 | Cancer Res. | pmid:16357169 |
Zgórka G | Retention behavior of silica-bonded and novel polymeric reversed-phase sorbents in studies on flavones as chemotaxonomic markers of Scutellaria L. genus. | 2006 | J Chromatogr A | pmid:16364344 |
Rayyan S et al. | Flavone C-glycosides from leaves of Oxalis triangularis. | 2005 | J. Agric. Food Chem. | pmid:16366694 |
Rossoni G et al. | Wild artichoke prevents the age-associated loss of vasomotor function. | 2005 | J. Agric. Food Chem. | pmid:16366729 |
Shimada H et al. | Characteristics and inhibition by flavonoids of 20alpha-hydroxysteroid dehydrogenase activity in mouse tissues. | 2006 | Life Sci. | pmid:16376383 |
Zhao DB et al. | [Studies on flavonoids from herb of Artemisia ordosica]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16381463 |
Li H et al. | Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. | 2005 | Planta Med. | pmid:16395649 |
Sheu YW et al. | Cytotoxic flavonoids and new chromenes from Ficus formosana f. formosana. | 2005 | Planta Med. | pmid:16395655 |
Sawatzky DA et al. | The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo. | 2006 | Am. J. Pathol. | pmid:16400007 |
Meyer H et al. | Bioavailability of apigenin from apiin-rich parsley in humans. | 2006 | Ann. Nutr. Metab. | pmid:16407641 |
Cárdenas M et al. | Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines. | 2006 | Bioorg. Med. Chem. | pmid:16412650 |
Li FX et al. | Overexpression of the Saussurea medusa chalcone isomerase gene in S. involucrata hairy root cultures enhances their biosynthesis of apigenin. | 2006 | Phytochemistry | pmid:16427667 |
Takeda E et al. | Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1. | 2005 | Cell Struct. Funct. | pmid:16428860 |
Koo H et al. | Influence of apigenin on gtf gene expression in Streptococcus mutans UA159. | 2006 | Antimicrob. Agents Chemother. | pmid:16436708 |
Ahlenstiel T et al. | Improved cold preservation of kidney tubular cells by means of adding bioflavonoids to organ preservation solutions. | 2006 | Transplantation | pmid:16436967 |
Ryu SW et al. | Downregulation of protein kinase CKII is associated with cellular senescence. | 2006 | FEBS Lett. | pmid:16442104 |
Eyong KO et al. | Newbouldiaquinone A: A naphthoquinone-anthraquinone ether coupled pigment, as a potential antimicrobial and antimalarial agent from Newbouldia laevis. | 2006 | Phytochemistry | pmid:16442576 |
Baliga MS and Katiyar SK | Chemoprevention of photocarcinogenesis by selected dietary botanicals. | 2006 | Photochem. Photobiol. Sci. | pmid:16465310 |
Ko JH et al. | Molecular cloning, expression and characterization of a glycosyltransferase from rice. | 2006 | Plant Cell Rep. | pmid:16477404 |
Gormann R et al. | Newbouldiosides A-C, phenylethanoid glycosides from the stem bark of Newbouldia laevis. | 2006 | Phytochemistry | pmid:16497346 |
Li H et al. | Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 | J. Mol. Graph. Model. | pmid:16497524 |
Gao HM et al. | [Pharmacokinetics and metabolites of scutellarin in normal and model rats]. | 2005 | Yao Xue Xue Bao | pmid:16499088 |
Deschamps JD et al. | Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases. | 2006 | Bioorg. Med. Chem. | pmid:16500106 |
Mohanty I et al. | Effect of Curcuma longa and Ocimum sanctum on myocardial apoptosis in experimentally induced myocardial ischemic-reperfusion injury. | 2006 | BMC Complement Altern Med | pmid:16504000 |
Cai H et al. | A simple HPLC method for the determination of apigenin in mouse tissues. | 2006 | Biomed. Chromatogr. | pmid:16506281 |
Xu X et al. | Determination of flavonoids in Portulaca oleracea L. by capillary electrophoresis with electrochemical detection. | 2006 | J Pharm Biomed Anal | pmid:16516429 |
Ahn BH et al. | Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells. | 2006 | Exp. Mol. Med. | pmid:16520553 |
Hong YJ et al. | The flavonoid glycosides and procyanidin composition of Deglet Noor dates (Phoenix dactylifera). | 2006 | J. Agric. Food Chem. | pmid:16536626 |
Capasso R et al. | Inhibition of rat vas deferens contractions by flavonoids in-vitro. | 2006 | J. Pharm. Pharmacol. | pmid:16536906 |
Avwioro OG et al. | Collagen and muscle stain obtained from Sorghum bicolor. | 2006 | Scand. J. Clin. Lab. Invest. | pmid:16537249 |
Seo HS et al. | Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha. | 2006 | Breast Cancer Res. Treat. | pmid:16541309 |
Al-Fayez M et al. | Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, apigenin and quercetin. | 2006 | Cancer Chemother. Pharmacol. | pmid:16552572 |
Way TD and Lin JK | Role of HER2/HER3 co-receptor in breast carcinogenesis. | 2005 | Future Oncol | pmid:16556064 |
Wu C et al. | Antiproliferative activities of parthenolide and golden feverfew extract against three human cancer cell lines. | 2006 | J Med Food | pmid:16579729 |
Li X et al. | NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells. | 2006 | Mol. Cell. Biol. | pmid:16581776 |
Xiong F et al. | Determination of scutellarin in mouse plasma and different tissues by high-performance liquid chromatography. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16600699 |
Hirano T et al. | Luteolin, a flavonoid, inhibits CD40 ligand expression by activated human basophils. | 2006 | Int. Arch. Allergy Immunol. | pmid:16601352 |
Cimanga RK et al. | Cytotoxicity and in vitro susceptibility of Entamoeba histolytica to Morinda morindoides leaf extracts and its isolated constituents. | 2006 | J Ethnopharmacol | pmid:16603327 |
McKay DL and Blumberg JB | A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). | 2006 | Phytother Res | pmid:16628544 |
Hyung Ko J et al. | Glycosylation of flavonoids with a glycosyltransferase from Bacillus cereus. | 2006 | FEMS Microbiol. Lett. | pmid:16640583 |
Reis LS et al. | Matricaria chamomilla CH12 decreases handling stress in Nelore calves. | 2006 | J. Vet. Sci. | pmid:16645346 |
Shukla S and Gupta S | Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft. | 2006 | Mol. Cancer Ther. | pmid:16648554 |
Horinaka M et al. | The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand. | 2006 | Mol. Cancer Ther. | pmid:16648565 |
Soares R and Azevedo I | Apigenin: is it a pro- or anti-inflammatory agent? | 2006 | Am. J. Pathol. | pmid:16651640 |
Woo ER et al. | Inhibition of nuclear factor-kappaB activation by 2',8''-biapigenin. | 2006 | Biol. Pharm. Bull. | pmid:16651730 |
Flamand N et al. | Development of genotoxicity test procedures with Episkin, a reconstructed human skin model: towards new tools for in vitro risk assessment of dermally applied compounds? | 2006 | Mutat. Res. | pmid:16675293 |
MacDonald ML et al. | Identifying off-target effects and hidden phenotypes of drugs in human cells. | 2006 | Nat. Chem. Biol. | pmid:16680159 |
Lo WL et al. | [Pharmacokinetics of breviscapine liposomes following intravenous injection in Beagle dogs]. | 2006 | Yao Xue Xue Bao | pmid:16683523 |
Mead J and McNair N | Antiparasitic activity of flavonoids and isoflavones against Cryptosporidium parvum and Encephalitozoon intestinalis. | 2006 | FEMS Microbiol. Lett. | pmid:16684116 |
Park BY et al. | Isolation of flavonoids, a biscoumarin and an amide from the flower buds of Daphne genkwa and the evaluation of their anti-complement activity. | 2006 | Phytother Res | pmid:16685682 |
Ahmad KA et al. | Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells. | 2006 | Mol. Cancer Res. | pmid:16687488 |
Tsai PJ et al. | Streptococcus pyogenes induces epithelial inflammatory responses through NF-kappaB/MAPK signaling pathways. | 2006 | Microbes Infect. | pmid:16702013 |
Zhou Q et al. | [The synthesis, characterization and in situ intestinal absorption of different molecular weight scutellarin-PEG conjugates]. | 2006 | Sheng Wu Yi Xue Gong Cheng Xue Za Zhi | pmid:16706365 |
Kim BG et al. | Regioselectivity of 7-O-methyltransferase of poplar to flavones. | 2006 | J. Biotechnol. | pmid:16713650 |
Chen X et al. | Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration. | 2006 | Drug Metab. Dispos. | pmid:16714374 |
Chemler JA et al. | Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. | 2006 | Microb. Cell Fact. | pmid:16719921 |
Liu W et al. | [Effect of three flavones on enzyme activity of recombinant human phosphoinositide 3-kinase p110beta catalytic subunit]. | 2006 | Zhong Yao Cai | pmid:16722316 |
Shimada H et al. | Effects of quinones and flavonoids on the reduction of all-trans retinal to all-trans retinol in pig heart. | 2006 | Eur. J. Pharmacol. | pmid:16730705 |
Schlupper D et al. | Influence of biotransformation of luteolin, luteolin 7-O-glucoside, 3',4'-dihydroxyflavone and apigenin by cultured rat hepatocytes on antioxidative capacity and inhibition of EGF receptor tyrosine kinase activity. | 2006 | Planta Med. | pmid:16732514 |
Bandyopadhyay S et al. | Attenuation of osteoclastogenesis and osteoclast function by apigenin. | 2006 | Biochem. Pharmacol. | pmid:16750176 |
Noel S et al. | Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay. | 2006 | Toxicol In Vitro | pmid:16759833 |
Peterson S et al. | Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. | 2006 | Food Chem. Toxicol. | pmid:16762476 |
Volpi N and Bergonzini G | Analysis of flavonoids from propolis by on-line HPLC-electrospray mass spectrometry. | 2006 | J Pharm Biomed Anal | pmid:16762525 |
Li X et al. | Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys. | 2006 | Phytochemistry | pmid:16777159 |
Zhu XX et al. | [Effect of vitexia-rhamnoside (V-R) on vasomotor factors expression of endothelial cell]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16780160 |
Kachadourian R and Day BJ | Flavonoid-induced glutathione depletion: potential implications for cancer treatment. | 2006 | Free Radic. Biol. Med. | pmid:16781454 |
Yoon MS et al. | Apigenin inhibits immunostimulatory function of dendritic cells: Implication of immunotherapeutic adjuvant. | 2006 | Mol. Pharmacol. | pmid:16782805 |
Gao M et al. | Two-step purification of scutellarin from Erigeron breviscapus (vant.) Hand. Mazz. by high-speed counter-current chromatography. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16790369 |
Suh SJ et al. | Ochnaflavone inhibits TNF-alpha-induced human VSMC proliferation via regulation of cell cycle, ERK1/2, and MMP-9. | 2006 | J. Cell. Biochem. | pmid:16795041 |
Sadhu SK et al. | Prostaglandin inhibitory and antioxidant components of Cistus laurifolius, a Turkish medicinal plant. | 2006 | J Ethnopharmacol | pmid:16814498 |
Yano S et al. | Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice. | 2006 | J. Agric. Food Chem. | pmid:16819936 |
Vargo MA et al. | Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16844095 |
Koukoulitsa C et al. | Polar constituents from the aerial parts of Origanum vulgare L. Ssp. hirtum growing wild in Greece. | 2006 | J. Agric. Food Chem. | pmid:16848522 |
Nagai S et al. | Kinetic study of the quenching reaction of singlet oxygen by flavonoids in ethanol solution. | 2005 | J Phys Chem B | pmid:16851486 |
Qu LB et al. | [Interaction of bovine serum albumin with luteolin and apigenin]. | 2006 | Yao Xue Xue Bao | pmid:16856482 |
Coward L et al. | Quantitative determination of apogossypol, a pro-apoptotic analog of gossypol, in mouse plasma using LC/MS/MS. | 2006 | J Pharm Biomed Anal | pmid:16859853 |
Innocenti G et al. | In vitro estrogenic activity of Achillea millefolium L. | 2007 | Phytomedicine | pmid:16860978 |
Jiao RH et al. | An apigenin-derived xanthine oxidase inhibitor from Palhinhaea cernua. | 2006 | J. Nat. Prod. | pmid:16872152 |
Zang M et al. | Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. | 2006 | Diabetes | pmid:16873680 |