apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Asthma D001249 52 associated lipids
Astrocytoma D001254 15 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cystitis D003556 23 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Gastritis D005756 27 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Leiomyoma D007889 8 associated lipids
Leukemia D007938 74 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Melanoma D008545 69 associated lipids
Memory Disorders D008569 33 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neuroblastoma D009447 66 associated lipids
Pain D010146 64 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Parkinson Disease D010300 53 associated lipids
Precancerous Conditions D011230 48 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Seizures D012640 87 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Thrombosis D013927 49 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Translocation, Genetic D014178 20 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Cocaine-Related Disorders D019970 3 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Brain Infarction D020520 17 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Genomic Instability D042822 7 associated lipids
Chromosomal Instability D043171 5 associated lipids
Premature Birth D047928 6 associated lipids
Lymphoma, Primary Effusion D054685 2 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Gao HM et al. [Pharmacokinetics and metabolites of scutellarin in normal and model rats]. 2005 Yao Xue Xue Bao pmid:16499088
He B et al. [A new method of calibration and positioning in quantitative analysis of multicomponents by single marker]. 2012 Yao Xue Xue Bao pmid:23460972
Jiang XH et al. [Study on the pharmacokinetics of scutellarin in dogs]. 2003 Yao Xue Xue Bao pmid:12958843
Li J and Chen YT [Two flavonoids from Lagopsis supina]. 2002 Yao Xue Xue Bao pmid:12579758
Ren YL and Yang JS [Study on chemical constituents of Hemistepta lyrata Bunge]. 2001 Yao Xue Xue Bao pmid:12579973
Lo WL et al. [Pharmacokinetics of breviscapine liposomes following intravenous injection in Beagle dogs]. 2006 Yao Xue Xue Bao pmid:16683523
Tian Y et al. [Apigenin glycosides from Euphorbia humifusa wild]. 2009 Yao Xue Xue Bao pmid:19618725
Chen ZN et al. [Spectral analysis of clerodendrin, isolated from Clerodendron trichotomum Thunb]. 1988 Yao Xue Xue Bao pmid:3257032
Lin M and Li SZ [Studies on the chemical constituents of Populus tomentosa carr]. 1993 Yao Xue Xue Bao pmid:8249602
Sun XY et al. [Chemical constituents of Trichosanthes kirilowii Maxim]. 2012 Yao Xue Xue Bao pmid:22993858
Li LL and Chen XM [Preparation and spectral characterization of apigenin molecularly imprinted polymer]. 2009 Yao Xue Xue Bao pmid:20055154
Shen YX et al. [Studies on the flavonoids from Dendranthema lavandulifolium]. 1997 Yao Xue Xue Bao pmid:11596327
Fu XZ et al. [Design, synthesis and anti-oxidative evaluation of L-amino acid prodrugs of scutellarein]. 2011 Yao Xue Xue Bao pmid:21800542
Qu LB et al. [Interaction of bovine serum albumin with luteolin and apigenin]. 2006 Yao Xue Xue Bao pmid:16856482
Luo P et al. Scutellarin isolated from Erigeron multiradiatus inhibits high glucose-mediated vascular inflammation. 2008 Yakugaku Zasshi pmid:18758143
Yasukawa K et al. [Studies on the constituents in the water extracts in crude drugs. IV. On the roots of Stellaria dichotoma L. var lanceolata Bge. (2(2)) (author's transl)]. 1982 Yakugaku Zasshi pmid:7108760
Zheng YN et al. Effects of compounds in leaves of Salix matsudana on arachidonic acid metabolism. 2005 Yakugaku Zasshi pmid:16327246
Liang ZD et al. [Effect of Apigenin on proliferation, cell cycle and apoptosis of mouse T cells in vitro]. 2008 Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi pmid:18394337
Xu C et al. Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines. 2015 Xenobiotica pmid:25869249
Galijatovic A et al. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. 1999 Xenobiotica pmid:10647910