apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Paredes-Gonzalez X et al. | Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications. | 2014 | AAPS J | pmid:24830944 |
Baiga TJ et al. | Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx. | 2008 | ACS Chem. Biol. | pmid:18376812 |
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Sahin M et al. | Effects of lycopene and apigenin on human umbilical vein endothelial cells in vitro under angiogenic stimulation. | 2012 | Acta Histochem. | pmid:21474164 |
Hashemi M et al. | Anti-mutagenic and pro-apoptotic effects of apigenin on human chronic lymphocytic leukemia cells. | 2010 Sep-Oct | Acta Med Iran | pmid:21287458 |
Ovodov YS | Bioglycans and natural glycosides as a promising research topic in bioorganic chemistriy. | 2010 | Acta Naturae | pmid:22649639 |
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Bylka W and Matławska I | Flavonoids from Aquilegia vulgaris L. Part II. Derivatives of apigenin and luteolin. | 1997 Jul-Aug | Acta Pol Pharm | pmid:9511462 |
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Kowalczyk A et al. | Insights into novel anticancer applications for apigenin. | 2017 | Adv Clin Exp Med | pmid:29211364 |
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Koo H | Strategies to enhance the biological effects of fluoride on dental biofilms. | 2008 | Adv. Dent. Res. | pmid:18694872 |
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Zhu F et al. | [Effect of emodin and apigenin on invasion of human ovarian carcinoma HO-8910PM cells in vitro]. | 2003 | Ai Zheng | pmid:12703988 |
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He X et al. | Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat. | 2017 | Am. J. Chin. Med. | pmid:29121796 |
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Dong LY et al. | Mechanisms of vitexin preconditioning effects on cultured neonatal rat cardiomyocytes with anoxia and reoxygenation. | 2008 | Am. J. Chin. Med. | pmid:18457368 |
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