apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Niisato N et al. | Involvement of cytosolic Cl- in osmoregulation of alpha-ENaC gene expression. | 2004 | Am. J. Physiol. Renal Physiol. | pmid:15292045 |
Malik S et al. | Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28566504 |
Illek B et al. | Structural determinants for activation and block of CFTR-mediated chloride currents by apigenin. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11078699 |
Galietta LV et al. | Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11600438 |
Lim M et al. | Modulation of deltaF508 cystic fibrosis transmembrane regulator trafficking and function with 4-phenylbutyrate and flavonoids. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:15191910 |
Scippo ML et al. | Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. | 2004 | Anal Bioanal Chem | pmid:14579009 |
Diniz A et al. | Characterization of interactions between polyphenolic compounds and human serum proteins by capillary electrophoresis. | 2008 | Anal Bioanal Chem | pmid:18418586 |
Mantzouris D et al. | HPLC-DAD-MS analysis of dyes identified in textiles from Mount Athos. | 2011 | Anal Bioanal Chem | pmid:21271239 |
Tang D et al. | Simultaneous chemical fingerprint and quantitative analysis of Ginkgo biloba extract by HPLC-DAD. | 2010 | Anal Bioanal Chem | pmid:20191266 |
Cao Y et al. | Analysis of flavonoids in Ginkgo biloba L. and its phytopharmaceuticals by capillary electrophoresis with electrochemical detection. | 2002 | Anal Bioanal Chem | pmid:12324852 |
Lech K and Jarosz M | Novel methodology for the extraction and identification of natural dyestuffs in historical textiles by HPLC-UV-Vis-ESI MS. Case study: chasubles from the Wawel Cathedral collection. | 2011 | Anal Bioanal Chem | pmid:21188578 |
Mylonaki S et al. | Optimisation of the extraction of olive (Olea europaea) leaf phenolics using water/ethanol-based solvent systems and response surface methodology. | 2008 | Anal Bioanal Chem | pmid:18762919 |
Valianou L et al. | Comparison of extraction methods for the analysis of natural dyes in historical textiles by high-performance liquid chromatography. | 2009 | Anal Bioanal Chem | pmid:19798487 |
Singh N et al. | Synthesis and characterization of a SIRT6 open tubular column: predicting deacetylation activity using frontal chromatography. | 2013 | Anal. Biochem. | pmid:23376017 |
Exarchou V et al. | LC-UV-solid-phase extraction-NMR-MS combined with a cryogenic flow probe and its application to the identification of compounds present in Greek oregano. | 2003 | Anal. Chem. | pmid:14616013 |
Gao M et al. | Microwave-assisted extraction of scutellarin from Erigeron breviscapus Hand-Mazz and its determination by high-performance liquid chromatography. | 2007 | Anal. Chim. Acta | pmid:17481403 |
Gouvea DR et al. | A new HPLC-DAD-MS/MS method for the simultaneous determination of major compounds in the crude extract of Lychnophora salicifolia Mart. (Brazilian arnicão) leaves: application to chemical variability evaluation. | 2012 | Anal. Chim. Acta | pmid:23021804 |
Jones MD et al. | Investigating sub-2 μm particle stationary phase supercritical fluid chromatography coupled to mass spectrometry for chemical profiling of chamomile extracts. | 2014 | Anal. Chim. Acta | pmid:25261902 |
Ozyürek M et al. | Measurement of xanthine oxidase inhibition activity of phenolics and flavonoids with a modified cupric reducing antioxidant capacity (CUPRAC) method. | 2009 | Anal. Chim. Acta | pmid:19231354 |
Christophoridou S and Dais P | Detection and quantification of phenolic compounds in olive oil by high resolution 1H nuclear magnetic resonance spectroscopy. | 2009 | Anal. Chim. Acta | pmid:19166735 |