apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Lymphoma, Primary Effusion D054685 2 associated lipids
Premature Birth D047928 6 associated lipids
Chromosomal Instability D043171 5 associated lipids
Genomic Instability D042822 7 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Brain Infarction D020520 17 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Cocaine-Related Disorders D019970 3 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Weight Loss D015431 56 associated lipids
Weight Gain D015430 101 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Translocation, Genetic D014178 20 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thrombosis D013927 49 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Seizures D012640 87 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Precancerous Conditions D011230 48 associated lipids
Parkinson Disease D010300 53 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pain D010146 64 associated lipids
Neuroblastoma D009447 66 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Memory Disorders D008569 33 associated lipids
Melanoma D008545 69 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Leukemia D007938 74 associated lipids
Leiomyoma D007889 8 associated lipids
Insulin Resistance D007333 99 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Glioma D005910 112 associated lipids
Glioblastoma D005909 27 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Gastritis D005756 27 associated lipids
Encephalitis D004660 15 associated lipids
Edema D004487 152 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Cystitis D003556 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Colitis D003092 69 associated lipids
Brain Ischemia D002545 89 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Body Weight D001835 333 associated lipids
Astrocytoma D001254 15 associated lipids
Asthma D001249 52 associated lipids
Alzheimer Disease D000544 76 associated lipids
Adenocarcinoma D000230 166 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Sang SM et al. [Studies on the flavonol glycosides from the seeds of Vaccaria segetalis]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12512436
Yuan K et al. [Simultaneous determination of four glycosylflavones from Lophatherum gracile by RP-HPLC]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19166010
Yang SC et al. [Study on optimal harvest time of Erigeron breviscapus]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19260301
Zhao DB et al. [Studies on flavonoids from herb of Artemisia ordosica]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16381463
Zhao DB et al. [Studies on chemical constituents of Acroptilon repens]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17285986
You HS et al. [Pharmacokinetic and tissue distribution study of scutellarin in rats]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18027669
Liu Z et al. [Determination of orientin and vitexin in Trollius chinesis preparation by HPLC]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15656135
Ding L et al. [Studies on the flavonoid constituents in herb of Eremosparton songoricum]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15714817
Wang LS et al. [Study on the chemical constituents from Picria fel-tarrae]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15719682
Zhao DB et al. [Studies on chemical constituents in herb of Chondrilla piptocoma]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16011281
He Y et al. [Simultaneous determination of chlorogenic acid and vitexin 2"-rhamnoside in Crataegi Fructus extracts by HPLC]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22715732
He CH et al. [Study on intestinal absorption kinetics of apigenin in rats]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23944080
Zheng XX et al. [Role of ERK/FoxO3a signal axis in inhibitory effect of vitexin 1 (VB-1) in HepG2 cell proliferation]. 2014 Zhongguo Zhong Yao Za Zhi pmid:25011268
Li YR et al. [Quality standard study on Vigna radiata]. 2014 Zhongguo Zhong Yao Za Zhi pmid:24754176
Pang LL et al. [Inhibitory effects of apigenin on the expression of GATA-3 and Th2 cytokines in asthmatic mice]. 2010 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:20669675
Guo LL et al. [Effect of scutellarin on expressions of nicotinic acetylcholine receptor protein and mRNA in the brains of dementia rats]. 2011 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:21823425
Tian Y et al. [The effect of apigenin on reproductive axis in female rats]. 2011 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21845881
Li XQ et al. [Chemical constituents from leaves of Paulownia fortunei]. 2008 Zhong Yao Cai pmid:18998567
Liu C et al. [Neuroprotective effects of apigenin on acute transient focal cerebral ischemia-reperfusion injury in rats]. 2008 Zhong Yao Cai pmid:18998572
Rao GX et al. [Studies on the chemical constituents of the leaves of Polygonum multiflorum]. 2009 Zhong Yao Cai pmid:19764327