apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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Yin F et al. | Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO). | 1999 Sep-Oct | Anticancer Res. | pmid:10628390 |
Chan JY et al. | Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation. | 2009 | Anticancer Res. | pmid:19661313 |
Alcaraz M et al. | Effects of bisphosphonates in combination with ionizing radiation and antioxidants on the growth of prostate and melanoma cells lines. | 2013 | Anticancer Res. | pmid:23898082 |
Seo HS et al. | Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells. | 2014 | Anticancer Res. | pmid:24922650 |
Koo H et al. | Influence of apigenin on gtf gene expression in Streptococcus mutans UA159. | 2006 | Antimicrob. Agents Chemother. | pmid:16436708 |
Wong IL et al. | Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania. | 2007 | Antimicrob. Agents Chemother. | pmid:17194831 |
Bach A et al. | The antioxidant quercetin inhibits cellular proliferation via HIF-1-dependent induction of p21WAF. | 2010 | Antioxid. Redox Signal. | pmid:19958256 |
Mahmood N et al. | Inhibition of HIV infection by flavanoids. | 1993 | Antiviral Res. | pmid:8279812 |
Lv X et al. | Apigenin inhibits enterovirus 71 replication through suppressing viral IRES activity and modulating cellular JNK pathway. | 2014 | Antiviral Res. | pmid:24971492 |
Nagai T et al. | In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase. | 1992 | Antiviral Res. | pmid:1444327 |
Choi HJ et al. | Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus. | 2009 | Antiviral Res. | pmid:18992773 |
Evers DL et al. | Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action. | 2005 | Antiviral Res. | pmid:16188329 |
Shukla S et al. | Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer. | 2014 | Apoptosis | pmid:24563225 |
Bhandari D et al. | Dual function surface-enhanced Raman active extractor for the detection of environmental contaminants. | 2009 | Appl Spectrosc | pmid:19470216 |
Nisha VM et al. | Apigenin and quercetin ameliorate mitochondrial alterations by tunicamycin-induced ER stress in 3T3-L1 adipocytes. | 2014 | Appl. Biochem. Biotechnol. | pmid:25106896 |
Bai Y et al. | Covalent Immobilization of Human Placental 17β-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications. | 2017 | Appl. Biochem. Biotechnol. | pmid:27933483 |
Schoefer L et al. | Anaerobic degradation of flavonoids by Clostridium orbiscindens. | 2003 | Appl. Environ. Microbiol. | pmid:14532034 |
Xia F et al. | Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus. | 2015 | Appl. Environ. Microbiol. | pmid:26475103 |
Braune A and Blaut M | Intestinal bacterium Eubacterium cellulosolvens deglycosylates flavonoid C- and O-glucosides. | 2012 | Appl. Environ. Microbiol. | pmid:22961906 |
He XZ et al. | Regioselective synthesis of plant (iso)flavone glycosides in Escherichia coli. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18568307 |
Miyahisa I et al. | Combinatorial biosynthesis of flavones and flavonols in Escherichia coli. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16133333 |
Chen L et al. | Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. | 2017 | Arch Gerontol Geriatr | pmid:28743056 |
SEIKEL MK and GEISSMAN TA | The flavonoid constituents of barley (Horedum vulgare). I. Saponarin. | 1957 | Arch. Biochem. Biophys. | pmid:13459424 |
Miro FA et al. | Persistent nuclear accumulation of protein kinase CK2 during the G1-phase of the cell cycle does not depend on the ERK1/2 pathway but requires active protein synthesis. | 2002 | Arch. Biochem. Biophys. | pmid:12361704 |
Mukai R et al. | Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction. | 2010 | Arch. Biochem. Biophys. | pmid:20450880 |
Miyoshi N et al. | Dietary flavonoid apigenin is a potential inducer of intracellular oxidative stress: the role in the interruptive apoptotic signal. | 2007 | Arch. Biochem. Biophys. | pmid:17870050 |
Kanazawa K et al. | Bioavailable flavonoids to suppress the formation of 8-OHdG in HepG2 cells. | 2006 | Arch. Biochem. Biophys. | pmid:17052680 |
Long LH et al. | Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media. | 2010 | Arch. Biochem. Biophys. | pmid:20558131 |
Green MD et al. | Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols. | 1995 | Arch. Biochem. Biophys. | pmid:7574722 |
Bardales JR et al. | CK2-mediated phosphorylation of a type II regulatory subunit of cAMP-dependent protein kinase from the mollusk Mytilus galloprovincialis. | 2007 | Arch. Biochem. Biophys. | pmid:17379180 |
Huh S et al. | A cell-based system for screening hair growth-promoting agents. | 2009 | Arch. Dermatol. Res. | pmid:19277688 |
Majtan J et al. | Fir honeydew honey flavonoids inhibit TNF-α-induced MMP-9 expression in human keratinocytes: a new action of honey in wound healing. | 2013 | Arch. Dermatol. Res. | pmid:23812412 |
Ulanowska K et al. | Differential antibacterial activity of genistein arising from global inhibition of DNA, RNA and protein synthesis in some bacterial strains. | 2006 | Arch. Microbiol. | pmid:16328542 |
Baldasquin-Caceres B et al. | Chemopreventive potential of phenolic compounds in oral carcinogenesis. | 2014 | Arch. Oral Biol. | pmid:25033381 |
Ketkaew Y et al. | Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. | 2017 | Arch. Oral Biol. | pmid:27886571 |
Silvan S and Manoharan S | Apigenin prevents deregulation in the expression pattern of cell-proliferative, apoptotic, inflammatory and angiogenic markers during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. | 2013 | Arch. Oral Biol. | pmid:22776109 |
Lyu SY and Park WB | Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids. | 2005 | Arch. Pharm. Res. | pmid:15974445 |
Tang H et al. | Investigation on the interactions of scutellarin and scutellarein with bovine serum albumin using spectroscopic and molecular docking techniques. | 2015 | Arch. Pharm. Res. | pmid:25577334 |
Lee S et al. | Phytochemical constituents from the herba of Artemisia apiacea. | 2002 | Arch. Pharm. Res. | pmid:12135098 |
Lee JH et al. | Anti-inflammatory mechanisms of apigenin: inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion molecules. | 2007 | Arch. Pharm. Res. | pmid:18038911 |
Choi SI et al. | Mechanism of apoptosis induced by apigenin in HepG2 human hepatoma cells: involvement of reactive oxygen species generated by NADPH oxidase. | 2007 | Arch. Pharm. Res. | pmid:18038912 |
Sim GS et al. | Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast. | 2007 | Arch. Pharm. Res. | pmid:17424933 |
Thao NT et al. | Simultaneous determination of bioactive flavonoids in some selected Korean thistles by high-performance liquid chromatography. | 2011 | Arch. Pharm. Res. | pmid:21547678 |
Myoung HJ et al. | Apigenin isolated from the seeds of Perilla frutescens britton var crispa (Benth.) inhibits food intake in C57BL/6J mice. | 2010 | Arch. Pharm. Res. | pmid:21116776 |
Jeong HJ et al. | Inhibition of aromatase activity by flavonoids. | 1999 | Arch. Pharm. Res. | pmid:10403137 |
Kim JW et al. | Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation. | 2012 | Arch. Pharm. Res. | pmid:22370792 |
Gopalakrishnan A et al. | Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells. | 2006 | Arch. Pharm. Res. | pmid:16964758 |
Yoon YA et al. | Relationships between the larval growth inhibition of Caenorhabditis elegans by apigenin derivatives and their structures. | 2006 | Arch. Pharm. Res. | pmid:16903079 |
Park HS et al. | Antioxidant flavone glycosides from the leaves of Sasa borealis. | 2007 | Arch. Pharm. Res. | pmid:17366736 |
Han XH et al. | Monoamine oxidase inhibitory components from Cayratia japonica. | 2007 | Arch. Pharm. Res. | pmid:17328236 |