apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with apigenin?
Related references are published most in these journals:
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What lipids are associated with apigenin?
Related references are published most in these journals:
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What genes are associated with apigenin?
Related references are published most in these journals:
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sui H et al. | [Effect of high dose apigenin on antioxidase activity and DNA damage in rats]. | 2009 | Wei Sheng Yan Jiu | pmid:19267072 |
| Sui H et al. | [Endothelium-dependent vasorelaxation effects induced by apigenin on the thoracic aorta of rats and its possible mechanism]. | 2011 | Wei Sheng Yan Jiu | pmid:21861336 |
| Chang CW et al. | Daphne Genkwa sieb. Et zucc. Water-soluble extracts act on enterovirus 71 by inhibiting viral entry. | 2012 | Viruses | pmid:22590685 |
| Qian S et al. | Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity. | 2015 | Viruses | pmid:25835532 |
| Shibata C et al. | The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels. | 2014 | Virology | pmid:25092460 |
| Qin W et al. | Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose. | 2016 | Vascul. Pharmacol. | pmid:27473516 |
| Chen F et al. | An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. | 2017 | Ultrason Sonochem | pmid:28427633 |
| Kawamura H et al. | Ultrasonically enhanced extraction of luteolin and apigenin from the leaves of Perilla frutescens (L.) Britt. using liquid carbon dioxide and ethanol. | 2016 | Ultrason Sonochem | pmid:26584980 |
| Medhat AM et al. | Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. | 2017 | Tumour Biol. | pmid:29022496 |
| Hassoun SM et al. | Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. | 2017 | Tumour Biol. | pmid:28651490 |
| Chen J et al. | The apoptotic effect of apigenin on human gastric carcinoma cells through mitochondrial signal pathway. | 2014 | Tumour Biol. | pmid:24805829 |
| Wan Y et al. | miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. | 2017 | Tumour Biol. | pmid:28381178 |
| Nasr-Bouzaiene N et al. | Immunomodulatory and cellular antioxidant activities of pure compounds from Teucrium ramosissimum Desf. | 2016 | Tumour Biol. | pmid:26692099 |
| Ahlenstiel T et al. | Improved cold preservation of kidney tubular cells by means of adding bioflavonoids to organ preservation solutions. | 2006 | Transplantation | pmid:16436967 |
| Ibanez S et al. | Plant insecticidal toxins in ecological networks. | 2012 | Toxins (Basel) | pmid:22606374 |
| Huang H et al. | effects of natural flavonoids on photosynthetic activity and cell integrity in Microcystis aeruginosa. | 2015 | Toxins (Basel) | pmid:25584428 |
| Schrader KK | Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). | 2010 | Toxins (Basel) | pmid:22069655 |
| Zhong Y et al. | Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. | 2017 | Toxicon | pmid:28734981 |
| Yingprasertchai S et al. | Hyaluronidase inhibitors (sodium cromoglycate and sodium auro-thiomalate) reduce the local tissue damage and prolong the survival time of mice injected with Naja kaouthia and Calloselasma rhodostoma venoms. | 2003 | Toxicon | pmid:14602119 |
| Çelik H et al. | In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase. | 2013 | Toxicology | pmid:23567315 |
| Androutsopoulos VP et al. | CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells. | 2009 | Toxicology | pmid:19666078 |
| Chaudhary A and Willett KL | Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John's wort. | 2006 | Toxicology | pmid:16271822 |
| Khan TH and Sultana S | Apigenin induces apoptosis in Hep G2 cells: possible role of TNF-alpha and IFN-gamma. | 2006 | Toxicology | pmid:16289292 |
| Sanderson JT et al. | Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. | 2004 | Toxicol. Sci. | pmid:15319488 |
| Jin UH et al. | Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. | 2018 | Toxicol. Sci. | pmid:29584932 |
| Alhusainy W et al. | Matrix modulation of the bioactivation of estragole by constituents of different alkenylbenzene-containing herbs and spices and physiologically based biokinetic modeling of possible in vivo effects. | 2012 | Toxicol. Sci. | pmid:22649189 |
| Hong H et al. | Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. | 2015 | Toxicol. Sci. | pmid:25349334 |
| Barlas N et al. | The estrogenic effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar albino rats. | 2014 | Toxicol. Lett. | pmid:24487097 |
| Das S et al. | Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro. | 2013 | Toxicol. Lett. | pmid:24070738 |
| Wu DG et al. | Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells. | 2014 | Toxicol. Lett. | pmid:24148603 |
| Li Y et al. | Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. | 2018 | Toxicol. Lett. | pmid:29753067 |
| Ratajewski M et al. | Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. | 2015 | Toxicol. Lett. | pmid:25455453 |
| Lim H et al. | Flavonoids interfere with NLRP3 inflammasome activation. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29960001 |
| Balasubramanian S and Eckert RL | Keratinocyte proliferation, differentiation, and apoptosis--differential mechanisms of regulation by curcumin, EGCG and apigenin. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17493651 |
| Sarró E et al. | A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22155090 |
| Cheng LC and Li LA | Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22172629 |
| van Meeuwen JA et al. | (Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17482226 |
| Gaballah HH et al. | Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28025107 |
| Lee WJ et al. | Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells. | 2008 | Toxicol. Appl. Pharmacol. | pmid:17961621 |
| Lecomte S et al. | Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28396216 |
| Dai J et al. | Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells. | 2016 | Toxicol. Appl. Pharmacol. | pmid:27664007 |
| Wang L et al. | Apigenin suppresses migration and invasion of transformed cells through down-regulation of C-X-C chemokine receptor 4 expression. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23743303 |
| Kim DI et al. | Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: isolation of flavonoids of apigenin and luteolin as acting compounds. | 2005 | Toxicol. Appl. Pharmacol. | pmid:15922007 |
| van Meeuwen JA et al. | Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts--a comparative study. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18201740 |
| Fischer L et al. | Potential hazards to embryo implantation: A human endometrial in vitro model to identify unwanted antigestagenic actions of chemicals. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22414680 |
| Gulluce M et al. | Isolation of a flavonoid, apigenin 7-O-glucoside, from Mentha longifolia (L.) Hudson subspecies longifolia and its genotoxic potency. | 2015 | Toxicol Ind Health | pmid:23377117 |
| Gulluce M et al. | Determination of antimutagenic properties of apigenin-7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp. longifolia with yeast DEL assay. | 2013 | Toxicol Ind Health | pmid:22491724 |
| Heijnen CG et al. | Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. | 2001 | Toxicol In Vitro | pmid:11259863 |
| Uddin Q et al. | The biflavonoid, amentoflavone degrades DNA in the presence of copper ions. | 2004 | Toxicol In Vitro | pmid:15130600 |
| Wakx A et al. | New in vitro biomarkers to detect toxicity in human placental cells: The example of benzo[A]pyrene. | 2016 | Toxicol In Vitro | pmid:26657896 |