apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Modolo LV et al. | Nitric oxide synthase-mediated phytoalexin accumulation in soybean cotyledons in response to the Diaporthe phaseolorum f. sp. meridionalis elicitor. | 2002 | Plant Physiol. | pmid:12427995 |
| Couladis M et al. | Antioxidant activity of polyphenols from Hypericum triquetrifolium Turra. | 2002 | Phytother Res | pmid:12458485 |
| Gradolatto A et al. | Could apigenin metabolism explain the estrogenic effect of this flavonoid in the female immature rat? | 2002 | IARC Sci. Publ. | pmid:12484224 |
| Koo H et al. | Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. | 2002 | Oral Microbiol. Immunol. | pmid:12485324 |
| Leslie EM et al. | Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1). | 2003 | Drug Metab. Dispos. | pmid:12485947 |
| Snyder RD and Gillies PJ | Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells. | 2002 | Environ. Mol. Mutagen. | pmid:12489117 |
| Wang H et al. | Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex. | 2002 | Planta Med. | pmid:12494329 |
| Xing Y et al. | [Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation]. | 2002 | Zhonghua Yi Xue Za Zhi | pmid:12509912 |
| Sang SM et al. | [Studies on the flavonol glycosides from the seeds of Vaccaria segetalis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512436 |
| Olszanecki R et al. | Flavonoids and nitric oxide synthase. | 2002 | J. Physiol. Pharmacol. | pmid:12512693 |
| Zhang WD et al. | [Studies on flavone constituents of Erigeron breviscapus (Vant.) Hand.-Mazz]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516462 |
| Zhang J et al. | [Studies on chemical constituents of leaves of Salix matsudana Koidz and their influence on lipolysis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516463 |
| Morimoto M et al. | Insect antifeedant activity of flavones and chromones against Spodoptera litura. | 2003 | J. Agric. Food Chem. | pmid:12517100 |
| Sánchez-Rabaneda F et al. | Liquid chromatographic/electrospray ionization tandem mass spectrometric study of the phenolic composition of cocoa (Theobroma cacao). | 2003 | J Mass Spectrom | pmid:12526004 |
| Wang M et al. | Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.). | 2003 | J. Agric. Food Chem. | pmid:12537429 |
| Fan CQ and Yue JM | Biologically active phenols from Saussurea medusa. | 2003 | Bioorg. Med. Chem. | pmid:12537999 |
| Li J and Chen YT | [Two flavonoids from Lagopsis supina]. | 2002 | Yao Xue Xue Bao | pmid:12579758 |
| Ren YL and Yang JS | [Study on chemical constituents of Hemistepta lyrata Bunge]. | 2001 | Yao Xue Xue Bao | pmid:12579973 |
| Goutman JD et al. | Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors. | 2003 | Eur. J. Pharmacol. | pmid:12586201 |
| Huet M | Factors affecting the molecular structure and the agglutinating ability of concanavalin A and other lectins. | 1975 | Eur. J. Biochem. | pmid:1259 |
| Basile A et al. | Effects of seven pure flavonoids from mosses on germination and growth of Tortula muralis HEDW (Bryophyta) and Raphanus sativus L (Magnoliophyta). | 2003 | Phytochemistry | pmid:12591270 |
| Liu H et al. | [Study on effects of scutellarin on scavenging reactive oxygen]. | 2002 | Zhong Yao Cai | pmid:12599762 |
| Chen J et al. | Metabolism of flavonoids via enteric recycling: role of intestinal disposition. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12604700 |
| Sasaki N et al. | Protective effects of flavonoids on the cytotoxicity of linoleic acid hydroperoxide toward rat pheochromocytoma PC12 cells. | 2003 | Chem. Biol. Interact. | pmid:12606158 |
| Rojas S et al. | Calmodulin inhibitors from Leucophyllum ambiguum. | 2003 | J. Nat. Prod. | pmid:12608853 |
| Mead JR et al. | Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription. | 2003 | J. Biol. Chem. | pmid:12609974 |
| Whitehead SA and Lacey M | Phytoestrogens inhibit aromatase but not 17beta-hydroxysteroid dehydrogenase (HSD) type 1 in human granulosa-luteal cells: evidence for FSH induction of 17beta-HSD. | 2003 | Hum. Reprod. | pmid:12615812 |
| McPhail DB et al. | Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy. | 2003 | J. Agric. Food Chem. | pmid:12617605 |
| Suominen L et al. | Activation of the nodA promoter by the nodD genes of Rhizobium galegae induced by synthetic flavonoids or Galega orientalis root exudate. | 2003 | FEMS Microbiol. Lett. | pmid:12620625 |
| Kavvadias D et al. | Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. | 2003 | Planta Med. | pmid:12624814 |
| Ahlenstiel T et al. | Bioflavonoids attenuate renal proximal tubular cell injury during cold preservation in Euro-Collins and University of Wisconsin solutions. | 2003 | Kidney Int. | pmid:12631120 |
| Yee SB et al. | Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells. | 2003 | Arch. Pharm. Res. | pmid:12643593 |
| Orska-GawryÅ› J et al. | Identification of natural dyes in archeological Coptic textiles by liquid chromatography with diode array detection. | 2003 | J Chromatogr A | pmid:12650256 |
| Caci E et al. | CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12651632 |
| Fukui Y et al. | A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3',5'-hydroxylase gene. | 2003 | Phytochemistry | pmid:12657292 |
| Owen RW et al. | Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drupes. | 2003 | Food Chem. Toxicol. | pmid:12659724 |
| Matsuda H et al. | Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action. | 2003 | Bioorg. Med. Chem. | pmid:12670650 |
| Nakazawa T et al. | Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test. | 2003 | Biol. Pharm. Bull. | pmid:12673028 |
| Oliveira RR et al. | High-speed countercurrent chromatography as a valuable tool to isolate C-glycosylflavones from Cecropia lyratiloba Miquel. | 2003 Mar-Apr | Phytochem Anal | pmid:12693634 |
| Greenham J et al. | Identification of lipophilic flavones and flavonols by comparative HPLC, TLC and UV spectral analysis. | Phytochem Anal | pmid:12693635 | |
| Boué SM et al. | Identification of flavone aglycones and glycosides in soybean pods by liquid chromatography-tandem mass spectrometry. | 2003 | J Chromatogr A | pmid:12703901 |
| Zhu F et al. | [Effect of emodin and apigenin on invasion of human ovarian carcinoma HO-8910PM cells in vitro]. | 2003 | Ai Zheng | pmid:12703988 |
| Ogawa M et al. | Nuclear translocation of Xenopus laevis paxillin. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12727207 |
| Sadhu SK et al. | Separation of Leucas aspera, a medicinal plant of Bangladesh, guided by prostaglandin inhibitory and antioxidant activities. | 2003 | Chem. Pharm. Bull. | pmid:12736464 |
| Lin YT et al. | Degradation of flavonoid aglycones by rabbit, rat and human fecal flora. | 2003 | Biol. Pharm. Bull. | pmid:12736527 |
| Agrelli J et al. | Herbivore-induced responses in alfalfa (Medicago sativa). | 2003 | J. Chem. Ecol. | pmid:12737260 |
| Hessenauer A et al. | Inhibition of CK2 activity provokes different responses in hormone-sensitive and hormone-refractory prostate cancer cells. | 2003 | Int. J. Oncol. | pmid:12738992 |
| Kim MH | Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases. | 2003 | J. Cell. Biochem. | pmid:12761886 |
| Hou CC et al. | Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica. | 2003 | J. Nat. Prod. | pmid:12762795 |
| Konstantinopoulou M et al. | Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity. | 2003 | J. Nat. Prod. | pmid:12762812 |