apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kowalczyk A et al. | Insights into novel anticancer applications for apigenin. | 2017 | Adv Clin Exp Med | pmid:29211364 |
| Zhong Y et al. | Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. | 2017 | Toxicon | pmid:28734981 |
| Min JW et al. | Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. | 2017 | Oncotarget | pmid:28424420 |
| Perrott KM et al. | Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. | 2017 | Geroscience | pmid:28378188 |
| Stump TA et al. | The antiproliferative and apoptotic effects of apigenin on glioblastoma cells. | 2017 | J. Pharm. Pharmacol. | pmid:28349530 |
| Sun XP et al. | Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. | 2017 | Arch. Pharm. Res. | pmid:28315259 |
| Granato M et al. | Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death. | 2017 | J. Exp. Clin. Cancer Res. | pmid:29179721 |
| Zhou RJ et al. | Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28867192 |
| Shan S et al. | Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. | 2017 | J. Agric. Food Chem. | pmid:28829588 |
| Britto SM et al. | Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. | 2017 | Mutat. Res. | pmid:28735741 |
| Jangdey MS et al. | Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma. | 2017 | Drug Deliv | pmid:28687053 |
| Li J et al. | Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. | 2017 | World J. Gastroenterol. | pmid:28611514 |
| Chen JL and Ko WC | Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. | 2017 | Eur. J. Pharmacol. | pmid:28603044 |
| Espargaró A et al. | Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. | 2017 | J. Nat. Prod. | pmid:28128562 |
| Zhou Z et al. | Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. | 2017 | Anticancer Drugs | pmid:28125432 |
| Erdogan S et al. | The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. | 2017 | Biomed. Pharmacother. | pmid:28107698 |
| Thirusangu P et al. | Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28104392 |
| Tang D et al. | Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. | 2017 | Expert Opin Drug Metab Toxicol | pmid:27766890 |
| Wong TY et al. | Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. | 2017 | Biomed. Pharmacother. | pmid:29198743 |
| Gao Y et al. | Hepatic, gastric and intestinal first-pass effects of vitexin-2''-O-rhamnoside in rats by ultra-high-performance liquid chromatography. | 2016 | Biomed. Chromatogr. | pmid:26031900 |
| Cardenas H et al. | Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function. | 2016 | Int J Mol Sci | pmid:26938530 |
| GarcÃa-MartÃnez O et al. | Phenolic Compounds in Extra Virgin Olive Oil Stimulate Human Osteoblastic Cell Proliferation. | 2016 | PLoS ONE | pmid:26930190 |
| Dong ZX et al. | An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin. | 2016 | Molecules | pmid:26927039 |
| Cao HH et al. | Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma. | 2016 | Sci Rep | pmid:26911838 |
| Wu G et al. | Growth temperature and genotype both play important roles in sorghum grain phenolic composition. | 2016 | Sci Rep | pmid:26907726 |
| Bridgeman BB et al. | Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention. | 2016 | Cell. Signal. | pmid:26876613 |
| Verma S et al. | Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations. | 2016 | PLoS ONE | pmid:26863418 |
| Asanagi M et al. | Tributyltin induces G2/M cell cycle arrest via NAD(+)-dependent isocitrate dehydrogenase in human embryonic carcinoma cells. | 2016 | J Toxicol Sci | pmid:26961604 |
| Pápay ZE et al. | Development of oral site-specific pellets containing flavonoid extract with antioxidant activity. | 2016 | Eur J Pharm Sci | pmid:27989856 |
| He M et al. | A review on the pharmacological effects of vitexin and isovitexin. | 2016 | Fitoterapia | pmid:27693342 |
| Dai J et al. | Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells. | 2016 | Toxicol. Appl. Pharmacol. | pmid:27664007 |
| Mudge EM et al. | Single-Laboratory Validation for the Determination of Flavonoids in Hawthorn Leaves and Finished Products by LC-UV. | 2016 | Planta Med. | pmid:27776376 |
| Whitehouse S et al. | Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties. | 2016 | Phytomedicine | pmid:27765370 |
| Li Q et al. | Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. | 2016 | J Clin Neurosci | pmid:27742373 |
| Zhao S et al. | Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-κB and MAPK signaling pathway. | 2016 | Int. Immunopharmacol. | pmid:27728897 |
| Choi S et al. | Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo. | 2016 | Int. J. Mol. Med. | pmid:27279007 |
| Hlila MB et al. | Characterisation of phenolic antioxidants in Scabiosa arenaria flowers by LC-ESI-MS/MS and NMR. | 2016 | J. Pharm. Pharmacol. | pmid:27230582 |
| Terpinc P et al. | LC-MS analysis of phenolic compounds and antioxidant activity of buckwheat at different stages of malting. | 2016 | Food Chem | pmid:27211614 |
| Kandhare AD et al. | Development and validation of HPLC method for vicenin-1 isolated from fenugreek seeds in rat plasma: application to pharmacokinetic, tissue distribution and excretion studies. | 2016 | Pharm Biol | pmid:27181500 |
| Liu M et al. | Rapid screening of transferrin-binders in the flowers of Bauhinia blakeana Dunn by on-line high-performance liquid chromatography-diode-array detector-electrospray ionization-ion-trap-time-of-flight-mass spectrometry-transferrin-fluorescence detection system. | 2016 | J Chromatogr A | pmid:27178150 |
| Ren B et al. | Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats. | 2016 | Eur. J. Pharmacol. | pmid:26801071 |
| Dos Santos KC et al. | Passiflora actinia hydroalcoholic extract and its major constituent, isovitexin, are neuroprotective against glutamate-induced cell damage in mice hippocampal slices. | 2016 | J. Pharm. Pharmacol. | pmid:26800497 |
| Luan RL et al. | Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice. | 2016 | Inflammation | pmid:26782361 |
| Wang Z et al. | Scutellarin protects cardiomyocyte ischemia-reperfusion injury by reducing apoptosis and oxidative stress. | 2016 | Life Sci. | pmid:26775564 |
| Ku SK and Bae JS | Vicenin-2 and scolymoside inhibit high-glucose-induced vascular inflammation in vitro and in vivo. | 2016 | Can. J. Physiol. Pharmacol. | pmid:26766560 |
| Hou K et al. | Ionic liquids-lithium salts pretreatment followed by ultrasound-assisted extraction of vitexin-4″-O-glucoside, vitexin-2″-O-rhamnoside and vitexin from Phyllostachys edulis leaves. | 2016 | J Chromatogr A | pmid:26763300 |
| Guimarães R et al. | Wild Roman chamomile extracts and phenolic compounds: enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase. | 2016 | Food Funct | pmid:26446815 |
| Li R et al. | Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain. | 2016 | Behav. Brain Res. | pmid:26416673 |
| Pápay ZE et al. | Comparative evaluation of the effect of cyclodextrins and pH on aqueous solubility of apigenin. | 2016 | J Pharm Biomed Anal | pmid:26363816 |
| Venditti A et al. | Phytochemical analysis of Achillea ligustica All. from Lipari Island (Aeolian Islands). | 2016 | Nat. Prod. Res. | pmid:26327332 |