apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with apigenin?
Related references are published most in these journals:
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What lipids are associated with apigenin?
Related references are published most in these journals:
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What genes are associated with apigenin?
Related references are published most in these journals:
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cai H et al. | A simple HPLC method for the determination of apigenin in mouse tissues. | 2006 | Biomed. Chromatogr. | pmid:16506281 |
| Gao Y et al. | Hepatic, gastric and intestinal first-pass effects of vitexin-2''-O-rhamnoside in rats by ultra-high-performance liquid chromatography. | 2016 | Biomed. Chromatogr. | pmid:26031900 |
| Liang M et al. | Quantitative LC/MS/MS method and in vivo pharmacokinetic studies of vitexin rhamnoside, a bioactive constituent on cardiovascular system from hawthorn. | 2007 | Biomed. Chromatogr. | pmid:17294503 |
| de Moraes SL et al. | Liquid chromatography-tandem mass spectrometric method for determination of the anti-inflammatory compound vicenin-2 in the leaves of L. ericoides Mart. | 2007 | Biomed. Chromatogr. | pmid:17428019 |
| Gao R et al. | Simultaneous determination of oleanolic acid, ursolic acid, quercetin and apigenin in Swertia mussotii Franch by capillary zone electrophoresis with running buffer modifier. | 2015 | Biomed. Chromatogr. | pmid:25042239 |
| Li D et al. | Pharmacokinetic study of three active flavonoid glycosides in rat after intravenous administration of Trollius ledebourii extract by liquid chromatography. | 2008 | Biomed. Chromatogr. | pmid:18651602 |
| Correia H et al. | Polyphenolic profile characterization of Agrimonia eupatoria L. by HPLC with different detection devices. | 2006 | Biomed. Chromatogr. | pmid:15981197 |
| Srinivas NR | Is the inhibition of the liver uptake and biliary excretion, via transporters, the likely mechanism for the increased exposure of vitexin-2''-O-rhamnoside with bile salts in rats? | 2016 | Biomed. Chromatogr. | pmid:26928602 |
| Yan C et al. | Simultaneous determination of vitexin and isovitexin in rat plasma after oral administration of Santalum album L. leaves extract by liquid chromatography tandem mass spectrometry. | 2013 | Biomed. Chromatogr. | pmid:22706896 |
| Yue ME et al. | Determination of six bioactive components of Saussurea katochaete by capillary electrophoresis. | 2007 | Biomed. Chromatogr. | pmid:17236245 |
| Deb DD et al. | In vitro safety evaluation and anticlastogenic effect of BacoMind on human lymphocytes. | 2008 | Biomed. Environ. Sci. | pmid:18478974 |
| Zheng QS et al. | Mechanisms of apigenin-7-glucoside as a hepatoprotective agent. | 2005 | Biomed. Environ. Sci. | pmid:15861781 |
| Yang M et al. | Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway. | 2018 | Biomed. Pharmacother. | pmid:30021365 |
| Zhang Y et al. | Apigenin suppresses mouse peritoneal fibrosis by down-regulating miR34a expression. | 2018 | Biomed. Pharmacother. | pmid:29966983 |
| Palacz-Wrobel M et al. | Effect of apigenin, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW-264.7 macrophages. | 2017 | Biomed. Pharmacother. | pmid:28738536 |
| Yang J et al. | Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells. | 2018 | Biomed. Pharmacother. | pmid:29680738 |
| Mustapha N et al. | Compounds isolated from the aerial part of Crataegus azarolus inhibit growth of B16F10 melanoma cells and exert a potent inhibition of the melanin synthesis. | 2015 | Biomed. Pharmacother. | pmid:25661350 |
| Kalivarathan J et al. | Apigenin attenuates hippocampal oxidative events, inflammation and pathological alterations in rats fed high fat, fructose diet. | 2017 | Biomed. Pharmacother. | pmid:28237914 |
| Jiang J et al. | Vitexin reverses the autophagy dysfunction to attenuate MCAO-induced cerebral ischemic stroke via mTOR/Ulk1 pathway. | 2018 | Biomed. Pharmacother. | pmid:29710456 |
| Hu WJ et al. | Apigenin enhances the antitumor effects of cetuximab in nasopharyngeal carcinoma by inhibiting EGFR signaling. | 2018 | Biomed. Pharmacother. | pmid:29604587 |
| Srivastava A et al. | Swertisin ameliorates diabetes by triggering pancreatic progenitors for islet neogenesis in Streptozotocin treated BALB/c mice. | 2018 | Biomed. Pharmacother. | pmid:29428671 |
| Venturini CL et al. | Vitexin inhibits inflammation in murine ovalbumin-induced allergic asthma. | 2018 | Biomed. Pharmacother. | pmid:29091859 |
| Mokashi P et al. | Swertisin rich fraction from Enicostema littorale ameliorates hyperglycemia and hyperlipidemia in high-fat fed diet and low dose streptozotacin induced type 2 diabetes mellitus in rats. | 2017 | Biomed. Pharmacother. | pmid:29031588 |
| Liu Y et al. | Effects of apigenin pretreatment against renal ischemia/reperfusion injury via activation of the JAK2/STAT3 pathway. | 2017 | Biomed. Pharmacother. | pmid:28962085 |
| Erdogan S et al. | The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. | 2017 | Biomed. Pharmacother. | pmid:28107698 |
| Ganai SA | Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer. | 2017 | Biomed. Pharmacother. | pmid:27930986 |
| Aseervatham GS et al. | Expression pattern of NMDA receptors reveals antiepileptic potential of apigenin 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice. | 2016 | Biomed. Pharmacother. | pmid:27470339 |
| Wong TY et al. | Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. | 2017 | Biomed. Pharmacother. | pmid:29198743 |
| Carugo D et al. | Contrast agent-free sonoporation: The use of an ultrasonic standing wave microfluidic system for the delivery of pharmaceutical agents. | 2011 | Biomicrofluidics | pmid:22662060 |
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| Arioka S et al. | Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase. | 2010 | Bioorg. Med. Chem. | pmid:20097567 |
| Liu GB et al. | Synthesis of a novel series of diphenolic chromone derivatives as inhibitors of NO production in LPS-activated RAW264.7 macrophages. | 2010 | Bioorg. Med. Chem. | pmid:20363145 |
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| Chen H et al. | Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo. | 2014 | Bioorg. Med. Chem. | pmid:24837156 |
| Mavel S et al. | Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1). | 2006 | Bioorg. Med. Chem. | pmid:16263302 |
| Wang QQ et al. | Synthesis, nitric oxide release, and α-glucosidase inhibition of nitric oxide donating apigenin and chrysin derivatives. | 2014 | Bioorg. Med. Chem. | pmid:24508143 |
| Sagrera G et al. | Synthesis and antifungal activities of natural and synthetic biflavonoids. | 2011 | Bioorg. Med. Chem. | pmid:21530273 |
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