apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| You L et al. | Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. | 2017 | Bioorg. Med. Chem. Lett. | pmid:29157862 |
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| Ozawa M et al. | TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19026536 |
| Li NG et al. | Design, synthesis and biological evaluation of glucose-containing scutellarein derivatives as neuroprotective agents based on metabolic mechanism of scutellarin in vivo. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23177255 |
| Ko HH et al. | Anti-inflammatory flavonoids and pterocarpanoid from Crotalaria pallida and C. assamica. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15013012 |
| Ryu YB et al. | Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19660948 |
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| Yu MS et al. | Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22578462 |
| Li S et al. | Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20724155 |
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| Bonesi M et al. | The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20167484 |
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| Chen X et al. | Effect of scutellarin on the metabolism and pharmacokinetics of clopidogrel in rats. | 2015 | Biopharm Drug Dispos | pmid:25256597 |
| Liu W et al. | Preliminary enrichment and separation of genistein and apigenin from extracts of pigeon pea roots by macroporous resins. | 2010 | Bioresour. Technol. | pmid:20153169 |
| Ueda H et al. | A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14745173 |
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| Yun CS et al. | Expression of parsley flavone synthase I establishes the flavone biosynthetic pathway in Arabidopsis thaliana. | 2008 | Biosci. Biotechnol. Biochem. | pmid:18391443 |
| Kawai K et al. | Clerodendrin I, a New Neoclerodane Diterpenoid from Clerodendron trichotomum. | 1999 | Biosci. Biotechnol. Biochem. | pmid:26300171 |
| Aida Y et al. | Synthesis of 7-methoxyapigeninidin and its fungicidal activity against Gloeocercospora sorghi. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8987602 |
| Iwashita K et al. | Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11055382 |
| Miyake Y et al. | Isolation of antioxidative phenolic glucosides from lemon juice and their suppressive effect on the expression of blood adhesion molecules. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17690486 |
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| Seo HS et al. | Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells. | 2015 | Biosci. Rep. | pmid:26500281 |
| Choi SH et al. | Glycosylation of various flavonoids by recombinant oleandomycin glycosyltransferase from Streptomyces antibioticus in batch and repeated batch modes. | 2012 | Biotechnol. Lett. | pmid:22116386 |
| Chockalingam S et al. | Biogenesis, characterization, and the effect of vicenin-gold nanoparticles on glucose utilization in 3T3-L1 adipocytes: a bioinformatic approach to illuminate its interaction with PTP 1B and AMPK. | Biotechnol. Prog. | pmid:26014104 | |
| Barros GO et al. | Phenolics removal from transgenic Lemna minor extracts expressing mAb and impact on mAb production cost. | Biotechnol. Prog. | pmid:21485031 | |
| Lorentz A et al. | Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins. | 2002 | Blood | pmid:11807000 |
| Shehata M et al. | Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia. | 2010 | Blood | pmid:20576813 |
| Lee W and Bae JS | Antithrombotic and antiplatelet activities of vicenin-2. | 2015 | Blood Coagul. Fibrinolysis | pmid:26126169 |
| Lee YJ et al. | Characterization of flavone synthase I from rice. | 2008 | BMB Rep | pmid:18304453 |
| Scuro LS et al. | Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation. | 2004 | BMC Biochem. | pmid:15102332 |
| Dong H et al. | Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells. | 2010 | BMC Biochem. | pmid:20553580 |
| Clark ST and Verwoerd WS | A systems approach to identifying correlated gene targets for the loss of colour pigmentation in plants. | 2011 | BMC Bioinformatics | pmid:21849042 |
| Lin CH et al. | Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. | 2015 | BMC Cancer | pmid:26675309 |
| Yang J et al. | Antioxidant intervention of smoking-induced lung tumor in mice by vitamin E and quercetin. | 2008 | BMC Cancer | pmid:19099597 |
| Menendez JA et al. | tabAnti-HER2 (erbB-2) oncogene effects of phenolic compounds directly isolated from commercial Extra-Virgin Olive Oil (EVOO). | 2008 | BMC Cancer | pmid:19094209 |
| Menendez JA et al. | Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells. | 2007 | BMC Cancer | pmid:17490486 |
| Xie ZH et al. | 5-allyl-7-gen-difluoromethoxychrysin enhances TRAIL-induced apoptosis in human lung carcinoma A549 cells. | 2011 | BMC Cancer | pmid:21801359 |
| Lu Y et al. | Covalent attachment of the plant natural product naringenin to small glass and ceramic beads. | 2005 | BMC Chem Biol | pmid:16216122 |
| Tang LI et al. | Screening of anti-dengue activity in methanolic extracts of medicinal plants. | 2012 | BMC Complement Altern Med | pmid:22244370 |