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The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. |
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Molecules |
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Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. |
2017 |
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Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. |
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J Complement Integr Med |
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Homogenate-assisted Vacuum-powered Bubble Extraction of Moso Bamboo Flavonoids for On-line Scavenging Free Radical Capacity Analysis. |
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Molecules |
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Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells. |
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Molecules |
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Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives. |
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Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma. |
2017 |
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Quantification of apigenin trimethyl ether in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study. |
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J Pharm Biomed Anal |
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Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines. |
2017 |
Oxid Med Cell Longev |
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Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. |
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Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer. |
2017 |
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Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. |
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Vitexin alleviates lipopolysaccharide‑induced islet cell injury by inhibiting HMGB1 release. |
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Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. |
2017 |
Geroscience |
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2017 |
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2017 |
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Extraction and Estimation of Secondary Metabolites from Date Palm Cell Suspension Cultures. |
2017 |
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Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones. |
2017 |
Molecules |
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Metabolites identificaion of two bioactive constituents in Trollius ledebourii in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. |
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2017 |
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2017 |
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Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. |
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Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. |
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Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. |
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An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC. |
2017 |
Molecules |
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Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice. |
2017 |
Mol Nutr Food Res |
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Novel apigenin-loaded sodium hyaluronate nano-assemblies for targeting tumor cells. |
2017 |
Carbohydr Polym |
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2017 |
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Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase. |
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Pharmacol Rep |
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Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema. |
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Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. |
2017 |
Mol Med Rep |
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Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. |
2017 |
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Intranasal administration of brain-targeted HP-β-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia. |
2017 |
J. Pharm. Pharmacol. |
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Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. |
2017 |
Int. J. Antimicrob. Agents |
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Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland. |
2017 |
Nat. Prod. Res. |
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Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity. |
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Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. |
2017 |
Menopause |
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Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. |
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Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. |
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Solubility and dissolution rate improvement of the inclusion complex of apigenin with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation and solvent removal combination methods. |
2017 |
Drug Dev Ind Pharm |
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Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. |
2017 |
Eur. J. Pharmacol. |
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miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. |
2017 |
Tumour Biol. |
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Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. |
2017 |
Biochim Biophys Acta Rev Cancer |
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Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system. |
2017 |
Drug Dev Ind Pharm |
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Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage. |
2017 |
J Clin Neurosci |
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Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation. |
2017 |
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Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. |
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Planta Med. |
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Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activation. |
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Mol. Immunol. |
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Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells. |
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Apigenin alleviates STZ-induced diabetic cardiomyopathy. |
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Comparative pharmacokinetic profiles of selected irreversible tyrosine kinase inhibitors, neratinib and pelitinib, with apigenin in rat plasma by UPLC-MS/MS. |
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J Pharm Biomed Anal |
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Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension. |
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Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. |
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Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. |
2017 |
Anticancer Drugs |
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The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. |
2017 |
Biomed. Pharmacother. |
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Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression. |
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Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. |
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Cholinesterase inhibitory, anti-amyloidogenic and neuroprotective effect of the medicinal plant Grewia tiliaefolia - An in vitro and in silico study. |
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Pharm Biol |
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Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer. |
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Fitoterapia |
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Phytochemistry |
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Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. |
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Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study. |
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J Chromatogr Sci |
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Scutellarin Attenuates Microglia-Mediated Neuroinflammation and Promotes Astrogliosis in Cerebral Ischemia - A Therapeutic Consideration. |
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Curr. Med. Chem. |
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Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. |
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J Asian Nat Prod Res |
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Elucidation of Antiangiogenic Potential of Vitexin Obtained from Cucumis sativus Targeting Hsp90 Protein: A Novel Multipathway Targeted Approach to Restrain Angiogenic Phenomena. |
2017 |
Med Chem |
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Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. |
2017 |
Expert Opin Drug Metab Toxicol |
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Identification of a flavonoid C-glycoside as potent antioxidant. |
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Effect of the storage time and temperature on phenolic compounds of sorghum grain and flour. |
2017 |
Food Chem |
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2017 |
J. Photochem. Photobiol. B, Biol. |
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Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. |
2017 |
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Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. |
2017 |
Nutrients |
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