| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jin UH et al. | Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. | 2018 | Toxicol. Sci. | pmid:29584932 |
| Elhennawy MG and Lin HS | Dose- and time-dependent pharmacokinetics of apigenin trimethyl ether. | 2018 | Eur J Pharm Sci | pmid:29574080 |
| Malar DS et al. | Vitexin inhibits Aβ induced toxicity in Neuro-2a cells by augmenting Nrf-2/HO-1 dependent antioxidant pathway and regulating lipid homeostasis by the activation of LXR-α. | 2018 | Toxicol In Vitro | pmid:29545167 |
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| Cheruvu HS et al. | LC-MS/MS method for the simultaneous quantification of luteolin, wedelolactone and apigenin in mice plasma using hansen solubility parameters for liquid-liquid extraction: Application to pharmacokinetics of Eclipta alba chloroform fraction. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29518720 |
| Zengin G et al. | Multiple pharmacological approaches on Fibigia eriocarpa extracts by in vitro and computational assays. | 2018 | Fundam Clin Pharmacol | pmid:29505673 |
| Yang YC and Wei MC | Development and characterization of a green procedure for apigenin extraction from Scutellaria barbata D. Don. | 2018 | Food Chem | pmid:29478557 |
| Chassagne F et al. | A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases. | 2018 | Fitoterapia | pmid:29477305 |
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| Steyns JM and van Brederode J | Variation in the substrate specificity of allozymes catalyzing flavone-O-glucoside biosynthesis in Silene plants. | 1986 | Biochem. Genet. | pmid:2943268 |
| Tao Y et al. | Pharmacokinetic comparisons of six components from raw and vinegar-processed Daphne genkwa aqueous extracts following oral administration in rats by employing UHPLC-MS/MS approaches. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29428673 |
| Srivastava A et al. | Swertisin ameliorates diabetes by triggering pancreatic progenitors for islet neogenesis in Streptozotocin treated BALB/c mice. | 2018 | Biomed. Pharmacother. | pmid:29428671 |
| Zhu Q et al. | Comparison of flavonoids and isoflavonoids to inhibit rat and human 11β-hydroxysteroid dehydrogenase 1 and 2. | 2018 | Steroids | pmid:29425740 |
| Brauch D et al. | Changes in isovitexin-O-glycosylation during the development of young barley plants. | 2018 | Phytochemistry | pmid:29421507 |
| Sun Q et al. | Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29408335 |
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| Ashokkumar R et al. | Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29406244 |
| Zhang X et al. | Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway. | 2018 | Free Radic. Res. | pmid:29400110 |
| Melguizo-RodrÃguez L et al. | Effect of olive oil phenolic compounds on osteoblast differentiation. | 2018 | Eur. J. Clin. Invest. | pmid:29392706 |
| Ni G et al. | Synthesis of Scutellarein Derivatives with a Long Aliphatic Chain and Their Biological Evaluation against Human Cancer Cells. | 2018 | Molecules | pmid:29389889 |
| Liu X et al. | Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches. | 2018 | Nat Commun | pmid:29386648 |
| Rimal H et al. | Hydroxylation of Resveratrol with DoxA In Vitro: An Enzyme with the Potential for the Bioconversion of a Bioactive Stilbene. | 2018 | J. Microbiol. Biotechnol. | pmid:29385664 |
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| Cornara L et al. | Zornia latifolia: a smart drug being adulterated by Stylosanthes guianensis. | 2018 | Int. J. Legal Med. | pmid:29362872 |
| Lv SX and Qiao X | Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29355527 |
| Zhang G et al. | Vitexin induces G2/M‑phase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells. | 2018 | Mol Med Rep | pmid:29328424 |
| Kim A and Lee CS | Apigenin reduces the Toll-like receptor-4-dependent activation of NF-κB by suppressing the Akt, mTOR, JNK, and p38-MAPK. | 2018 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:29264665 |
| Kang CH et al. | Apigenin promotes TRAIL-mediated apoptosis regardless of ROS generation. | 2018 | Food Chem. Toxicol. | pmid:29247770 |
| Vollmer M et al. | Mutual Interaction of Phenolic Compounds and Microbiota: Metabolism of Complex Phenolic Apigenin-C- and Kaempferol-O-Derivatives by Human Fecal Samples. | 2018 | J. Agric. Food Chem. | pmid:29236499 |
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| Gaitan E et al. | Antithyroid and goitrogenic effects of millet: role of C-glycosylflavones. | 1989 | J. Clin. Endocrinol. Metab. | pmid:2921306 |
| Kowalczyk A et al. | Insights into novel anticancer applications for apigenin. | 2017 | Adv Clin Exp Med | pmid:29211364 |
| Zhang J et al. | The potential application of strategic released apigenin from polymeric carrier in pulmonary fibrosis. | Exp. Lung Res. | pmid:29206498 | |
| Wong TY et al. | Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. | 2017 | Biomed. Pharmacother. | pmid:29198743 |
| Gao AM et al. | Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis. | 2018 | Chem. Biol. Interact. | pmid:29191453 |
| Baluchnejadmojarad T et al. | Scutellarin alleviates lipopolysaccharide-induced cognitive deficits in the rat: Insights into underlying mechanisms. | 2018 | Int. Immunopharmacol. | pmid:29190543 |
| Granato M et al. | Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death. | 2017 | J. Exp. Clin. Cancer Res. | pmid:29179721 |
| Fan H et al. | Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. | 2017 | Med. Sci. Monit. | pmid:29172017 |
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| Gómez-Zorita S et al. | Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes. | 2017 | J Transl Med | pmid:29162103 |
| Wang J et al. | Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. | 2017 | Int J Nanomedicine | pmid:29158673 |
| You L et al. | Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. | 2017 | Bioorg. Med. Chem. Lett. | pmid:29157862 |
| Jeong KM et al. | Identification of Major Flavone C-Glycosides and Their Optimized Extraction from Cymbidium kanran Using Deep Eutectic Solvents. | 2017 | Molecules | pmid:29156555 |
| Bai HH et al. | Hydroxycinnamoylmalated flavone C-glycosides from Lemna japonica. | 2018 | Fitoterapia | pmid:29154864 |
| Radulovic K et al. | A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation. | 2018 | Mucosal Immunol | pmid:29139477 |
| Wu T et al. | Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1). | 2017 | Pharmacol Rep | pmid:29128807 |
| Liao M et al. | Metabolites identificaion of two bioactive constituents in Trollius ledebourii in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29127056 |