apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Asthma D001249 52 associated lipids
Astrocytoma D001254 15 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cystitis D003556 23 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Gastritis D005756 27 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Hemolysis D006461 131 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Hwang SH et al. Simultaneous Ultra Performance Liquid Chromatography Determination and Antioxidant Activity of Linarin, Luteolin, Chlorogenic Acid and Apigenin in Different Parts of Compositae Species. 2016 Molecules pmid:27886116
Lee SW et al. Alpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced Apoptosis. 2016 PLoS ONE pmid:27851782
Basílio N et al. Analogs of Natural 3-Deoxyanthocyanins: O-Glucosides of the 4',7-Dihydroxyflavylium Ion and the Deep Influence of Glycosidation on Color. 2016 Int J Mol Sci pmid:27775619
Li Y et al. Pharmacokinetic Comparison of Scutellarin and Paeoniflorin in Sham-Operated and Middle Cerebral Artery Occlusion Ischemia and Reperfusion Injury Rats after Intravenous Administration of Xin-Shao Formula. 2016 Molecules pmid:27617986
Tian X et al. Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C. 2016 Biol. Pharm. Bull. pmid:26581323
Mudge EM et al. Single-Laboratory Validation for the Determination of Flavonoids in Hawthorn Leaves and Finished Products by LC-UV. 2016 Planta Med. pmid:27776376
Whitehouse S et al. Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties. 2016 Phytomedicine pmid:27765370
Li Q et al. Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. 2016 J Clin Neurosci pmid:27742373
Hlila MB et al. Characterisation of phenolic antioxidants in Scabiosa arenaria flowers by LC-ESI-MS/MS and NMR. 2016 J. Pharm. Pharmacol. pmid:27230582
Terpinc P et al. LC-MS analysis of phenolic compounds and antioxidant activity of buckwheat at different stages of malting. 2016 Food Chem pmid:27211614
Kandhare AD et al. Development and validation of HPLC method for vicenin-1 isolated from fenugreek seeds in rat plasma: application to pharmacokinetic, tissue distribution and excretion studies. 2016 Pharm Biol pmid:27181500
Luan RL et al. Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice. 2016 Inflammation pmid:26782361
Wang Z et al. Scutellarin protects cardiomyocyte ischemia-reperfusion injury by reducing apoptosis and oxidative stress. 2016 Life Sci. pmid:26775564
Ku SK and Bae JS Vicenin-2 and scolymoside inhibit high-glucose-induced vascular inflammation in vitro and in vivo. 2016 Can. J. Physiol. Pharmacol. pmid:26766560
Pápay ZE et al. Comparative evaluation of the effect of cyclodextrins and pH on aqueous solubility of apigenin. 2016 J Pharm Biomed Anal pmid:26363816
Chang CY et al. Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus. 2015 Eur. J. Pharmacol. pmid:26007643
Zhang X et al. Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways. 2015 Mol. Cell. Biochem. pmid:25994505
Wong TY et al. The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68. 2015 Br. J. Nutr. pmid:25978649
Banerjee K et al. Probing the potential of apigenin liposomes in enhancing bacterial membrane perturbation and integrity loss. 2015 J Colloid Interface Sci pmid:25965432
Mastantuono T et al. Effects of Citrus Flavonoids Against Microvascular Damage Induced by Hypoperfusion and Reperfusion in Rat Pial Circulation. 2015 Microcirculation pmid:25944567
Sang ZP et al. Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. 2015 Chem Biol Drug Des pmid:25941042
Seo HS et al. Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells. 2015 Mol Med Rep pmid:25936427
Chen YJ et al. Scutellarin attenuates endothelium-dependent aasodilation impairment induced by hypoxia reoxygenation, through regulating the PKG signaling pathway in rat coronary artery. 2015 Chin J Nat Med pmid:25908623
Paredes-Gonzalez X et al. Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin. 2015 Biopharm Drug Dispos pmid:25904312
Li Y et al. Pharmacokinetics and tissue distribution study of Isovitexin in rats by HPLC-MS/MS. 2015 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:25902051
Wang Q et al. Inhibition of autophagy ameliorates atherogenic inflammation by augmenting apigenin-induced macrophage apoptosis. 2015 Int. Immunopharmacol. pmid:25899084
Shi T et al. [Effect of apigenin on protein expressions of PPARs in liver tissues of rats with nonalcoholic steatohepatitis]. 2015 Zhonghua Gan Zang Bing Za Zhi pmid:25880979
Xu C et al. Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines. 2015 Xenobiotica pmid:25869249
Wei L et al. Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions. 2015 J Sep Sci pmid:25866087
Zhang G et al. Effects of germination on the nutritional properties, phenolic profiles, and antioxidant activities of buckwheat. 2015 J. Food Sci. pmid:25858540
Wang Y et al. Vitexin protects brain against ischemia/reperfusion injury via modulating mitogen-activated protein kinase and apoptosis signaling in mice. 2015 Phytomedicine pmid:25837275
Sang Z et al. Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease. 2015 Eur J Med Chem pmid:25778991
Fonseca-Silva F et al. Effect of Apigenin on Leishmania amazonensis Is Associated with Reactive Oxygen Species Production Followed by Mitochondrial Dysfunction. 2015 J. Nat. Prod. pmid:25768915
Gidaro MC et al. Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products. 2015 Planta Med. pmid:25590364
María Landete J et al. Effect of soaking and fermentation on content of phenolic compounds of soybean (Glycine max cv. Merit) and mung beans (Vigna radiata [L] Wilczek). 2015 Int J Food Sci Nutr pmid:25582183
Tang H et al. Investigation on the interactions of scutellarin and scutellarein with bovine serum albumin using spectroscopic and molecular docking techniques. 2015 Arch. Pharm. Res. pmid:25577334
Del Turco S et al. Synthetic analogues of flavonoids with improved activity against platelet activation and aggregation as novel prototypes of food supplements. 2015 Food Chem pmid:25577111
Guzelmeric E et al. Development and validation of an HPTLC method for apigenin 7-O-glucoside in chamomile flowers and its application for fingerprint discrimination of chamomile-like materials. 2015 J Pharm Biomed Anal pmid:25575175
Liu W et al. Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells. 2015 Int. J. Mol. Med. pmid:25573459
Yu XD et al. Biological evaluation and molecular docking of baicalin and scutellarin as Helicobacter pylori urease inhibitors. 2015 J Ethnopharmacol pmid:25557028
Yang L et al. Enhanced action of apigenin and naringenin combination on estrogen receptor activation in non-malignant colonocytes: implications on sorghum-derived phytoestrogens. 2015 Food Funct pmid:25553799
Zhang S et al. Studies on the interaction of apigenin with calf thymus DNA by spectroscopic methods. 2015 Spectrochim Acta A Mol Biomol Spectrosc pmid:25459730
Suh YA et al. Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells. 2015 Int. J. Oncol. pmid:25544427
Russo D et al. Antioxidant activities and quali-quantitative analysis of different Smallanthus sonchifolius [(Poepp. and Endl.) H. Robinson] landrace extracts. 2015 Nat. Prod. Res. pmid:25533266
Heredia-Vieira SC et al. Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves. 2015 J. Nat. Prod. pmid:25517504
Germanò MP et al. Anti-angiogenic activity of Entada africana root. 2015 Nat. Prod. Res. pmid:25482106
Saeed M et al. Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking. 2015 J. Nutr. Biochem. pmid:25459885
Scholz P and Keck CM Flavonoid nanocrystals produced by ARTcrystal®-technology. 2015 Int J Pharm pmid:25448550
Wang XS et al. Effects of vitexin on the pharmacokinetics and mRNA expression of CYP isozymes in rats. 2015 Phytother Res pmid:25447838
Singh V et al. Apigenin manipulates the ubiquitin-proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells. 2015 Eur J Nutr pmid:25408199
Wu PS et al. Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. 2015 PLoS ONE pmid:26087007
Morimoto Y et al. Apigenin as an anti-quinolone-resistance antibiotic. 2015 Int. J. Antimicrob. Agents pmid:26526895
Seo HS et al. Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells. 2015 Biosci. Rep. pmid:26500281
Xia F et al. Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus. 2015 Appl. Environ. Microbiol. pmid:26475103
Nakajima A et al. A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1β-treated hepatocytes. 2015 Biosci. Biotechnol. Biochem. pmid:25266050
Li L et al. Scutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα. 2015 PLoS ONE pmid:26440524
Willenberg I et al. Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity. 2015 PLoS ONE pmid:26440517
Chen X et al. Effect of scutellarin on the metabolism and pharmacokinetics of clopidogrel in rats. 2015 Biopharm Drug Dispos pmid:25256597
Shukla S et al. Apigenin blocks IKKα activation and suppresses prostate cancer progression. 2015 Oncotarget pmid:26435478
Kim M et al. Deglycosylation of isoflavone C-glycosides by newly isolated human intestinal bacteria. 2015 J. Sci. Food Agric. pmid:25199800
Lakshmanan A et al. Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin. 2015 Oncotarget pmid:26397139
Shukla S et al. Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice. 2015 PLoS ONE pmid:26379052
Sun J et al. Chemical Constituents and Antibacterial Properties of Indocalamus latifolius McClure Leaves, the Packaging Material for "Zongzi". 2015 Molecules pmid:26343625
Fang J et al. Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1. 2015 Mol Med Rep pmid:26300442
Falcone Ferreyra ML et al. The Identification of Maize and Arabidopsis Type I FLAVONE SYNTHASEs Links Flavones with Hormones and Biotic Interactions. 2015 Plant Physiol. pmid:26269546
Cattaneo L et al. Anti-Proliferative Effect of Rosmarinus officinalis L. Extract on Human Melanoma A375 Cells. 2015 PLoS ONE pmid:26176704
Jeon BJ et al. Apigenin inhibits indoxyl sulfate-induced endoplasmic reticulum stress and anti-proliferative pathways, CHOP and IL-6/p21, in human renal proximal tubular cells. 2015 Eur Rev Med Pharmacol Sci pmid:26166660
Zhang Y et al. Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway. 2015 Eur J Histochem pmid:26150153
Tang H et al. Comparative Metabolomic Analysis of the Neuroprotective Effects of Scutellarin and Scutellarein against Ischemic Insult. 2015 PLoS ONE pmid:26147971
Ma X et al. Acylation of Antioxidant of Bamboo Leaves with Fatty Acids by Lipase and the Acylated Derivatives' Efficiency in the Inhibition of Acrylamide Formation in Fried Potato Crisps. 2015 PLoS ONE pmid:26098744
Gao R et al. Simultaneous determination of oleanolic acid, ursolic acid, quercetin and apigenin in Swertia mussotii Franch by capillary zone electrophoresis with running buffer modifier. 2015 Biomed. Chromatogr. pmid:25042239
Nakamura K et al. Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone. 2015 Biol. Pharm. Bull. pmid:25810454
Mrazek AA et al. Apigenin inhibits pancreatic stellate cell activity in pancreatitis. 2015 J. Surg. Res. pmid:25799526
Liu L et al. Characterization of the intestinal absorption of seven flavonoids from the flowers of Trollius chinensis using the Caco-2 cell monolayer model. 2015 PLoS ONE pmid:25789809
Ji P et al. Antiviral activity of Paulownia tomentosa against enterovirus 71 of hand, foot, and mouth disease. 2015 Biol. Pharm. Bull. pmid:25744451
Yuan Y et al. Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia. 2015 J Neuroinflammation pmid:25600517
Li KC et al. Apigenin-7-glycoside prevents LPS-induced acute lung injury via downregulation of oxidative enzyme expression and protein activation through inhibition of MAPK phosphorylation. 2015 Int J Mol Sci pmid:25590301
Huang H et al. effects of natural flavonoids on photosynthetic activity and cell integrity in Microcystis aeruginosa. 2015 Toxins (Basel) pmid:25584428
Shi X et al. Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo. 2015 Int. J. Mol. Med. pmid:25394920
Chomicki G et al. The velamen protects photosynthetic orchid roots against UV-B damage, and a large dated phylogeny implies multiple gains and losses of this function during the Cenozoic. 2015 New Phytol. pmid:25345817
Chang X et al. Protective effect of apigenin on Freund's complete adjuvant-induced arthritis in rats via inhibiting P2X7/NF-κB pathway. 2015 Chem. Biol. Interact. pmid:25935278
Zhang T et al. Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. 2015 Chem. Biol. Interact. pmid:25557508
Aslan E and Adem S In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. 2015 J. Biochem. Mol. Toxicol. pmid:25388478
Yamagata K et al. Dietary polyphenols regulate endothelial function and prevent cardiovascular disease. 2015 Nutrition pmid:25466651
Santos BL et al. Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression. 2015 Chem. Biol. Interact. pmid:26408079
Ratajewski M et al. Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. 2015 Toxicol. Lett. pmid:25455453
Kim SH et al. Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells. 2015 Anticancer Res. pmid:26637867
Li H et al. Separation of vitexin-4″-O-glucoside and vitexin-2″-O-rhamnoside from hawthorn leaves extracts using macroporous resins. 2015 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:26562804
Zemanova L et al. Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment. 2015 J. Nat. Prod. pmid:26529431
Samet I et al. Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. 2015 Differentiation pmid:26299581
Zhang L et al. Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells. 2015 Food Funct pmid:26292725
Li W et al. Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4). 2015 Biochem. Pharmacol. pmid:26291395
Lin S et al. Inhibition of chrysin on xanthine oxidase activity and its inhibition mechanism. 2015 Int. J. Biol. Macromol. pmid:26275460
Farimani MM et al. Seco-ursane-type Triterpenoids from Salvia urmiensis with Apoptosis-inducing Activity. 2015 Planta Med. pmid:26252828
Lee W et al. Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo. 2015 Can. J. Physiol. Pharmacol. pmid:26243020
Bao YY et al. Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo. 2015 Oncol. Rep. pmid:26238658
Long HP et al. Involvenflavones A-F, six new flavonoids with 3'-aryl substituent from Selaginella involven. 2015 Fitoterapia pmid:26226107
Zhan YY et al. Inhibitory Effect of Apigenin on Pharmacokinetics of Venlafaxine in vivo and in vitro. 2015 Pharmacology pmid:26202346
Min JW et al. Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model. 2015 Neuropharmacology pmid:26187393
Hong H et al. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. 2015 Toxicol. Sci. pmid:25349334