| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Gastrointestinal Diseases | D005767 | 20 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chaudhary A and Willett KL | Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John's wort. | 2006 | Toxicology | pmid:16271822 |
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| Domingo-Domenech J et al. | Activation of nuclear factor-kappaB in human prostate carcinogenesis and association to biochemical relapse. | 2005 | Br. J. Cancer | pmid:16278667 |
| Park J et al. | Inhibition of interleukin-4 production in activated T cells via down-regulation of NF-AT DNA binding activity by apigenin, a flavonoid present in dietary plants. | 2006 | Immunol. Lett. | pmid:16280168 |
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| Khan TH and Sultana S | Apigenin induces apoptosis in Hep G2 cells: possible role of TNF-alpha and IFN-gamma. | 2006 | Toxicology | pmid:16289292 |
| Hu XM et al. | Neuroprotective effects of scutellarin on rat neuronal damage induced by cerebral ischemia/reperfusion. | 2005 | Acta Pharmacol. Sin. | pmid:16297343 |
| Nassar MI | Flavonoid triglycosides from the seeds of Syzygium aromaticum. | 2006 | Carbohydr. Res. | pmid:16297892 |
| Young JE et al. | Phytochemical phenolics in organically grown vegetables. | 2005 | Mol Nutr Food Res | pmid:16302198 |
| Labib S et al. | Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds. | 2006 | Mol Nutr Food Res | pmid:16317785 |
| Li LP and Jiang HD | Determination and assay validation of luteolin and apigenin in human urine after oral administration of tablet of Chrysanthemum morifolium extract by HPLC. | 2006 | J Pharm Biomed Anal | pmid:16318906 |
| Delazar A et al. | Two acylated flavonoid glycosides from Stachys bombycina, and their free radical scavenging activity. | 2005 | Pharmazie | pmid:16320954 |
| Capodice JL et al. | Complementary and alternative medicine for chronic prostatitis/chronic pelvic pain syndrome. | 2005 | Evid Based Complement Alternat Med | pmid:16322807 |
| Cushnie TP and Lamb AJ | Antimicrobial activity of flavonoids. | 2005 | Int. J. Antimicrob. Agents | pmid:16323269 |
| Yu ZW et al. | [Study on chemical constituents from Incarvillea arguta and their accelerating PC-12 cell differentiation]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16323541 |
| Kim JY et al. | Eupatilin blocks mediator release via tyrosine kinase inhibition in activated guinea pig lung mast cells. | 2005 | J. Toxicol. Environ. Health Part A | pmid:16326424 |
| Zheng YN et al. | Effects of compounds in leaves of Salix matsudana on arachidonic acid metabolism. | 2005 | Yakugaku Zasshi | pmid:16327246 |
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| Meyer H et al. | Bioavailability of apigenin from apiin-rich parsley in humans. | 2006 | Ann. Nutr. Metab. | pmid:16407641 |
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| Li FX et al. | Overexpression of the Saussurea medusa chalcone isomerase gene in S. involucrata hairy root cultures enhances their biosynthesis of apigenin. | 2006 | Phytochemistry | pmid:16427667 |
| Takeda E et al. | Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1. | 2005 | Cell Struct. Funct. | pmid:16428860 |
| Koo H et al. | Influence of apigenin on gtf gene expression in Streptococcus mutans UA159. | 2006 | Antimicrob. Agents Chemother. | pmid:16436708 |
| Ahlenstiel T et al. | Improved cold preservation of kidney tubular cells by means of adding bioflavonoids to organ preservation solutions. | 2006 | Transplantation | pmid:16436967 |
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| Ko JH et al. | Molecular cloning, expression and characterization of a glycosyltransferase from rice. | 2006 | Plant Cell Rep. | pmid:16477404 |
| Gormann R et al. | Newbouldiosides A-C, phenylethanoid glycosides from the stem bark of Newbouldia laevis. | 2006 | Phytochemistry | pmid:16497346 |
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| Deschamps JD et al. | Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases. | 2006 | Bioorg. Med. Chem. | pmid:16500106 |
| Mohanty I et al. | Effect of Curcuma longa and Ocimum sanctum on myocardial apoptosis in experimentally induced myocardial ischemic-reperfusion injury. | 2006 | BMC Complement Altern Med | pmid:16504000 |
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| Seo HS et al. | Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha. | 2006 | Breast Cancer Res. Treat. | pmid:16541309 |
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| Cimanga RK et al. | Cytotoxicity and in vitro susceptibility of Entamoeba histolytica to Morinda morindoides leaf extracts and its isolated constituents. | 2006 | J Ethnopharmacol | pmid:16603327 |
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| Peterson S et al. | Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. | 2006 | Food Chem. Toxicol. | pmid:16762476 |
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| Vargo MA et al. | Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16844095 |
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