apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Asthma D001249 52 associated lipids
Astrocytoma D001254 15 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cystitis D003556 23 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Gastritis D005756 27 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Hemolysis D006461 131 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
de Santana Aquino DF et al. Anti-hyperalgesic and Anti-inflammatory Activity of Alternanthera Maritima Extract and 2″-O-α-L-rhamnopyranosylvitexin in Mice. 2015 Inflammation pmid:26045342
Yin Q et al. In vitro-assessment of putative antiprogestin activities of phytochemicals and synthetic UV absorbers in human endometrial Ishikawa cells. 2015 Gynecol. Endocrinol. pmid:26036805
Liu X et al. Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway. 2015 Oncol. Rep. pmid:26035210
Supuran CT Nanoparticles for controlled release of anti-biofilm agents WO2014130994 (A1): a patent evaluation. 2015 Expert Opin Ther Pat pmid:26028186
Zhang T et al. Apigenin protects blood-brain barrier and ameliorates early brain injury by inhibiting TLR4-mediated inflammatory pathway in subarachnoid hemorrhage rats. 2015 Int. Immunopharmacol. pmid:26028151
Su ZR et al. Discovery of xanthine oxidase inhibitors and/or α-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin. 2015 Bioorg. Med. Chem. Lett. pmid:26022844
Boudjelal A et al. Antidiabetic Effects of Aqueous Infusions of Artemisia herba-alba and Ajuga iva in Alloxan-Induced Diabetic Rats. 2015 Planta Med. pmid:26018915
Chang CY et al. Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus. 2015 Eur. J. Pharmacol. pmid:26007643
Zhang X et al. Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways. 2015 Mol. Cell. Biochem. pmid:25994505
Wong TY et al. The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68. 2015 Br. J. Nutr. pmid:25978649
Banerjee K et al. Probing the potential of apigenin liposomes in enhancing bacterial membrane perturbation and integrity loss. 2015 J Colloid Interface Sci pmid:25965432
Mastantuono T et al. Effects of Citrus Flavonoids Against Microvascular Damage Induced by Hypoperfusion and Reperfusion in Rat Pial Circulation. 2015 Microcirculation pmid:25944567
Patil RH et al. Apigenin inhibits PMA-induced expression of pro-inflammatory cytokines and AP-1 factors in A549 cells. 2015 Mol. Cell. Biochem. pmid:25666088
Mustapha N et al. Compounds isolated from the aerial part of Crataegus azarolus inhibit growth of B16F10 melanoma cells and exert a potent inhibition of the melanin synthesis. 2015 Biomed. Pharmacother. pmid:25661350
Mascaraque C et al. Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium. 2015 Br. J. Nutr. pmid:25654996
Costa G et al. Flavan hetero-dimers in the Cymbopogon citratus infusion tannin fraction and their contribution to the antioxidant activity. 2015 Food Funct pmid:25652784
Arango D et al. Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation. 2015 Mol Nutr Food Res pmid:25641956
Sang Z et al. Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease. 2015 Bioorg. Med. Chem. pmid:25614117
Xiong F et al. Integrated pharmacokinetics and biodistribution of multiple flavonoid C-glycosides components in rat after oral administration of Abrus mollis extract and correlations with bio-effects. 2015 J Ethnopharmacol pmid:25614108
Gidaro MC et al. Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products. 2015 Planta Med. pmid:25590364
María Landete J et al. Effect of soaking and fermentation on content of phenolic compounds of soybean (Glycine max cv. Merit) and mung beans (Vigna radiata [L] Wilczek). 2015 Int J Food Sci Nutr pmid:25582183
Tang H et al. Investigation on the interactions of scutellarin and scutellarein with bovine serum albumin using spectroscopic and molecular docking techniques. 2015 Arch. Pharm. Res. pmid:25577334
Del Turco S et al. Synthetic analogues of flavonoids with improved activity against platelet activation and aggregation as novel prototypes of food supplements. 2015 Food Chem pmid:25577111
Guzelmeric E et al. Development and validation of an HPTLC method for apigenin 7-O-glucoside in chamomile flowers and its application for fingerprint discrimination of chamomile-like materials. 2015 J Pharm Biomed Anal pmid:25575175
Liu W et al. Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells. 2015 Int. J. Mol. Med. pmid:25573459
Li LH et al. Apigenin inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells. 2015 Int J Clin Exp Pathol pmid:26722444
Pereira C et al. Infusions of artichoke and milk thistle represent a good source of phenolic acids and flavonoids. 2015 Food Funct pmid:25367590
Hu XY et al. 5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma. 2015 Clin. Exp. Pharmacol. Physiol. pmid:25363523
Zhu Y et al. Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer. 2015 Mol Med Rep pmid:25351792
Liu J et al. Apigenin inhibits HeLa sphere-forming cells through inactivation of casein kinase 2α. 2015 Mol Med Rep pmid:25334018
Shibamoto T A novel gas chromatographic method for determination of malondialdehyde from oxidized DNA. 2015 Methods Mol. Biol. pmid:25323498
Wu PS et al. Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. 2015 PLoS ONE pmid:26087007
Amini R et al. Apigenin modulates the expression levels of pro-inflammatory mediators to reduce the human insulin amyloid-induced oxidant damages in SK-N-MC cells. 2015 Hum Exp Toxicol pmid:25304968
Nakajima A et al. A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1β-treated hepatocytes. 2015 Biosci. Biotechnol. Biochem. pmid:25266050
Farkas O et al. Polymethoxyflavone Apigenin-Trimethylether Suppresses LPS-Induced Inflammatory Response in Nontransformed Porcine Intestinal Cell Line IPEC-J2. 2015 Oxid Med Cell Longev pmid:26180592
Chen X et al. Effect of scutellarin on the metabolism and pharmacokinetics of clopidogrel in rats. 2015 Biopharm Drug Dispos pmid:25256597
Shukla S et al. Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice. 2015 PLoS ONE pmid:26379052
Sun J et al. Chemical Constituents and Antibacterial Properties of Indocalamus latifolius McClure Leaves, the Packaging Material for "Zongzi". 2015 Molecules pmid:26343625
Fang J et al. Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1. 2015 Mol Med Rep pmid:26300442
Falcone Ferreyra ML et al. The Identification of Maize and Arabidopsis Type I FLAVONE SYNTHASEs Links Flavones with Hormones and Biotic Interactions. 2015 Plant Physiol. pmid:26269546
Cattaneo L et al. Anti-Proliferative Effect of Rosmarinus officinalis L. Extract on Human Melanoma A375 Cells. 2015 PLoS ONE pmid:26176704
Jeon BJ et al. Apigenin inhibits indoxyl sulfate-induced endoplasmic reticulum stress and anti-proliferative pathways, CHOP and IL-6/p21, in human renal proximal tubular cells. 2015 Eur Rev Med Pharmacol Sci pmid:26166660
Zhang Y et al. Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway. 2015 Eur J Histochem pmid:26150153
Tang H et al. Comparative Metabolomic Analysis of the Neuroprotective Effects of Scutellarin and Scutellarein against Ischemic Insult. 2015 PLoS ONE pmid:26147971
Ma X et al. Acylation of Antioxidant of Bamboo Leaves with Fatty Acids by Lipase and the Acylated Derivatives' Efficiency in the Inhibition of Acrylamide Formation in Fried Potato Crisps. 2015 PLoS ONE pmid:26098744
Shiota C et al. Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes. 2015 J. Nutr. Sci. Vitaminol. pmid:26052151
Dadheech N et al. Swertisin an Anti-Diabetic Compound Facilitate Islet Neogenesis from Pancreatic Stem/Progenitor Cells via p-38 MAP Kinase-SMAD Pathway: An In-Vitro and In-Vivo Study. 2015 PLoS ONE pmid:26047129
Zhang W et al. A new and efficient synthesis of 6-O-methylscutellarein, the major metabolite of the natural medicine scutellarin. 2015 Molecules pmid:26042857
Lee H et al. Biosynthesis of Two Flavones, Apigenin and Genkwanin, in Escherichia coli. 2015 J. Microbiol. Biotechnol. pmid:25975614
Banerjee K and Mandal M Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells. 2015 Redox Biol pmid:25965143
Kumar KK et al. Pharmacokinetic drug interactions between apigenin, rutin and paclitaxel mediated by P-glycoprotein in rats. 2015 Eur J Drug Metab Pharmacokinet pmid:24871039
Shi X et al. Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo. 2015 Int. J. Mol. Med. pmid:25394920
Chomicki G et al. The velamen protects photosynthetic orchid roots against UV-B damage, and a large dated phylogeny implies multiple gains and losses of this function during the Cenozoic. 2015 New Phytol. pmid:25345817
Avelino-Flores Mdel C et al. Cytotoxic activity of the methanolic extract of Turnera diffusa Willd on breast cancer cells. 2015 J Med Food pmid:25299247
Aslan E and Adem S In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. 2015 J. Biochem. Mol. Toxicol. pmid:25388478
Ratajewski M et al. Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. 2015 Toxicol. Lett. pmid:25455453
Sun H et al. Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling. 2015 J. Agric. Food Chem. pmid:26066637
An F et al. Attenuation of oxidative stress of erythrocytes by the plant-derived flavonoids vitexin and apigenin. 2015 Pharmazie pmid:26790189
Lin CH et al. Thrombin-induced IL-8/CXCL8 release is mediated by CK2, MSK1, and NF-κB pathways in human lung epithelial cells. 2015 Eur. J. Pharmacol. pmid:26463037
Shi ZH et al. Synthesis of scutellarein derivatives to increase biological activity and water solubility. 2015 Bioorg. Med. Chem. pmid:26455656
Yang X et al. Apigenin attenuates myocardial ischemia/reperfusion injury via the inactivation of p38 mitogen‑activated protein kinase. 2015 Mol Med Rep pmid:26398147
Liu Y et al. High-resolution hyaluronidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-necrosis constituents in Chinese plants used to treat snakebite. 2015 Phytochemistry pmid:26386983
Guimarães CC et al. The glycosylated flavonoids vitexin, isovitexin, and quercetrin isolated from Serjania erecta Radlk (Sapindaceae) leaves protect PC12 cells against amyloid-β25-35 peptide-induced toxicity. 2015 Food Chem. Toxicol. pmid:26385725
Samet I et al. Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. 2015 Differentiation pmid:26299581
Zhang L et al. Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells. 2015 Food Funct pmid:26292725
Li W et al. Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4). 2015 Biochem. Pharmacol. pmid:26291395
Hong H et al. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. 2015 Toxicol. Sci. pmid:25349334
Zhang CJ et al. [Simultaneous determination of four flavone C-glycosides in Phyllostachys edulis leaves by high-performance liquid chromatography with ultraviolet spectrometry]. 2014 Guang Pu Xue Yu Guang Pu Fen Xi pmid:25532365
Guo H et al. Apigenin mediated protection of OGD-evoked neuron-like injury in differentiated PC12 cells. 2014 Neurochem. Res. pmid:25208641
Wang D et al. Scutellarin inhibits high glucose-induced and hypoxia-mimetic agent-induced angiogenic effects in human retinal endothelial cells through reactive oxygen species/hypoxia-inducible factor-1α/vascular endothelial growth factor pathway. 2014 J. Cardiovasc. Pharmacol. pmid:25192544
Yang X et al. Nanosuspension development of scutellarein as an active and rapid orally absorbed precursor of its BCS class IV glycoside scutellarin. 2014 J Pharm Sci pmid:25187229
Watanabe Y et al. Phytotoxic potential of Onopordum acanthium L. (Asteraceae). 2014 Chem. Biodivers. pmid:25146768
Fang L et al. Application of isoabsorption plots generated by high-performance liquid chromatography with diode array detection to the development of multicomponent quantitative analysis of traditional herbal medicines. 2014 J Sep Sci pmid:25146493
Nisha VM et al. Apigenin and quercetin ameliorate mitochondrial alterations by tunicamycin-induced ER stress in 3T3-L1 adipocytes. 2014 Appl. Biochem. Biotechnol. pmid:25106896
Patil SP et al. Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice. 2014 Neuropharmacology pmid:25087727
Jung WW Protective effect of apigenin against oxidative stress-induced damage in osteoblastic cells. 2014 Int. J. Mol. Med. pmid:24573323
Xue HF et al. Hepatic, gastric, and intestinal first-pass effects of vitexin in rats. 2014 Pharm Biol pmid:24555505
Simeonova R et al. Protective effects of the apigenin-O/C-diglucoside saponarin from Gypsophila trichotoma on carbone tetrachloride-induced hepatotoxicity in vitro/in vivo in rats. 2014 Phytomedicine pmid:24011529
Wang F et al. Host-guest inclusion system of scutellarein with 2-hydroxypropyl-beta-cyclodextrin: preparation, characterization, and anticancer activity. 2014 J Biomater Sci Polym Ed pmid:24555409
Wei W et al. Effects of vitexin-2"-O-rhamnoside and vitexin-4"-O-glucoside on growth and oxidative stress-induced cell apoptosis of human adipose-derived stem cells. 2014 J. Pharm. Pharmacol. pmid:24533889
Kumar D and Bhat ZA Apigenin 7-glucoside from Stachys tibetica Vatke and its anxiolytic effect in rats. 2014 Phytomedicine pmid:24462214
Popović M et al. The flavonoid apigenin delays forgetting of passive avoidance conditioning in rats. 2014 J. Psychopharmacol. (Oxford) pmid:24284476
Xu YY et al. Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal carcinoma Hep-2 cells: an in vitro study. 2014 Int J Clin Exp Pathol pmid:25120770
Vamanu E Antioxidant properties of mushroom mycelia obtained by batch cultivation and tocopherol content affected by extraction procedures. 2014 Biomed Res Int pmid:25110715
Tsalkidou EG et al. The effects of apigenin on the expression of Fas/FasL apoptotic pathway in warm liver ischemia-reperfusion injury in rats. 2014 Biomed Res Int pmid:25110657
Warat M et al. Chrysin, apigenin and acacetin inhibit tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) on activated RAW264.7 macrophages. 2014 Int J Mol Sci pmid:24979133
Jiang NH et al. Analysis of the transcriptome of Erigeron breviscapus uncovers putative scutellarin and chlorogenic acids biosynthetic genes and genetic markers. 2014 PLoS ONE pmid:24956277
Nakatsu D et al. JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet. 2014 Genes Cells pmid:24889144
Ding SM et al. Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion. 2014 Int J Nanomedicine pmid:24872695
Chen H et al. Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo. 2014 Bioorg. Med. Chem. pmid:24837156
Yang L et al. Neuroprotective effects of vitexin by inhibition of NMDA receptors in primary cultures of mouse cerebral cortical neurons. 2014 Mol. Cell. Biochem. pmid:24141792
Wu DG et al. Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells. 2014 Toxicol. Lett. pmid:24148603
Han XJ et al. Functional characterization of a Plagiochasma appendiculatum flavone synthase I showing flavanone 2-hydroxylase activity. 2014 FEBS Lett. pmid:24859082
Seo HS et al. Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells. 2014 Anticancer Res. pmid:24922650
Lin Z et al. In vivo effects of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 by cocktail probe drugs in rats. 2014 Pharmazie pmid:25073400
Singh PP and Chauhan SM Activity-guided isolation of antioxidants from the leaves of Terminalia arjuna. 2014 Nat. Prod. Res. pmid:24484080
Je HG et al. The inhibitory effect of vitexin on the agonist-induced regulation of vascular contractility. 2014 Pharmazie pmid:24716414
Kim MA et al. Apigenin isolated from Daphne genkwa Siebold et Zucc. inhibits 3T3-L1 preadipocyte differentiation through a modulation of mitotic clonal expansion. 2014 Life Sci. pmid:24582594
Li YR et al. [Quality standard study on Vigna radiata]. 2014 Zhongguo Zhong Yao Za Zhi pmid:24754176
Guedj F et al. Prenatal treatment of Down syndrome: a reality? 2014 Curr. Opin. Obstet. Gynecol. pmid:24573065