| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nazaruk J and Gudej J | Flavonoid compounds from the flowers of Cirsium rivulare (Jacq.) All. | 2003 Jan-Feb | Acta Pol Pharm | pmid:12848373 |
| Patora J and Klimek B | Flavonoids from lemon balm (Melissa officinalis L., Lamiaceae). | 2002 Mar-Apr | Acta Pol Pharm | pmid:12365606 |
| Matławska I and Sikorska M | Flavonoid compounds in the flowers of Abutilon indicum (L.) Sweet (Malvaceae). | 2002 May-Jun | Acta Pol Pharm | pmid:12230251 |
| Matławska I | Flavonoid compounds in the flowers of Kitaibelia vitifolia Willd. (Malvaceae). | 2001 Mar-Apr | Acta Pol Pharm | pmid:11501790 |
| Bylka W | Isovitexin o-glucosides from Aquilegia vulgaris L. | 2001 Jul-Aug | Acta Pol Pharm | pmid:11693732 |
| Nazaruk J and Gudej J | Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L. | 2001 Sep-Oct | Acta Pol Pharm | pmid:11876448 |
| Bylka W and Matławska I | Flavonoids from Aquilegia vulgaris L. Part II. Derivatives of apigenin and luteolin. | 1997 Jul-Aug | Acta Pol Pharm | pmid:9511462 |
| Modnicki D et al. | Flavonoids and phenolic acids of Nepeta cataria L. var. citriodora (Becker) Balb. (Lamiaceae). | 2007 May-Jun | Acta Pol Pharm | pmid:17695148 |
| Nazaruk J | Flavonoid aglycones and phytosterols from the Erigeron acris L. herb. | 2006 Jul-Aug | Acta Pol Pharm | pmid:17203871 |
| Mazol I et al. | Polyphenolic compounds from Platycodon grandiflorum A. DC. | 2004 May-Jun | Acta Pol Pharm | pmid:15481246 |
| Krcatović E et al. | Inhibition of tobacco mosaic virus infection by quercetin and vitexin. | 2008 | Acta Virol. | pmid:18564899 |
| Horbowicz M et al. | Effects of methyl jasmonate on accumulation of flavonoids in seedlings of common buckwheat (Fagopyrum esculentum Moench). | 2011 | Acta. Biol. Hung. | pmid:21840829 |
| Dhawan K | Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective. | 2003 | Addict Biol | pmid:14690874 |
| Kowalczyk A et al. | Insights into novel anticancer applications for apigenin. | 2017 | Adv Clin Exp Med | pmid:29211364 |
| Koo H and Jeon JG | Naturally occurring molecules as alternative therapeutic agents against cariogenic biofilms. | 2009 | Adv. Dent. Res. | pmid:19717411 |
| Koo H | Strategies to enhance the biological effects of fluoride on dental biofilms. | 2008 | Adv. Dent. Res. | pmid:18694872 |
| Shu-Yao Z et al. | In vitro evidence of possible influence of scutellarein towards bile acids' metabolism. | 2013 | Afr Health Sci | pmid:24250288 |
| Hashem FA et al. | Phenolic compounds and bioactivity of leaves of Mayodendron igneum Kurz. | 2007 | Afr J Tradit Complement Altern Med | pmid:20161894 |
| Ito M et al. | GSTT1 is upregulated by oxidative stress through p38-MK2 signaling pathway in human granulosa cells: possible association with mitochondrial activity. | 2011 | Aging (Albany NY) | pmid:22207314 |
| Martins I et al. | Hormesis, cell death and aging. | 2011 | Aging (Albany NY) | pmid:21931183 |