| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Palacz-Wrobel M et al. | Effect of apigenin, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW-264.7 macrophages. | 2017 | Biomed. Pharmacother. | pmid:28738536 |
| Pate KM et al. | Anthoxanthin Polyphenols Attenuate Aβ Oligomer-induced Neuronal Responses Associated with Alzheimer's Disease. | 2017 | CNS Neurosci Ther | pmid:27864869 |
| Chen L et al. | Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. | 2017 | Arch Gerontol Geriatr | pmid:28743056 |
| Gao C et al. | Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells. | 2017 | Oncol. Rep. | pmid:28737827 |
| Ghazanfar K et al. | Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. | 2017 | J Complement Integr Med | pmid:28731312 |
| Sun Y et al. | Homogenate-assisted Vacuum-powered Bubble Extraction of Moso Bamboo Flavonoids for On-line Scavenging Free Radical Capacity Analysis. | 2017 | Molecules | pmid:28696360 |
| Seo HS et al. | Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells. | 2017 | Oncol. Rep. | pmid:28656316 |
| Spilovska K et al. | Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation. | 2017 | Molecules | pmid:28621747 |
| Salmani JMM et al. | Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives. | 2017 | Chin J Nat Med | pmid:28558867 |
| Elmasri WA et al. | Multitargeted Flavonoid Inhibition of the Pathogenic Bacterium Staphylococcus aureus: A Proteomic Characterization. | 2017 | J. Proteome Res. | pmid:28541047 |
| Yang PM et al. | Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma. | 2017 | Oncotarget | pmid:28526810 |
| Elhennawy MG and Lin HS | Quantification of apigenin trimethyl ether in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study. | 2017 | J Pharm Biomed Anal | pmid:28494337 |
| Wu CC et al. | Inhibition of Epstein-Barr virus reactivation by the flavonoid apigenin. | 2017 | J. Biomed. Sci. | pmid:28056971 |
| Anusha C et al. | Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. | 2017 | Chem. Biol. Interact. | pmid:28389404 |
| Molina Prats P et al. | The therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis - a pilot study using a Syrian hamster model. | 2017 | J. Oral Pathol. Med. | pmid:27378179 |
| Liao M et al. | Metabolites identificaion of two bioactive constituents in Trollius ledebourii in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29127056 |
| Liu Y et al. | Effects of apigenin pretreatment against renal ischemia/reperfusion injury via activation of the JAK2/STAT3 pathway. | 2017 | Biomed. Pharmacother. | pmid:28962085 |
| Wu Y et al. | Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase. | 2017 | Neurochem. Int. | pmid:28947342 |
| Lee JA et al. | Effects of friedelin on the intestinal permeability and bioavailability of apigenin. | 2017 | Pharmacol Rep | pmid:28939344 |
| Tamayose CI et al. | Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema. | 2017 | Int J Mol Sci | pmid:28906474 |
| Zhang L et al. | Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. | 2017 | Mol Med Rep | pmid:28849116 |
| Tu F et al. | Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. | 2017 | Med. Sci. Monit. | pmid:28821706 |
| Liu S and Ho PC | Intranasal administration of brain-targeted HP-β-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia. | 2017 | J. Pharm. Pharmacol. | pmid:28809432 |
| Fallatah O and Georges E | Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. | 2017 | Int. J. Antimicrob. Agents | pmid:28807879 |
| Feng X et al. | Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. | 2017 | Biochem. Pharmacol. | pmid:28414138 |
| Li G et al. | Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28408212 |
| Wu W et al. | Solubility and dissolution rate improvement of the inclusion complex of apigenin with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation and solvent removal combination methods. | 2017 | Drug Dev Ind Pharm | pmid:28402147 |
| Wan Y et al. | miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. | 2017 | Tumour Biol. | pmid:28381178 |
| Singhal SS et al. | Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. | 2017 | Biochim Biophys Acta Rev Cancer | pmid:28359741 |
| Zhang Z et al. | Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system. | 2017 | Drug Dev Ind Pharm | pmid:28358225 |
| Han Y et al. | Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage. | 2017 | J Clin Neurosci | pmid:28342702 |
| Bian M et al. | Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation. | 2017 | Brain Res. | pmid:28336272 |
| Crascì L et al. | Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. | 2017 | Planta Med. | pmid:28288492 |
| Zhang S et al. | Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activation. | 2017 | Mol. Immunol. | pmid:28288411 |
| Zhao G et al. | Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells. | 2017 | Oncol. Rep. | pmid:28260058 |
| Bolzon LB et al. | Apigenin-7-O-glucoside oxidation catalyzed by P450-bioinspired systems. | 2017 | J. Inorg. Biochem. | pmid:28236787 |
| Wang F et al. | Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression. | 2017 | Chem. Biol. Interact. | pmid:28803762 |
| Gaballah HH et al. | Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28025107 |
| Sheeja Malar D et al. | Cholinesterase inhibitory, anti-amyloidogenic and neuroprotective effect of the medicinal plant Grewia tiliaefolia - An in vitro and in silico study. | 2017 | Pharm Biol | pmid:27931177 |
| Ganai SA | Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer. | 2017 | Biomed. Pharmacother. | pmid:27930986 |
| Tseng TH et al. | Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 expression. | 2017 | Environ. Toxicol. | pmid:26872304 |
| Zou Z et al. | Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii. | 2017 | Fitoterapia | pmid:27889540 |
| Zou Z et al. | Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii. | 2017 | Phytochemistry | pmid:27889245 |
| Ketkaew Y et al. | Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. | 2017 | Arch. Oral Biol. | pmid:27886571 |
| Liu H et al. | Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study. | 2017 | J Chromatogr Sci | pmid:27884870 |
| Wu CY et al. | Scutellarin Attenuates Microglia-Mediated Neuroinflammation and Promotes Astrogliosis in Cerebral Ischemia - A Therapeutic Consideration. | 2017 | Curr. Med. Chem. | pmid:27855618 |
| Guo TT et al. | Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. | 2017 | J Asian Nat Prod Res | pmid:27848262 |
| Wen L et al. | Identification of a flavonoid C-glycoside as potent antioxidant. | 2017 | Free Radic. Biol. Med. | pmid:28587909 |
| Oliveira KG et al. | Effect of the storage time and temperature on phenolic compounds of sorghum grain and flour. | 2017 | Food Chem | pmid:27596435 |
| Salazar-Aguilar S et al. | Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. | 2017 | Nutrients | pmid:28757593 |