apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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Zhong Y et al. | Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. | 2017 | Toxicon | pmid:28734981 |
Min JW et al. | Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. | 2017 | Oncotarget | pmid:28424420 |
Wu CC et al. | Inhibition of Epstein-Barr virus reactivation by the flavonoid apigenin. | 2017 | J. Biomed. Sci. | pmid:28056971 |
Perrott KM et al. | Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. | 2017 | Geroscience | pmid:28378188 |
Stump TA et al. | The antiproliferative and apoptotic effects of apigenin on glioblastoma cells. | 2017 | J. Pharm. Pharmacol. | pmid:28349530 |
Grigalius I and Petrikaite V | Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones. | 2017 | Molecules | pmid:29215574 |
Ganesan K and Xu B | Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. | 2017 | Ann. N. Y. Acad. Sci. | pmid:28891090 |
Zhou RJ et al. | Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28867192 |
Shan S et al. | Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. | 2017 | J. Agric. Food Chem. | pmid:28829588 |
Britto SM et al. | Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. | 2017 | Mutat. Res. | pmid:28735741 |
Jangdey MS et al. | Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma. | 2017 | Drug Deliv | pmid:28687053 |
Che Ahmad Tantowi NA et al. | Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. | 2017 | Menopause | pmid:28640163 |
Li J et al. | Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. | 2017 | World J. Gastroenterol. | pmid:28611514 |
Chen JL and Ko WC | Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. | 2017 | Eur. J. Pharmacol. | pmid:28603044 |
Wei X et al. | Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension. | 2017 | Clin. Sci. | pmid:28143892 |
Espargaró A et al. | Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. | 2017 | J. Nat. Prod. | pmid:28128562 |
Zhou Z et al. | Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. | 2017 | Anticancer Drugs | pmid:28125432 |
Erdogan S et al. | The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. | 2017 | Biomed. Pharmacother. | pmid:28107698 |
Tang D et al. | Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. | 2017 | Expert Opin Drug Metab Toxicol | pmid:27766890 |
Wong TY et al. | Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. | 2017 | Biomed. Pharmacother. | pmid:29198743 |