apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Chen S et al. | [Studies on flavonoids from Aquilegia oxysepala Trautv. et Mey]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12242797 |
Galijatovic A et al. | Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. | 1999 | Xenobiotica | pmid:10647910 |
Wang IK et al. | Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. | 1999 | Eur. J. Cancer | pmid:10673981 |
Kawai K et al. | Clerodendrin I, a New Neoclerodane Diterpenoid from Clerodendron trichotomum. | 1999 | Biosci. Biotechnol. Biochem. | pmid:26300171 |
Aljancić I et al. | Flavones and sesquiterpene lactones from Achillea atrata subsp. multifida: antimicrobial activity. | 1999 | J. Nat. Prod. | pmid:10395518 |
Jeong HJ et al. | Inhibition of aromatase activity by flavonoids. | 1999 | Arch. Pharm. Res. | pmid:10403137 |
Takasaki M et al. | Cancer chemopreventive agents (antitumor-promoters) from Ajuga decumbens. | 1999 | J. Nat. Prod. | pmid:10425119 |
Uma Devi P et al. | In vivo radioprotection by ocimum flavonoids: survival of mice. | 1999 | Radiat. Res. | pmid:9973087 |
Breinholt V et al. | Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat. | 1999 | Xenobiotica | pmid:10647909 |
Kitsos CM and Stadtländer CT | Helicobacter pylori in liquid culture: evaluation of growth rates and ultrastructure. | 1998 | Curr. Microbiol. | pmid:9705648 |
Kuiper GG et al. | Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. | 1998 | Endocrinology | pmid:9751507 |
Bylka W and Matławska I | Flavonoids from Aquilegia vulgaris L. Part II. Derivatives of apigenin and luteolin. | 1997 Jul-Aug | Acta Pol Pharm | pmid:9511462 |
Lin YM et al. | In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora. | 1997 | J. Nat. Prod. | pmid:9322359 |
Shen YX et al. | [Studies on the flavonoids from Dendranthema lavandulifolium]. | 1997 | Yao Xue Xue Bao | pmid:11596327 |
Critchfield JW et al. | Inhibition of HIV activation in latently infected cells by flavonoid compounds. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8825617 |
Lyckander IM and Malterud KE | Lipophilic flavonoids from Orthosiphon spicatus prevent oxidative inactivation of 15-lipoxygenase. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804120 |
Akama T et al. | Novel 5-aminoflavone derivatives as specific antitumor agents in breast cancer. | 1996 | J. Med. Chem. | pmid:8784443 |
Palomino OM et al. | Isoscutellarein 7-glucosyl(1-->2)xyloside from sixteen species of Sideritis. | 1996 | Phytochemistry | pmid:8728059 |
Aida Y et al. | Synthesis of 7-methoxyapigeninidin and its fungicidal activity against Gloeocercospora sorghi. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8987602 |
Schüssler M et al. | Functional and antiischaemic effects of Monoacetyl-vitexinrhamnoside in different in vitro models. | 1995 | Gen. Pharmacol. | pmid:8690247 |
Venturella P et al. | Three acylated flavone glycosides from Sideritis syriaca. | 1995 | Phytochemistry | pmid:7772308 |
Gaitan E et al. | Antithyroid effects in vivo and in vitro of vitexin: a C-glucosylflavone in millet. | 1995 | J. Clin. Endocrinol. Metab. | pmid:7714083 |
Green MD et al. | Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols. | 1995 | Arch. Biochem. Biophys. | pmid:7574722 |
Green MD et al. | Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. | 1994 Sep-Oct | Drug Metab. Dispos. | pmid:7835232 |
Fesen MR et al. | Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. | 1994 | Biochem. Pharmacol. | pmid:7520698 |
Fullas F et al. | Cytotoxic constituents of Baccharis gaudichaudiana. | 1994 | J. Nat. Prod. | pmid:7931367 |
Merfort I et al. | In vivo skin penetration studies of camomile flavones. | 1994 | Pharmazie | pmid:8073060 |
Liu M et al. | An acylated flavone C-glycoside from Glycyrrhiza eurycarpa. | 1994 | Phytochemistry | pmid:7765208 |
Toki K et al. | (Delphinidin 3-gentiobiosyl) (apigenin 7-glucosyl) malonate from the flowers of Eichhornia crassipes. | 1994 | Phytochemistry | pmid:7765361 |
Hertog MG et al. | Dietary flavonoids and cancer risk in the Zutphen Elderly Study. | 1994 | Nutr Cancer | pmid:14502846 |
Mahmood N et al. | Inhibition of HIV infection by flavanoids. | 1993 | Antiviral Res. | pmid:8279812 |
Engelhardt UH et al. | Determination of flavone C-glycosides in tea. | 1993 | Z Lebensm Unters Forsch | pmid:8237118 |
Tschiersch K and Hölzl J | [Absorption and excretion of apigenin, apigenin-7-glycoside and herniarin after oral administration of extracts of Matricaria recutita (L.) (syn. Chamomilla recutita (L.) Rauschert)]. | 1993 | Pharmazie | pmid:8415854 |
Fuchs J and Milbradt R | Skin anti-inflammatory activity of apigenin-7-glucoside in rats. | 1993 | Arzneimittelforschung | pmid:7683883 |
Lin M and Li SZ | [Studies on the chemical constituents of Populus tomentosa carr]. | 1993 | Yao Xue Xue Bao | pmid:8249602 |
Pomilio AB et al. | Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana. | 1992 | J Ethnopharmacol | pmid:1608273 |
Brinkworth RI et al. | Flavones are inhibitors of HIV-1 proteinase. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1445308 |
Nagai T et al. | In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase. | 1992 | Antiviral Res. | pmid:1444327 |
Wang SX et al. | Synthesis, characterization, and antibacterial activity of transition metal complexes with 5-hydroxy-7,4'-dimethoxyflavone. | 1992 | J. Inorg. Biochem. | pmid:1402876 |
Ono K et al. | Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. | 1990 | Eur. J. Biochem. | pmid:1695572 |
Hirano T et al. | Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2749004 |
Gaitan E et al. | Antithyroid and goitrogenic effects of millet: role of C-glycosylflavones. | 1989 | J. Clin. Endocrinol. Metab. | pmid:2921306 |
Silfen J et al. | Bioflavonoid effects on in vitro cultures of Plasmodium falciparum. Inhibition of permeation pathways induced in the host cell membrane by the intraerythrocytic parasite. | 1988 | Biochem. Pharmacol. | pmid:3058128 |
Chen ZN et al. | [Spectral analysis of clerodendrin, isolated from Clerodendron trichotomum Thunb]. | 1988 | Yao Xue Xue Bao | pmid:3257032 |
Occhiuto F et al. | Study on the action mechanism of some flavones through registration of intracardiac potentials in anesthetized dogs. | 1988 | Pharmacol Res Commun | pmid:3211997 |
Steyns JM and van Brederode J | Variation in the substrate specificity of allozymes catalyzing flavone-O-glucoside biosynthesis in Silene plants. | 1986 | Biochem. Genet. | pmid:2943268 |
Barberan FA et al. | Isoscutellarein-7-O-[allosyl (1----2) glucoside] from Sideritis leucantha. | 1985 Jan-Feb | J. Nat. Prod. | pmid:4009184 |
Oksüz S et al. | 6-Methoxylated and C-glycosyl flavonoids from Centaurea species. | 1984 Sep-Oct | J. Nat. Prod. | pmid:6512542 |
Fourie TG and Snyckers FO | A flavone with antiinflammatory activity from the roots of Rhus undulata. | 1984 Nov-Dec | J. Nat. Prod. | pmid:6241941 |
Li LD et al. | Studies on hawthorn and its active principle. II. Effects on cultured rat heart cells deprived of oxygen and glucose. | 1984 | J Tradit Chin Med | pmid:6570503 |
Matern U et al. | Conformational changes of apigenin 7-O-(6-O-malonylglucoside), a vacuolar pigment from parsley, with solvent composition and proton concentration. | 1983 | Eur. J. Biochem. | pmid:6303788 |
Yasukawa K et al. | [Studies on the constituents in the water extracts in crude drugs. IV. On the roots of Stellaria dichotoma L. var lanceolata Bge. (2(2)) (author's transl)]. | 1982 | Yakugaku Zasshi | pmid:7108760 |
Della Loggia R et al. | [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them]. | 1981 Sep-Oct | Riv Neurol | pmid:6118937 |
Prabhakar MC et al. | Pharmacological investigations on vitexin. | 1981 | Planta Med. | pmid:7330108 |
Huet M | Factors affecting the molecular structure and the agglutinating ability of concanavalin A and other lectins. | 1975 | Eur. J. Biochem. | pmid:1259 |
Ciaceri G and Attaguile G | [Influence of luteoline, apigenine and acacetine on experimental gastric ulcer]. | 1972 | Minerva Med. | pmid:5025773 |
SEIKEL MK and GEISSMAN TA | The flavonoid constituents of barley (Horedum vulgare). I. Saponarin. | 1957 | Arch. Biochem. Biophys. | pmid:13459424 |
McEWEN WK | Steric deformation; the synthesis of N-methyl etioporphyrin. | 1946 | J. Am. Chem. Soc. | pmid:21022260 |
Iwashina T et al. | Analysis of flavonoids in pubescence of soybean near-isogenic lines for pubescence color loci. | J. Hered. | pmid:16985083 | |
Chockalingam S et al. | Biogenesis, characterization, and the effect of vicenin-gold nanoparticles on glucose utilization in 3T3-L1 adipocytes: a bioinformatic approach to illuminate its interaction with PTP 1B and AMPK. | Biotechnol. Prog. | pmid:26014104 | |
pmid:28024940 | ||||
Deepak M et al. | Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC. | Phytochem Anal | pmid:15688952 | |
Greenham J et al. | Identification of lipophilic flavones and flavonols by comparative HPLC, TLC and UV spectral analysis. | Phytochem Anal | pmid:12693635 | |
Bai H et al. | Apigenin induced MCF-7 cell apoptosis-associated reactive oxygen species. | Scanning | pmid:25327419 | |
Zhang J et al. | The potential application of strategic released apigenin from polymeric carrier in pulmonary fibrosis. | Exp. Lung Res. | pmid:29206498 | |
Utispan K et al. | Propolis Extracted from the Stingless Bee Trigona sirindhornae Inhibited S. mutans Activity In Vitro. | Oral Health Prev Dent | pmid:28674707 | |
Guan Z et al. | Identification and quantitation of phenolic compounds from the seed and pomace of Perilla frutescens using HPLC/PDA and HPLC-ESI/QTOF/MS/MS. | Phytochem Anal | pmid:24737524 | |
pmid:15360311 | ||||
Zam W and Khadour A | Impact of Phytochemicals and Dietary Patterns on Epigenome and Cancer. | Nutr Cancer | pmid:28094554 | |
Stanisavljević NS et al. | Identification of Phenolic Compounds from Seed Coats of Differently Colored European Varieties of Pea (Pisum sativum L.) and Characterization of Their Antioxidant and In Vitro Anticancer Activities. | Nutr Cancer | pmid:27348025 | |
Barros GO et al. | Phenolics removal from transgenic Lemna minor extracts expressing mAb and impact on mAb production cost. | Biotechnol. Prog. | pmid:21485031 | |
Galicka A et al. | Differential effect of flavonoids on glycosaminoglycan content and distribution in skin fibroblasts of patients with type I osteogenesis imperfecta. | Mol Med Rep | pmid:21472276 | |
pmid: | ||||
pmid:21176927 | ||||
Choudhary MI et al. | Hemiterpene glucosides and other constituents from Spiraea canescens. | Phytochemistry | pmid:19747701 | |
Guo X et al. | Synergistic interactions of apigenin, naringin, quercetin and emodin on inhibition of 3T3-L1 preadipocyte differentiation and pancreas lipase activity. | Obes Res Clin Pract | pmid:26314502 | |
pmid:22949589 |