apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
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What lipids are associated with apigenin?
Related references are published most in these journals:
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| He X et al. | Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat. | 2017 | Am. J. Chin. Med. | pmid:29121796 |
| Wu W et al. | Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique. | 2017 | Drug Deliv | pmid:29115900 |
| Agah S et al. | Complementary cereals and legumes for health: Synergistic interaction of sorghum flavones and cowpea flavonols against LPS-induced inflammation in colonic myofibroblasts. | 2017 | Mol Nutr Food Res | pmid:28155259 |
| Jin X et al. | Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. | 2017 | Int J Nanomedicine | pmid:28761344 |
| Gu T et al. | Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative. | 2017 | Molecules | pmid:28635646 |
| Nurdiana S et al. | Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin. | 2017 | BMC Complement Altern Med | pmid:28576138 |
| Kalivarathan J et al. | Apigenin attenuates hippocampal oxidative events, inflammation and pathological alterations in rats fed high fat, fructose diet. | 2017 | Biomed. Pharmacother. | pmid:28237914 |
| Wang N et al. | Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense. | 2017 | In Vitro Cell. Dev. Biol. Anim. | pmid:28181104 |
| Jeong KM et al. | Identification of Major Flavone C-Glycosides and Their Optimized Extraction from Cymbidium kanran Using Deep Eutectic Solvents. | 2017 | Molecules | pmid:29156555 |
| Wu T et al. | Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1). | 2017 | Pharmacol Rep | pmid:29128807 |
| Hassoun SM et al. | Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. | 2017 | Tumour Biol. | pmid:28651490 |
| Sang Y et al. | Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. | 2017 | Food Funct | pmid:28598487 |
| Chen F et al. | An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. | 2017 | Ultrason Sonochem | pmid:28427633 |
| Lin CM et al. | Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling. | 2017 | Sci Rep | pmid:28337019 |
| Pápay ZE et al. | Study on the Pulmonary Delivery System of Apigenin-Loaded Albumin Nanocarriers with Antioxidant Activity. | 2017 | J Aerosol Med Pulm Drug Deliv | pmid:28282259 |
| Banerjee K et al. | Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions. | 2017 | J Colloid Interface Sci | pmid:28012918 |
| Ke Y et al. | Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27998773 |
| Li Y et al. | Pharmacokinetic Study of Swertisin by HPLC-MS/MS After Intravenous Administration in Rats. | 2017 | J Chromatogr Sci | pmid:27993862 |
| Lecomte S et al. | Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28396216 |
| Gutiérrez-Venegas G and González-Rosas Z | Apigenin reduce lipoteichoic acid-induced inflammatory response in rat cardiomyoblast cells. | 2017 | Arch. Pharm. Res. | pmid:27193174 |