apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sun XP et al. | Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. | 2017 | Arch. Pharm. Res. | pmid:28315259 |
Kwak JH et al. | Cytotoxic phenolic compounds from Chionanthus retusus. | 2009 | Arch. Pharm. Res. | pmid:20162394 |
Tang H et al. | Investigation on the interactions of scutellarin and scutellarein with bovine serum albumin using spectroscopic and molecular docking techniques. | 2015 | Arch. Pharm. Res. | pmid:25577334 |
Kim JM and Yun-Choi HS | Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica. | 2008 | Arch. Pharm. Res. | pmid:18704331 |
Lee JH et al. | Anti-inflammatory mechanisms of apigenin: inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion molecules. | 2007 | Arch. Pharm. Res. | pmid:18038911 |
Choi SI et al. | Mechanism of apoptosis induced by apigenin in HepG2 human hepatoma cells: involvement of reactive oxygen species generated by NADPH oxidase. | 2007 | Arch. Pharm. Res. | pmid:18038912 |
Kim JH et al. | The isolation and antioxidative effects of vitexin from Acer palmatum. | 2005 | Arch. Pharm. Res. | pmid:15789751 |
Sim GS et al. | Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast. | 2007 | Arch. Pharm. Res. | pmid:17424933 |
Thao NT et al. | Simultaneous determination of bioactive flavonoids in some selected Korean thistles by high-performance liquid chromatography. | 2011 | Arch. Pharm. Res. | pmid:21547678 |
Kim JS et al. | Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity. | 2006 | Arch. Pharm. Res. | pmid:16964755 |
Myoung HJ et al. | Apigenin isolated from the seeds of Perilla frutescens britton var crispa (Benth.) inhibits food intake in C57BL/6J mice. | 2010 | Arch. Pharm. Res. | pmid:21116776 |
Gutiérrez-Venegas G and González-Rosas Z | Apigenin reduce lipoteichoic acid-induced inflammatory response in rat cardiomyoblast cells. | 2017 | Arch. Pharm. Res. | pmid:27193174 |
Jang DS et al. | Constituents of the flowers of Platycodon grandiflorum with inhibitory activity on advanced glycation end products and rat lens aldose reductase in vitro. | 2010 | Arch. Pharm. Res. | pmid:20607492 |
Kim HJ et al. | Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes. | 2005 | Arch. Pharm. Res. | pmid:16276964 |
Jeong HJ et al. | Inhibition of aromatase activity by flavonoids. | 1999 | Arch. Pharm. Res. | pmid:10403137 |
Chen Z et al. | High-performance liquid chromatographic determination and pharmacokinetic study of apigenin-7-O-β-D-glucoside in rat plasma after intravenous administration. | 2011 | Arch. Pharm. Res. | pmid:21656359 |
Jeong DM et al. | Comparative antioxidant activity and HPLC profiles of some selected Korean thistles. | 2008 | Arch. Pharm. Res. | pmid:18277604 |
Kim JW et al. | Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation. | 2012 | Arch. Pharm. Res. | pmid:22370792 |
Gopalakrishnan A et al. | Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells. | 2006 | Arch. Pharm. Res. | pmid:16964758 |
Han XH et al. | Monoamine oxidase inhibitory components from Cayratia japonica. | 2007 | Arch. Pharm. Res. | pmid:17328236 |