apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Rodriguez IF et al. | Morphological, histological, chemical and functional characterization of Prosopis alba flours of different particle sizes. | 2019 | Food Chem | pmid:30372982 |
Li ZM et al. | Vitexin alleviates streptozotocin-induced sexual dysfunction and fertility impairments in male mice via modulating the hypothalamus-pituitary-gonadal axis. | 2019 | Chem. Biol. Interact. | pmid:30365938 |
Zheng YZ et al. | The Substituent Effect on the Radical Scavenging Activity of Apigenin. | 2018 | Molecules | pmid:30103379 |
Baruah TJ et al. | Vicenin-2: a potential radiosensitizer of non-small cell lung cancer cells. | 2018 | Mol. Biol. Rep. | pmid:30099686 |
Chen S et al. | A UPLC-ESI-MS/MS Method for Simultaneous Quantitation of Chlorogenic Acid, Scutellarin, and Scutellarein in Rat Plasma: Application to a Comparative Pharmacokinetic Study in Sham-Operated and MCAO Rats after Oral Administration of Extract. | 2018 | Molecules | pmid:30037063 |
Yang M et al. | Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway. | 2018 | Biomed. Pharmacother. | pmid:30021365 |
Vollmer M et al. | Mutual Interaction of Phenolic Compounds and Microbiota: Metabolism of Complex Phenolic Apigenin-C- and Kaempferol-O-Derivatives by Human Fecal Samples. | 2018 | J. Agric. Food Chem. | pmid:29236499 |
Gao AM et al. | Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis. | 2018 | Chem. Biol. Interact. | pmid:29191453 |
Park S et al. | Apigenin induces ROS-dependent apoptosis and ER stress in human endometriosis cells. | 2018 | J. Cell. Physiol. | pmid:28617956 |
Pei Y et al. | Combined effect of apigenin and ferulic acid on frozen-thawed boar sperm quality. | 2018 | Anim. Sci. J. | pmid:29708294 |
Feng Y et al. | Apigenin-7-O-β-d-(-6″-p-coumaroyl)-glucopyranoside pretreatment attenuates myocardial ischemia/reperfusion injury via activating AMPK signaling. | 2018 | Life Sci. | pmid:29705352 |
Malar DS et al. | Grewia tiliaefolia and its active compound vitexin regulate the expression of glutamate transporters and protect Neuro-2a cells from glutamate toxicity. | 2018 | Life Sci. | pmid:29704481 |
Hadrich F and Sayadi S | Apigetrin inhibits adipogenesis in 3T3-L1 cells by downregulating PPARγ and CEBP-α. | 2018 | Lipids Health Dis | pmid:29695233 |
Lu Y et al. | Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway. | 2018 | PLoS ONE | pmid:29694408 |
Gurunathan S et al. | Antibacterial Efficacy of Silver Nanoparticles on Endometritis Caused by and in Dairy Cattle. | 2018 | Int J Mol Sci | pmid:29659523 |
Baluchnejadmojarad T et al. | Scutellarin alleviates lipopolysaccharide-induced cognitive deficits in the rat: Insights into underlying mechanisms. | 2018 | Int. Immunopharmacol. | pmid:29190543 |
Akogou FU et al. | Extraction methods and food uses of a natural red colorant from dye sorghum. | 2018 | J. Sci. Food Agric. | pmid:28600852 |
Abdel-Salam NA et al. | Flavonoids of Alcea rosea L. and their immune stimulant, antioxidant and cytotoxic activities on hepatocellular carcinoma HepG-2 cell line. | 2018 | Nat. Prod. Res. | pmid:28580799 |
Kiyekbayeva L et al. | Phytochemical constituents and antioxidant activity of Echinops albicaulis. | 2018 | Nat. Prod. Res. | pmid:28475371 |
Mirzoeva S et al. | Apigenin Inhibits UVB-Induced Skin Carcinogenesis: The Role of Thrombospondin-1 as an Anti-Inflammatory Factor. | 2018 | Neoplasia | pmid:30118999 |