apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Afifi FU et al. | Effect of isoorientin isolated from Arum palaestinum on uterine smooth muscle of rats and guinea pigs. | 1999 | J Ethnopharmacol | pmid:10465658 |
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Galijatovic A et al. | Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. | 1999 | Xenobiotica | pmid:10647910 |
Segaert S et al. | The flavonoid apigenin suppresses vitamin D receptor expression and vitamin D responsiveness in normal human keratinocytes. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10652242 |
Chan EC et al. | Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10672869 |
Wang IK et al. | Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. | 1999 | Eur. J. Cancer | pmid:10673981 |
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Trochon V et al. | Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression. | 2000 | Int. J. Cancer | pmid:10699950 |
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Romanová D et al. | Determination of apigenin in rat plasma by high-performance liquid chromatography. | 2000 | J Chromatogr A | pmid:10722103 |
Avallone R et al. | Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. | 2000 | Biochem. Pharmacol. | pmid:10751547 |
McVean M et al. | Increase in wild-type p53 stability and transactivational activity by the chemopreventive agent apigenin in keratinocytes. | 2000 | Carcinogenesis | pmid:10753197 |
O'Gorman DM et al. | Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals. | 2000 | Leukemia | pmid:10764145 |
Song DH et al. | Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. | 2000 | J. Biol. Chem. | pmid:10806215 |
Bible KC et al. | Flavopiridol binds to duplex DNA. | 2000 | Cancer Res. | pmid:10811119 |
Pieroni A et al. | Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae). | 2000 | J Ethnopharmacol | pmid:10837985 |
Wang W et al. | Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines. | 2000 | Mol. Carcinog. | pmid:10900467 |
Caltagirone S et al. | Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. | 2000 | Int. J. Cancer | pmid:10918203 |
Yoshikawa M et al. | Medicinal foodstuffs. XVIII. Phytoestrogens from the aerial part of Petroselinum crispum MIll. (Parsley) and structures of 6"-acetylapiin and a new monoterpene glycoside, petroside. | 2000 | Chem. Pharm. Bull. | pmid:10923837 |
Ecay TW et al. | Wortmannin inhibition of forskolin-stimulated chloride secretion by T84 cells. | 2000 | Biochim. Biophys. Acta | pmid:10930508 |
Zanoli P et al. | Behavioral characterisation of the flavonoids apigenin and chrysin. | 2000 | Fitoterapia | pmid:10930722 |
Breinholt V et al. | Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability. | 2000 | Food Chem. Toxicol. | pmid:10942316 |
Mucaji P et al. | [Apigenin-7-methylglucuronide from Cynara cardunculus L]. | 2000 | Ceska Slov Farm | pmid:10953447 |
Uma Devi P et al. | Radiation protection by the ocimum flavonoids orientin and vicenin: mechanisms of action. | 2000 | Radiat. Res. | pmid:11023610 |
De Santi C et al. | Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. | 2000 | Xenobiotica | pmid:11055264 |
Iwashita K et al. | Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11055382 |
Illek B et al. | Structural determinants for activation and block of CFTR-mediated chloride currents by apigenin. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11078699 |
Wang CN et al. | The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. | 2001 | J. Biol. Chem. | pmid:11083861 |
Chen SB et al. | Aquiledine and isoaquiledine, novel flavonoid alkaloids from Aquilegia ecalcarata. | 2001 | J. Nat. Prod. | pmid:11170673 |
Galati G et al. | Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation. | 2001 | Free Radic. Biol. Med. | pmid:11182292 |
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Greenham J et al. | A distinctive flavonoid chemistry for the anomalous genus Biebersteinia. | 2001 | Phytochemistry | pmid:11198823 |
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Raso GM et al. | Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. | 2001 | Life Sci. | pmid:11213362 |
Ashida H | Suppressive effects of flavonoids on dioxin toxicity. | 2000 | Biofactors | pmid:11216487 |
Heijnen CG et al. | Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. | 2001 | Toxicol In Vitro | pmid:11259863 |
Mitchell KA et al. | Flavonoid characters contributing to the taxonomic revision of the Hebe parviflora complex. | 2001 | Phytochemistry | pmid:11261578 |
Stochmal A et al. | Alfalfa (Medicago sativa L.) flavonoids. 1. Apigenin and luteolin glycosides from aerial parts. | 2001 | J. Agric. Food Chem. | pmid:11262024 |
Makino T et al. | Inhibitory effect of decoction of Perilla frutescens on cultured murine mesangial cell proliferation and quantitative analysis of its active constituents. | 2001 | Planta Med. | pmid:11270716 |
Hanyaloglu AC et al. | Casein kinase II sites in the intracellular C-terminal domain of the thyrotropin-releasing hormone receptor and chimeric gonadotropin-releasing hormone receptors contribute to beta-arrestin-dependent internalization. | 2001 | J. Biol. Chem. | pmid:11278484 |
Yin F et al. | Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. | 2001 Jan-Feb | Anticancer Res. | pmid:11299771 |
Leslie EM et al. | Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. | 2001 | Mol. Pharmacol. | pmid:11306701 |
Casagrande F and Darbon JM | Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. | 2001 | Biochem. Pharmacol. | pmid:11322924 |
Liang YC et al. | Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. | 2001 | FEBS Lett. | pmid:11343698 |
Griffith AP and Collison MW | Improved methods for the extraction and analysis of isoflavones from soy-containing foods and nutritional supplements by reversed-phase high-performance liquid chromatography and liquid chromatography-mass spectrometry. | 2001 | J Chromatogr A | pmid:11355838 |
Huang X et al. | 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors. | 2001 | J. Med. Chem. | pmid:11384234 |
Nejaty H et al. | Differing effects of endocrine-disrupting chemicals on basal and FSH-stimulated progesterone production in rat granulosa-luteal cells. | 2001 | Exp. Biol. Med. (Maywood) | pmid:11395928 |
Fischer H et al. | Partial restoration of defective chloride conductance in DeltaF508 CF mice by trimethylamine oxide. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11404245 |
Miean KH and Mohamed S | Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. | 2001 | J. Agric. Food Chem. | pmid:11410016 |
Tammi R et al. | Hyaluronan enters keratinocytes by a novel endocytic route for catabolism. | 2001 | J. Biol. Chem. | pmid:11451952 |
Stochmal A et al. | Acylated apigenin glycosides from alfalfa (Medicago sativa L.) var. Artal. | 2001 | Phytochemistry | pmid:11454348 |
Allen SW et al. | The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression. | 2001 | Drug Metab. Dispos. | pmid:11454723 |
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Begum AA et al. | Specific flavonoids induced nod gene expression and pre-activated nod genes of Rhizobium leguminosarum increased pea (Pisum sativum L.) and lentil (Lens culinaris L.) nodulation in controlled growth chamber environments. | 2001 | J. Exp. Bot. | pmid:11457914 |
Matławska I | Flavonoid compounds in the flowers of Kitaibelia vitifolia Willd. (Malvaceae). | 2001 Mar-Apr | Acta Pol Pharm | pmid:11501790 |
Gobbi M et al. | In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. | 2001 | Pharmacopsychiatry | pmid:11518075 |
Aquino R et al. | Phenolic constituents and antioxidant activity of an extract of Anthuriumversicolor leaves. | 2001 | J. Nat. Prod. | pmid:11520218 |
Kyriakopoulou I et al. | Samioside, a new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities from Phlomis samia. | 2001 | J. Nat. Prod. | pmid:11520237 |
Haribal M and Renwick JA | Seasonal and population variation in flavonoid and alliarinoside content of Alliaria petiolata. | 2001 | J. Chem. Ecol. | pmid:11521398 |
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Abou-Zaid MM et al. | Acylated flavone C-glycosides from Cucumis sativus. | 2001 | Phytochemistry | pmid:11524127 |
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Gupta S et al. | Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11573952 |
Witte MC et al. | Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry. | 2001 | Eur. J. Neurosci. | pmid:11576187 |
Kong LD et al. | Glycosides and xanthine oxidase inhibitors from Conyza bonariensis. | 2001 | Phytochemistry | pmid:11576616 |
Neff L et al. | NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci. | 2001 | Cell. Microbiol. | pmid:11580755 |
Qu J et al. | Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry. | 2001 | J Chromatogr A | pmid:11587333 |
Lindenmeyer F et al. | Apigenin acts on the tumor cell invasion process and regulates protease production. | 2001 | Nutr Cancer | pmid:11588896 |
Ricupero DA et al. | Apigenin decreases expression of the myofibroblast phenotype. | 2001 | FEBS Lett. | pmid:11591363 |
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Galietta LV et al. | Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11600438 |
Makino T et al. | Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice. | 2001 | Biol. Pharm. Bull. | pmid:11642335 |
Vrinda B and Uma Devi P | Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin. | 2001 | Mutat. Res. | pmid:11673069 |
Shen J et al. | Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha. | 2001 | J. Immunol. | pmid:11673497 |
Bylka W | Isovitexin o-glucosides from Aquilegia vulgaris L. | 2001 Jul-Aug | Acta Pol Pharm | pmid:11693732 |
Brahmbhatt SR et al. | Study of biochemical prevalence indicators for the assessment of iodine deficiency disorders in adults at field conditions in Gujarat (India). | 2001 | Asia Pac J Clin Nutr | pmid:11708609 |
Boveris AD et al. | Antioxidant capacity of a 3-deoxyanthocyanidin from soybean. | 2001 | Phytochemistry | pmid:11730874 |
Lans C et al. | Medicinal and ethnoveterinary remedies of hunters in Trinidad. | 2001 | BMC Complement Altern Med | pmid:11737880 |
Lu J et al. | Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils. | 2002 | Clin. Chim. Acta | pmid:11750278 |
Lautraite S et al. | Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. | 2002 | Mutagenesis | pmid:11752233 |
Fiorani M et al. | Intracellular flavonoids as electron donors for extracellular ferricyanide reduction in human erythrocytes. | 2002 | Free Radic. Biol. Med. | pmid:11755318 |
Kitada C et al. | Differential expression of two cytochrome P450s involved in the biosynthesis of flavones and anthocyanins in chemo-varietal forms of Perilla frutescens. | 2001 | Plant Cell Physiol. | pmid:11773526 |
Kobayashi T et al. | Effect of flavonoids on cell cycle progression in prostate cancer cells. | 2002 | Cancer Lett. | pmid:11790449 |
Llorens F et al. | Apigenin and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation. | 2002 | FEBS Lett. | pmid:11801244 |
Lorentz A et al. | Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins. | 2002 | Blood | pmid:11807000 |
McVean M et al. | A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin. | 2002 | Mol. Carcinog. | pmid:11807956 |
Tatsuta A et al. | Suppression by apigenin of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. | 2000 | Clin. Exp. Metastasis | pmid:11827069 |
Landesman-Bollag E et al. | Protein kinase CK2: signaling and tumorigenesis in the mammary gland. | 2001 | Mol. Cell. Biochem. | pmid:11827167 |
Lee WR et al. | Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. | 2002 | Biochem. Pharmacol. | pmid:11841797 |
Frangne N et al. | Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. | 2002 | Plant Physiol. | pmid:11842175 |
Rozema J et al. | The role of UV-B radiation in aquatic and terrestrial ecosystems--an experimental and functional analysis of the evolution of UV-absorbing compounds. | 2002 | J. Photochem. Photobiol. B, Biol. | pmid:11849977 |