apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sikorska M et al. | Application of mass spectrometric techniques for structural analysis of apigenin 8-C-(6"-O-glucopyranosyl) glucopyranoside--a novel flavonoid C-diglycoside. | 2003 | Rapid Commun. Mass Spectrom. | pmid:12811762 |
| Cavaliere C et al. | Identification and mass spectrometric characterization of glycosylated flavonoids in Triticum durum plants by high-performance liquid chromatography with tandem mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:16200659 |
| Abad-GarcÃa B et al. | New features on the fragmentation and differentiation of C-glycosidic flavone isomers by positive electrospray ionization and triple quadrupole mass spectrometry. | 2008 | Rapid Commun. Mass Spectrom. | pmid:18470889 |
| Madeira PJ et al. | Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric and semi-empirical calculations study of five isoflavone aglycones. | 2010 | Rapid Commun. Mass Spectrom. | pmid:21072799 |
| Ferreres F et al. | Approach to the study of C-glycosyl flavones acylated with aliphatic and aromatic acids from Spergularia rubra by high-performance liquid chromatography-photodiode array detection/electrospray ionization multi-stage mass spectrometry. | 2011 | Rapid Commun. Mass Spectrom. | pmid:21337631 |
| Taupin P | Neurogenic drugs and compounds. | 2010 | Recent Pat CNS Drug Discov | pmid:20636273 |
| Banerjee K and Mandal M | Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells. | 2015 | Redox Biol | pmid:25965143 |
| Vitcheva V et al. | Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. | 2011 | Redox Rep. | pmid:21722413 |
| Kandhare AD et al. | Acute and repeated doses (28 days) oral toxicity study of Vicenin-1, a flavonoid glycoside isolated from fenugreek seeds in laboratory mice. | 2016 | Regul. Toxicol. Pharmacol. | pmid:27773753 |
| Li X et al. | Acute and subacute toxicological evaluation of scutellarin in rodents. | 2011 | Regul. Toxicol. Pharmacol. | pmid:21382428 |
| Wang X et al. | Effect of apigenin on apoptosis induced by renal ischemia/reperfusion injury in vivo and in vitro. | 2018 | Ren Fail | pmid:30278824 |
| Stroheker T et al. | Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats: a comparative study. | 2003 Jul-Aug | Reprod. Toxicol. | pmid:12849853 |
| van Vugt-Lussenburg BMA et al. | Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity. | 2018 | Reprod. Toxicol. | pmid:29162470 |
| Hirano T et al. | Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2749004 |
| Hanganu D et al. | The study of some polyphenolic compounds from Melissa officinalis L. (Lamiaceae). | 2008 Apr-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:19295032 |
| de Font-Réaulx Rojas E and Dorazco-Barragan G | [Clinical stabilisation in neurodegenerative diseases: clinical study in phase II]. | 2010 | Rev Neurol | pmid:20443170 |
| Shahi J and Singh A | Effect of bioactive compounds extracted from euphorbious plants on hematological and biochemical parameters of Channa punctatus. | 2011 Sep-Oct | Rev. Inst. Med. Trop. Sao Paulo | pmid:22012451 |
| Jun JB et al. | Dietary flavonoid apigenin inhibits endothelin-1-induced contraction of collagen gel. | 2010 | Rheumatol. Int. | pmid:20012048 |
| Della Loggia R et al. | [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them]. | 1981 Sep-Oct | Riv Neurol | pmid:6118937 |
| Sidibé el H | [Thyroid diseases in sub-Saharan Africa]. | 2007 Jan-Mar | Sante | pmid:17897900 |
| Tsaroucha AK et al. | Intraperitoneal administration of apigenin in liver ischemia/reperfusion injury protective effects. | 2016 | Saudi J Gastroenterol | pmid:27976636 |
| Avwioro OG et al. | Collagen and muscle stain obtained from Sorghum bicolor. | 2006 | Scand. J. Clin. Lab. Invest. | pmid:16537249 |
| Bai H et al. | Apigenin induced MCF-7 cell apoptosis-associated reactive oxygen species. | Scanning | pmid:25327419 | |
| Zhu H et al. | Apigenin induced apoptosis in esophageal carcinoma cells by destruction membrane structures. | 2016 | Scanning | pmid:26435325 |
| Brown JS | Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: an endocrine-disruption theory of schizophrenia. | 2009 | Schizophr Bull | pmid:18245062 |
| El-Alfy TS et al. | A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. | 2011 Oct-Dec | Sci Pharm | pmid:22145118 |
| Hsu CW et al. | Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. | 2014 | Sci Rep | pmid:25257666 |
| Hicks DF et al. | Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. | 2017 | Sci Rep | pmid:28256512 |
| Chen M et al. | Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner. | 2016 | Sci Rep | pmid:27752089 |
| Cao HH et al. | Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma. | 2016 | Sci Rep | pmid:26911838 |
| Wu G et al. | Growth temperature and genotype both play important roles in sorghum grain phenolic composition. | 2016 | Sci Rep | pmid:26907726 |
| Zhu Q et al. | Antinociceptive effects of vitexin in a mouse model of postoperative pain. | 2016 | Sci Rep | pmid:26763934 |
| Lin CM et al. | Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling. | 2017 | Sci Rep | pmid:28337019 |
| Balez R et al. | Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease. | 2016 | Sci Rep | pmid:27514990 |
| Ohno M et al. | The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice. | 2013 | Sci Rep | pmid:23989853 |
| Silva DB et al. | Mass spectrometry of flavonoid vicenin-2, based sunlight barriers in Lychnophora species. | 2014 | Sci Rep | pmid:24603617 |
| Das MC et al. | Attenuation of Pseudomonas aeruginosa biofilm formation by Vitexin: A combinatorial study with azithromycin and gentamicin. | 2016 | Sci Rep | pmid:27000525 |
| Técher D et al. | Contribution of Miscanthus x giganteus root exudates to the biostimulation of PAH degradation: an in vitro study. | 2011 | Sci. Total Environ. | pmid:21782215 |
| Albrechtova J et al. | Dual inoculation with mycorrhizal and saprotrophic fungi applicable in sustainable cultivation improves the yield and nutritive value of onion. | 2012 | ScientificWorldJournal | pmid:22666113 |
| Gohari AR et al. | Evaluation of the cytotoxicity of Satureja spicigera and its main compounds. | 2012 | ScientificWorldJournal | pmid:22623883 |
| Xu H et al. | Antioxidative activities and active compounds of extracts from Catalpa plant leaves. | 2014 | ScientificWorldJournal | pmid:25431795 |
| Chelyn JL et al. | Analysis of flavone C-glycosides in the leaves of Clinacanthus nutans (Burm. f.) Lindau by HPTLC and HPLC-UV/DAD. | 2014 | ScientificWorldJournal | pmid:25405231 |
| Wang H et al. | Microwave-assisted simultaneous extraction of luteolin and apigenin from tree peony pod and evaluation of its antioxidant activity. | 2014 | ScientificWorldJournal | pmid:25405227 |
| Zhang W et al. | [Determination of scutellarin and rutin in Shenfukang capsules by reversed-phase high performance liquid chromatography]. | 2004 | Se Pu | pmid:15712871 |
| Mülazımoğlu AD et al. | Dithiooxamide modified glassy carbon electrode for the studies of non-aqueous media: electrochemical behaviors of quercetin on the electrode surface. | 2012 | Sensors (Basel) | pmid:22666010 |
| Popov-Raljić JV et al. | Sensory evaluation of pralines containing different honey products. | 2010 | Sensors (Basel) | pmid:22163633 |
| Zhou Q et al. | [The synthesis, characterization and in situ intestinal absorption of different molecular weight scutellarin-PEG conjugates]. | 2006 | Sheng Wu Yi Xue Gong Cheng Xue Za Zhi | pmid:16706365 |
| Li S et al. | [Pharmacokinetics of scutellarin in rabbits]. | 2003 | Sheng Wu Yi Xue Gong Cheng Xue Za Zhi | pmid:14716879 |
| Praveena R et al. | Experimental and DFT studies on the antioxidant activity of a C-glycoside from Rhynchosia capitata. | 2013 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:23246319 |
| Zhang S et al. | Studies on the interaction of apigenin with calf thymus DNA by spectroscopic methods. | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25459730 |
| Naseem B et al. | Interaction of flavonoids, the naturally occurring antioxidants with different media: a UV-visible spectroscopic study. | 2010 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:20163982 |
| Zhao XN et al. | Spectroscopic studies on the interaction of bovine serum albumin with surfactants and apigenin. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22561754 |
| Mariappan G et al. | The spectroscopic properties of anticancer drug Apigenin investigated by using DFT calculations, FT-IR, FT-Raman and NMR analysis. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22617215 |
| Bi S et al. | An investigation on the interaction of DNA with hesperetin/apigenin in the presence of CTAB by resonance Rayleigh light scattering technique and its analytical application. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22336048 |
| Wu Y et al. | In-line monitoring of extraction process of scutellarein from Erigeron breviscapus (vant.) Hand-Mazz based on qualitative and quantitative uses of near-infrared spectroscopy. | 2011 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:21561801 |
| Chen T et al. | E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation. | 2010 | Stem Cells | pmid:20521328 |
| Yi J et al. | Phytoecdysteroids and glycoceramides from Eriophyton wallchii. | 2004 | Steroids | pmid:15582536 |
| Zhu Q et al. | Comparison of flavonoids and isoflavonoids to inhibit rat and human 11β-hydroxysteroid dehydrogenase 1 and 2. | 2018 | Steroids | pmid:29425740 |
| Toh MF et al. | Biological characterization of non-steroidal progestins from botanicals used for women's health. | 2012 | Steroids | pmid:22484153 |
| Yamagata K et al. | Stroke status evoked adhesion molecule genetic alterations in astrocytes isolated from stroke-prone spontaneously hypertensive rats and the apigenin inhibition of their expression. | 2010 | Stroke Res Treat | pmid:20700422 |
| Blaylock RL and Maroon J | Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system. | 2012 | Surg Neurol Int | pmid:22439110 |
| Nováková L et al. | Development and application of UHPLC-MS/MS method for the determination of phenolic compounds in Chamomile flowers and Chamomile tea extracts. | 2010 | Talanta | pmid:20801328 |
| Abad-GarcÃa B et al. | On line characterization of 58 phenolic compounds in Citrus fruit juices from Spanish cultivars by high-performance liquid chromatography with photodiode-array detection coupled to electrospray ionization triple quadrupole mass spectrometry. | 2012 | Talanta | pmid:22967544 |
| Nalewajko-Sieliwoniuk E et al. | Determination of the flavonoids/antioxidant levels in Cirsium oleraceum and Cirsium rivulare extracts with cerium(IV)-rhodamine 6G chemiluminescence detection. | 2012 | Talanta | pmid:22817953 |
| Liu Q et al. | Metabolism profile of scutellarin in urine following oral administration to rats by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. | 2009 | Talanta | pmid:19782195 |
| Yang DZ et al. | Development of a novel method combining HPLC fingerprint and multi-ingredients quantitative analysis for quality evaluation of traditional Chinese medicine preparation. | 2011 | Talanta | pmid:21726714 |
| Ballus CA et al. | Use of multivariate statistical techniques to optimize the simultaneous separation of 13 phenolic compounds from extra-virgin olive oil by capillary electrophoresis. | 2011 | Talanta | pmid:21215853 |
| Polásek M et al. | Use of molybdate as novel complex-forming selector in the analysis of polyhydric phenols by capillary zone electrophoresis. | 2006 | Talanta | pmid:18970553 |
| Zhang S et al. | Simultaneous determination of flavonoids in chrysanthemum by capillary zone electrophoresis with running buffer modifiers. | 2008 | Talanta | pmid:18656658 |
| Russo EB | Cannabinoids in the management of difficult to treat pain. | 2008 | Ther Clin Risk Manag | pmid:18728714 |
| Lakshmanan A et al. | Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells. | 2014 | Thyroid | pmid:24400871 |
| Heijnen CG et al. | Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. | 2001 | Toxicol In Vitro | pmid:11259863 |
| Malar DS et al. | Vitexin inhibits Aβ induced toxicity in Neuro-2a cells by augmenting Nrf-2/HO-1 dependent antioxidant pathway and regulating lipid homeostasis by the activation of LXR-α. | 2018 | Toxicol In Vitro | pmid:29545167 |
| Sadeghipour M et al. | Flavonoids and tyrosine nitration: structure-activity relationship correlation with enthalpy of formation. | 2005 | Toxicol In Vitro | pmid:15649628 |
| Zhang Q et al. | Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis. | 2009 | Toxicol In Vitro | pmid:19397994 |
| Uddin Q et al. | The biflavonoid, amentoflavone degrades DNA in the presence of copper ions. | 2004 | Toxicol In Vitro | pmid:15130600 |
| Siddique YH et al. | Antigenotoxic effect of apigenin against anti-cancerous drugs. | 2008 | Toxicol In Vitro | pmid:18206345 |
| Wakx A et al. | New in vitro biomarkers to detect toxicity in human placental cells: The example of benzo[A]pyrene. | 2016 | Toxicol In Vitro | pmid:26657896 |
| Noel S et al. | Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay. | 2006 | Toxicol In Vitro | pmid:16759833 |
| Lu N et al. | Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: effects of some flavonoids. | 2009 | Toxicol In Vitro | pmid:19286453 |
| Gulluce M et al. | Isolation of a flavonoid, apigenin 7-O-glucoside, from Mentha longifolia (L.) Hudson subspecies longifolia and its genotoxic potency. | 2015 | Toxicol Ind Health | pmid:23377117 |
| Gulluce M et al. | Determination of antimutagenic properties of apigenin-7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp. longifolia with yeast DEL assay. | 2013 | Toxicol Ind Health | pmid:22491724 |
| Lim H et al. | Flavonoids interfere with NLRP3 inflammasome activation. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29960001 |
| Balasubramanian S and Eckert RL | Keratinocyte proliferation, differentiation, and apoptosis--differential mechanisms of regulation by curcumin, EGCG and apigenin. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17493651 |
| Sarró E et al. | A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22155090 |
| Cheng LC and Li LA | Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22172629 |
| van Meeuwen JA et al. | (Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17482226 |
| Gaballah HH et al. | Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28025107 |
| Lee WJ et al. | Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells. | 2008 | Toxicol. Appl. Pharmacol. | pmid:17961621 |
| Lecomte S et al. | Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28396216 |
| Dai J et al. | Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells. | 2016 | Toxicol. Appl. Pharmacol. | pmid:27664007 |
| Wang L et al. | Apigenin suppresses migration and invasion of transformed cells through down-regulation of C-X-C chemokine receptor 4 expression. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23743303 |
| Kim DI et al. | Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by Scutellaria barbata D. Don in vitro: isolation of flavonoids of apigenin and luteolin as acting compounds. | 2005 | Toxicol. Appl. Pharmacol. | pmid:15922007 |
| van Meeuwen JA et al. | Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts--a comparative study. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18201740 |
| Fischer L et al. | Potential hazards to embryo implantation: A human endometrial in vitro model to identify unwanted antigestagenic actions of chemicals. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22414680 |
| Barlas N et al. | The estrogenic effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar albino rats. | 2014 | Toxicol. Lett. | pmid:24487097 |
| Das S et al. | Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro. | 2013 | Toxicol. Lett. | pmid:24070738 |
| Wu DG et al. | Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells. | 2014 | Toxicol. Lett. | pmid:24148603 |
| Li Y et al. | Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. | 2018 | Toxicol. Lett. | pmid:29753067 |
| Ratajewski M et al. | Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. | 2015 | Toxicol. Lett. | pmid:25455453 |