apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mo SF et al. | Hypouricemic action of selected flavonoids in mice: structure-activity relationships. | 2007 | Biol. Pharm. Bull. | pmid:17666819 |
| Mizoyama Y et al. | Inhibitory effect of flavonoids on N-acetylation of 5-aminosalicylic acid in cultured rat hepatocytes. | 2004 | Biol. Pharm. Bull. | pmid:15340238 |
| Lin YT et al. | Degradation of flavonoid aglycones by rabbit, rat and human fecal flora. | 2003 | Biol. Pharm. Bull. | pmid:12736527 |
| Nagao T et al. | Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. | 2002 | Biol. Pharm. Bull. | pmid:12132661 |
| Nakazawa T et al. | Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test. | 2003 | Biol. Pharm. Bull. | pmid:12673028 |
| Morimitsu Y et al. | Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations. | 2004 | Biol. Pharm. Bull. | pmid:15133252 |
| Hasegawa E et al. | Effect of polyphenols on production of steroid hormones from human adrenocortical NCI-H295R cells. | 2013 | Biol. Pharm. Bull. | pmid:23370353 |
| Iwaoka E et al. | Allergy-preventive effects of the flowers of Impatiens textori. | 2010 | Biol. Pharm. Bull. | pmid:20410612 |
| Han JY et al. | Protection of apigenin against kainate-induced excitotoxicity by anti-oxidative effects. | 2012 | Biol. Pharm. Bull. | pmid:22975493 |
| Suh KS et al. | Apigenin attenuates 2-deoxy-D-ribose-induced oxidative cell damage in HIT-T15 pancreatic β-cells. | 2012 | Biol. Pharm. Bull. | pmid:22223348 |
| Muanprasat C et al. | Identification of new small molecule inhibitors of cystic fibrosis transmembrane conductance regulator protein: in vitro and in vivo studies. | 2007 | Biol. Pharm. Bull. | pmid:17329846 |
| Li W et al. | Antihyperglycemic effect of Cephalotaxus sinensis leaves and GLUT-4 translocation facilitating activity of its flavonoid constituents. | 2007 | Biol. Pharm. Bull. | pmid:17541165 |
| Nomura M et al. | Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells. | 2008 | Biol. Pharm. Bull. | pmid:18591783 |
| Eltayeb AA et al. | Antagonistic effect of scutellarin on the toxicity of selenium in rat livers. | 2004 | Biol Trace Elem Res | pmid:15131321 |
| Tan M et al. | Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin. | 2009 | Bioinorg Chem Appl | pmid:19830248 |
| Sahay A and Shakya M | Structure prediction of dihydroflavonol 4- reductase and anthocyanidin synthase from spinach. | 2010 | Bioinformation | pmid:21364828 |
| Kundu S and Roy D | Structural study of biologically significant ligands with major birch pollen allergen Betv1 by docking and molecular dynamics simulation. | 2010 | Bioinformation | pmid:20978606 |
| Mishra S et al. | A molecular model for diacylglycerol acyltransferase from Mortierella ramanniana var. angulispora. | 2009 | Bioinformation | pmid:19759814 |
| Paris D et al. | Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanism. | 2011 | Bioinformation | pmid:21738321 |
| Ganugapati J et al. | Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus. | 2012 | Bioinformation | pmid:22493522 |
| Tsuchiya H et al. | Membrane-rigidifying effects of anti-cancer dietary factors. | 2002 | Biofactors | pmid:14530593 |
| Ashida H | Suppressive effects of flavonoids on dioxin toxicity. | 2000 | Biofactors | pmid:11216487 |
| Yi L et al. | Differential suppression of intracellular reactive oxygen species-mediated signaling pathway in vascular endothelial cells by several subclasses of flavonoids. | 2012 | Biochimie | pmid:22683914 |
| Tomaino A et al. | Antioxidant activity and phenolic profile of pistachio (Pistacia vera L., variety Bronte) seeds and skins. | 2010 | Biochimie | pmid:20388531 |
| Xiao J et al. | Molecular property-binding affinity relationship of flavonoids for common rat plasma proteins in vitro. | 2011 | Biochimie | pmid:20831890 |
| Choudhury D et al. | Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin. | 2013 | Biochimie | pmid:23485682 |
| Kim K et al. | Galectin-3 expression in macrophages is signaled by Ras/MAP kinase pathway and up-regulated by modified lipoproteins. | 2003 | Biochim. Biophys. Acta | pmid:12788225 |
| Paoli P et al. | The insulin-mimetic effect of Morin: a promising molecule in diabetes treatment. | 2013 | Biochim. Biophys. Acta | pmid:23352912 |
| Pawlikowska-Pawlęga B et al. | FTIR, (1)H NMR and EPR spectroscopy studies on the interaction of flavone apigenin with dipalmitoylphosphatidylcholine liposomes. | 2013 | Biochim. Biophys. Acta | pmid:23088916 |
| Ecay TW et al. | Wortmannin inhibition of forskolin-stimulated chloride secretion by T84 cells. | 2000 | Biochim. Biophys. Acta | pmid:10930508 |
| Caruana M et al. | Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro. | 2012 | Biochim. Biophys. Acta | pmid:22634381 |
| Chan LP et al. | Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin. | 2012 | Biochim. Biophys. Acta | pmid:22554915 |
| Shimmyo Y et al. | Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. | 2008 | Biochim. Biophys. Acta | pmid:18295609 |
| King JC et al. | Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. | 2012 | Biochim. Biophys. Acta | pmid:22227579 |
| Lagoa R et al. | Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria. | 2011 | Biochim. Biophys. Acta | pmid:22015496 |
| Singhal SS et al. | Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. | 2017 | Biochim Biophys Acta Rev Cancer | pmid:28359741 |
| Yang LL et al. | Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. | 2017 | Biochim Biophys Acta Mol Basis Dis | pmid:27903431 |
| Xie LP et al. | Inhibitory effects of some flavonoids on the activity of mushroom tyrosinase. | 2003 | Biochemistry Mosc. | pmid:12765534 |
| Thapa A et al. | Biflavonoids are superior to monoflavonoids in inhibiting amyloid-β toxicity and fibrillogenesis via accumulation of nontoxic oligomer-like structures. | 2011 | Biochemistry | pmid:21322641 |
| Lolli G et al. | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. | 2012 | Biochemistry | pmid:22794353 |
| Shanle EK et al. | Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligands. | 2011 | Biochem. Pharmacol. | pmid:21924251 |
| Comalada M et al. | Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. | 2006 | Biochem. Pharmacol. | pmid:16934226 |
| Casagrande F and Darbon JM | Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. | 2001 | Biochem. Pharmacol. | pmid:11322924 |
| Walle T et al. | Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. | 2007 | Biochem. Pharmacol. | pmid:17250812 |
| Ansó E et al. | Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism. | 2010 | Biochem. Pharmacol. | pmid:20153296 |
| Bandyopadhyay S et al. | Attenuation of osteoclastogenesis and osteoclast function by apigenin. | 2006 | Biochem. Pharmacol. | pmid:16750176 |
| Avallone R et al. | Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. | 2000 | Biochem. Pharmacol. | pmid:10751547 |
| Silfen J et al. | Bioflavonoid effects on in vitro cultures of Plasmodium falciparum. Inhibition of permeation pathways induced in the host cell membrane by the intraerythrocytic parasite. | 1988 | Biochem. Pharmacol. | pmid:3058128 |
| López-Posadas R et al. | Effect of flavonoids on rat splenocytes, a structure-activity relationship study. | 2008 | Biochem. Pharmacol. | pmid:18590707 |
| Chen Y et al. | Glucuronidation of flavonoids by recombinant UGT1A3 and UGT1A9. | 2008 | Biochem. Pharmacol. | pmid:18565494 |
| Feng X et al. | Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. | 2017 | Biochem. Pharmacol. | pmid:28414138 |
| Lee WR et al. | Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. | 2002 | Biochem. Pharmacol. | pmid:11841797 |
| Verbeek R et al. | The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells. | 2004 | Biochem. Pharmacol. | pmid:15276069 |
| van Meeteren ME et al. | Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease. | 2004 | Biochem. Pharmacol. | pmid:15104250 |
| Mandery K et al. | Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. | 2010 | Biochem. Pharmacol. | pmid:20797388 |
| Fesen MR et al. | Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. | 1994 | Biochem. Pharmacol. | pmid:7520698 |
| Hougee S et al. | Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages. | 2005 | Biochem. Pharmacol. | pmid:15627476 |
| Niisato N et al. | Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells. | 2004 | Biochem. Pharmacol. | pmid:14757180 |
| Verbeek R et al. | Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice. | 2005 | Biochem. Pharmacol. | pmid:15946653 |
| During A and Larondelle Y | The O-methylation of chrysin markedly improves its intestinal anti-inflammatory properties: Structure-activity relationships of flavones. | 2013 | Biochem. Pharmacol. | pmid:24134915 |
| Ko WC et al. | Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. | 2004 | Biochem. Pharmacol. | pmid:15476679 |
| van Zanden JJ et al. | Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2. | 2005 | Biochem. Pharmacol. | pmid:15670588 |
| Chen D et al. | Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. | 2005 | Biochem. Pharmacol. | pmid:15857606 |
| Liu Y et al. | Effects of the natural flavone trimethylapigenin on cardiac potassium currents. | 2012 | Biochem. Pharmacol. | pmid:22583923 |
| Arango D et al. | Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair. | 2012 | Biochem. Pharmacol. | pmid:22985621 |
| Nagaprashantha LD et al. | Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer. | 2011 | Biochem. Pharmacol. | pmid:21803027 |
| O'Prey J et al. | Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells. | 2003 | Biochem. Pharmacol. | pmid:14609732 |
| Campbell EL et al. | The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. | 2004 | Biochem. Pharmacol. | pmid:15451406 |
| Keum YS and Jeong YJ | Development of chemical inhibitors of the SARS coronavirus: viral helicase as a potential target. | 2012 | Biochem. Pharmacol. | pmid:22935448 |
| Li W et al. | Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4). | 2015 | Biochem. Pharmacol. | pmid:26291395 |
| Laberge RM et al. | Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress. | 2007 | Biochem. Pharmacol. | pmid:17359940 |
| Vargo MA et al. | Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16844095 |
| Wiejak J et al. | Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. | 2013 | Biochem. J. | pmid:23782265 |
| Sarno S et al. | Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). | 2003 | Biochem. J. | pmid:12816539 |
| Llorens F et al. | The N-terminal domain of the human eIF2beta subunit and the CK2 phosphorylation sites are required for its function. | 2006 | Biochem. J. | pmid:16225457 |
| Steyns JM and van Brederode J | Variation in the substrate specificity of allozymes catalyzing flavone-O-glucoside biosynthesis in Silene plants. | 1986 | Biochem. Genet. | pmid:2943268 |
| Sun Q et al. | Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29408335 |
| Ashokkumar R et al. | Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29406244 |
| Lv SX and Qiao X | Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29355527 |
| Ogawa M et al. | Nuclear translocation of Xenopus laevis paxillin. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12727207 |
| Karmakar S et al. | Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19695221 |
| Zhou RJ et al. | Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28867192 |
| Li G et al. | Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28408212 |
| Brinkworth RI et al. | Flavones are inhibitors of HIV-1 proteinase. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1445308 |
| Thirusangu P et al. | Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28104392 |
| Ke Y et al. | Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27998773 |
| Hirano T et al. | Luteolin, a flavonoid, inhibits AP-1 activation by basophils. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16343431 |
| Gao ZX et al. | Scutellarin promotes in vitro angiogenesis in human umbilical vein endothelial cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20709020 |
| Lin CM et al. | Molecular modeling of flavonoids that inhibits xanthine oxidase. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054758 |
| Zhang GH et al. | The anti-HIV-1 effect of scutellarin. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16023998 |
| Gupta S et al. | Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11573952 |
| Segaert S et al. | The flavonoid apigenin suppresses vitamin D receptor expression and vitamin D responsiveness in normal human keratinocytes. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10652242 |
| Liu Q et al. | Apigenin inhibits cell migration through MAPK pathways in human bladder smooth muscle cells. | 2011 | Biocell | pmid:22423483 |
| Wang W et al. | [A new natural product from the roots of Hedysarum multijugum]. | 2005 | Beijing Da Xue Xue Bao | pmid:16224530 |
| Coleta M et al. | Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity. | 2008 | Behav. Brain Res. | pmid:18249450 |
| Lee HE et al. | Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property. | 2016 | Behav. Brain Res. | pmid:26996316 |
| Li R et al. | Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain. | 2016 | Behav. Brain Res. | pmid:26416673 |
| Gilani AH et al. | Antispasmodic effects of Rooibos tea (Aspalathus linearis) is mediated predominantly through K+ -channel activation. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:17076689 |
| Soyman Z et al. | Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary. | 2017 | Balkan Med J | pmid:28443590 |
| Somarathna KI et al. | A short-term intervention trial on HIV positive patients using a Sri Lankan classical rasayana drug - Ranahamsa Rasayanaya. | 2010 | Ayu | pmid:22131710 |