apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zam W and Khadour A | Impact of Phytochemicals and Dietary Patterns on Epigenome and Cancer. | Nutr Cancer | pmid:28094554 | |
Wang F et al. | Vitexin alleviates lipopolysaccharide‑induced islet cell injury by inhibiting HMGB1 release. | 2017 | Mol Med Rep | pmid:28098903 |
Thirusangu P et al. | Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28104392 |
Erdogan S et al. | The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. | 2017 | Biomed. Pharmacother. | pmid:28107698 |
Zhou Z et al. | Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. | 2017 | Anticancer Drugs | pmid:28125432 |
Espargaró A et al. | Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. | 2017 | J. Nat. Prod. | pmid:28128562 |
Wei X et al. | Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension. | 2017 | Clin. Sci. | pmid:28143892 |
Nelson N et al. | Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer. | 2017 | PLoS ONE | pmid:28152014 |
Agah S et al. | Complementary cereals and legumes for health: Synergistic interaction of sorghum flavones and cowpea flavonols against LPS-induced inflammation in colonic myofibroblasts. | 2017 | Mol Nutr Food Res | pmid:28155259 |
Maher HM et al. | Comparative pharmacokinetic profiles of selected irreversible tyrosine kinase inhibitors, neratinib and pelitinib, with apigenin in rat plasma by UPLC-MS/MS. | 2017 | J Pharm Biomed Anal | pmid:28167419 |
Liu HJ et al. | Apigenin alleviates STZ-induced diabetic cardiomyopathy. | 2017 | Mol. Cell. Biochem. | pmid:28176247 |
Wang N et al. | Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense. | 2017 | In Vitro Cell. Dev. Biol. Anim. | pmid:28181104 |
Souza RP et al. | Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines. | 2017 | Oxid Med Cell Longev | pmid:28191273 |
Bolzon LB et al. | Apigenin-7-O-glucoside oxidation catalyzed by P450-bioinspired systems. | 2017 | J. Inorg. Biochem. | pmid:28236787 |
Kalivarathan J et al. | Apigenin attenuates hippocampal oxidative events, inflammation and pathological alterations in rats fed high fat, fructose diet. | 2017 | Biomed. Pharmacother. | pmid:28237914 |
Wang J et al. | Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy. | 2017 | J Nanobiotechnology | pmid:28249594 |
Rašković A et al. | Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model. | 2017 | Eur J Drug Metab Pharmacokinet | pmid:28255865 |
Hicks DF et al. | Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. | 2017 | Sci Rep | pmid:28256512 |
Zhao G et al. | Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells. | 2017 | Oncol. Rep. | pmid:28260058 |
Verma S et al. | Natural polyphenolic inhibitors against the antiapoptotic BCL-2. | 2017 | J. Recept. Signal Transduct. Res. | pmid:28264627 |
Golea L et al. | Phytochemical components and biological activities of Silene arenarioides Desf. | 2017 | Nat. Prod. Res. | pmid:28278644 |
Ferrazzi P et al. | Pollination effects on antioxidant content of Perilla frutescens seeds analysed by NMR spectroscopy. | 2017 | Nat. Prod. Res. | pmid:28278651 |
Pápay ZE et al. | Study on the Pulmonary Delivery System of Apigenin-Loaded Albumin Nanocarriers with Antioxidant Activity. | 2017 | J Aerosol Med Pulm Drug Deliv | pmid:28282259 |
Zhang S et al. | Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activation. | 2017 | Mol. Immunol. | pmid:28288411 |
Crascì L et al. | Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. | 2017 | Planta Med. | pmid:28288492 |
Sun XP et al. | Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. | 2017 | Arch. Pharm. Res. | pmid:28315259 |
Bian M et al. | Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation. | 2017 | Brain Res. | pmid:28336272 |
Lin CM et al. | Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling. | 2017 | Sci Rep | pmid:28337019 |
Bougioukas I et al. | Apigenin Reduces NF-κB and Subsequent Cytokine Production as Protective Effect in a Rodent Animal Model of Lung Ischemia-Reperfusion Injury. | 2018 | J Invest Surg | pmid:28340319 |
Han Y et al. | Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage. | 2017 | J Clin Neurosci | pmid:28342702 |
Stump TA et al. | The antiproliferative and apoptotic effects of apigenin on glioblastoma cells. | 2017 | J. Pharm. Pharmacol. | pmid:28349530 |
Zhang Z et al. | Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system. | 2017 | Drug Dev Ind Pharm | pmid:28358225 |
Singhal SS et al. | Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. | 2017 | Biochim Biophys Acta Rev Cancer | pmid:28359741 |
Mahajan UB et al. | The Protective Effect of Apigenin on Myocardial Injury in Diabetic Rats mediating Activation of the PPAR-γ Pathway. | 2017 | Int J Mol Sci | pmid:28375162 |
Perrott KM et al. | Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. | 2017 | Geroscience | pmid:28378188 |
Wan Y et al. | miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. | 2017 | Tumour Biol. | pmid:28381178 |
Anusha C et al. | Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. | 2017 | Chem. Biol. Interact. | pmid:28389404 |
Abu Bakar AR et al. | Experimental and computational approaches to reveal the potential of Ficus deltoidea leaves extract as α-amylase inhibitor. | 2018 | Nat. Prod. Res. | pmid:28391727 |
Lecomte S et al. | Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28396216 |
Wu W et al. | Solubility and dissolution rate improvement of the inclusion complex of apigenin with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation and solvent removal combination methods. | 2017 | Drug Dev Ind Pharm | pmid:28402147 |
Li G et al. | Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28408212 |
Feng X et al. | Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. | 2017 | Biochem. Pharmacol. | pmid:28414138 |
Mohammad F E et al. | Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity. | 2017 | J. Biochem. Mol. Toxicol. | pmid:28422384 |
Meng S et al. | Apigenin inhibits renal cell carcinoma cell proliferation. | 2017 | Oncotarget | pmid:28423637 |
Min JW et al. | Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. | 2017 | Oncotarget | pmid:28424420 |
Chen F et al. | An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. | 2017 | Ultrason Sonochem | pmid:28427633 |
Alvin JW and Lacy DB | Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. | 2017 | J. Struct. Biol. | pmid:28433497 |
Bauer D et al. | Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells. | 2017 | PLoS ONE | pmid:28441391 |
Soyman Z et al. | Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary. | 2017 | Balkan Med J | pmid:28443590 |
Adaszyńska-Skwirzyńska M and Dzięcioł M | Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland. | 2017 | Nat. Prod. Res. | pmid:28449600 |
Das A et al. | Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:28456117 |
Karim R et al. | Development and evaluation of injectable nanosized drug delivery systems for apigenin. | 2017 | Int J Pharm | pmid:28456651 |
Han T et al. | Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation. | 2017 | Eur J Med Chem | pmid:28458133 |
Ninfali P et al. | C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review. | 2017 | Phytother Res | pmid:28464411 |
Kiyekbayeva L et al. | Phytochemical constituents and antioxidant activity of Echinops albicaulis. | 2018 | Nat. Prod. Res. | pmid:28475371 |
Wen L et al. | An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC. | 2017 | Molecules | pmid:28486427 |
Elhennawy MG and Lin HS | Quantification of apigenin trimethyl ether in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study. | 2017 | J Pharm Biomed Anal | pmid:28494337 |
Yang PM et al. | Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma. | 2017 | Oncotarget | pmid:28526810 |
Elmasri WA et al. | Multitargeted Flavonoid Inhibition of the Pathogenic Bacterium Staphylococcus aureus: A Proteomic Characterization. | 2017 | J. Proteome Res. | pmid:28541047 |
Fernandes LM et al. | Genotoxicity and Antigenotoxicity Assessments of the Flavonoid Vitexin by the Drosophila melanogaster Somatic Mutation and Recombination Test. | 2017 | J Med Food | pmid:28541831 |
Yao HM et al. | [Effects of apigenin on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells]. | 2017 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:28545285 |
Salmani JMM et al. | Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives. | 2017 | Chin J Nat Med | pmid:28558867 |
Malik S et al. | Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28566504 |
Nurdiana S et al. | Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin. | 2017 | BMC Complement Altern Med | pmid:28576138 |
Abdel-Salam NA et al. | Flavonoids of Alcea rosea L. and their immune stimulant, antioxidant and cytotoxic activities on hepatocellular carcinoma HepG-2 cell line. | 2018 | Nat. Prod. Res. | pmid:28580799 |
Wen L et al. | Identification of a flavonoid C-glycoside as potent antioxidant. | 2017 | Free Radic. Biol. Med. | pmid:28587909 |
Sang Y et al. | Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. | 2017 | Food Funct | pmid:28598487 |
Akogou FU et al. | Extraction methods and food uses of a natural red colorant from dye sorghum. | 2018 | J. Sci. Food Agric. | pmid:28600852 |
Chen JL and Ko WC | Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. | 2017 | Eur. J. Pharmacol. | pmid:28603044 |
Li J et al. | Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. | 2017 | World J. Gastroenterol. | pmid:28611514 |
Park S et al. | Apigenin induces ROS-dependent apoptosis and ER stress in human endometriosis cells. | 2018 | J. Cell. Physiol. | pmid:28617956 |
Spilovska K et al. | Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation. | 2017 | Molecules | pmid:28621747 |
Gaspar MC et al. | Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract. | 2018 | Nat. Prod. Res. | pmid:28627294 |
Gu T et al. | Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative. | 2017 | Molecules | pmid:28635646 |
Che Ahmad Tantowi NA et al. | Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. | 2017 | Menopause | pmid:28640163 |
Hassoun SM et al. | Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. | 2017 | Tumour Biol. | pmid:28651490 |
Seo HS et al. | Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells. | 2017 | Oncol. Rep. | pmid:28656316 |
Utispan K et al. | Propolis Extracted from the Stingless Bee Trigona sirindhornae Inhibited S. mutans Activity In Vitro. | Oral Health Prev Dent | pmid:28674707 | |
Perez-Leal O et al. | Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. | 2017 | J. Biol. Chem. | pmid:28684421 |
Jangdey MS et al. | Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma. | 2017 | Drug Deliv | pmid:28687053 |
Sun Y et al. | Homogenate-assisted Vacuum-powered Bubble Extraction of Moso Bamboo Flavonoids for On-line Scavenging Free Radical Capacity Analysis. | 2017 | Molecules | pmid:28696360 |
Ghazanfar K et al. | Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. | 2017 | J Complement Integr Med | pmid:28731312 |
Zhong Y et al. | Apigenin attenuates patulin-induced apoptosis in HEK293 cells by modulating ROS-mediated mitochondrial dysfunction and caspase signal pathway. | 2017 | Toxicon | pmid:28734981 |
Britto SM et al. | Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. | 2017 | Mutat. Res. | pmid:28735741 |
Gao C et al. | Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells. | 2017 | Oncol. Rep. | pmid:28737827 |
Palacz-Wrobel M et al. | Effect of apigenin, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW-264.7 macrophages. | 2017 | Biomed. Pharmacother. | pmid:28738536 |
Chen L et al. | Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. | 2017 | Arch Gerontol Geriatr | pmid:28743056 |
Naik PM and Al-Khayri JM | Extraction and Estimation of Secondary Metabolites from Date Palm Cell Suspension Cultures. | 2017 | Methods Mol. Biol. | pmid:28755356 |
Salazar-Aguilar S et al. | Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. | 2017 | Nutrients | pmid:28757593 |
Renda G et al. | Evaluation of in vivo analgesic activity of Scrophularia kotscyhana and isolation of bioactive compounds through activity-guided fractionation. | 2018 | Nat. Prod. Res. | pmid:28758426 |
Jin X et al. | Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. | 2017 | Int J Nanomedicine | pmid:28761344 |
Wang M et al. | Apigenin Impacts the Growth of the Gut Microbiota and Alters the Gene Expression of Enterococcus. | 2017 | Molecules | pmid:28771188 |
Wang F et al. | Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression. | 2017 | Chem. Biol. Interact. | pmid:28803762 |
Fallatah O and Georges E | Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. | 2017 | Int. J. Antimicrob. Agents | pmid:28807879 |
Liu S and Ho PC | Intranasal administration of brain-targeted HP-β-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia. | 2017 | J. Pharm. Pharmacol. | pmid:28809432 |
Tan GF et al. | AgFNS overexpression increase apigenin and decrease anthocyanins in petioles of transgenic celery. | 2017 | Plant Sci. | pmid:28818381 |
Tu F et al. | Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. | 2017 | Med. Sci. Monit. | pmid:28821706 |
Li F et al. | Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy. | 2017 | Oxid Med Cell Longev | pmid:28828145 |
Shan S et al. | Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. | 2017 | J. Agric. Food Chem. | pmid:28829588 |
Viacava GE et al. | Characterization of phenolic compounds in green and red oak-leaf lettuce cultivars by UHPLC-DAD-ESI-QToF/MS using MS scan mode. | 2017 | J Mass Spectrom | pmid:28833875 |