apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Koo H et al. | Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. | 2003 | J. Antimicrob. Chemother. | pmid:14563892 |
Scippo ML et al. | Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. | 2004 | Anal Bioanal Chem | pmid:14579009 |
Zhong D et al. | Determination of scutellarin in rat plasma by high-performance liquid chromatography with ultraviolet detection. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14581083 |
Miyazawa M and Hisama M | Antimutagenic activity of flavonoids from Chrysanthemum morifolium. | 2003 | Biosci. Biotechnol. Biochem. | pmid:14586095 |
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Way TD et al. | Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. | 2004 | J. Biol. Chem. | pmid:14602723 |
Zhang JL et al. | Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR. | 2003 | J Asian Nat Prod Res | pmid:14604233 |
Van Dross R et al. | The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines. | 2003 | J. Nutr. | pmid:14608117 |
O'Prey J et al. | Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells. | 2003 | Biochem. Pharmacol. | pmid:14609732 |
Mateos R et al. | Antioxidant effect of phenolic compounds, alpha-tocopherol, and other minor components in virgin olive oil. | 2003 | J. Agric. Food Chem. | pmid:14611189 |
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Liu H et al. | Protective effects of scutellarin on superoxide-induced oxidative stress in rat cortical synaptosomes. | 2003 | Acta Pharmacol. Sin. | pmid:14627495 |
Liu Y et al. | Enteric disposition and recycling of flavonoids and ginkgo flavonoids. | 2003 | J Altern Complement Med | pmid:14629841 |
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Gharzouli K and Holzer P | Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin, naringenin, apigenin and genistein. | 2004 | Pharmacology | pmid:14646351 |
Jarry H et al. | Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones. | 2003 | Planta Med. | pmid:14648399 |
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Takano-Ishikawa Y et al. | Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha. | 2003 | Phytother Res | pmid:14669262 |
Boué SM and Raina AK | Effects of plant flavonoids on fecundity, survival, and feeding of the Formosan subterranean termite. | 2003 | J. Chem. Ecol. | pmid:14682534 |
Wang LS et al. | Chemical taxonomy of the Xibei tree peony from China by floral pigmentation. | 2004 | J. Plant Res. | pmid:14685820 |
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Gradolatto A et al. | Metabolism of apigenin by rat liver phase I and phase ii enzymes and by isolated perfused rat liver. | 2004 | Drug Metab. Dispos. | pmid:14709621 |
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Cushnie TP et al. | Assessment of the antibacterial activity of selected flavonoids and consideration of discrepancies between previous reports. | 2003 | Microbiol. Res. | pmid:14717448 |
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