apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Modolo LV et al. | Nitric oxide synthase-mediated phytoalexin accumulation in soybean cotyledons in response to the Diaporthe phaseolorum f. sp. meridionalis elicitor. | 2002 | Plant Physiol. | pmid:12427995 |
| Liu H et al. | [Study on effects of scutellarin on scavenging reactive oxygen]. | 2002 | Zhong Yao Cai | pmid:12599762 |
| Koo H et al. | Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. | 2002 | Oral Microbiol. Immunol. | pmid:12485324 |
| Wang H et al. | Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex. | 2002 | Planta Med. | pmid:12494329 |
| Xing Y et al. | [Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation]. | 2002 | Zhonghua Yi Xue Za Zhi | pmid:12509912 |
| Gradolatto A et al. | Could apigenin metabolism explain the estrogenic effect of this flavonoid in the female immature rat? | 2002 | IARC Sci. Publ. | pmid:12484224 |
| Han DH et al. | Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224631 |
| Olszanecki R et al. | Flavonoids and nitric oxide synthase. | 2002 | J. Physiol. Pharmacol. | pmid:12512693 |
| Agati G et al. | Flavonoid distribution in tissues of Phillyrea latifolia L. leaves as estimated by microspectrofluorometry and multispectral fluorescence microimaging. | 2002 | Photochem. Photobiol. | pmid:12403458 |
| Miro FA et al. | Persistent nuclear accumulation of protein kinase CK2 during the G1-phase of the cell cycle does not depend on the ERK1/2 pathway but requires active protein synthesis. | 2002 | Arch. Biochem. Biophys. | pmid:12361704 |
| Zétola M et al. | CNS activities of liquid and spray-dried extracts from Lippia alba-Verbenaceae (Brazilian false melissa). | 2002 | J Ethnopharmacol | pmid:12241997 |
| Lee S et al. | Phytochemical constituents from the herba of Artemisia apiacea. | 2002 | Arch. Pharm. Res. | pmid:12135098 |
| Exarchou V et al. | Antioxidant activities and phenolic composition of extracts from Greek oregano, Greek sage, and summer savory. | 2002 | J. Agric. Food Chem. | pmid:12207464 |
| Snyder RD and Gillies PJ | Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells. | 2002 | Environ. Mol. Mutagen. | pmid:12489117 |
| Mastuda H et al. | Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells. | 2002 | Bioorg. Med. Chem. | pmid:12150856 |
| Hien TV et al. | Radioprotective effects of vitexina for breast cancer patients undergoing radiotherapy with cobalt-60. | 2002 | Integr Cancer Ther | pmid:14664747 |
| Cao Y et al. | Analysis of flavonoids in Ginkgo biloba L. and its phytopharmaceuticals by capillary electrophoresis with electrochemical detection. | 2002 | Anal Bioanal Chem | pmid:12324852 |
| Tsuchiya H et al. | Membrane-rigidifying effects of anti-cancer dietary factors. | 2002 | Biofactors | pmid:14530593 |
| Couladis M et al. | Antioxidant activity of polyphenols from Hypericum triquetrifolium Turra. | 2002 | Phytother Res | pmid:12458485 |
| Ma T et al. | High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. | 2002 | J. Biol. Chem. | pmid:12161441 |
| Sampson L et al. | Flavonol and flavone intakes in US health professionals. | 2002 | J Am Diet Assoc | pmid:12396158 |
| Grayer RJ et al. | Scutellarein 4'-methyl ether glycosides as taxonomic markers in Teucridium and Tripora (Lamiaceae, Ajugoideae). | 2002 | Phytochemistry | pmid:12127590 |
| Gil-Izquierdo A et al. | Effect of processing techniques at industrial scale on orange juice antioxidant and beneficial health compounds. | 2002 | J. Agric. Food Chem. | pmid:12188615 |
| Kim TJ et al. | Effects of apigenin on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells. | 2002 | Planta Med. | pmid:12142993 |
| Channavajhala P and Seldin DC | Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis. | 2002 | Oncogene | pmid:12149649 |
| Aboutabl EA et al. | Phytochemical and pharmacological studies on Sideritis taurica Stephan ex Wild. | 2002 | J Ethnopharmacol | pmid:12241993 |
| Rager I et al. | Rapid quantification of constituents in St. John's wort extracts by NIR spectroscopy. | 2002 | J Pharm Biomed Anal | pmid:12008122 |
| Kim MK et al. | Relationships of urinary phyto-oestrogen excretion to BMD in postmenopausal women. | 2002 | Clin. Endocrinol. (Oxf) | pmid:11940043 |
| Vanhoenacker G et al. | Chemotaxonomic features associated with flavonoids of cannabinoid-free cannabis (Cannabis sativa subsp. sativa L.) in relation to hops (Humulus lupulus L.). | 2002 | Nat Prod Lett | pmid:11942684 |
| Lin CM et al. | Prevention of cellular ROS damage by isovitexin and related flavonoids. | 2002 | Planta Med. | pmid:11988866 |
| Tsai SC and Seto E | Regulation of histone deacetylase 2 by protein kinase CK2. | 2002 | J. Biol. Chem. | pmid:12082111 |
| Gupta S et al. | Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells. | 2002 | Oncogene | pmid:12032841 |
| Zhu CC et al. | Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation. | 2002 | J. Biol. Chem. | pmid:12023974 |
| Usia T et al. | Constituents of Chinese propolis and their antiproliferative activities. | 2002 | J. Nat. Prod. | pmid:12027739 |
| Patora J and Klimek B | Flavonoids from lemon balm (Melissa officinalis L., Lamiaceae). | 2002 Mar-Apr | Acta Pol Pharm | pmid:12365606 |
| Matławska I and Sikorska M | Flavonoid compounds in the flowers of Abutilon indicum (L.) Sweet (Malvaceae). | 2002 May-Jun | Acta Pol Pharm | pmid:12230251 |
| Zhang S et al. | Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. | 2003 | Environ. Health Perspect. | pmid:14644660 |
| Pikulski M and Brodbelt JS | Differentiation of flavonoid glycoside isomers by using metal complexation and electrospray ionization mass spectrometry. | 2003 | J. Am. Soc. Mass Spectrom. | pmid:14652191 |
| Szostek B et al. | Investigation of natural dyes occurring in historical Coptic textiles by high-performance liquid chromatography with UV-Vis and mass spectrometric detection. | 2003 | J Chromatogr A | pmid:14521314 |
| Xie C et al. | Flavone C-glycosides from Viola yedoensis MAKINO. | 2003 | Chem. Pharm. Bull. | pmid:14519932 |
| Wang H et al. | Up-regulation of endothelial nitric-oxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12975498 |
| Oku H et al. | Antipruritic effects of the fruits of Chaenomeles sinensis. | 2003 | Biol. Pharm. Bull. | pmid:12843634 |
| Yee SB et al. | Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells. | 2003 | Arch. Pharm. Res. | pmid:12643593 |
| Sikorska M et al. | Application of mass spectrometric techniques for structural analysis of apigenin 8-C-(6"-O-glucopyranosyl) glucopyranoside--a novel flavonoid C-diglycoside. | 2003 | Rapid Commun. Mass Spectrom. | pmid:12811762 |
| Miller CP et al. | Constrained phytoestrogens and analogues as ERbeta selective ligands. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12824043 |
| Caci E et al. | CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12651632 |
| Schulte-Löbbert S et al. | Development of a high-performance-liquid-chromatographic method for the determination of biapigenin in biorelevant media. | 2003 | J Pharm Biomed Anal | pmid:12946531 |
| Jiang XH et al. | [Study on the pharmacokinetics of scutellarin in dogs]. | 2003 | Yao Xue Xue Bao | pmid:12958843 |
| Boué SM et al. | Identification of flavone aglycones and glycosides in soybean pods by liquid chromatography-tandem mass spectrometry. | 2003 | J Chromatogr A | pmid:12703901 |
| Zhu F et al. | [Effect of emodin and apigenin on invasion of human ovarian carcinoma HO-8910PM cells in vitro]. | 2003 | Ai Zheng | pmid:12703988 |
| Nakazawa T et al. | Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test. | 2003 | Biol. Pharm. Bull. | pmid:12673028 |
| Ogawa M et al. | Nuclear translocation of Xenopus laevis paxillin. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12727207 |
| Hessenauer A et al. | Inhibition of CK2 activity provokes different responses in hormone-sensitive and hormone-refractory prostate cancer cells. | 2003 | Int. J. Oncol. | pmid:12738992 |
| Wang M et al. | Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.). | 2003 | J. Agric. Food Chem. | pmid:12537429 |
| Springsteel MF et al. | Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. | 2003 | Bioorg. Med. Chem. | pmid:12927873 |
| Beyer G and Melzig MF | Effects of selected flavonoids and caffeic acid derivatives on hypoxanthine-xanthine oxidase-induced toxicity in cultivated human cells. | 2003 | Planta Med. | pmid:14750029 |
| Hu M et al. | Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12893842 |
| Smolinski AT and Pestka JJ | Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew). | 2003 | Food Chem. Toxicol. | pmid:12909272 |
| Dias C et al. | Structural elucidation of natural 2-hydroxy di- and tricarboxylic acids and esters, phenylpropanoid esters and a flavonoid from Autonoë madeirensis using gas chromatographic/electron ionization, electrospray ionization and tandem mass spectrometric techniques. | 2003 | J Mass Spectrom | pmid:14696202 |
| Chan TS et al. | Simultaneous detection of the antioxidant and pro-oxidant activity of dietary polyphenolics in a peroxidase system. | 2003 | Free Radic. Res. | pmid:12911276 |
| Simirgiotis MJ et al. | New dammarane triterpenes from the aerial parts of Ibicella lutea grown in Argentina. | 2003 | J. Nat. Prod. | pmid:14695802 |
| Farah M et al. | 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12842827 |
| Hou CC et al. | Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica. | 2003 | J. Nat. Prod. | pmid:12762795 |
| Agrelli J et al. | Herbivore-induced responses in alfalfa (Medicago sativa). | 2003 | J. Chem. Ecol. | pmid:12737260 |
| Matsuda H et al. | Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action. | 2003 | Bioorg. Med. Chem. | pmid:12670650 |
| Owen RW et al. | Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drupes. | 2003 | Food Chem. Toxicol. | pmid:12659724 |
| Miyazawa M and Hisama M | Antimutagenic activity of flavonoids from Chrysanthemum morifolium. | 2003 | Biosci. Biotechnol. Biochem. | pmid:14586095 |
| Kavvadias D et al. | Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. | 2003 | Planta Med. | pmid:12624814 |
| Basile A et al. | Effects of seven pure flavonoids from mosses on germination and growth of Tortula muralis HEDW (Bryophyta) and Raphanus sativus L (Magnoliophyta). | 2003 | Phytochemistry | pmid:12591270 |
| Fan CQ and Yue JM | Biologically active phenols from Saussurea medusa. | 2003 | Bioorg. Med. Chem. | pmid:12537999 |
| McPhail DB et al. | Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy. | 2003 | J. Agric. Food Chem. | pmid:12617605 |
| Boué SM and Raina AK | Effects of plant flavonoids on fecundity, survival, and feeding of the Formosan subterranean termite. | 2003 | J. Chem. Ecol. | pmid:14682534 |
| Whitehead SA and Lacey M | Phytoestrogens inhibit aromatase but not 17beta-hydroxysteroid dehydrogenase (HSD) type 1 in human granulosa-luteal cells: evidence for FSH induction of 17beta-HSD. | 2003 | Hum. Reprod. | pmid:12615812 |
| Picerno P et al. | Phenolic constituents and antioxidant properties of Xanthosoma violaceum leaves. | 2003 | J. Agric. Food Chem. | pmid:14558757 |
| Pedras MS et al. | Phytoalexins from Thlaspi arvense, a wild crucifer resistant to virulent Leptosphaeria maculans: structures, syntheses and antifungal activity. | 2003 | Phytochemistry | pmid:14561510 |
| Koo H et al. | Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. | 2003 | J. Antimicrob. Chemother. | pmid:14563892 |
| Naderi GA et al. | Anti-oxidant effect of flavonoids on the susceptibility of LDL oxidation. | 2003 | Mol. Cell. Biochem. | pmid:12841362 |
| Jarry H et al. | Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones. | 2003 | Planta Med. | pmid:14648399 |
| Li H et al. | [Studies on chemical constituents from Phyllostachys pubescens]. | 2003 | Zhong Yao Cai | pmid:14649200 |
| Zhong D et al. | Determination of scutellarin in rat plasma by high-performance liquid chromatography with ultraviolet detection. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14581083 |
| Goutman JD et al. | Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors. | 2003 | Eur. J. Pharmacol. | pmid:12586201 |
| Konstantinopoulou M et al. | Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity. | 2003 | J. Nat. Prod. | pmid:12762812 |
| Peterson J et al. | Flavonoid intake and breast cancer risk: a case--control study in Greece. | 2003 | Br. J. Cancer | pmid:14520456 |
| Liu YM et al. | Study on pharmacokinetics of scutellarin in rabbits. | 2003 | Yao Xue Xue Bao | pmid:14730903 |
| Safari MR and Sheikh N | Effects of flavonoids on the susceptibility of low-density lipoprotein to oxidative modification. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878454 |
| Gabrieli C and Kokkalou E | A new acetylated glucoside of luteolin and two flavone glucosides from Lavandula stoechas ssp. stoechas. | 2003 | Pharmazie | pmid:12857010 |
| Zhang JL et al. | Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR. | 2003 | J Asian Nat Prod Res | pmid:14604233 |
| Van Dross R et al. | The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines. | 2003 | J. Nutr. | pmid:14608117 |
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| Cushnie TP et al. | Assessment of the antibacterial activity of selected flavonoids and consideration of discrepancies between previous reports. | 2003 | Microbiol. Res. | pmid:14717448 |
| Amakura Y et al. | Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. | 2003 | Biol. Pharm. Bull. | pmid:14646185 |
| Liu H et al. | Protective effects of scutellarin on superoxide-induced oxidative stress in rat cortical synaptosomes. | 2003 | Acta Pharmacol. Sin. | pmid:14627495 |
| Dhawan K | Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective. | 2003 | Addict Biol | pmid:14690874 |
| Kim MH | Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteases. | 2003 | J. Cell. Biochem. | pmid:12761886 |
| Fukui Y et al. | A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3',5'-hydroxylase gene. | 2003 | Phytochemistry | pmid:12657292 |
| Xie LP et al. | Inhibitory effects of some flavonoids on the activity of mushroom tyrosinase. | 2003 | Biochemistry Mosc. | pmid:12765534 |
| Sasaki N et al. | Protective effects of flavonoids on the cytotoxicity of linoleic acid hydroperoxide toward rat pheochromocytoma PC12 cells. | 2003 | Chem. Biol. Interact. | pmid:12606158 |
| Ueda Y et al. | Effects on blood pressure decrease in response to PAF of Impatiens textori MIQ. | 2003 | Biol. Pharm. Bull. | pmid:14519965 |
| Sarno S et al. | Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). | 2003 | Biochem. J. | pmid:12816539 |
| Orska-GawryÅ› J et al. | Identification of natural dyes in archeological Coptic textiles by liquid chromatography with diode array detection. | 2003 | J Chromatogr A | pmid:12650256 |