apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lans C et al. | Ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada. | 2006 | J Ethnobiol Ethnomed | pmid:16893454 |
| Au A et al. | Effect of dietary apigenin on colonic ornithine decarboxylase activity, aberrant crypt foci formation, and tumorigenesis in different experimental models. | 2006 | Nutr Cancer | pmid:16898869 |
| Yoon YA et al. | Relationships between the larval growth inhibition of Caenorhabditis elegans by apigenin derivatives and their structures. | 2006 | Arch. Pharm. Res. | pmid:16903079 |
| Agrawal A et al. | Regulation of the p14ARF-Mdm2-p53 pathway: an overview in breast cancer. | 2006 | Exp. Mol. Pathol. | pmid:16919268 |
| Hong H and Liu GQ | Scutellarin protects PC12 cells from oxidative stress-induced apoptosis. | 2006 | J Asian Nat Prod Res | pmid:16931419 |
| Comalada M et al. | Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. | 2006 | Biochem. Pharmacol. | pmid:16934226 |
| Singh RP and Agarwal R | Mechanisms of action of novel agents for prostate cancer chemoprevention. | 2006 | Endocr. Relat. Cancer | pmid:16954429 |
| Ono K et al. | Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. | 1990 | Eur. J. Biochem. | pmid:1695572 |
| Zhou Q et al. | Synthesis, characterization and in situ intestinal absorption of different molecular weight scutellarin-PEG conjugates. | 2006 | Pharmazie | pmid:16964704 |
| Kim JS et al. | Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity. | 2006 | Arch. Pharm. Res. | pmid:16964755 |
| Gopalakrishnan A et al. | Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells. | 2006 | Arch. Pharm. Res. | pmid:16964758 |
| Rice S et al. | Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells. | 2006 | J. Steroid Biochem. Mol. Biol. | pmid:16965912 |
| Seeram NP et al. | Pistachio skin phenolics are destroyed by bleaching resulting in reduced antioxidative capacities. | 2006 | J. Agric. Food Chem. | pmid:16968060 |
| Sousa A et al. | Phenolics and antimicrobial activity of traditional stoned table olives 'alcaparra'. | 2006 | Bioorg. Med. Chem. | pmid:16971127 |
| Balasubramanian S et al. | Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311. | 2006 | J. Biol. Chem. | pmid:16982614 |
| Iwashina T et al. | Analysis of flavonoids in pubescence of soybean near-isogenic lines for pubescence color loci. | J. Hered. | pmid:16985083 | |
| Lotito SB and Frei B | Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism. | 2006 | J. Biol. Chem. | pmid:16987811 |
| Das A et al. | Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to flavonoids. | 2006 | Int. J. Cancer | pmid:16988947 |
| Cao F et al. | Prodrugs of scutellarin: ethyl, benzyl and N,N-diethylglycolamide ester synthesis, physicochemical properties, intestinal metabolism and oral bioavailability in the rats. | 2006 | Eur J Pharm Sci | pmid:16997537 |
| Cao F et al. | [Ester prodrug of scutellarin: synthesis, physicochemical property and degradation]. | 2006 | Yao Xue Xue Bao | pmid:17007349 |
| Lemmens-Gruber R et al. | Investigation of the spasmolytic activity of the flavonoid fraction of Achillea millefolium s.l. on isolated guinea-pig ilea. | 2006 | Arzneimittelforschung | pmid:17009839 |
| Puppala D et al. | Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation. | 2007 | Carcinogenesis | pmid:17012224 |
| Miyaichi Y et al. | Studies on Nepalese crude drugs. XXIX. Chemical constituents of Dronapuspi, the whole herb of Leucas cephalotes SPRENG. | 2006 | Chem. Pharm. Bull. | pmid:17015972 |
| Wätjen W et al. | Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells. | 2007 | Food Chem. Toxicol. | pmid:17045382 |
| Japón-Luján R and Luque de Castro MD | Superheated liquid extraction of oleuropein and related biophenols from olive leaves. | 2006 | J Chromatogr A | pmid:17045596 |
| Dai C et al. | [Studies on chemical constituents from moss Rhodobryum roseum II]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17048608 |
| Hua Y and Wang HQ | [Studies on the flavonoids from whole herbs of Seriphidium terrae-albae]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17048665 |
| Kanazawa K et al. | Bioavailable flavonoids to suppress the formation of 8-OHdG in HepG2 cells. | 2006 | Arch. Biochem. Biophys. | pmid:17052680 |
| Kazazić SP et al. | Gas-phase ligation of Fe+ and Cu+ ions with some flavonoids. | 2006 | J. Agric. Food Chem. | pmid:17061811 |
| Fang J et al. | Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. | 2007 | Carcinogenesis | pmid:17071632 |
| Loizzo MR et al. | Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae). | 2007 | Phytother Res | pmid:17072829 |
| Tong X et al. | Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition. | 2007 | Mol. Cell. Biol. | pmid:17074806 |
| Gilani AH et al. | Antispasmodic effects of Rooibos tea (Aspalathus linearis) is mediated predominantly through K+ -channel activation. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:17076689 |
| Zabala G et al. | Transcriptome changes in the phenylpropanoid pathway of Glycine max in response to Pseudomonas syringae infection. | 2006 | BMC Plant Biol. | pmid:17083738 |
| Cai H et al. | Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties. | 2007 | Cancer Chemother. Pharmacol. | pmid:17089164 |
| Schütz K et al. | Quantitative determination of phenolic compounds in artichoke-based dietary supplements and pharmaceuticals by high-performance liquid chromatography. | 2006 | J. Agric. Food Chem. | pmid:17090127 |
| Hamada M et al. | TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers. | 2006 | J. Agric. Food Chem. | pmid:17090139 |
| Kumazawa Y et al. | Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha. | 2006 | Curr. Pharm. Des. | pmid:17100629 |
| Wang Q and Morris ME | Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo. | 2007 | Drug Metab. Dispos. | pmid:17108059 |
| MaurÃcio Duarte-Almeida J et al. | Antioxidant activity of phenolics compounds from sugar cane (Saccharum officinarum L.) juice. | 2006 | Plant Foods Hum Nutr | pmid:17123161 |
| Johannot L and Somerset SM | Age-related variations in flavonoid intake and sources in the Australian population. | 2006 | Public Health Nutr | pmid:17125569 |
| Chen D et al. | Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells. | 2007 | Front. Biosci. | pmid:17127432 |
| Mak P et al. | Apigenin suppresses cancer cell growth through ERbeta. | 2006 | Neoplasia | pmid:17132221 |
| Watanabe N et al. | The chemopreventive flavonoid apigenin confers radiosensitizing effect in human tumor cells grown as monolayers and spheroids. | 2007 | J. Radiat. Res. | pmid:17132915 |
| Fu Y et al. | Preparative separation of vitexin and isovitexin from pigeonpea extracts with macroporous resins. | 2007 | J Chromatogr A | pmid:17140590 |
| Patel D et al. | Apigenin and cancer chemoprevention: progress, potential and promise (review). | 2007 | Int. J. Oncol. | pmid:17143534 |
| Kanerva A et al. | Chlorpromazine and apigenin reduce adenovirus replication and decrease replication associated toxicity. | 2007 | J Gene Med | pmid:17149790 |
| Chan KF et al. | Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells. | 2006 | J. Med. Chem. | pmid:17154505 |
| Aviel-Ronen S et al. | Large fragment Bst DNA polymerase for whole genome amplification of DNA from formalin-fixed paraffin-embedded tissues. | 2006 | BMC Genomics | pmid:17156491 |
| Kanchanapoom T | Aromatic diglycosides from Cladogynos orientalis. | 2007 | Phytochemistry | pmid:17161443 |
| Jiang JG et al. | Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17164144 |
| Glasl S et al. | Choleretic effects of the Mongolian medicinal plant Saussurea amara in the isolated perfused rat liver. | 2007 | Planta Med. | pmid:17177133 |
| Harnly JM et al. | Flavonoid content of U.S. fruits, vegetables, and nuts. | 2006 | J. Agric. Food Chem. | pmid:17177529 |
| Rigano D et al. | Antibacterial activity of flavonoids and phenylpropanoids from Marrubium globosum ssp. libanoticum. | 2007 | Phytother Res | pmid:17186490 |
| Van Dross RT et al. | Modulation of UVB-induced and basal cyclooxygenase-2 (COX-2) expression by apigenin in mouse keratinocytes: role of USF transcription factors. | 2007 | Mol. Carcinog. | pmid:17186551 |
| Briante R et al. | Antioxidant/prooxidant effects of dietary non-flavonoid phenols on the Cu2+-induced oxidation of human low-density lipoprotein (LDL). | 2004 | Chem. Biodivers. | pmid:17191812 |
| Feng Y et al. | Iridoid glucosides and flavones from the aerial parts of Avicennia marina. | 2006 | Chem. Biodivers. | pmid:17193312 |
| Wong IL et al. | Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania. | 2007 | Antimicrob. Agents Chemother. | pmid:17194831 |
| Ujiki MB et al. | Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest. | 2006 | Mol. Cancer | pmid:17196098 |
| Choi HJ et al. | Vitexin, an HIF-1alpha inhibitor, has anti-metastatic potential in PC12 cells. | 2006 | Mol. Cells | pmid:17202857 |
| Nazaruk J | Flavonoid aglycones and phytosterols from the Erigeron acris L. herb. | 2006 Jul-Aug | Acta Pol Pharm | pmid:17203871 |
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| Shih CH et al. | Quantitative analysis of anticancer 3-deoxyanthocyanidins in infected sorghum seedlings. | 2007 | J. Agric. Food Chem. | pmid:17227050 |
| Chen T et al. | Absorption and excretion of luteolin and apigenin in rats after oral administration of Chrysanthemum morifolium extract. | 2007 | J. Agric. Food Chem. | pmid:17227053 |
| Tan ZH et al. | The protective action of scutellarin against immunological liver injury induced by concanavalin A and its effect on pro-inflammatory cytokines in mice. | 2007 | J. Pharm. Pharmacol. | pmid:17227628 |
| Yue ME et al. | Determination of six bioactive components of Saussurea katochaete by capillary electrophoresis. | 2007 | Biomed. Chromatogr. | pmid:17236245 |
| Zou Y and Chiou GC | Apigenin inhibits laser-induced choroidal neovascularization and regulates endothelial cell function. | 2006 | J Ocul Pharmacol Ther | pmid:17238808 |
| Walle T et al. | Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. | 2007 | Biochem. Pharmacol. | pmid:17250812 |
| Lin LZ et al. | Detection and quantification of glycosylated flavonoid malonates in celery, Chinese celery, and celery seed by LC-DAD-ESI/MS. | 2007 | J. Agric. Food Chem. | pmid:17253711 |
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| Tatemoto H et al. | Inhibition of boar sperm hyaluronidase activity by tannic acid reduces polyspermy during in vitro fertilization of porcine oocytes. | 2006 | Zygote | pmid:17266786 |
| Yamauchi H et al. | Two new glycosides from the whole plants of Glechoma hederacea L. | 2007 | Chem. Pharm. Bull. | pmid:17268115 |
| Yu Y et al. | Validate antibacterial mode and find main bioactive components of traditional Chinese medicine Aquilegia oxysepala. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17276058 |
| Heimler D et al. | Polyphenol content and antioxidative activity in some species of freshly consumed salads. | 2007 | J. Agric. Food Chem. | pmid:17279769 |
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| Ung D and Nagar S | Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1. | 2007 | Drug Metab. Dispos. | pmid:17293380 |
| Liang M et al. | Quantitative LC/MS/MS method and in vivo pharmacokinetic studies of vitexin rhamnoside, a bioactive constituent on cardiovascular system from hawthorn. | 2007 | Biomed. Chromatogr. | pmid:17294503 |
| Lohner K et al. | Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo. | 2007 | Mol Nutr Food Res | pmid:17295420 |
| Jeong YJ et al. | Attenuation of monocyte adhesion and oxidised LDL uptake in luteolin-treated human endothelial cells exposed to oxidised LDL. | 2007 | Br. J. Nutr. | pmid:17313705 |
| Zhu JT et al. | Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death. | 2007 | J. Agric. Food Chem. | pmid:17323972 |
| Lans C et al. | Ethnoveterinary medicines used for ruminants in British Columbia, Canada. | 2007 | J Ethnobiol Ethnomed | pmid:17324258 |
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