apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with apigenin?
Related references are published most in these journals:
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What lipids are associated with apigenin?
Related references are published most in these journals:
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What genes are associated with apigenin?
Related references are published most in these journals:
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zheng YZ et al. | The Substituent Effect on the Radical Scavenging Activity of Apigenin. | 2018 | Molecules | pmid:30103379 |
| Lv SX and Qiao X | Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29355527 |
| Vollmer M et al. | Mutual Interaction of Phenolic Compounds and Microbiota: Metabolism of Complex Phenolic Apigenin-C- and Kaempferol-O-Derivatives by Human Fecal Samples. | 2018 | J. Agric. Food Chem. | pmid:29236499 |
| Zhao Q et al. | Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensis. | 2018 | Mol Plant | pmid:28842248 |
| Park S et al. | Apigenin induces ROS-dependent apoptosis and ER stress in human endometriosis cells. | 2018 | J. Cell. Physiol. | pmid:28617956 |
| Alzoman NZ et al. | CE-DAD Determination of Scutellarein and Caffeic Acid in Abelia triflora Crude Extract. | 2018 | J Chromatogr Sci | pmid:29750262 |
| Jiang J et al. | Vitexin reverses the autophagy dysfunction to attenuate MCAO-induced cerebral ischemic stroke via mTOR/Ulk1 pathway. | 2018 | Biomed. Pharmacother. | pmid:29710456 |
| Pei Y et al. | Combined effect of apigenin and ferulic acid on frozen-thawed boar sperm quality. | 2018 | Anim. Sci. J. | pmid:29708294 |
| Feng Y et al. | Apigenin-7-O-β-d-(-6″-p-coumaroyl)-glucopyranoside pretreatment attenuates myocardial ischemia/reperfusion injury via activating AMPK signaling. | 2018 | Life Sci. | pmid:29705352 |
| Baluchnejadmojarad T et al. | Scutellarin alleviates lipopolysaccharide-induced cognitive deficits in the rat: Insights into underlying mechanisms. | 2018 | Int. Immunopharmacol. | pmid:29190543 |
| Abdel-Salam NA et al. | Flavonoids of Alcea rosea L. and their immune stimulant, antioxidant and cytotoxic activities on hepatocellular carcinoma HepG-2 cell line. | 2018 | Nat. Prod. Res. | pmid:28580799 |
| Kiyekbayeva L et al. | Phytochemical constituents and antioxidant activity of Echinops albicaulis. | 2018 | Nat. Prod. Res. | pmid:28475371 |
| Chang JH et al. | Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses. | 2018 | J. Exp. Clin. Cancer Res. | pmid:30134935 |
| Mirzoeva S et al. | Apigenin Inhibits UVB-Induced Skin Carcinogenesis: The Role of Thrombospondin-1 as an Anti-Inflammatory Factor. | 2018 | Neoplasia | pmid:30118999 |
| You L et al. | Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. | 2017 | Bioorg. Med. Chem. Lett. | pmid:29157862 |
| He X et al. | Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat. | 2017 | Am. J. Chin. Med. | pmid:29121796 |
| Wu W et al. | Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique. | 2017 | Drug Deliv | pmid:29115900 |
| Jin X et al. | Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. | 2017 | Int J Nanomedicine | pmid:28761344 |
| Gu T et al. | Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative. | 2017 | Molecules | pmid:28635646 |
| Nurdiana S et al. | Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin. | 2017 | BMC Complement Altern Med | pmid:28576138 |
| Hicks DF et al. | Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. | 2017 | Sci Rep | pmid:28256512 |
| Yang LL et al. | Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. | 2017 | Biochim Biophys Acta Mol Basis Dis | pmid:27903431 |
| Ferrazzi P et al. | Pollination effects on antioxidant content of Perilla frutescens seeds analysed by NMR spectroscopy. | 2017 | Nat. Prod. Res. | pmid:28278651 |
| Verma S et al. | Natural polyphenolic inhibitors against the antiapoptotic BCL-2. | 2017 | J. Recept. Signal Transduct. Res. | pmid:28264627 |
| Kalivarathan J et al. | Apigenin attenuates hippocampal oxidative events, inflammation and pathological alterations in rats fed high fat, fructose diet. | 2017 | Biomed. Pharmacother. | pmid:28237914 |
| Wang N et al. | Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense. | 2017 | In Vitro Cell. Dev. Biol. Anim. | pmid:28181104 |
| Fan H et al. | Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. | 2017 | Med. Sci. Monit. | pmid:29172017 |
| Gu C et al. | Preparation of Vitexin Nanoparticles by Combining the Antisolvent Precipitation and High Pressure Homogenization Approaches Followed by Lyophilization for Dissolution Rate Enhancement. | 2017 | Molecules | pmid:29165376 |
| Jeong KM et al. | Identification of Major Flavone C-Glycosides and Their Optimized Extraction from Cymbidium kanran Using Deep Eutectic Solvents. | 2017 | Molecules | pmid:29156555 |
| Wu T et al. | Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1). | 2017 | Pharmacol Rep | pmid:29128807 |
| Perez-Leal O et al. | Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. | 2017 | J. Biol. Chem. | pmid:28684421 |
| Hassoun SM et al. | Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. | 2017 | Tumour Biol. | pmid:28651490 |
| Sang Y et al. | Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. | 2017 | Food Funct | pmid:28598487 |
| Malik S et al. | Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28566504 |
| Karim R et al. | Development and evaluation of injectable nanosized drug delivery systems for apigenin. | 2017 | Int J Pharm | pmid:28456651 |
| Soyman Z et al. | Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary. | 2017 | Balkan Med J | pmid:28443590 |
| Chen F et al. | An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. | 2017 | Ultrason Sonochem | pmid:28427633 |
| Lin CM et al. | Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling. | 2017 | Sci Rep | pmid:28337019 |
| Yang N et al. | Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. | 2017 | Mol Med Rep | pmid:28035355 |
| Banerjee K et al. | Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions. | 2017 | J Colloid Interface Sci | pmid:28012918 |
| Ke Y et al. | Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27998773 |
| Li Y et al. | Pharmacokinetic Study of Swertisin by HPLC-MS/MS After Intravenous Administration in Rats. | 2017 | J Chromatogr Sci | pmid:27993862 |
| Lecomte S et al. | Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28396216 |
| Tan YQ et al. | Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells. | 2017 | Mol. Cell. Biochem. | pmid:27778136 |
| Pápay ZE et al. | Controlled Release Oral Delivery of Apigenin Containing Pellets with Antioxidant Activity. | 2017 | Curr Drug Deliv | pmid:27264725 |
| Gutiérrez-Venegas G and González-Rosas Z | Apigenin reduce lipoteichoic acid-induced inflammatory response in rat cardiomyoblast cells. | 2017 | Arch. Pharm. Res. | pmid:27193174 |
| Wang J et al. | Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. | 2017 | Int J Nanomedicine | pmid:29158673 |
| Hassan SM et al. | Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice. | 2017 | Pharm Biol | pmid:28064632 |
| Golea L et al. | Phytochemical components and biological activities of Silene arenarioides Desf. | 2017 | Nat. Prod. Res. | pmid:28278644 |
| Gómez-Zorita S et al. | Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes. | 2017 | J Transl Med | pmid:29162103 |