apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Insulin Resistance D007333 99 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Brain Ischemia D002545 89 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Baruah TJ et al. Vicenin-2: a potential radiosensitizer of non-small cell lung cancer cells. 2018 Mol. Biol. Rep. pmid:30099686
Chen S et al. A UPLC-ESI-MS/MS Method for Simultaneous Quantitation of Chlorogenic Acid, Scutellarin, and Scutellarein in Rat Plasma: Application to a Comparative Pharmacokinetic Study in Sham-Operated and MCAO Rats after Oral Administration of Extract. 2018 Molecules pmid:30037063
Yang M et al. Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway. 2018 Biomed. Pharmacother. pmid:30021365
van Dooren I et al. In vitro gastrointestinal biotransformation and characterization of a Desmodium adscendens decoction: the first step in unravelling its behaviour in the human body. 2018 J. Pharm. Pharmacol. pmid:30003542
Gao AM et al. Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis. 2018 Chem. Biol. Interact. pmid:29191453
Bai HH et al. Hydroxycinnamoylmalated flavone C-glycosides from Lemna japonica. 2018 Fitoterapia pmid:29154864
Park S et al. Apigenin induces ROS-dependent apoptosis and ER stress in human endometriosis cells. 2018 J. Cell. Physiol. pmid:28617956
Malar DS et al. Grewia tiliaefolia and its active compound vitexin regulate the expression of glutamate transporters and protect Neuro-2a cells from glutamate toxicity. 2018 Life Sci. pmid:29704481
Hadrich F and Sayadi S Apigetrin inhibits adipogenesis in 3T3-L1 cells by downregulating PPARγ and CEBP-α. 2018 Lipids Health Dis pmid:29695233
Lu Y et al. Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway. 2018 PLoS ONE pmid:29694408
Gurunathan S et al. Antibacterial Efficacy of Silver Nanoparticles on Endometritis Caused by and in Dairy Cattle. 2018 Int J Mol Sci pmid:29659523
Akogou FU et al. Extraction methods and food uses of a natural red colorant from dye sorghum. 2018 J. Sci. Food Agric. pmid:28600852
Kiyekbayeva L et al. Phytochemical constituents and antioxidant activity of Echinops albicaulis. 2018 Nat. Prod. Res. pmid:28475371
Bougioukas I et al. Apigenin Reduces NF-κB and Subsequent Cytokine Production as Protective Effect in a Rodent Animal Model of Lung Ischemia-Reperfusion Injury. 2018 J Invest Surg pmid:28340319
Palacz-Wrobel M et al. Effect of apigenin, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW-264.7 macrophages. 2017 Biomed. Pharmacother. pmid:28738536
He X et al. Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat. 2017 Am. J. Chin. Med. pmid:29121796
Wu W et al. Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique. 2017 Drug Deliv pmid:29115900
Tu F et al. Angiogenic effects of apigenin on endothelial cells after hypoxia-reoxygenation via the caveolin-1 pathway. 2017 Int. J. Mol. Med. pmid:29039442
Dang Y et al. Protective effects of apigenin against acrylonitrile-induced subchronic sperm injury in rats. 2017 Food Chem. Toxicol. pmid:28963002
Mehmood K et al. In Vitro Effect of Apigenin and Danshen in Tibial Dyschondroplasia Through Inhibition of Heat-Shock Protein 90 and Vascular Endothelial Growth Factor Expressions in Avian Growth Plate Cells. 2017 Avian Dis. pmid:28957003
Agah S et al. Complementary cereals and legumes for health: Synergistic interaction of sorghum flavones and cowpea flavonols against LPS-induced inflammation in colonic myofibroblasts. 2017 Mol Nutr Food Res pmid:28155259
Viacava GE et al. Characterization of phenolic compounds in green and red oak-leaf lettuce cultivars by UHPLC-DAD-ESI-QToF/MS using MS scan mode. 2017 J Mass Spectrom pmid:28833875
Li F et al. Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy. 2017 Oxid Med Cell Longev pmid:28828145
Tan GF et al. AgFNS overexpression increase apigenin and decrease anthocyanins in petioles of transgenic celery. 2017 Plant Sci. pmid:28818381
Pate KM et al. Anthoxanthin Polyphenols Attenuate Aβ Oligomer-induced Neuronal Responses Associated with Alzheimer's Disease. 2017 CNS Neurosci Ther pmid:27864869
Wang M et al. Apigenin Impacts the Growth of the Gut Microbiota and Alters the Gene Expression of Enterococcus. 2017 Molecules pmid:28771188
Chen L et al. Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. 2017 Arch Gerontol Geriatr pmid:28743056
Gao C et al. Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells. 2017 Oncol. Rep. pmid:28737827
Ghazanfar K et al. Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. 2017 J Complement Integr Med pmid:28731312
Jin X et al. Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. 2017 Int J Nanomedicine pmid:28761344
Sun Y et al. Homogenate-assisted Vacuum-powered Bubble Extraction of Moso Bamboo Flavonoids for On-line Scavenging Free Radical Capacity Analysis. 2017 Molecules pmid:28696360
Gu T et al. Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative. 2017 Molecules pmid:28635646
Seo HS et al. Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells. 2017 Oncol. Rep. pmid:28656316
Spilovska K et al. Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation. 2017 Molecules pmid:28621747
Salmani JMM et al. Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives. 2017 Chin J Nat Med pmid:28558867
Elmasri WA et al. Multitargeted Flavonoid Inhibition of the Pathogenic Bacterium Staphylococcus aureus: A Proteomic Characterization. 2017 J. Proteome Res. pmid:28541047
Anusha C et al. Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. 2017 Chem. Biol. Interact. pmid:28389404
Wang N et al. Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense. 2017 In Vitro Cell. Dev. Biol. Anim. pmid:28181104
Telange DR et al. Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential. 2017 Eur J Pharm Sci pmid:27939619
Yao H et al. DPPH·-luminol chemiluminescence system and its application in the determination of scutellarin in pharmaceutical injections and rat plasma with flow injection analysis. 2017 Luminescence pmid:27860193
Molina Prats P et al. The therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis - a pilot study using a Syrian hamster model. 2017 J. Oral Pathol. Med. pmid:27378179
Zhang L et al. Comparative study of the binding of 3 flavonoids to the fat mass and obesity-associated protein by spectroscopy and molecular modeling. 2017 J. Mol. Recognit. pmid:28058739
Bhatt V et al. Simultaneous quantification and identification of flavonoids, lignans, coumarin and amides in leaves of Zanthoxylum armatum using UPLC-DAD-ESI-QTOF-MS/MS. 2017 J Pharm Biomed Anal pmid:27693952
Wu T et al. Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1). 2017 Pharmacol Rep pmid:29128807
Hou L et al. Scutellarin Inhibits Proliferation, Invasion, and Tumorigenicity in Human Breast Cancer Cells by Regulating HIPPO-YAP Signaling Pathway. 2017 Med. Sci. Monit. pmid:29079722
Kulikovskii VF et al. Study of Sedative Tea Phytocomplex within the Framework of Studies Aimed at Creation of a Rectal Dosage Form with Antihistaminic Effect. 2017 Bull. Exp. Biol. Med. pmid:29063320
Mokashi P et al. Swertisin rich fraction from Enicostema littorale ameliorates hyperglycemia and hyperlipidemia in high-fat fed diet and low dose streptozotacin induced type 2 diabetes mellitus in rats. 2017 Biomed. Pharmacother. pmid:29031588
Choi WH et al. Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice. 2017 Mol Nutr Food Res pmid:28971573
Zhao T et al. Novel apigenin-loaded sodium hyaluronate nano-assemblies for targeting tumor cells. 2017 Carbohydr Polym pmid:28962787
Liu Y et al. Effects of apigenin pretreatment against renal ischemia/reperfusion injury via activation of the JAK2/STAT3 pathway. 2017 Biomed. Pharmacother. pmid:28962085
Wu Y et al. Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase. 2017 Neurochem. Int. pmid:28947342
Lee JA et al. Effects of friedelin on the intestinal permeability and bioavailability of apigenin. 2017 Pharmacol Rep pmid:28939344
Sang Y et al. Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. 2017 Food Funct pmid:28598487
Tamayose CI et al. Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema. 2017 Int J Mol Sci pmid:28906474
Malik S et al. Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. 2017 Am. J. Physiol. Renal Physiol. pmid:28566504
Yao HM et al. [Effects of apigenin on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells]. 2017 Zhonghua Xin Xue Guan Bing Za Zhi pmid:28545285
Zhang L et al. Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. 2017 Mol Med Rep pmid:28849116
Fernandes LM et al. Genotoxicity and Antigenotoxicity Assessments of the Flavonoid Vitexin by the Drosophila melanogaster Somatic Mutation and Recombination Test. 2017 J Med Food pmid:28541831
Tu F et al. Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. 2017 Med. Sci. Monit. pmid:28821706
Ninfali P et al. C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review. 2017 Phytother Res pmid:28464411
Liu S and Ho PC Intranasal administration of brain-targeted HP-β-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia. 2017 J. Pharm. Pharmacol. pmid:28809432
Han T et al. Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation. 2017 Eur J Med Chem pmid:28458133
Fallatah O and Georges E Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. 2017 Int. J. Antimicrob. Agents pmid:28807879
Adaszyńska-Skwirzyńska M and Dzięcioł M Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland. 2017 Nat. Prod. Res. pmid:28449600
Mohammad F E et al. Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity. 2017 J. Biochem. Mol. Toxicol. pmid:28422384
Feng X et al. Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. 2017 Biochem. Pharmacol. pmid:28414138
Li G et al. Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. 2017 Biochem. Biophys. Res. Commun. pmid:28408212
Wu W et al. Solubility and dissolution rate improvement of the inclusion complex of apigenin with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation and solvent removal combination methods. 2017 Drug Dev Ind Pharm pmid:28402147
Wan Y et al. miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. 2017 Tumour Biol. pmid:28381178
Singhal SS et al. Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. 2017 Biochim Biophys Acta Rev Cancer pmid:28359741
Zhang Z et al. Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system. 2017 Drug Dev Ind Pharm pmid:28358225
Han Y et al. Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage. 2017 J Clin Neurosci pmid:28342702
Bian M et al. Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation. 2017 Brain Res. pmid:28336272
Crascì L et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. 2017 Planta Med. pmid:28288492
Zhang S et al. Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activation. 2017 Mol. Immunol. pmid:28288411
Lin CM et al. Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling. 2017 Sci Rep pmid:28337019
Pápay ZE et al. Study on the Pulmonary Delivery System of Apigenin-Loaded Albumin Nanocarriers with Antioxidant Activity. 2017 J Aerosol Med Pulm Drug Deliv pmid:28282259
Rašković A et al. Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model. 2017 Eur J Drug Metab Pharmacokinet pmid:28255865
Jangdey MS et al. Development and optimization of apigenin-loaded transfersomal system for skin cancer delivery: in vitro evaluation. 2017 Artif Cells Nanomed Biotechnol pmid:28050929
Ke Y et al. Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. 2017 Biochem. Biophys. Res. Commun. pmid:27998773
Li Y et al. Pharmacokinetic Study of Swertisin by HPLC-MS/MS After Intravenous Administration in Rats. 2017 J Chromatogr Sci pmid:27993862
Wang B and Zhao XH Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells. 2017 Oncol. Rep. pmid:27959417
Bai Y et al. Covalent Immobilization of Human Placental 17β-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications. 2017 Appl. Biochem. Biotechnol. pmid:27933483
Wang F et al. Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression. 2017 Chem. Biol. Interact. pmid:28803762
Gaballah HH et al. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. 2017 Toxicol. Appl. Pharmacol. pmid:28025107
Sheeja Malar D et al. Cholinesterase inhibitory, anti-amyloidogenic and neuroprotective effect of the medicinal plant Grewia tiliaefolia - An in vitro and in silico study. 2017 Pharm Biol pmid:27931177
Ganai SA Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer. 2017 Biomed. Pharmacother. pmid:27930986
Tseng TH et al. Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 expression. 2017 Environ. Toxicol. pmid:26872304
Zou Z et al. Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii. 2017 Fitoterapia pmid:27889540
Zou Z et al. Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii. 2017 Phytochemistry pmid:27889245
Ketkaew Y et al. Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. 2017 Arch. Oral Biol. pmid:27886571
Liu H et al. Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study. 2017 J Chromatogr Sci pmid:27884870
Wu CY et al. Scutellarin Attenuates Microglia-Mediated Neuroinflammation and Promotes Astrogliosis in Cerebral Ischemia - A Therapeutic Consideration. 2017 Curr. Med. Chem. pmid:27855618
Lecomte S et al. Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation. 2017 Toxicol. Appl. Pharmacol. pmid:28396216
Oh HK et al. Swertisin ameliorates pre-pulse inhibition deficits and cognitive impairment induced by MK-801 in mice. 2017 J. Psychopharmacol. (Oxford) pmid:27729563
Guzelmeric E et al. Quality assessment of marketed chamomile tea products by a validated HPTLC method combined with multivariate analysis. 2017 J Pharm Biomed Anal pmid:27693951
Wen L et al. Identification of a flavonoid C-glycoside as potent antioxidant. 2017 Free Radic. Biol. Med. pmid:28587909
Oliveira KG et al. Effect of the storage time and temperature on phenolic compounds of sorghum grain and flour. 2017 Food Chem pmid:27596435
Gutiérrez-Venegas G and González-Rosas Z Apigenin reduce lipoteichoic acid-induced inflammatory response in rat cardiomyoblast cells. 2017 Arch. Pharm. Res. pmid:27193174
Das A et al. Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage. 2017 J. Photochem. Photobiol. B, Biol. pmid:28456117