| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Stroheker T et al. | Steroid activities comparison of natural and food wrap compounds in human breast cancer cell lines. | 2004 | Food Chem. Toxicol. | pmid:15110097 |
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| Gutierrez-Lugo MT et al. | Lipoxygenase inhibition by anadanthoflavone, a new flavonoid from the aerial parts of Anadenanthera colubrina. | 2004 | Planta Med. | pmid:15114507 |
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| Eltayeb AA et al. | Antagonistic effect of scutellarin on the toxicity of selenium in rat livers. | 2004 | Biol Trace Elem Res | pmid:15131321 |
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| Hirano T et al. | Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. | 2004 | Int. Arch. Allergy Immunol. | pmid:15153793 |
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| Sanderson JT et al. | Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. | 2004 | Toxicol. Sci. | pmid:15319488 |
| Chen CC et al. | Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. | 2004 | Mol. Pharmacol. | pmid:15322261 |
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| Mizoyama Y et al. | Inhibitory effect of flavonoids on N-acetylation of 5-aminosalicylic acid in cultured rat hepatocytes. | 2004 | Biol. Pharm. Bull. | pmid:15340238 |
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| pmid:15360311 | ||||
| Matsufuji H and Shibamoto T | Inhibition of malonaldehyde formation in oxidized calf thymus DNA with synthetic and natural antioxidants. | 2004 | J. Agric. Food Chem. | pmid:15373421 |
| Calderone V et al. | Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels. | 2004 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:15378228 |
| Svehliková V et al. | Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert). | 2004 | Phytochemistry | pmid:15381003 |
| Osada M et al. | Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein. | 2004 | FEBS Lett. | pmid:15388333 |
| Campbell EL et al. | The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. | 2004 | Biochem. Pharmacol. | pmid:15451406 |
| Maciel ME et al. | Inhibition of the rat breast cytosolic bioactivation of ethanol to acetaldehyde by some plant polyphenols and folic acid. | 2004 | Nutr Cancer | pmid:15456641 |
| Losi G et al. | Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons. | 2004 | Eur. J. Pharmacol. | pmid:15464088 |
| Gradolatto A et al. | Pharmacokinetics and metabolism of apigenin in female and male rats after a single oral administration. | 2005 | Drug Metab. Dispos. | pmid:15466493 |
| Ko WC et al. | Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. | 2004 | Biochem. Pharmacol. | pmid:15476679 |
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| Morrissey C et al. | Apigenin drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells. | 2005 | Prostate | pmid:15486995 |
| Shenouda NS et al. | Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. | 2004 | Nutr Cancer | pmid:15489213 |
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| Czyz J et al. | Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro. | 2005 | Int. J. Cancer | pmid:15523693 |
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| Ponce MA et al. | Flavonoids from shoots, roots and roots exudates of Brassica alba. | 2004 | Phytochemistry | pmid:15541742 |
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| Yi J et al. | Phytoecdysteroids and glycoceramides from Eriophyton wallchii. | 2004 | Steroids | pmid:15582536 |
| Takagaki N et al. | Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway. | 2005 | Int. J. Oncol. | pmid:15586239 |
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| Wong CH et al. | Blood-testis barrier dynamics are regulated by {alpha}2-macroglobulin via the c-Jun N-terminal protein kinase pathway. | 2005 | Endocrinology | pmid:15618353 |
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| Way TD et al. | Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer cells. | 2005 | FEBS Lett. | pmid:15620704 |
| Hougee S et al. | Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages. | 2005 | Biochem. Pharmacol. | pmid:15627476 |
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| Nayak V and Devi PU | Protection of mouse bone marrow against radiation-induced chromosome damage and stem cell death by the ocimum flavonoids orientin and vicenin. | 2005 | Radiat. Res. | pmid:15658892 |
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| Weldon CB et al. | PKC-mediated survival signaling in breast carcinoma cells: a role for MEK1-AP1 signaling. | 2005 | Int. J. Oncol. | pmid:15703835 |
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