| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Palacz-Wrobel M et al. | Effect of apigenin, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW-264.7 macrophages. | 2017 | Biomed. Pharmacother. | pmid:28738536 |
| Tu F et al. | Angiogenic effects of apigenin on endothelial cells after hypoxia-reoxygenation via the caveolin-1 pathway. | 2017 | Int. J. Mol. Med. | pmid:29039442 |
| Dang Y et al. | Protective effects of apigenin against acrylonitrile-induced subchronic sperm injury in rats. | 2017 | Food Chem. Toxicol. | pmid:28963002 |
| Mehmood K et al. | In Vitro Effect of Apigenin and Danshen in Tibial Dyschondroplasia Through Inhibition of Heat-Shock Protein 90 and Vascular Endothelial Growth Factor Expressions in Avian Growth Plate Cells. | 2017 | Avian Dis. | pmid:28957003 |
| Viacava GE et al. | Characterization of phenolic compounds in green and red oak-leaf lettuce cultivars by UHPLC-DAD-ESI-QToF/MS using MS scan mode. | 2017 | J Mass Spectrom | pmid:28833875 |
| Li F et al. | Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy. | 2017 | Oxid Med Cell Longev | pmid:28828145 |
| Tan GF et al. | AgFNS overexpression increase apigenin and decrease anthocyanins in petioles of transgenic celery. | 2017 | Plant Sci. | pmid:28818381 |
| Wang M et al. | Apigenin Impacts the Growth of the Gut Microbiota and Alters the Gene Expression of Enterococcus. | 2017 | Molecules | pmid:28771188 |
| Chen L et al. | Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. | 2017 | Arch Gerontol Geriatr | pmid:28743056 |
| Gao C et al. | Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells. | 2017 | Oncol. Rep. | pmid:28737827 |
| Ghazanfar K et al. | Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. | 2017 | J Complement Integr Med | pmid:28731312 |
| Anusha C et al. | Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. | 2017 | Chem. Biol. Interact. | pmid:28389404 |
| Telange DR et al. | Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential. | 2017 | Eur J Pharm Sci | pmid:27939619 |
| Yao H et al. | DPPH·-luminol chemiluminescence system and its application in the determination of scutellarin in pharmaceutical injections and rat plasma with flow injection analysis. | 2017 | Luminescence | pmid:27860193 |
| Molina Prats P et al. | The therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis - a pilot study using a Syrian hamster model. | 2017 | J. Oral Pathol. Med. | pmid:27378179 |
| Bhatt V et al. | Simultaneous quantification and identification of flavonoids, lignans, coumarin and amides in leaves of Zanthoxylum armatum using UPLC-DAD-ESI-QTOF-MS/MS. | 2017 | J Pharm Biomed Anal | pmid:27693952 |
| Hou L et al. | Scutellarin Inhibits Proliferation, Invasion, and Tumorigenicity in Human Breast Cancer Cells by Regulating HIPPO-YAP Signaling Pathway. | 2017 | Med. Sci. Monit. | pmid:29079722 |
| Kulikovskii VF et al. | Study of Sedative Tea Phytocomplex within the Framework of Studies Aimed at Creation of a Rectal Dosage Form with Antihistaminic Effect. | 2017 | Bull. Exp. Biol. Med. | pmid:29063320 |
| Mokashi P et al. | Swertisin rich fraction from Enicostema littorale ameliorates hyperglycemia and hyperlipidemia in high-fat fed diet and low dose streptozotacin induced type 2 diabetes mellitus in rats. | 2017 | Biomed. Pharmacother. | pmid:29031588 |
| Choi WH et al. | Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice. | 2017 | Mol Nutr Food Res | pmid:28971573 |
| Zhao T et al. | Novel apigenin-loaded sodium hyaluronate nano-assemblies for targeting tumor cells. | 2017 | Carbohydr Polym | pmid:28962787 |
| Liu Y et al. | Effects of apigenin pretreatment against renal ischemia/reperfusion injury via activation of the JAK2/STAT3 pathway. | 2017 | Biomed. Pharmacother. | pmid:28962085 |
| Wu Y et al. | Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase. | 2017 | Neurochem. Int. | pmid:28947342 |
| Lee JA et al. | Effects of friedelin on the intestinal permeability and bioavailability of apigenin. | 2017 | Pharmacol Rep | pmid:28939344 |
| Tamayose CI et al. | Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema. | 2017 | Int J Mol Sci | pmid:28906474 |
| Yao HM et al. | [Effects of apigenin on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells]. | 2017 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:28545285 |
| Fernandes LM et al. | Genotoxicity and Antigenotoxicity Assessments of the Flavonoid Vitexin by the Drosophila melanogaster Somatic Mutation and Recombination Test. | 2017 | J Med Food | pmid:28541831 |
| Ninfali P et al. | C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review. | 2017 | Phytother Res | pmid:28464411 |
| Han T et al. | Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation. | 2017 | Eur J Med Chem | pmid:28458133 |
| Adaszyńska-Skwirzyńska M and Dzięcioł M | Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland. | 2017 | Nat. Prod. Res. | pmid:28449600 |
| Mohammad F E et al. | Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity. | 2017 | J. Biochem. Mol. Toxicol. | pmid:28422384 |
| Feng X et al. | Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. | 2017 | Biochem. Pharmacol. | pmid:28414138 |
| Li G et al. | Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28408212 |
| Wu W et al. | Solubility and dissolution rate improvement of the inclusion complex of apigenin with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation and solvent removal combination methods. | 2017 | Drug Dev Ind Pharm | pmid:28402147 |
| Wan Y et al. | miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. | 2017 | Tumour Biol. | pmid:28381178 |
| Singhal SS et al. | Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. | 2017 | Biochim Biophys Acta Rev Cancer | pmid:28359741 |
| Rašković A et al. | Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model. | 2017 | Eur J Drug Metab Pharmacokinet | pmid:28255865 |
| Jangdey MS et al. | Development and optimization of apigenin-loaded transfersomal system for skin cancer delivery: in vitro evaluation. | 2017 | Artif Cells Nanomed Biotechnol | pmid:28050929 |
| Wang B and Zhao XH | Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells. | 2017 | Oncol. Rep. | pmid:27959417 |
| Bai Y et al. | Covalent Immobilization of Human Placental 17β-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications. | 2017 | Appl. Biochem. Biotechnol. | pmid:27933483 |
| Gaballah HH et al. | Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28025107 |
| Sheeja Malar D et al. | Cholinesterase inhibitory, anti-amyloidogenic and neuroprotective effect of the medicinal plant Grewia tiliaefolia - An in vitro and in silico study. | 2017 | Pharm Biol | pmid:27931177 |
| Ganai SA | Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer. | 2017 | Biomed. Pharmacother. | pmid:27930986 |
| Tseng TH et al. | Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 expression. | 2017 | Environ. Toxicol. | pmid:26872304 |
| Zou Z et al. | Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii. | 2017 | Fitoterapia | pmid:27889540 |
| Zou Z et al. | Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii. | 2017 | Phytochemistry | pmid:27889245 |
| Oh HK et al. | Swertisin ameliorates pre-pulse inhibition deficits and cognitive impairment induced by MK-801 in mice. | 2017 | J. Psychopharmacol. (Oxford) | pmid:27729563 |
| Guzelmeric E et al. | Quality assessment of marketed chamomile tea products by a validated HPTLC method combined with multivariate analysis. | 2017 | J Pharm Biomed Anal | pmid:27693951 |
| Oliveira KG et al. | Effect of the storage time and temperature on phenolic compounds of sorghum grain and flour. | 2017 | Food Chem | pmid:27596435 |
| Das A et al. | Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:28456117 |