| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cohen MF et al. | Synergistic effect of deoxyanthocyanins from symbiotic fern Azolla spp. on hrmA gene induction in the cyanobacterium Nostoc punctiforme. | 2002 | Mol. Plant Microbe Interact. | pmid:12236594 |
| Engelmann C et al. | Apigenin--strong cytostatic and anti-angiogenic action in vitro contrasted by lack of efficacy in vivo. | 2002 | Phytomedicine | pmid:12403156 |
| Droillard M et al. | Different protein kinase families are activated by osmotic stresses in Arabidopsis thaliana cell suspensions. Involvement of the MAP kinases AtMPK3 and AtMPK6. | 2002 | FEBS Lett. | pmid:12220631 |
| Takahama U et al. | Oxidation of quercetin by salivary components. Quercetin-dependent reduction of salivary nitrite under acidic conditions producing nitric oxide. | 2002 | J. Agric. Food Chem. | pmid:12105964 |
| Modolo LV et al. | Nitric oxide synthase-mediated phytoalexin accumulation in soybean cotyledons in response to the Diaporthe phaseolorum f. sp. meridionalis elicitor. | 2002 | Plant Physiol. | pmid:12427995 |
| Salah AM et al. | Estrogenic and cholinergic properties of the methanol extract of Ruellia praetermissa Sceinf. ex. Lindau (Acanthaceae) in female rats. | 2002 | Phytomedicine | pmid:11924764 |
| Gradolatto A et al. | Could apigenin metabolism explain the estrogenic effect of this flavonoid in the female immature rat? | 2002 | IARC Sci. Publ. | pmid:12484224 |
| Olszanecki R et al. | Flavonoids and nitric oxide synthase. | 2002 | J. Physiol. Pharmacol. | pmid:12512693 |
| Xu YQ et al. | [Recognition of three classes of skullcaps by FTIR spectroscopy combined with artificial neural networks]. | 2002 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12914171 |
| Lee S et al. | Phytochemical constituents from the herba of Artemisia apiacea. | 2002 | Arch. Pharm. Res. | pmid:12135098 |
| Prescott AG et al. | In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana. | 2002 | Phytochemistry | pmid:12126705 |
| Exarchou V et al. | Antioxidant activities and phenolic composition of extracts from Greek oregano, Greek sage, and summer savory. | 2002 | J. Agric. Food Chem. | pmid:12207464 |
| Mastuda H et al. | Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells. | 2002 | Bioorg. Med. Chem. | pmid:12150856 |
| Hien TV et al. | Radioprotective effects of vitexina for breast cancer patients undergoing radiotherapy with cobalt-60. | 2002 | Integr Cancer Ther | pmid:14664747 |
| Lee WR et al. | Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. | 2002 | Biochem. Pharmacol. | pmid:11841797 |
| Ohno S et al. | Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells. | 2002 | J. Steroid Biochem. Mol. Biol. | pmid:11948020 |
| Zou L et al. | Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products. | 2002 | Phytomedicine | pmid:12046870 |
| Myhrstad MC et al. | Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. | 2002 | Free Radic. Biol. Med. | pmid:11864778 |
| Lin CM et al. | Molecular modeling of flavonoids that inhibits xanthine oxidase. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054758 |
| Fiorani M et al. | Intracellular flavonoids as electron donors for extracellular ferricyanide reduction in human erythrocytes. | 2002 | Free Radic. Biol. Med. | pmid:11755318 |
| Rawel HM et al. | Interactions of different phenolic acids and flavonoids with soy proteins. | 2002 | Int. J. Biol. Macromol. | pmid:12063116 |
| Lautraite S et al. | Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. | 2002 | Mutagenesis | pmid:11752233 |
| Frangne N et al. | Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. | 2002 | Plant Physiol. | pmid:11842175 |
| Afaq F et al. | Botanical antioxidants for chemoprevention of photocarcinogenesis. | 2002 | Front. Biosci. | pmid:11897547 |
| Kobayashi T et al. | Effect of flavonoids on cell cycle progression in prostate cancer cells. | 2002 | Cancer Lett. | pmid:11790449 |
| Llorens F et al. | Apigenin and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation. | 2002 | FEBS Lett. | pmid:11801244 |
| McVean M et al. | A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin. | 2002 | Mol. Carcinog. | pmid:11807956 |
| Rozema J et al. | The role of UV-B radiation in aquatic and terrestrial ecosystems--an experimental and functional analysis of the evolution of UV-absorbing compounds. | 2002 | J. Photochem. Photobiol. B, Biol. | pmid:11849977 |
| Breinholt VM et al. | In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids. | 2002 | Food Chem. Toxicol. | pmid:11955666 |
| Ross JA and Kasum CM | Dietary flavonoids: bioavailability, metabolic effects, and safety. | 2002 | Annu. Rev. Nutr. | pmid:12055336 |
| Tsai SC and Seto E | Regulation of histone deacetylase 2 by protein kinase CK2. | 2002 | J. Biol. Chem. | pmid:12082111 |
| Gupta S et al. | Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells. | 2002 | Oncogene | pmid:12032841 |
| Zhu CC et al. | Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation. | 2002 | J. Biol. Chem. | pmid:12023974 |
| Usia T et al. | Constituents of Chinese propolis and their antiproliferative activities. | 2002 | J. Nat. Prod. | pmid:12027739 |
| Patora J and Klimek B | Flavonoids from lemon balm (Melissa officinalis L., Lamiaceae). | 2002 Mar-Apr | Acta Pol Pharm | pmid:12365606 |
| Matławska I and Sikorska M | Flavonoid compounds in the flowers of Abutilon indicum (L.) Sweet (Malvaceae). | 2002 May-Jun | Acta Pol Pharm | pmid:12230251 |
| Ogawa M et al. | Nuclear translocation of Xenopus laevis paxillin. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12727207 |
| Hessenauer A et al. | Inhibition of CK2 activity provokes different responses in hormone-sensitive and hormone-refractory prostate cancer cells. | 2003 | Int. J. Oncol. | pmid:12738992 |
| Wang M et al. | Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.). | 2003 | J. Agric. Food Chem. | pmid:12537429 |
| Schoefer L et al. | Anaerobic degradation of flavonoids by Clostridium orbiscindens. | 2003 | Appl. Environ. Microbiol. | pmid:14532034 |
| Basile A et al. | Effects of seven pure flavonoids from mosses on germination and growth of Tortula muralis HEDW (Bryophyta) and Raphanus sativus L (Magnoliophyta). | 2003 | Phytochemistry | pmid:12591270 |
| Fan CQ and Yue JM | Biologically active phenols from Saussurea medusa. | 2003 | Bioorg. Med. Chem. | pmid:12537999 |
| Boué SM and Raina AK | Effects of plant flavonoids on fecundity, survival, and feeding of the Formosan subterranean termite. | 2003 | J. Chem. Ecol. | pmid:14682534 |
| Takano-Ishikawa Y et al. | Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha. | 2003 | Phytother Res | pmid:14669262 |
| Sánchez-Rabaneda F et al. | Liquid chromatographic/electrospray ionization tandem mass spectrometric study of the phenolic composition of cocoa (Theobroma cacao). | 2003 | J Mass Spectrom | pmid:12526004 |
| Goutman JD et al. | Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors. | 2003 | Eur. J. Pharmacol. | pmid:12586201 |
| Cheng YB et al. | [Study on chemical constituents in rhizome of Smilax perfoliate]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015307 |
| Liu H et al. | Protective effects of scutellarin on superoxide-induced oxidative stress in rat cortical synaptosomes. | 2003 | Acta Pharmacol. Sin. | pmid:14627495 |
| Dhawan K | Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective. | 2003 | Addict Biol | pmid:14690874 |
| Sasaki N et al. | Protective effects of flavonoids on the cytotoxicity of linoleic acid hydroperoxide toward rat pheochromocytoma PC12 cells. | 2003 | Chem. Biol. Interact. | pmid:12606158 |