| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Banerjee K et al. | Probing the potential of apigenin liposomes in enhancing bacterial membrane perturbation and integrity loss. | 2015 | J Colloid Interface Sci | pmid:25965432 |
| Mastantuono T et al. | Effects of Citrus Flavonoids Against Microvascular Damage Induced by Hypoperfusion and Reperfusion in Rat Pial Circulation. | 2015 | Microcirculation | pmid:25944567 |
| Sang ZP et al. | Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. | 2015 | Chem Biol Drug Des | pmid:25941042 |
| Seo HS et al. | Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells. | 2015 | Mol Med Rep | pmid:25936427 |
| Chen YJ et al. | Scutellarin attenuates endothelium-dependent aasodilation impairment induced by hypoxia reoxygenation, through regulating the PKG signaling pathway in rat coronary artery. | 2015 | Chin J Nat Med | pmid:25908623 |
| Paredes-Gonzalez X et al. | Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin. | 2015 | Biopharm Drug Dispos | pmid:25904312 |
| Li Y et al. | Pharmacokinetics and tissue distribution study of Isovitexin in rats by HPLC-MS/MS. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25902051 |
| Wang Q et al. | Inhibition of autophagy ameliorates atherogenic inflammation by augmenting apigenin-induced macrophage apoptosis. | 2015 | Int. Immunopharmacol. | pmid:25899084 |
| Shi T et al. | [Effect of apigenin on protein expressions of PPARs in liver tissues of rats with nonalcoholic steatohepatitis]. | 2015 | Zhonghua Gan Zang Bing Za Zhi | pmid:25880979 |
| Xu C et al. | Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines. | 2015 | Xenobiotica | pmid:25869249 |
| Wei L et al. | Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions. | 2015 | J Sep Sci | pmid:25866087 |
| Zhang G et al. | Effects of germination on the nutritional properties, phenolic profiles, and antioxidant activities of buckwheat. | 2015 | J. Food Sci. | pmid:25858540 |
| Wang Y et al. | Vitexin protects brain against ischemia/reperfusion injury via modulating mitogen-activated protein kinase and apoptosis signaling in mice. | 2015 | Phytomedicine | pmid:25837275 |
| Sang Z et al. | Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease. | 2015 | Eur J Med Chem | pmid:25778991 |
| Del Turco S et al. | Synthetic analogues of flavonoids with improved activity against platelet activation and aggregation as novel prototypes of food supplements. | 2015 | Food Chem | pmid:25577111 |
| Guzelmeric E et al. | Development and validation of an HPTLC method for apigenin 7-O-glucoside in chamomile flowers and its application for fingerprint discrimination of chamomile-like materials. | 2015 | J Pharm Biomed Anal | pmid:25575175 |
| Liu W et al. | Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells. | 2015 | Int. J. Mol. Med. | pmid:25573459 |
| Yu XD et al. | Biological evaluation and molecular docking of baicalin and scutellarin as Helicobacter pylori urease inhibitors. | 2015 | J Ethnopharmacol | pmid:25557028 |
| Yang L et al. | Enhanced action of apigenin and naringenin combination on estrogen receptor activation in non-malignant colonocytes: implications on sorghum-derived phytoestrogens. | 2015 | Food Funct | pmid:25553799 |
| Zhang S et al. | Studies on the interaction of apigenin with calf thymus DNA by spectroscopic methods. | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25459730 |
| Suh YA et al. | Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells. | 2015 | Int. J. Oncol. | pmid:25544427 |
| Russo D et al. | Antioxidant activities and quali-quantitative analysis of different Smallanthus sonchifolius [(Poepp. and Endl.) H. Robinson] landrace extracts. | 2015 | Nat. Prod. Res. | pmid:25533266 |
| Djouossi MG et al. | Antimicrobial and antioxidant flavonoids from the leaves of Oncoba spinosa Forssk. (Salicaceae). | 2015 | BMC Complement Altern Med | pmid:25928352 |
| Heredia-Vieira SC et al. | Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves. | 2015 | J. Nat. Prod. | pmid:25517504 |
| Germanò MP et al. | Anti-angiogenic activity of Entada africana root. | 2015 | Nat. Prod. Res. | pmid:25482106 |
| Saeed M et al. | Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking. | 2015 | J. Nutr. Biochem. | pmid:25459885 |
| Scholz P and Keck CM | Flavonoid nanocrystals produced by ARTcrystal®-technology. | 2015 | Int J Pharm | pmid:25448550 |
| Wang XS et al. | Effects of vitexin on the pharmacokinetics and mRNA expression of CYP isozymes in rats. | 2015 | Phytother Res | pmid:25447838 |
| Singh V et al. | Apigenin manipulates the ubiquitin-proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells. | 2015 | Eur J Nutr | pmid:25408199 |
| Li LH et al. | Apigenin inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells. | 2015 | Int J Clin Exp Pathol | pmid:26722444 |
| Lin CH et al. | Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. | 2015 | BMC Cancer | pmid:26675309 |
| Hasnat MA et al. | Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition. | 2015 | Molecules | pmid:26633318 |
| Lee JA et al. | Resveratrol as a Bioenhancer to Improve Anti-Inflammatory Activities of Apigenin. | 2015 | Nutrients | pmid:26610561 |
| Fang M et al. | Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats. | 2015 | BMC Neurosci | pmid:26608466 |
| Mangoyi R et al. | Isolation and characterization of an antifungal compound 5-hydroxy-7,4'-dimethoxyflavone from Combretum zeyheri. | 2015 | BMC Complement Altern Med | pmid:26573005 |
| Morimoto Y et al. | Apigenin as an anti-quinolone-resistance antibiotic. | 2015 | Int. J. Antimicrob. Agents | pmid:26526895 |
| Seo HS et al. | Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells. | 2015 | Biosci. Rep. | pmid:26500281 |
| Xia F et al. | Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus. | 2015 | Appl. Environ. Microbiol. | pmid:26475103 |
| Kim M et al. | Deglycosylation of isoflavone C-glycosides by newly isolated human intestinal bacteria. | 2015 | J. Sci. Food Agric. | pmid:25199800 |
| Gao R et al. | Simultaneous determination of oleanolic acid, ursolic acid, quercetin and apigenin in Swertia mussotii Franch by capillary zone electrophoresis with running buffer modifier. | 2015 | Biomed. Chromatogr. | pmid:25042239 |
| Lee H et al. | Biosynthesis of Two Flavones, Apigenin and Genkwanin, in Escherichia coli. | 2015 | J. Microbiol. Biotechnol. | pmid:25975614 |
| Banerjee K and Mandal M | Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells. | 2015 | Redox Biol | pmid:25965143 |
| Zeng P et al. | Apigenin Attenuates Atherogenesis through Inducing Macrophage Apoptosis via Inhibition of AKT Ser473 Phosphorylation and Downregulation of Plasminogen Activator Inhibitor-2. | 2015 | Oxid Med Cell Longev | pmid:25960827 |
| del Cerro P et al. | Regulatory nodD1 and nodD2 genes of Rhizobium tropici strain CIAT 899 and their roles in the early stages of molecular signaling and host-legume nodulation. | 2015 | BMC Genomics | pmid:25880529 |
| Long L et al. | Protective effects of scutellarin on type II diabetes mellitus-induced testicular damages related to reactive oxygen species/Bcl-2/Bax and reactive oxygen species/microcirculation/staving pathway in diabetic rat. | 2015 | J Diabetes Res | pmid:25861655 |
| Lin H et al. | A new and practical synthetic method for the synthesis of 6-O-methyl-scutellarein: one metabolite of scutellarin in vivo. | 2015 | Int J Mol Sci | pmid:25854429 |
| Qian S et al. | Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity. | 2015 | Viruses | pmid:25835532 |
| Kang I et al. | Effects of Mung Bean (Vigna radiata L.) Ethanol Extracts Decrease Proinflammatory Cytokine-Induced Lipogenesis in the KK-Ay Diabese Mouse Model. | 2015 | J Med Food | pmid:25826234 |
| Liu L et al. | Effect of luteolin and apigenin on the expression of Oct-4, Sox2, and c-Myc in dental pulp cells with in vitro culture. | 2015 | Biomed Res Int | pmid:25815323 |
| Nakamura K et al. | Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone. | 2015 | Biol. Pharm. Bull. | pmid:25810454 |
| Mrazek AA et al. | Apigenin inhibits pancreatic stellate cell activity in pancreatitis. | 2015 | J. Surg. Res. | pmid:25799526 |
| Liu L et al. | Characterization of the intestinal absorption of seven flavonoids from the flowers of Trollius chinensis using the Caco-2 cell monolayer model. | 2015 | PLoS ONE | pmid:25789809 |
| Ji P et al. | Antiviral activity of Paulownia tomentosa against enterovirus 71 of hand, foot, and mouth disease. | 2015 | Biol. Pharm. Bull. | pmid:25744451 |
| Yamagata K et al. | Dietary polyphenols regulate endothelial function and prevent cardiovascular disease. | 2015 | Nutrition | pmid:25466651 |
| Chen RB et al. | Deep Sequencing Reveals the Effect of MeJA on Scutellarin Biosynthesis in Erigeron breviscapus. | 2015 | PLoS ONE | pmid:26656917 |
| Kim SH et al. | Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells. | 2015 | Anticancer Res. | pmid:26637867 |
| Li H et al. | Separation of vitexin-4″-O-glucoside and vitexin-2″-O-rhamnoside from hawthorn leaves extracts using macroporous resins. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:26562804 |
| Zemanova L et al. | Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment. | 2015 | J. Nat. Prod. | pmid:26529431 |
| Zhang L et al. | Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells. | 2015 | Food Funct | pmid:26292725 |
| Li W et al. | Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4). | 2015 | Biochem. Pharmacol. | pmid:26291395 |
| Lin S et al. | Inhibition of chrysin on xanthine oxidase activity and its inhibition mechanism. | 2015 | Int. J. Biol. Macromol. | pmid:26275460 |
| Farimani MM et al. | Seco-ursane-type Triterpenoids from Salvia urmiensis with Apoptosis-inducing Activity. | 2015 | Planta Med. | pmid:26252828 |
| Lee W et al. | Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo. | 2015 | Can. J. Physiol. Pharmacol. | pmid:26243020 |
| Bao YY et al. | Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo. | 2015 | Oncol. Rep. | pmid:26238658 |
| Long HP et al. | Involvenflavones A-F, six new flavonoids with 3'-aryl substituent from Selaginella involven. | 2015 | Fitoterapia | pmid:26226107 |
| Zhan YY et al. | Inhibitory Effect of Apigenin on Pharmacokinetics of Venlafaxine in vivo and in vitro. | 2015 | Pharmacology | pmid:26202346 |
| Min JW et al. | Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model. | 2015 | Neuropharmacology | pmid:26187393 |
| Palmieri D et al. | Estrogen receptor activation protects against TNF-α-induced endothelial dysfunction. | 2014 | Angiology | pmid:23427281 |
| Mirzoeva S et al. | Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3- and Src-dependent mechanism. | 2014 | Mol. Carcinog. | pmid:23359392 |
| Bai Y et al. | Novel pyrano and vinylphenol adducts of deoxyanthocyanidins in sorghum sourdough. | 2014 | J. Agric. Food Chem. | pmid:25370078 |
| Wang X et al. | Simultaneous determination of three glucuronide conjugates of scutellarein in rat plasma by LC-MS/MS for pharmacokinetic study of breviscapine. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24999248 |
| Lv X et al. | Apigenin inhibits enterovirus 71 replication through suppressing viral IRES activity and modulating cellular JNK pathway. | 2014 | Antiviral Res. | pmid:24971492 |
| Wang J et al. | Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-kB pathway. | 2014 | Inflammation | pmid:24958013 |
| Kim KC et al. | Axl receptor tyrosine kinase is a novel target of apigenin for the inhibition of cell proliferation. | 2014 | Int. J. Mol. Med. | pmid:24926787 |
| Wang E et al. | Protective effects of apigenin against furan-induced toxicity in mice. | 2014 | Food Funct | pmid:24914499 |
| Caruso ÃP et al. | Binding of antioxidant flavone isovitexin to human serum albumin investigated by experimental and computational assays. | 2014 | J Pharm Biomed Anal | pmid:24905290 |
| Li LZ et al. | Flavonoids and other constituents from Aletris spicata and their chemotaxonomic significance. | 2014 | Nat. Prod. Res. | pmid:24896299 |
| Li L et al. | Inhibition of human efflux transporter ABCC2 (MRP2) by self-emulsifying drug delivery system: influences of concentration and combination of excipients. | 2014 | J Pharm Pharm Sci | pmid:25579428 |
| Tong X et al. | Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1. | 2014 | Oncotarget | pmid:25526033 |
| Xu H et al. | Antioxidative activities and active compounds of extracts from Catalpa plant leaves. | 2014 | ScientificWorldJournal | pmid:25431795 |
| Yuan Y et al. | Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia. | 2014 | BMC Neurosci | pmid:25416145 |
| Chelyn JL et al. | Analysis of flavone C-glycosides in the leaves of Clinacanthus nutans (Burm. f.) Lindau by HPTLC and HPLC-UV/DAD. | 2014 | ScientificWorldJournal | pmid:25405231 |
| Lopez-Jornet P et al. | Effects of potassium apigenin and verbena extract on the wound healing process of SKH-1 mouse skin. | 2014 | Int Wound J | pmid:23136845 |
| Choi JS et al. | Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin. | 2014 | Food Chem. Toxicol. | pmid:24291393 |
| Wang JG et al. | Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma. | 2014 | Oncol. Rep. | pmid:24247909 |
| Shen LN et al. | Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes. | 2014 | Int J Pharm | pmid:24269286 |
| Farag MA et al. | Profiling the chemical content of Ficus lyrata extracts via UPLC-PDA-qTOF-MS and chemometrics. | 2014 | Nat. Prod. Res. | pmid:24934244 |
| Chen R et al. | Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal pigment epithelial cells. | 2014 | Mol. Vis. | pmid:24623967 |
| Sharma H et al. | Plant flavone apigenin binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells. | 2014 | PLoS ONE | pmid:24614817 |
| Silva DB et al. | Mass spectrometry of flavonoid vicenin-2, based sunlight barriers in Lychnophora species. | 2014 | Sci Rep | pmid:24603617 |
| Sahreen S et al. | Comprehensive assessment of phenolics and antiradical potential of Rumex hastatus D. Don. roots. | 2014 | BMC Complement Altern Med | pmid:24507200 |
| Moawad A et al. | Two new dihydroamentoflavone glycosides from Cycas revoluta. | 2014 | Nat. Prod. Res. | pmid:24404954 |
| Liu Q et al. | Bioactive diterpenoids and flavonoids from the aerial parts of Scoparia dulcis. | 2014 | J. Nat. Prod. | pmid:24955889 |
| Gouvea DR et al. | Evaluation of intestinal permeability of vicenin-2 and lychnopholic acid from Lychnophora salicifolia (Brazilian arnicão) using Caco-2 cells. | 2014 | J. Nat. Prod. | pmid:24279746 |
| You HS et al. | Influence of the gastrointestinal microflora and efflux transporters on the absorption of scutellarin and scutellarein. | 2014 | Phytother Res | pmid:24504668 |
| Vázquez JA | Modeling of chemical inhibition from amyloid protein aggregation kinetics. | 2014 | BMC Pharmacol Toxicol | pmid:24572069 |
| Lee Y et al. | Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells. | 2014 | Int. J. Oncol. | pmid:24626522 |
| Shukla S et al. | Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer. | 2014 | Apoptosis | pmid:24563225 |
| Harrison ME et al. | Exposure of breast cancer cells to a subcytotoxic dose of apigenin causes growth inhibition, oxidative stress, and hypophosphorylation of Akt. | 2014 | Exp. Mol. Pathol. | pmid:25019465 |
| Pisonero-Vaquero S et al. | Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin. | 2014 | Lab. Invest. | pmid:24492281 |